KR960022498A - 에스큘레틴 유도체, 그의 제조방법 및 약학조성물 - Google Patents

에스큘레틴 유도체, 그의 제조방법 및 약학조성물 Download PDF

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KR960022498A
KR960022498A KR1019950059650A KR19950059650A KR960022498A KR 960022498 A KR960022498 A KR 960022498A KR 1019950059650 A KR1019950059650 A KR 1019950059650A KR 19950059650 A KR19950059650 A KR 19950059650A KR 960022498 A KR960022498 A KR 960022498A
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group
hydrogen atom
formula
alkyl group
compound
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KR1019950059650A
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고주 와따나베
고이찌 니이무라
도루 야마자끼
히로시 마루오까
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가지 히사쯔구
구레하 가가꾸 고교 가부시끼가이샤
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Publication of KR960022498A publication Critical patent/KR960022498A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 하기 일반식(Ⅰ)의 에스큘레틴 유도체 또는 그의 염에 관한 것이다.
상기 식에서, R1및 R2는 각각 독립적으로 -CON(R4)R5, 단당류잔기, 또는 아실화된 단당류잔기이고, R1또는 R2중 하나 이상은 -CON(R4)R5이고; R4및 R5는 각각 독립적으로 수소원자, 수산기 알킬기, 아릴기 또는 아르알킬기이거나, 또는 R4및 R5는 그들이 결합되어 있는 질소원자와 함께 3 내지 7원의 포화지환족 아미노를 형성하고; R3은 -COOR8, 수소원자, 수산기, 알킬기, 아릴기, 또는 아르알킬기이고, R3의 결합위치는 3 또는 4위치이고; R8은 수소원자 또는 알킬기이다.
상기 에스큘레틴 유도체는 매트릭스메탈로프로테이나제 저해활성을 갖는다.

Description

에스큘레틴 유도체, 그의 제조방법 및 약학조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식 (Ⅰ)의 에스큘레틴 유도체 또는 그의 염;
    상기 식에서, R1및 R2는 각각 독립적으로 -CON(R4)R5, 단당류잔기, 또는 아실화된 단당류잔기이고, R1또는 R2중 하나 이상은 -CON(R4)R5이고; R4및 R5는 각각 독립적으로 수소원자, 수산기 알킬기, 아릴기 또는 아르알킬기이거나, 또는 R4및 R5는 그들이 결합되어 있는 질소원자와 함께 3 내지 7원의 포화지환족 아미노를 형성하고; R3은 -COOR8, 수소원자, 수산기, 알킬기, 아릴기, 또는 아르알킬기이고, R3의 결합위치는 3 또는 4위치이고; R8은 수소원자 또는 알킬기이다.
  2. 하기 일반식 (XⅠ)의 화합물, 하기 일반식(Ⅱ)의 화합물, 또는 하기 일반식(Ⅱ')의 화합물과 하기 일반삭 (X)의 화합물을 반응시킴을 특징으로 하는, 제1항에 따른 일반식(Ⅰ)의 에스큘레틴 유도체 또는 그의 염의 제조방법;
    상기 식에서, -COOR8, 수소원자, 수산기, 알킬기, 아릴기, 또는 아르알킬기이고; R8은 수소원자 또는 알킬기이고; R6은 단당류 잔기 또는 아실화된 단당류 잔기이고; X는 할로겐기이고; R4및 R5는 각각 독립적으로 수소원자, 수산기, 알킬기, 아릴기, 또는 아르알킬기이거나, 또는 R4및 R5는 그들이 결합되여 있는 질소원자와 함께 3내지 7원의 포화지환족 아미노기를 형성한다.
  3. 제1항에 따른 일반식(Ⅰ)의 에스큘레틴 유도체 또는 약제학적으로 허용가능한 그의 염을 함유함을 특징으로 하는 약학조성물.
  4. 제3항에 있어서, 매트릭스메탈프로테이나제 저해제인 약학조성물.
  5. 제3항에 있어서, 관절중 치료제인 약학조성물.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019950059650A 1994-12-28 1995-12-27 에스큘레틴 유도체, 그의 제조방법 및 약학조성물 KR960022498A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP94-340016 1994-12-28
JP6340016A JP2902318B2 (ja) 1994-12-28 1994-12-28 エスクレチン誘導体、その製造方法及びマトリックスメタロプロテアーゼ阻害剤

Publications (1)

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KR960022498A true KR960022498A (ko) 1996-07-18

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Country Status (8)

Country Link
US (1) US5731293A (ko)
EP (1) EP0719770B1 (ko)
JP (1) JP2902318B2 (ko)
KR (1) KR960022498A (ko)
CN (1) CN1132755A (ko)
AU (1) AU678737B2 (ko)
CA (1) CA2166168A1 (ko)
DE (1) DE69520870T2 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5897880A (en) * 1995-09-29 1999-04-27 Lam Pharmaceuticals, Llc. Topical drug preparations
GB9609024D0 (en) * 1996-05-01 1996-07-03 Idg Uk Ltd Compounds
WO1998004572A1 (fr) * 1996-07-31 1998-02-05 Kureha Chemical Industry Co., Ltd. Nouveaux derives de coumarine et glycosides, et procedes pour la preparation de ces composes
US6303652B1 (en) * 1998-08-21 2001-10-16 Hughes Institute BTK inhibitors and methods for their identification and use
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
JP2006516252A (ja) * 2002-12-27 2006-06-29 アンジオテック インターナショナル アクツィエン ゲゼルシャフト コラーゲンおよびｍｍｐｉを用いる組成物および方法
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
WO2015107139A1 (en) 2014-01-17 2015-07-23 Proyecto De Biomedicina Cima, S.L. Compounds for use as antifibrinolytic agents
CN106866761B (zh) * 2017-02-13 2019-04-16 天津科技大学 疏花梣中一种香豆素苷的制备工艺
CN113440520A (zh) * 2021-04-12 2021-09-28 桂林医学院 七叶内酯衍生物在制备抗乙型肝炎病毒药物中的应用
CN116589440B (zh) * 2023-07-18 2023-09-19 峰成医药科技(天津)有限公司 一种甲基七叶亭乙酸酯钠的合成方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06312925A (ja) * 1993-03-02 1994-11-08 Kureha Chem Ind Co Ltd 軟骨保護剤及び新規エスクレチン誘導体
DE69423424T2 (de) * 1993-11-15 2006-08-10 Kureha Corp. Esculetinderivate, Verfahren zu deren Herstellung und deren Verwendung als pharmazeutische Zusammensetzungen

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AU678737B2 (en) 1997-06-05
DE69520870T2 (de) 2001-09-06
EP0719770B1 (en) 2001-05-09
JP2902318B2 (ja) 1999-06-07
CA2166168A1 (en) 1996-06-29
EP0719770A1 (en) 1996-07-03
AU4071095A (en) 1996-07-04
CN1132755A (zh) 1996-10-09
DE69520870D1 (de) 2001-06-13
US5731293A (en) 1998-03-24
JPH08183785A (ja) 1996-07-16

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