KR950701640A - 에리트로마이신 유도체(eryhromycin derivative) - Google Patents

에리트로마이신 유도체(eryhromycin derivative)

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Publication number
KR950701640A
KR950701640A KR1019940704274A KR19940704274A KR950701640A KR 950701640 A KR950701640 A KR 950701640A KR 1019940704274 A KR1019940704274 A KR 1019940704274A KR 19940704274 A KR19940704274 A KR 19940704274A KR 950701640 A KR950701640 A KR 950701640A
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KR
South Korea
Prior art keywords
group
hydrogen atom
atom
lower alkyl
alkyl group
Prior art date
Application number
KR1019940704274A
Other languages
English (en)
Other versions
KR100226311B1 (ko
Inventor
히로시 고가
쓰또무 사또
히사노리 다까나시
Original Assignee
나가야마 나오루
쥬우가이세이야구 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 나가야마 나오루, 쥬우가이세이야구 가부시끼가이샤 filed Critical 나가야마 나오루
Publication of KR950701640A publication Critical patent/KR950701640A/ko
Application granted granted Critical
Publication of KR100226311B1 publication Critical patent/KR100226311B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

하기 일반식(Ⅰ)로 나타낸 화합물 및 그의 염으로, 다른 공지의 에리트로마이신 유도체와 비교하여 위액에 의한 분해정보가 현저하게 낮으며, 소화관 운동을 촉진하는 우수한 활성을 가지고 있다.
식중, R1은 수소원자 또는 아실기이고; R2및 R3은 같거나 다르며, 각각 수소원자, 수산기, 아실옥시기 또는 아미노기를 나타내거나 R2와 R3와 함께 결합하여 =O 또는 -NOR10(여기서, R10은 수소원자 또는 저급 알킬기임)을 나타내고; R4은 수소원자 또는 저급 알킬기를 나타내고. 그리고 Y은 -NR5R6또는 -H+R7R8R9X-(여기서 R5,R6,R7,R8및 R9은 같거나 다르며, 각각 수소원자 임의로 치환된 저급 알킬기, 저급 알케닐기, 저급 알키닐기, 또는 시클로알킬기 또는 헤테로원자로서 산소원자, 질소원자 또는 황원자를 포함하는 3내지 7원 헤테로고리기를 나타내는 X는 음이온을 나타낸다. 단 R5및 R6, 또는 R7및 R8은 각각 인접 질소 원자와 함께 결합하여 아자시클로알킬기를 형성할 수도 있다)

Description

에리트로마이신 유도체(ERYHROMYCIN DERIVATIVE)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기 식(Ⅰ)로 표시되는 화합물 및 그의 염:
    [식중, R1은 수소원자 또는 아실기이고; R2및 R3은 같거나 다르며, 각각 수소원자, 수산기, 아실옥시기 또는 아미노기를 나타내거나 조합되어 이들이 =O 또는 -NOR10(여기서, R10은 수소원자 또는 저급 알킬기임)을 나타내고; R4은 수소원자 또는 저급 알킬기를 나타내고. 그리고 Y은 -NR5R6또는 -H+R7R8R9X-(식중 R5,R6,R7,R8및 R9은 같거나 다르며, 각각 수소원자 또는 비치환된 저급 알킬기, 저급 알케닐기, 저급 알키닐기, 시클로알킬기 또는 헤테로원자로서 산소원자, 질소원자 또는 황원자를 포함하는 3내지 7원 헤테로고리기를 나타내는 X는 음이온을 나타내며, 여기서 R5및 R6, 또는 R7및 R8은 각각 인접 질소원자와 함께 아자시클로알킬기를 형성할 수도 있다)을 나타낸다.]
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940704274A 1992-05-26 1993-05-26 에리트로마이신 유도체 KR100226311B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13382892 1992-05-26
JP92-133828 1992-05-26
PCT/JP1993/000702 WO1993024509A1 (en) 1992-05-26 1993-05-26 Erythromycin derivative

Publications (2)

Publication Number Publication Date
KR950701640A true KR950701640A (ko) 1995-04-28
KR100226311B1 KR100226311B1 (ko) 1999-10-15

Family

ID=15113997

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940704274A KR100226311B1 (ko) 1992-05-26 1993-05-26 에리트로마이신 유도체

Country Status (21)

Country Link
US (1) US5658888A (ko)
EP (1) EP0643068B1 (ko)
JP (1) JP3068367B2 (ko)
KR (1) KR100226311B1 (ko)
CN (1) CN1036199C (ko)
AT (1) ATE169927T1 (ko)
AU (1) AU659740B2 (ko)
CA (1) CA2117883C (ko)
DE (1) DE69320476T2 (ko)
DK (1) DK0643068T3 (ko)
ES (1) ES2120499T3 (ko)
HK (1) HK1009969A1 (ko)
HR (1) HRP930926B1 (ko)
IL (1) IL105810A (ko)
MY (1) MY113693A (ko)
SG (1) SG52785A1 (ko)
SI (1) SI9300281B (ko)
TW (1) TW240230B (ko)
WO (1) WO1993024509A1 (ko)
YU (1) YU48771B (ko)
ZA (1) ZA933679B (ko)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007204490A (ja) * 1995-08-03 2007-08-16 Chugai Pharmaceut Co Ltd エリスロマイシン誘導体の製造方法
ZA966601B (en) * 1995-08-03 1997-02-19 Chugai Pharmaceutical Co Ltd Process for producing erythromycin derivatives.
US6077943A (en) * 1996-03-01 2000-06-20 Takeda Chemical Industries, Ltd. Method of producing erythromycin derivative
WO1998003531A1 (fr) * 1996-07-24 1998-01-29 Chugai Seiyaku Kabushiki Kaisha Derives d'erythromycine
AU4968997A (en) * 1996-11-26 1998-06-22 Chugai Seiyaku Kabushiki Kaisha 13-membered ring macrolide compounds, medicine containing the same, and process for producing the same
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
EP1255763A2 (en) 2000-02-18 2002-11-13 Kosan Biosciences, Inc. Motilide compounds
RU2248981C2 (ru) 2000-09-01 2005-03-27 Чугаи Сейяку Кабусики Кайся Способ получения и очистки производных эритромицина
WO2002030943A1 (fr) 2000-10-12 2002-04-18 Chugai Seiyaku Kabushiki Kaisha Derive d'erythromycine possedant des nouvelles structures cristallines et procedes associes de production
DE60206921T2 (de) 2001-06-13 2006-07-20 Ube Industries, Ltd., Ube Verfahren zur herstellung von erythromycinverbindungen
TW200302830A (en) * 2002-01-11 2003-08-16 Chugai Pharmaceutical Co Ltd Anhydrate/hydrate of an erythromycin derivative and processes for preparing said anhydrate/hydrate
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
US20040010035A1 (en) * 2002-07-15 2004-01-15 Ciociola Arthur A. Gastrointestinal compositions
JP2005533101A (ja) * 2002-07-10 2005-11-04 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー アロステリック阻害剤又はマトリックス金属タンパク質分解酵素−１３の、セレコキシブでもバルデコキシブでもないシクロオキシゲナーゼ−２の選択的阻害剤との組合せ物
US6986901B2 (en) * 2002-07-15 2006-01-17 Warner-Lambert Company Llc Gastrointestinal compositions
CA2492846C (en) * 2002-08-29 2012-09-25 Kosan Biosciences, Inc. Motilide compounds
AR043050A1 (es) * 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
CN1780846A (zh) * 2003-03-05 2006-05-31 Rib－X医药品有限公司 双官能杂环化合物及其制备和使用方法
DK1633774T3 (da) * 2003-06-18 2010-05-25 Tranzyme Pharma Inc Makrocykliske motilinreceptorantagonister
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
WO2005042554A1 (en) * 2003-10-30 2005-05-12 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) * 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
CN102816194A (zh) 2004-02-27 2012-12-12 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法
TW200633714A (en) * 2004-12-28 2006-10-01 Chugai Pharmaceutical Co Ltd Drugs for the treatment and/or prophylaxis of gastroparesis symptom
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
WO2007025089A2 (en) 2005-08-24 2007-03-01 Rib-X Pharmaceutical, Inc. Triazole compounds and methods of making and using the same
WO2007025098A2 (en) 2005-08-24 2007-03-01 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
NZ568763A (en) * 2005-12-08 2010-04-30 Pfizer Method for demethylating the 3'-dimethylamino group of erythromycin compounds
CA2662897C (en) 2006-09-11 2017-11-07 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
CA2670482C (en) * 2006-12-05 2011-10-11 Pfizer Inc. Motilide polymorphs
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60218321A (ja) * 1984-04-13 1985-11-01 Satoshi Omura 消化管収縮運動促進剤
JPS6187625A (ja) * 1984-10-05 1986-05-06 Satoshi Omura 消化管収縮運動促進剤
US5008249A (en) * 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
JPH0759513B2 (ja) * 1985-08-31 1995-06-28 北里研究所（社団法人） 消化管収縮運動促進剤
DE3689758T2 (de) * 1985-08-31 1994-08-18 Kitasato Inst Erythromycinderivat und Verfahren zu dessen Herstellung.
MX9300278A (es) * 1992-01-21 1993-12-31 Abbott Lab Compuestos de arilalcoxifenoxi-imidazolina.

Also Published As

Publication number Publication date
CA2117883A1 (en) 1993-12-09
MY113693A (en) 2002-05-31
TW240230B (ko) 1995-02-11
AU659740B2 (en) 1995-05-25
SI9300281A (sl) 1993-12-31
AU4089793A (en) 1993-12-30
SG52785A1 (en) 1998-09-28
KR100226311B1 (ko) 1999-10-15
CN1036199C (zh) 1997-10-22
EP0643068B1 (en) 1998-08-19
DK0643068T3 (da) 1999-02-08
HRP930926B1 (en) 2000-10-31
CA2117883C (en) 2003-10-21
DE69320476T2 (de) 1999-03-25
DE69320476D1 (en) 1998-09-24
IL105810A0 (en) 1993-09-22
CN1081184A (zh) 1994-01-26
JP3068367B2 (ja) 2000-07-24
IL105810A (en) 1998-12-27
YU48771B (sh) 1999-12-27
HK1009969A1 (en) 1999-09-10
EP0643068A1 (en) 1995-03-15
ES2120499T3 (es) 1998-11-01
YU36693A (sh) 1996-07-24
SI9300281B (en) 2001-02-28
JPH0656873A (ja) 1994-03-01
EP0643068A4 (en) 1995-08-02
ZA933679B (en) 1993-12-21
WO1993024509A1 (en) 1993-12-09
HRP930926A2 (en) 1995-02-28
US5658888A (en) 1997-08-19
ATE169927T1 (de) 1998-09-15

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