EA199900512A1 - N-связанные сульфонамиды гетероциклических тиоэфиров - Google Patents
N-связанные сульфонамиды гетероциклических тиоэфировInfo
- Publication number
- EA199900512A1 EA199900512A1 EA199900512A EA199900512A EA199900512A1 EA 199900512 A1 EA199900512 A1 EA 199900512A1 EA 199900512 A EA199900512 A EA 199900512A EA 199900512 A EA199900512 A EA 199900512A EA 199900512 A1 EA199900512 A1 EA 199900512A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- gene
- peptidyl
- immunophilin proteins
- heterocyclic
- tioesters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
Abstract
Данное изобретение относится к нейротрофическим N-связанным сульфонамидам гетероциклических тиоэфиров, небольшим молекулам с низким молекулярным весом, имеющим сродство к иммунофилинам FKBP-типа, и к их применению в качестве ингибиторов ферментной активности, связанной с иммунофилинными белками, в частности ферментной активности пептидилпролилизомеразы или ротамазы.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/775,584 US5874449A (en) | 1996-12-31 | 1996-12-31 | N-linked sulfonamides of heterocyclic thioesters |
PCT/US1997/023526 WO1998029116A1 (en) | 1996-12-31 | 1997-12-22 | N-linked sulfonamides of heterocyclic thioesters |
US08/996,342 US6121273A (en) | 1996-12-31 | 1997-12-22 | N-linked sulfonamides of heterocyclic thioesters |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199900512A1 true EA199900512A1 (ru) | 2000-02-28 |
EA002593B1 EA002593B1 (ru) | 2002-06-27 |
Family
ID=27119069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900512A EA002593B1 (ru) | 1996-12-31 | 1997-12-22 | N-связанные сульфонамиды гетероциклических тиоэфиров |
Country Status (7)
Country | Link |
---|---|
US (3) | US6121273A (ru) |
JP (1) | JP2002515051A (ru) |
EA (1) | EA002593B1 (ru) |
NO (1) | NO992268L (ru) |
NZ (1) | NZ335480A (ru) |
PA (1) | PA8443901A1 (ru) |
PE (1) | PE62099A1 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274602B1 (en) * | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
US20010049381A1 (en) * | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
US5945441A (en) * | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
JP2002516843A (ja) * | 1998-06-03 | 2002-06-11 | ジー・ピー・アイ ニイル ホールディングス インコーポレィティッド | ヘテロサイクリックエステルおよびアミド発毛組成物およびその使用 |
US6429215B1 (en) | 1998-06-03 | 2002-08-06 | Gpi Nil Holdings, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
US7041283B1 (en) | 2001-02-16 | 2006-05-09 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Methods of using immunophilin binding drugs to improve integration and survival of neuronal cell transplants |
WO2004016167A1 (en) * | 2002-08-16 | 2004-02-26 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
EP1433778A1 (en) * | 2002-12-23 | 2004-06-30 | Jerini AG | Use of nitriles as rotamase inhibitors |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4070361A (en) * | 1977-04-21 | 1978-01-24 | E. R. Squibb & Sons, Inc. | Mercaptoalkylsulfonyl proline and pipecolic acid and esters thereof |
US5274097A (en) * | 1988-04-19 | 1993-12-28 | Bayer Aktiengesellschaft | 1,3-disubstituted pyrrolidines |
US5356890A (en) * | 1988-06-15 | 1994-10-18 | Brigham And Women's Hospital | S-nitroso derivatives of ace inhibitors and the use thereof |
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
JP3599287B2 (ja) * | 1993-04-28 | 2004-12-08 | 三菱化学株式会社 | スルホンアミド誘導体 |
AU699483B2 (en) * | 1994-03-07 | 1998-12-03 | Vertex Pharmaceuticals Incorporated | Sulphonamide derivatives as aspartyl protease inhibitors |
US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5717092A (en) * | 1996-03-29 | 1998-02-10 | Vertex Pharmaceuticals Inc. | Compounds with improved multi-drug resistance activity |
-
1997
- 1997-12-22 EA EA199900512A patent/EA002593B1/ru not_active IP Right Cessation
- 1997-12-22 JP JP52083498A patent/JP2002515051A/ja active Pending
- 1997-12-22 US US08/996,342 patent/US6121273A/en not_active Expired - Fee Related
- 1997-12-22 NZ NZ335480A patent/NZ335480A/en unknown
- 1997-12-31 PA PA19978443901A patent/PA8443901A1/es unknown
-
1998
- 1998-03-16 PE PE1998000182A patent/PE62099A1/es not_active Application Discontinuation
-
1999
- 1999-05-10 NO NO992268A patent/NO992268L/no not_active Application Discontinuation
-
2000
- 2000-03-01 US US09/516,239 patent/US6294551B1/en not_active Expired - Fee Related
-
2001
- 2001-08-10 US US09/925,630 patent/US20020049193A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO992268D0 (no) | 1999-05-10 |
US6121273A (en) | 2000-09-19 |
PE62099A1 (es) | 1999-06-17 |
EA002593B1 (ru) | 2002-06-27 |
US20020049193A1 (en) | 2002-04-25 |
US6294551B1 (en) | 2001-09-25 |
NZ335480A (en) | 2001-04-27 |
PA8443901A1 (es) | 2000-05-24 |
JP2002515051A (ja) | 2002-05-21 |
NO992268L (no) | 1999-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |