NO992268L - N-bundne sulfonamider av heterocykliske tioestere - Google Patents

N-bundne sulfonamider av heterocykliske tioestere

Info

Publication number
NO992268L
NO992268L NO992268A NO992268A NO992268L NO 992268 L NO992268 L NO 992268L NO 992268 A NO992268 A NO 992268A NO 992268 A NO992268 A NO 992268A NO 992268 L NO992268 L NO 992268L
Authority
NO
Norway
Prior art keywords
heterocyclic thioesters
linked sulfonamides
enzyme activity
sulfonamides
linked
Prior art date
Application number
NO992268A
Other languages
English (en)
Other versions
NO992268D0 (no
Inventor
Gregory S Hamilton
Jia-He Li
Wei Huang
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/775,584 external-priority patent/US5874449A/en
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of NO992268D0 publication Critical patent/NO992268D0/no
Publication of NO992268L publication Critical patent/NO992268L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Neurotrofiske småmolekylære W-bundne sulfonamider av heterocykliske tioestere med lav molekylvekt, som har en affinitet for immunofiliner w FKBP-type, og deres anven- delse som inhibitorer av enzymaktiviteten forbundet med immunofilinproteiner, spesielt peptidylprolyl-isomerase, dvs. rotamase, enzymaktivitet.
NO992268A 1996-12-31 1999-05-10 N-bundne sulfonamider av heterocykliske tioestere NO992268L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/775,584 US5874449A (en) 1996-12-31 1996-12-31 N-linked sulfonamides of heterocyclic thioesters
PCT/US1997/023526 WO1998029116A1 (en) 1996-12-31 1997-12-22 N-linked sulfonamides of heterocyclic thioesters
US08/996,342 US6121273A (en) 1996-12-31 1997-12-22 N-linked sulfonamides of heterocyclic thioesters

Publications (2)

Publication Number Publication Date
NO992268D0 NO992268D0 (no) 1999-05-10
NO992268L true NO992268L (no) 1999-08-30

Family

ID=27119069

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992268A NO992268L (no) 1996-12-31 1999-05-10 N-bundne sulfonamider av heterocykliske tioestere

Country Status (7)

Country Link
US (3) US6121273A (no)
JP (1) JP2002515051A (no)
EA (1) EA002593B1 (no)
NO (1) NO992268L (no)
NZ (1) NZ335480A (no)
PA (1) PA8443901A1 (no)
PE (1) PE62099A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274602B1 (en) * 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US5945441A (en) * 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US20010049381A1 (en) * 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
CA2334204A1 (en) * 1998-06-03 1999-12-09 Gpi Nil Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US7041283B1 (en) 2001-02-16 2006-05-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods of using immunophilin binding drugs to improve integration and survival of neuronal cell transplants
AU2003259846A1 (en) * 2002-08-16 2004-03-03 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
EP1433778A1 (en) * 2002-12-23 2004-06-30 Jerini AG Use of nitriles as rotamase inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070361A (en) * 1977-04-21 1978-01-24 E. R. Squibb & Sons, Inc. Mercaptoalkylsulfonyl proline and pipecolic acid and esters thereof
US5274097A (en) * 1988-04-19 1993-12-28 Bayer Aktiengesellschaft 1,3-disubstituted pyrrolidines
US5356890A (en) * 1988-06-15 1994-10-18 Brigham And Women's Hospital S-nitroso derivatives of ace inhibitors and the use thereof
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
JP3599287B2 (ja) * 1993-04-28 2004-12-08 三菱化学株式会社 スルホンアミド誘導体
DE69512220T2 (de) * 1994-03-07 2000-03-16 Vertex Pharmaceuticals Inc. Sulfonamidderivate als aspartylprotease-inhibitoren
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5717092A (en) * 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity

Also Published As

Publication number Publication date
EA002593B1 (ru) 2002-06-27
US6294551B1 (en) 2001-09-25
EA199900512A1 (ru) 2000-02-28
US20020049193A1 (en) 2002-04-25
PE62099A1 (es) 1999-06-17
NZ335480A (en) 2001-04-27
NO992268D0 (no) 1999-05-10
PA8443901A1 (es) 2000-05-24
JP2002515051A (ja) 2002-05-21
US6121273A (en) 2000-09-19

Similar Documents

Publication Publication Date Title
NO991433L (no) Heterosykliske estere og amider
MXPA99006120A (es) Sulfonamidas n-enlazadas de tioesteres heterociclicos.
NZ507720A (en) Effecting neuronal activity with heterocyclic thioesters and ketones
NO981903L (no) SmÕ-molekylµre inhibitorer for rotamase enzymaktivitet
SE9604097D0 (sv) Inhibitorer av rotamasenzymaktivitet
ES2131457B1 (es) Pequeños inhibidores de moleculas de la actividad de enzimas de rotamasa.
ATE246510T1 (de) Inhibitoren der aktivität der cyclophilin rotamase
WO1997046207A3 (en) Aromatic heterocyclic derivatives as enzyme inhibitors
WO2007013896A3 (en) Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
ATE293624T1 (de) Nicotinamide benzoanellierte-heterocyclische derivate als selektive inhibitoren der pde4 isoenzyme
DK1175402T3 (da) Piperidinderivater, der er nyttige som CCR5-antagonister
NO20010322L (no) Heterocykliske forbindelser som inhibitorer av rotamaseenzymer
BG103408A (en) N-bound carbamides and carbamates of heterocyclic thioesters
NO992268L (no) N-bundne sulfonamider av heterocykliske tioestere
NO991206D0 (no) Benzamidinderivater substituert med sykliske aminosyre- eller sykliske hydroksysyrederivater, og deres anvendelse som antikoagulanter
DK1060178T3 (da) Heterocyklisk forbindelser som inhibitorer af rotamase enzymer
NO983671L (no) Benzamidinderivater substituert med aminosyre- og hydroksysyrederivater, og deres anvendelse som antikoagulanter
DK1528923T3 (da) N-((3-oxo-2,3-dihydro-1H-isoindol-1-yl)-acetyl)guanidinderivater som NHE1-inhibitorer til behandling af infarkt og angina pectoris
NO992751L (no) N-bundet urinstoffer og karbamater av heterocykliske tioestere
TW200600496A (en) Heterocyclicesters and amides
WO2004058702A3 (en) 4-[(4-(carboxyethyl) piperidinyl) methyl] pyrrolidines as modulators of chemokine receptor activity
TR199801226A2 (xx) Rotamaz enzim etkinliği inhibitörleri.
ECSP982403A (es) Metodo de uso de compuestos neurotropicos de sulfonamidas
ATE179182T1 (de) Arginin ahnliche derivate als enzym-inhibitoren
ECSP982416A (es) Metodo de uso de carbamatos y ureas neurotropicos

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application