YU36693A - Derivati eritromicina - Google Patents
Derivati eritromicinaInfo
- Publication number
- YU36693A YU36693A YU36693A YU36693A YU36693A YU 36693 A YU36693 A YU 36693A YU 36693 A YU36693 A YU 36693A YU 36693 A YU36693 A YU 36693A YU 36693 A YU36693 A YU 36693A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hydrogen atom
- group
- lower alkyl
- erythromycin derivatives
- atom
- Prior art date
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 241000922351 Anoma Species 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
DERIVATI ERITROMICINA, jedinjenje predstavljeno opštom formulom gde R1 je atom vodonika ili acil grupa, R2 i R3 mogu biti isti ili različiti i svaki je atom vodonika, acil, aciloksi ili amino grupa ili zajedno grade =O ili =NDR10 gde R10 je atom vodonika ili niža alkil grupa, R4 je atom vodonika ili niža alkil grupa i Y predstavlja -NR5R6 ili -N+R7R8R9X-, gde R5, R6, R7, R8 i R9 mogu biti isti ili različiti i svaki je atom vodonika ili niža alkil, alkenil ili alkinil grupa koja može biti supstituisana ili 3-7člana cikloalkil grupa koja može da sadrži atom kiseonika, azota ili sumpora kao heteroatom i X predstavlja anjom, gde R5 i R6 i R7 i R8 mogu da grade azacikloalkil grupu zajedno sa susednim atomom azota, i njihove soli. Ova jedinjenja i njihove soli u znatno manjem stepenu podležu razlaganju pod dejstvom stomačne kiseline od dosada poznatih derivata eritromicina i poseduju izvanredno enterolikinezi stimulišući dejstvo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13382892 | 1992-05-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
YU36693A true YU36693A (sh) | 1996-07-24 |
YU48771B YU48771B (sh) | 1999-12-27 |
Family
ID=15113997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU36693A YU48771B (sh) | 1992-05-26 | 1993-05-25 | Derivati eritromicina |
Country Status (21)
Country | Link |
---|---|
US (1) | US5658888A (sh) |
EP (1) | EP0643068B1 (sh) |
JP (1) | JP3068367B2 (sh) |
KR (1) | KR100226311B1 (sh) |
CN (1) | CN1036199C (sh) |
AT (1) | ATE169927T1 (sh) |
AU (1) | AU659740B2 (sh) |
CA (1) | CA2117883C (sh) |
DE (1) | DE69320476T2 (sh) |
DK (1) | DK0643068T3 (sh) |
ES (1) | ES2120499T3 (sh) |
HK (1) | HK1009969A1 (sh) |
HR (1) | HRP930926B1 (sh) |
IL (1) | IL105810A (sh) |
MY (1) | MY113693A (sh) |
SG (1) | SG52785A1 (sh) |
SI (1) | SI9300281B (sh) |
TW (1) | TW240230B (sh) |
WO (1) | WO1993024509A1 (sh) |
YU (1) | YU48771B (sh) |
ZA (1) | ZA933679B (sh) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007204490A (ja) * | 1995-08-03 | 2007-08-16 | Chugai Pharmaceut Co Ltd | エリスロマイシン誘導体の製造方法 |
ZA966601B (en) * | 1995-08-03 | 1997-02-19 | Chugai Pharmaceutical Co Ltd | Process for producing erythromycin derivatives. |
US6077943A (en) * | 1996-03-01 | 2000-06-20 | Takeda Chemical Industries, Ltd. | Method of producing erythromycin derivative |
AU3634397A (en) * | 1996-07-24 | 1998-02-10 | Chugai Seiyaku Kabushiki Kaisha | Erythromycin derivatives |
US6100239A (en) * | 1996-11-26 | 2000-08-08 | Chugai Seiyaku Kabushiki Kaisha | 13-membered ring macrolide compound, medicine containing the same, and process for producing the same |
US5780605A (en) * | 1997-09-08 | 1998-07-14 | Abbott Laboratories | 6,9-bridged erythromycin derivatives |
CA2399198A1 (en) | 2000-02-18 | 2001-08-23 | Christopher Carreras | Motilide compounds |
AU8257701A (en) | 2000-09-01 | 2002-03-13 | Chugai Pharmaceutical Co Ltd | Process for producing erythromycin derivative |
EP1334726A4 (en) | 2000-10-12 | 2005-12-14 | Chugai Pharmaceutical Co Ltd | ERYTHROMYCIN DERIVATIVE WITH NOVEL CRYSTAL STRUCTURES AND METHOD FOR THE PRODUCTION THEREOF |
DE60206921T2 (de) | 2001-06-13 | 2006-07-20 | Ube Industries, Ltd., Ube | Verfahren zur herstellung von erythromycinverbindungen |
TW200302830A (en) * | 2002-01-11 | 2003-08-16 | Chugai Pharmaceutical Co Ltd | Anhydrate/hydrate of an erythromycin derivative and processes for preparing said anhydrate/hydrate |
EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
US20040010035A1 (en) * | 2002-07-15 | 2004-01-15 | Ciociola Arthur A. | Gastrointestinal compositions |
WO2004006902A1 (en) * | 2002-07-10 | 2004-01-22 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor or matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib |
US6986901B2 (en) * | 2002-07-15 | 2006-01-17 | Warner-Lambert Company Llc | Gastrointestinal compositions |
CN100363359C (zh) * | 2002-08-29 | 2008-01-23 | 菲塞股份有限公司 | 运动内酯化合物 |
US7091196B2 (en) | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
BRPI0408117A (pt) * | 2003-03-05 | 2006-03-01 | Rib X Pharmaceuticals Inc | compostos heterocìclicos bifuncionais e métodos de produção e uso dos mesmos |
ES2338789T3 (es) | 2003-06-18 | 2010-05-12 | Tranzyme Pharma Inc. | Antagonistas macrociclicos del receptor de motilina. |
US20050113319A1 (en) * | 2003-08-26 | 2005-05-26 | Christopher Carreras | 11-Deoxy-6,9-ether erythromycin compounds |
US7407941B2 (en) * | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
US20070149463A1 (en) * | 2003-10-30 | 2007-06-28 | Oyelere Adegboyega K | Bifunctional macrolide heterocyclic compounds and methods of making and using the same |
EP1699808A1 (en) * | 2003-11-18 | 2006-09-13 | Rib-X Pharmaceuticals, Inc. | Bifunctional macrolide heterocyclic compounds and methods of making and using the same |
US7211568B2 (en) * | 2003-12-18 | 2007-05-01 | Kosan Biosciences Incorporated | 9-Desoxoerythromycin compounds as prokinetic agents |
JP5383037B2 (ja) * | 2004-02-27 | 2014-01-08 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | 大環状化合物およびそれらを製造し使用する方法 |
TW200633714A (en) | 2004-12-28 | 2006-10-01 | Chugai Pharmaceutical Co Ltd | Drugs for the treatment and/or prophylaxis of gastroparesis symptom |
US7582611B2 (en) * | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
US8470985B2 (en) | 2005-08-24 | 2013-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
JP5395432B2 (ja) | 2005-08-24 | 2014-01-22 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | トリアゾール化合物ならびにこれを作製する方法および使用する方法 |
CA2632779A1 (en) * | 2005-12-08 | 2007-06-14 | Pfizer Inc. | Method for demethylating the 3'-dimethylamino group of erythromycin compounds |
EP2054429B1 (en) | 2006-09-11 | 2013-11-06 | Tranzyme Pharma, Inc. | Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders |
CN101547931B (zh) | 2006-12-05 | 2012-11-14 | 辉瑞有限公司 | 促动内酯多晶型 |
US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60218321A (ja) * | 1984-04-13 | 1985-11-01 | Satoshi Omura | 消化管収縮運動促進剤 |
JPS6187625A (ja) * | 1984-10-05 | 1986-05-06 | Satoshi Omura | 消化管収縮運動促進剤 |
JPH0759513B2 (ja) * | 1985-08-31 | 1995-06-28 | 北里研究所(社団法人) | 消化管収縮運動促進剤 |
US5008249A (en) * | 1985-08-31 | 1991-04-16 | Kitasato Kenkyusho | Therapeutic method of stimulating digestive tract contractile motion in mammals |
DE3689758T2 (de) * | 1985-08-31 | 1994-08-18 | Kitasato Inst | Erythromycinderivat und Verfahren zu dessen Herstellung. |
EP0623021B1 (en) * | 1992-01-21 | 1998-04-08 | Abbott Laboratories | 4''-deoxyerythromycin derivatives |
-
1993
- 1993-05-19 MY MYPI93000927A patent/MY113693A/en unknown
- 1993-05-24 HR HR930926A patent/HRP930926B1/xx not_active IP Right Cessation
- 1993-05-25 SI SI9300281A patent/SI9300281B/sl not_active IP Right Cessation
- 1993-05-25 IL IL10581093A patent/IL105810A/en not_active IP Right Cessation
- 1993-05-25 TW TW082104109A patent/TW240230B/zh active
- 1993-05-25 YU YU36693A patent/YU48771B/sh unknown
- 1993-05-26 CN CN93106467A patent/CN1036199C/zh not_active Expired - Fee Related
- 1993-05-26 DK DK93910399T patent/DK0643068T3/da active
- 1993-05-26 AU AU40897/93A patent/AU659740B2/en not_active Ceased
- 1993-05-26 SG SG1996009490A patent/SG52785A1/en unknown
- 1993-05-26 US US08/318,814 patent/US5658888A/en not_active Expired - Lifetime
- 1993-05-26 WO PCT/JP1993/000702 patent/WO1993024509A1/ja active IP Right Grant
- 1993-05-26 ES ES93910399T patent/ES2120499T3/es not_active Expired - Lifetime
- 1993-05-26 ZA ZA933679A patent/ZA933679B/xx unknown
- 1993-05-26 AT AT93910399T patent/ATE169927T1/de not_active IP Right Cessation
- 1993-05-26 JP JP5124514A patent/JP3068367B2/ja not_active Expired - Fee Related
- 1993-05-26 DE DE69320476T patent/DE69320476T2/de not_active Expired - Lifetime
- 1993-05-26 KR KR1019940704274A patent/KR100226311B1/ko not_active IP Right Cessation
- 1993-05-26 CA CA002117883A patent/CA2117883C/en not_active Expired - Fee Related
- 1993-05-26 EP EP93910399A patent/EP0643068B1/en not_active Expired - Lifetime
-
1998
- 1998-09-24 HK HK98110895A patent/HK1009969A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU4089793A (en) | 1993-12-30 |
AU659740B2 (en) | 1995-05-25 |
SI9300281B (en) | 2001-02-28 |
TW240230B (sh) | 1995-02-11 |
HRP930926B1 (en) | 2000-10-31 |
JPH0656873A (ja) | 1994-03-01 |
WO1993024509A1 (en) | 1993-12-09 |
CA2117883A1 (en) | 1993-12-09 |
MY113693A (en) | 2002-05-31 |
DK0643068T3 (da) | 1999-02-08 |
KR100226311B1 (ko) | 1999-10-15 |
SG52785A1 (en) | 1998-09-28 |
US5658888A (en) | 1997-08-19 |
ATE169927T1 (de) | 1998-09-15 |
CN1081184A (zh) | 1994-01-26 |
EP0643068A4 (en) | 1995-08-02 |
DE69320476D1 (en) | 1998-09-24 |
SI9300281A (sl) | 1993-12-31 |
ES2120499T3 (es) | 1998-11-01 |
YU48771B (sh) | 1999-12-27 |
DE69320476T2 (de) | 1999-03-25 |
ZA933679B (en) | 1993-12-21 |
KR950701640A (ko) | 1995-04-28 |
EP0643068A1 (en) | 1995-03-15 |
EP0643068B1 (en) | 1998-08-19 |
CN1036199C (zh) | 1997-10-22 |
IL105810A (en) | 1998-12-27 |
JP3068367B2 (ja) | 2000-07-24 |
HK1009969A1 (en) | 1999-09-10 |
CA2117883C (en) | 2003-10-21 |
IL105810A0 (en) | 1993-09-22 |
HRP930926A2 (en) | 1995-02-28 |
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