PE46599A1 - METHOD OF USE OF NEUROTROPIC CARBAMATES AND UREAS - Google Patents

METHOD OF USE OF NEUROTROPIC CARBAMATES AND UREAS

Info

Publication number
PE46599A1
PE46599A1 PE1998000117A PE00011798A PE46599A1 PE 46599 A1 PE46599 A1 PE 46599A1 PE 1998000117 A PE1998000117 A PE 1998000117A PE 00011798 A PE00011798 A PE 00011798A PE 46599 A1 PE46599 A1 PE 46599A1
Authority
PE
Peru
Prior art keywords
alkyl
alkyll
group
ch2ar
alkynyl
Prior art date
Application number
PE1998000117A
Other languages
Spanish (es)
Inventor
Gregory S Hamilton
Joseph P Steiner
Jia-He Li
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of PE46599A1 publication Critical patent/PE46599A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

METODO PARA EFECTIVIZAR UNA ACTIVIDAD NEURONAL EN UN ANIMAL, QUE CONSISTE: ADMINISTRAR AL ANIMAL UNA CANTIDAD NEUROTROPICAMENTE EFECTIVA DEL COMPUESTO DE FORMULA I, O UNA SAL, DONDE A ES CH2, O, NH, o N-ALQUILO C1-C4, B Y D SON, INDEPENDIENTEMENTE, Ar, H, ALQUILO C1-C6, ALQUENILO O ALQUINILO C3-C6 CON SUSTITUCION DE CICLOALQUILO C5-C7 o Ar; LOS CH2 DE LAS CADENAS DE ALQUILO SON REEMPLAZADOS POR UN HETEROATOMO: O, S, SO, SO2, Y NR, DONDE R PUEDE SER: H, ALQUILO C1-C4, ALQUENILO O ALQUINILO C3-C4, J PUEDE SER: H, ALQUILO C1-C6, ALQUENILO C3-C6 Y -CH2Ar, K PUEDE SER ALQUILO C1-C4, -CH2Ar Y CICLOHEXILMETILO, Z ES O o S, Y ES O o N, CUANDO Y ES O, ENTONCES R1 ES UN PAR SOLITARIO Y R2 PUEDE SER Ar, ALQUILO C1-C6 Y ALQUENILO O ALQUINILO C3-C6, Y CUANDO Y ES N, R1 Y R2 SE SELECCIONAN INDEPENDIENTEMENTE DEL GRUPO DE: Ar, ALQUILO C1-C6, ALQUENILO O ALQUINILO C3-C6 o R1 Y R2 SE TOMAN JUNTOS PARA FORMAR UN ANILLO HETEROCICLICO DE 5 A 6 MIEMBROS SELECCIONADOS DEL GRUPO DE PIRROLIDINA, IMIDAZOLIDINA, PIRAZOLIDINA, PIPERIDINA Y PIPERACINA, R3 Y R4 SE SELECCIONAN INDEPENDIENTEMENTE DEL GRUPO DE ALQUILO C1-C6, ALQUENILO C3-C6, H Y BENCILO o R3 Y R4 PUEDEN TOMARSE JUNTOS PARA FORMAR UN ANILLO HETEROCICLICO DE 5 A 6 MIEMBROS, X PUEDE SER: 4-METOXIFENILO, PIRACILO, QUINOLILO, PIRIMIDINILO, COMPUESTOS DE ISOXAZOILO, PIRIDILO, TIAZOLILO O TIENILOMETHOD FOR PERFORMING A NEURONAL ACTIVITY IN AN ANIMAL, WHICH CONSISTS: ADMINISTERING THE ANIMAL A NEUROTROPICALLY EFFECTIVE AMOUNT OF THE COMPOUND OF FORMULA I, OR A SALT, WHERE A IS CH2, O, NH, or N-ALKYL C1-C4, BYD SON, INDEPENDENTLY, Ar, H, C1-C6 ALKYL, C3-C6 ALKYL OR ALKYNYL WITH CYCLOALKYL C5-C7 OR Ar SUBSTITUTION; THE CH2 OF THE ALKYL CHAINS ARE REPLACED BY A HETEROATOM: O, S, SO, SO2, AND NR, WHERE R MAY BE: H, C1-C4 ALKYL, ALKYLL OR C3-C4 ALKYLL, J MAY BE: H, ALKYL C1-C6, ALKYLL C3-C6 AND -CH2Ar, K MAY BE ALKYL C1-C4, -CH2Ar AND CYCLOHEXILMETILO, Z IS O or S, Y IS O or N, WHEN Y IS O, THEN R1 IS A SOLITARY PAIR AND R2 MAY BE Ar, C1-C6 ALKYL AND ALKYNYL OR C3-C6 ALKYLL, AND WHEN Y IS N, R1 AND R2 ARE SELECTED INDEPENDENTLY FROM THE GROUP OF: Ar, C1-C6 ALKYL, OR C3-C6 ALKYLYL OR R1 AND R2 SE TOGETHER TOGETHER TO FORM A HETERO-CYCLIC RING OF 5 TO 6 SELECTED MEMBERS FROM THE GROUP OF PIRROLIDINE, IMIDAZOLIDINE, PIRAZOLIDINE, PIPERIDINE AND PIPERACINE, R3 AND R4 SELECTED FROM THE ALKYL GROUP C1-C6-CYO-C6 R4 MAY BE TAKEN TOGETHER TO FORM A HETERO CYCLIC RING OF 5 TO 6 MEMBERS, X MAY BE: 4-METOXYPHENYL, PIRACIL, QUINOLYL, PYRIMIDINYL, COMPOUNDS OF ISOXAZOIL, PIRIDYL, THIAZOLYL OR THEN ILO

PE1998000117A 1997-02-27 1998-02-19 METHOD OF USE OF NEUROTROPIC CARBAMATES AND UREAS PE46599A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80564697A 1997-02-27 1997-02-27

Publications (1)

Publication Number Publication Date
PE46599A1 true PE46599A1 (en) 1999-05-12

Family

ID=25192108

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000117A PE46599A1 (en) 1997-02-27 1998-02-19 METHOD OF USE OF NEUROTROPIC CARBAMATES AND UREAS

Country Status (9)

Country Link
EP (1) EP1001762A4 (en)
JP (1) JP2001513772A (en)
AR (1) AR011869A1 (en)
AU (1) AU6181698A (en)
CA (1) CA2281096A1 (en)
PA (1) PA8447901A1 (en)
PE (1) PE46599A1 (en)
WO (1) WO1998037882A1 (en)
ZA (1) ZA98825B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218424B1 (en) * 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US6242468B1 (en) * 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
GEP20043368B (en) 1998-07-17 2004-04-13 Agouron Pharma Compounds, Compositions, and Methods For Stimulating Neuronal Growth and Elongation
US6376517B1 (en) * 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US7338976B1 (en) * 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6395758B1 (en) * 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
BR0012327A (en) 1999-07-09 2002-07-02 Ortho Mcneil Pharm Inc Neurotrophic pyrrolidines and piperidines, and related compositions and methods
AU5606400A (en) 1999-07-09 2001-01-30 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods
US6544976B1 (en) 1999-07-09 2003-04-08 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods
EP1214293A1 (en) * 1999-09-08 2002-06-19 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
GT200000203A (en) 1999-12-01 2002-05-24 COMPOUNDS, COMPOSITIONS AND METHODS TO STIMULATE THE GROWTH AND ELONGATION OF NEURONS.
JP2004523490A (en) * 2000-11-28 2004-08-05 ギルフォード ファーマシュウティカルズ インコーポレイテッド Disubstituted carbocyclic cyclophilin binding compounds and their uses
US6656971B2 (en) * 2001-01-25 2003-12-02 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620971A (en) * 1991-05-09 1997-04-15 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5780484A (en) * 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds

Also Published As

Publication number Publication date
EP1001762A1 (en) 2000-05-24
CA2281096A1 (en) 1998-09-03
ZA98825B (en) 1998-10-19
EP1001762A4 (en) 2002-05-08
WO1998037882A1 (en) 1998-09-03
AU6181698A (en) 1998-09-18
AR011869A1 (en) 2000-09-13
JP2001513772A (en) 2001-09-04
PA8447901A1 (en) 2000-05-24

Similar Documents

Publication Publication Date Title
PE46599A1 (en) METHOD OF USE OF NEUROTROPIC CARBAMATES AND UREAS
DE3876211D1 (en) BENZOTHIADIAZOLES AND THEIR USE IN METHODS AND AGENTS AGAINST PLANT DISEASES.
ATE203234T1 (en) META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINOBENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS
EA200100487A1 (en) DERIVATIVES OF 2-AMINOTHIAZOLE, METHOD FOR THEIR RECOVERY AND USE OF THE SPECIFIED SUBSTANCES AS ANTIFE-CHEMICAL AGENTS
CO5590957A2 (en) AMINO-1,3,5-TRIAZINES REPLACED IN N WITH CHIRAL BICYCLE RADICALS, PROCEDURE FOR PREPARATION, COMPOSITIONS OF THE SAME AND ITS USE AS HERBICIDES AND REGULATORS OF GROWTH OF PLANTS
NZ334186A (en) Neurotrophic heterocyclic esters and amides with an affinity to FKBP-type immunophilins
PE46899A1 (en) N-PHENYL-SULFONAMIDE DERIVATIVES
ES2125372T3 (en) PIPERAZINE DERIVATIVES USEFUL AS CALMODULIN INHIBITORS.
ATE90107T1 (en) PEPTIDES WITH COLLAGENASE INHIBITING ACTIVITIES.
NZ512864A (en) Triazole compounds with dopamine-D3-receptor affinity
ES2053508T3 (en) COMPOUNDS OF 3-PIRROLIDINYL-THIO-1-AZABICICLO (3.2.0) HEPT-2-ENO-2-CARBOXILICOS.
PT92153A (en) PROCESS FOR THE PREPARATION OF 1,4-DIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MX165512B (en) CARBAMATE ADDITIVE FOR LUBRICATING COMPOSITION
NO915068L (en) PROCEDURE FOR THE PREPARATION OF NEW AMINO AND NITRO-containing TRICYCLIC COMPOUNDS
MX9207603A (en) DERIVATIVES OF ISOXAZOLCARBOXILIC ACIDS AND PROCEDURE FOR THEIR OBTAINING.
HUP0203275A2 (en) 1-cyclic amino-alkylcyclohexane compounds, pharmaceutical compositions thereof, and their use as anticonvulsants
PE58099A1 (en) UREAS AND CARBAMATES LINKED IN N OF HETERO CYCLIC ESTERS
KR910000133A (en) Amine
ES2057415T3 (en) BICYCLE DERIVATIVES.
BG60248B1 (en) METHOD FOR THE PREPARATION OF PHENOXYETHYLAMINE DERIVATIVES
GB1117036A (en) Plant growth regulants
ES8306752A1 (en) Pharmaceutically active compounds.
SE8302345D0 (en) PLEUROMUTILIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS
NO20022290L (en) Aryloxypropanolamines for improving livestock breeding
GB902082A (en) Baths for the production of electrolytic copper coatings

Legal Events

Date Code Title Description
FC Refusal