PA8447901A1 - METHOD OF USE OF NEUROTROPIC CARBAMATES AND UREAS - Google Patents

METHOD OF USE OF NEUROTROPIC CARBAMATES AND UREAS

Info

Publication number
PA8447901A1
PA8447901A1 PA19988447901A PA8447901A PA8447901A1 PA 8447901 A1 PA8447901 A1 PA 8447901A1 PA 19988447901 A PA19988447901 A PA 19988447901A PA 8447901 A PA8447901 A PA 8447901A PA 8447901 A1 PA8447901 A1 PA 8447901A1
Authority
PA
Panama
Prior art keywords
ureas
carbamates
neurotropic
immunifilines
peptidil
Prior art date
Application number
PA19988447901A
Other languages
Spanish (es)
Inventor
Jia-He Li
Gregory Hamilton
Joseph P Steiner
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of PA8447901A1 publication Critical patent/PA8447901A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

ESTA INVENCIÓN ESTA RELACIONADA CON UN MÉTODO DE USO DE CARBAMATOS Y UREAS DE BAJO PESO MOLECULAR Y DE MOLECULA PEQUEÑA, QUE TIENEN AFINIDAD CON LAS INMUNIFILINAS TIPO FKBP, COMO INHIBIDORES DE LA ACTIVIDAD ENZIMATICA ASOCIADA CON LAS PROTEINAS DE INMUNIFILINA, PARTICULARMENTE LA ACTIVIDAD ENZIMATICA DE LA PEPTIDIL-PROLIL ISOMERASA, O ROTAMASA.THIS INVENTION IS RELATED TO A METHOD OF USE OF LOW MOLECULAR WEIGHTS AND CARBAMATES AND UREAS, WHICH HAVE AFFINITY WITH THE FKBP TYPE IMMUNIFILINES, INHIBITORS OF THE ENZYMATIC ACTIVITY ASSOCIATED WITH THE PROTEIN ACTIVITY PEPTIDIL-PROLIL ISOMERASE, OR ROTAMASE.

PA19988447901A 1997-02-27 1998-02-26 METHOD OF USE OF NEUROTROPIC CARBAMATES AND UREAS PA8447901A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80564697A 1997-02-27 1997-02-27

Publications (1)

Publication Number Publication Date
PA8447901A1 true PA8447901A1 (en) 2000-05-24

Family

ID=25192108

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19988447901A PA8447901A1 (en) 1997-02-27 1998-02-26 METHOD OF USE OF NEUROTROPIC CARBAMATES AND UREAS

Country Status (9)

Country Link
EP (1) EP1001762A4 (en)
JP (1) JP2001513772A (en)
AR (1) AR011869A1 (en)
AU (1) AU6181698A (en)
CA (1) CA2281096A1 (en)
PA (1) PA8447901A1 (en)
PE (1) PE46599A1 (en)
WO (1) WO1998037882A1 (en)
ZA (1) ZA98825B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218424B1 (en) * 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US6242468B1 (en) * 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
PL345598A1 (en) 1998-07-17 2001-12-17 Agouron Pharma Compounds, compositions, and methods for stimulating neuronal growth and elongation
US6395758B1 (en) * 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US7338976B1 (en) * 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6376517B1 (en) * 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
WO2001004091A1 (en) 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods
WO2001004090A2 (en) * 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods
HUP0202249A3 (en) 1999-07-09 2003-01-28 Ortho Mcneil Pharm Inc Neurotrophic pyrrolidines and piperidines, compositions containing them and use of the compounds
EP1214293A1 (en) * 1999-09-08 2002-06-19 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
GT200000203A (en) 1999-12-01 2002-05-24 COMPOUNDS, COMPOSITIONS AND METHODS TO STIMULATE THE GROWTH AND ELONGATION OF NEURONS.
MXPA03004821A (en) * 2000-11-28 2004-03-26 Guilford Pharm Inc Bisubstituted carbocyclic cyclophilin binding compounds and theirus.
JP2004532187A (en) * 2001-01-25 2004-10-21 ギルフォード ファーマシュウティカルズ インコーポレイテッド Trisubstituted carbocyclic cyclophilin binding compounds and their uses
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620971A (en) * 1991-05-09 1997-04-15 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5780484A (en) * 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds

Also Published As

Publication number Publication date
AR011869A1 (en) 2000-09-13
PE46599A1 (en) 1999-05-12
JP2001513772A (en) 2001-09-04
EP1001762A4 (en) 2002-05-08
EP1001762A1 (en) 2000-05-24
AU6181698A (en) 1998-09-18
WO1998037882A1 (en) 1998-09-03
ZA98825B (en) 1998-10-19
CA2281096A1 (en) 1998-09-03

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