PE46599A1 - Metodo de uso de carbamatos y ureas neurotropicos - Google Patents

Metodo de uso de carbamatos y ureas neurotropicos

Info

Publication number
PE46599A1
PE46599A1 PE1998000117A PE00011798A PE46599A1 PE 46599 A1 PE46599 A1 PE 46599A1 PE 1998000117 A PE1998000117 A PE 1998000117A PE 00011798 A PE00011798 A PE 00011798A PE 46599 A1 PE46599 A1 PE 46599A1
Authority
PE
Peru
Prior art keywords
alkyl
alkyll
group
ch2ar
alkynyl
Prior art date
Application number
PE1998000117A
Other languages
English (en)
Inventor
Gregory S Hamilton
Joseph P Steiner
Jia-He Li
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of PE46599A1 publication Critical patent/PE46599A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

METODO PARA EFECTIVIZAR UNA ACTIVIDAD NEURONAL EN UN ANIMAL, QUE CONSISTE: ADMINISTRAR AL ANIMAL UNA CANTIDAD NEUROTROPICAMENTE EFECTIVA DEL COMPUESTO DE FORMULA I, O UNA SAL, DONDE A ES CH2, O, NH, o N-ALQUILO C1-C4, B Y D SON, INDEPENDIENTEMENTE, Ar, H, ALQUILO C1-C6, ALQUENILO O ALQUINILO C3-C6 CON SUSTITUCION DE CICLOALQUILO C5-C7 o Ar; LOS CH2 DE LAS CADENAS DE ALQUILO SON REEMPLAZADOS POR UN HETEROATOMO: O, S, SO, SO2, Y NR, DONDE R PUEDE SER: H, ALQUILO C1-C4, ALQUENILO O ALQUINILO C3-C4, J PUEDE SER: H, ALQUILO C1-C6, ALQUENILO C3-C6 Y -CH2Ar, K PUEDE SER ALQUILO C1-C4, -CH2Ar Y CICLOHEXILMETILO, Z ES O o S, Y ES O o N, CUANDO Y ES O, ENTONCES R1 ES UN PAR SOLITARIO Y R2 PUEDE SER Ar, ALQUILO C1-C6 Y ALQUENILO O ALQUINILO C3-C6, Y CUANDO Y ES N, R1 Y R2 SE SELECCIONAN INDEPENDIENTEMENTE DEL GRUPO DE: Ar, ALQUILO C1-C6, ALQUENILO O ALQUINILO C3-C6 o R1 Y R2 SE TOMAN JUNTOS PARA FORMAR UN ANILLO HETEROCICLICO DE 5 A 6 MIEMBROS SELECCIONADOS DEL GRUPO DE PIRROLIDINA, IMIDAZOLIDINA, PIRAZOLIDINA, PIPERIDINA Y PIPERACINA, R3 Y R4 SE SELECCIONAN INDEPENDIENTEMENTE DEL GRUPO DE ALQUILO C1-C6, ALQUENILO C3-C6, H Y BENCILO o R3 Y R4 PUEDEN TOMARSE JUNTOS PARA FORMAR UN ANILLO HETEROCICLICO DE 5 A 6 MIEMBROS, X PUEDE SER: 4-METOXIFENILO, PIRACILO, QUINOLILO, PIRIMIDINILO, COMPUESTOS DE ISOXAZOILO, PIRIDILO, TIAZOLILO O TIENILO
PE1998000117A 1997-02-27 1998-02-19 Metodo de uso de carbamatos y ureas neurotropicos PE46599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80564697A 1997-02-27 1997-02-27

Publications (1)

Publication Number Publication Date
PE46599A1 true PE46599A1 (es) 1999-05-12

Family

ID=25192108

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000117A PE46599A1 (es) 1997-02-27 1998-02-19 Metodo de uso de carbamatos y ureas neurotropicos

Country Status (9)

Country Link
EP (1) EP1001762A4 (es)
JP (1) JP2001513772A (es)
AR (1) AR011869A1 (es)
AU (1) AU6181698A (es)
CA (1) CA2281096A1 (es)
PA (1) PA8447901A1 (es)
PE (1) PE46599A1 (es)
WO (1) WO1998037882A1 (es)
ZA (1) ZA98825B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218424B1 (en) * 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US6242468B1 (en) * 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
AU756912B2 (en) 1998-07-17 2003-01-23 Agouron Pharmaceuticals, Inc. Compounds, compositions, and methods for stimulating neuronal growth and elongation
US6395758B1 (en) * 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6376517B1 (en) * 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US7338976B1 (en) * 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6323215B1 (en) 1999-07-09 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods
JP2003504367A (ja) 1999-07-09 2003-02-04 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 神経栄養性ピロリジン類およびピペリジン類、並びに関連組成物および方法
WO2001004091A1 (en) 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods
CA2383086A1 (en) * 1999-09-08 2001-03-15 Joseph P. Steiner Non-peptidic cyclophilin binding compounds and their use
GT200000203A (es) 1999-12-01 2002-05-24 Compuestos, composiciones y metodos para estimular el crecimiento y elongacion de neuronas.
EP1339668A2 (en) * 2000-11-28 2003-09-03 Guilford Pharmaceuticals Inc. Bisubstituted carbocyclic cyclophilin binding compounds and theirus
US6656971B2 (en) * 2001-01-25 2003-12-02 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620971A (en) * 1991-05-09 1997-04-15 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5780484A (en) * 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds

Also Published As

Publication number Publication date
AR011869A1 (es) 2000-09-13
CA2281096A1 (en) 1998-09-03
WO1998037882A1 (en) 1998-09-03
EP1001762A1 (en) 2000-05-24
PA8447901A1 (es) 2000-05-24
ZA98825B (en) 1998-10-19
EP1001762A4 (en) 2002-05-08
JP2001513772A (ja) 2001-09-04
AU6181698A (en) 1998-09-18

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