ES2079242T3 - Prcedimiento para preparar flunixina y sus productos intermedios. - Google Patents

Prcedimiento para preparar flunixina y sus productos intermedios.

Info

Publication number
ES2079242T3
ES2079242T3 ES93901398T ES93901398T ES2079242T3 ES 2079242 T3 ES2079242 T3 ES 2079242T3 ES 93901398 T ES93901398 T ES 93901398T ES 93901398 T ES93901398 T ES 93901398T ES 2079242 T3 ES2079242 T3 ES 2079242T3
Authority
ES
Spain
Prior art keywords
give
mta
acid
hydrolysing
cpd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93901398T
Other languages
English (en)
Inventor
Henry J Rectory Slopes Doran
Donald J Kingston Aven Coveney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2079242T3 publication Critical patent/ES2079242T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
    • C07C211/47—Toluidines; Homologues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN PROCESOS PARA PREPARAR UN PRODUCTO INTERMEDIO ESENCIAL, 2-METILO-3-TRIFLUOROMETILANILINA (MTA), ASI COMO NUEVOS PRODUCTOS INTERMEDIOS DE ELLOS.
ES93901398T 1991-12-20 1992-12-16 Prcedimiento para preparar flunixina y sus productos intermedios. Expired - Lifetime ES2079242T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81218391A 1991-12-20 1991-12-20

Publications (1)

Publication Number Publication Date
ES2079242T3 true ES2079242T3 (es) 1996-01-01

Family

ID=25208786

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93901398T Expired - Lifetime ES2079242T3 (es) 1991-12-20 1992-12-16 Prcedimiento para preparar flunixina y sus productos intermedios.

Country Status (20)

Country Link
US (2) US5484931A (es)
EP (1) EP0619809B1 (es)
JP (2) JP2535135B2 (es)
KR (1) KR100206629B1 (es)
AT (1) ATE129701T1 (es)
AU (1) AU659530B2 (es)
BG (1) BG62137B1 (es)
CA (1) CA2126210C (es)
CZ (2) CZ289634B6 (es)
DE (1) DE69205842T2 (es)
DK (1) DK0619809T3 (es)
ES (1) ES2079242T3 (es)
GR (1) GR3018476T3 (es)
HK (1) HK185796A (es)
HU (2) HU213473B (es)
NZ (1) NZ246433A (es)
PL (1) PL175962B1 (es)
RU (1) RU2081105C1 (es)
SK (1) SK280074B6 (es)
WO (1) WO1993013070A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2081105C1 (ru) * 1991-12-20 1997-06-10 Шеринг Корпорейшн Способы получения 2-метил-3-трифторметиланилина, производные трифторметилпиваланилида и способ их получения
JP2698306B2 (ja) * 1993-01-18 1998-01-19 セントラル硝子株式会社 ２−メチル−３−アミノベンゾトリフロライドの製造方法
FR2787445B1 (fr) * 1998-12-17 2001-01-19 Rhone Poulenc Agrochimie Procede de preparation de para-trifluoromethylanilines polyhalogenees
EP1903040A4 (en) 2005-07-05 2010-08-04 Banyu Pharma Co Ltd PROCESS FOR PRODUCING 4 (3H) -QUINAZOLINONE DERIVATIVE
EP2229149B1 (en) * 2007-12-14 2012-03-07 Intervet International B.V. Process for recovering flunixin from pharmaceutical compositions
US20110062039A1 (en) * 2009-09-16 2011-03-17 Prokop Marigale A Cord Management System for Appliances
CN102442944B (zh) * 2011-12-14 2014-01-01 齐鲁动物保健品有限公司 一种氟尼辛的制备方法
CN103570558A (zh) * 2013-11-11 2014-02-12 湖北中牧安达药业有限公司 一种2-甲基-3-三氟甲基苯胺的合成方法
CN104193674B (zh) * 2014-08-27 2016-05-25 济南久隆医药科技有限公司 一种氟尼辛葡甲胺的合成方法
CN107260664A (zh) * 2017-07-28 2017-10-20 吉林省力畜达动物药业有限公司 一种复方氟尼辛葡甲胺注射液及其制备方法
CN108586327B (zh) * 2018-04-25 2020-07-14 济南久隆医药科技有限公司 一种氟尼辛的合成方法
CN108911989B (zh) * 2018-08-15 2020-11-03 济南悟通生物科技有限公司 一种2-甲基-3-三氟甲基苯胺的合成方法
CN109206365B (zh) * 2018-09-13 2019-11-26 龙岩台迈三略制药有限公司 一种氟尼辛葡甲胺的制备方法
CN112394130B (zh) * 2020-12-02 2021-11-02 济南悟通生物科技有限公司 2-甲基-3-三氟甲基苯胺合成工艺中杂质的分析方法
CN113372264A (zh) * 2021-06-16 2021-09-10 宁夏常晟药业有限公司 一种2-[2-甲基-3-(三氟甲基)苯氨基]烟酸的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL123536C (es) * 1963-07-09
US3390172A (en) * 1964-03-27 1968-06-25 Parke Davis & Co Nu-(3-trifluoromethylphenyl)-anthranilic acids
US3337570A (en) * 1965-10-23 1967-08-22 Schering Corp Substituted nicotinic acids and method for the manufacture thereof
CH501624A (de) * 1965-10-23 1971-01-15 Scherico Ltd Verfahren zur Herstellung substituierter Nikotinsäuren
US3839344A (en) * 1973-03-28 1974-10-01 Schering Corp N-methyl d-glucamine salt of 2(2'-methyl-3'-trifluoromethylanilino)nicotinic acid
US3891761A (en) * 1973-03-28 1975-06-24 Schering Corp N-Methyl-d-glucamine salt of 2(2-methyl-3{40 -trifluoro-methylanilino) nicotinic acid in the treatment of pain
US4081451A (en) * 1975-03-20 1978-03-28 Schering Corporation Process for preparing 2-halogeno nicotinic acids
US4172095A (en) * 1977-06-10 1979-10-23 Schering Corporation Novel synthesis of 3-amino-2-methylbenzotrifluoride and the intermediates thereof
US4132737A (en) * 1978-02-27 1979-01-02 Eli Lilly And Company Trifluoromethyl substituted 1-aminoindanes
US4302599A (en) * 1979-09-10 1981-11-24 Schering Corporation Process for nitrating anilides
DE3014122A1 (de) * 1980-04-12 1981-10-15 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n,n-dimethyl-n' -(2-brom-4-methyl-phenyl)-triazen
JPS5813194A (ja) * 1981-07-15 1983-01-25 Fujitsu Denso Ltd ファン停止検出回路
EP0225175A3 (en) * 1985-11-28 1988-12-28 FISONS plc Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof
DE3726891A1 (de) * 1986-08-13 1988-02-18 Central Glass Co Ltd Neue dichlortrifluormethylnitrotoluole und deren umwandlung in aminotrifluormethyltoluole
US4831193A (en) * 1987-06-19 1989-05-16 Schering Corporation Synthesis of 3-amino-2-methylbenzotrifluoride
RU2081105C1 (ru) * 1991-12-20 1997-06-10 Шеринг Корпорейшн Способы получения 2-метил-3-трифторметиланилина, производные трифторметилпиваланилида и способ их получения
US5248781A (en) * 1992-09-21 1993-09-28 The Trustees Of Princeton University Preparation of substituted anilino-nicotinic acid derivatives

Also Published As

Publication number Publication date
SK68794A3 (en) 1995-02-08
AU659530B2 (en) 1995-05-18
CA2126210A1 (en) 1993-06-24
CZ138394A3 (en) 1995-03-15
HUT67575A (en) 1995-04-28
JP2535135B2 (ja) 1996-09-18
GR3018476T3 (en) 1996-03-31
CZ289831B6 (cs) 2002-04-17
DE69205842D1 (de) 1995-12-07
HU217545B (hu) 2000-02-28
NZ246433A (en) 1995-10-26
DK0619809T3 (da) 1995-12-04
JPH06511256A (ja) 1994-12-15
US5965735A (en) 1999-10-12
CZ289634B6 (cs) 2002-03-13
JP2679963B2 (ja) 1997-11-19
HU9401839D0 (en) 1994-09-28
AU3275793A (en) 1993-07-28
PL175962B1 (pl) 1999-03-31
JPH08104675A (ja) 1996-04-23
HU9700853D0 (en) 1997-06-30
US5484931A (en) 1996-01-16
EP0619809A1 (en) 1994-10-19
RU94035759A (ru) 1996-05-10
BG62137B1 (bg) 1999-03-31
WO1993013070A1 (en) 1993-07-08
DE69205842T2 (de) 1996-04-04
KR100206629B1 (ko) 1999-07-01
ATE129701T1 (de) 1995-11-15
HK185796A (en) 1996-10-11
HU213473B (en) 1997-06-30
RU2081105C1 (ru) 1997-06-10
SK280074B6 (sk) 1999-07-12
BG98817A (bg) 1995-03-31
CA2126210C (en) 1997-12-09
EP0619809B1 (en) 1995-11-02

Similar Documents

Publication Publication Date Title
ES2079242T3 (es) Prcedimiento para preparar flunixina y sus productos intermedios.
ES2039522T3 (es) Procedimiento para preparar un nuevo benzotiazol.
NO2006007I1 (no) (+)-(S)-2-(3-benzoylfenyl)-propionsyre-trometaminsalt(deksketoprofentrometamol)
UY23197A1 (es) Procedimiento para la preparacion de derivados del acido acetico
HU9302530D0 (en) Herbicidal pyridinesulphonamide compounds
ATE157080T1 (de) Ethanolaminderivate mit anti-pollakiurawirkung
NO965259L (no) Fremgangsmåte for fremstilling av <alfa>-metoksykarboksylsyre-metylamider og mellomprodukter som anvendes i fremgangsmåten
NO305755B1 (no) Nye aryloksymetyloksazoliner og farmas°ytiske preparater inneholdende dem
DE59507521D1 (de) Milde, wässrige, tensidische Zubereitungen für kosmetische Zwecke und Reinigungsmittel
MX9205385A (es) Perhidro-1-h-pirido(1,2-a)piracinas 2-sustituidas neurolepticas.
DK0620857T3 (da) Syntese af homochirale 2-hydroxysyrer
ES2098294T3 (es) Procedimiento para la preparacion de acidos acilaminometano-fosfonicos.
ES2097602T3 (es) Procedimiento perfeccionado para la elaboracion de ciclopropilnitrilo.
ES2121293T3 (es) Uso de trovafloxacina o derivados de la misma para la fabricacion de un medicamento para el tratamiento de infecciones por h. pylori.
DK1282619T3 (da) Fremgangsmåde til fremstilling af thiazolidindionderivater og mellemprodukter
DK0677513T3 (da) Octahydro-2-naphthalencarboxylsyrederivat, dets fremstilling og anvendelse
ES2173860T3 (es) Procedimiento de preparacion de derivados de derivados de aminoantraquinona.
WO2000056736A3 (en) Use of non-nucleoside reverse transcriptase inhibitor (mni) for the treatment of hiv infection
PT100098A (pt) Novos sais do acido 2-(2,6-dicloroanilino)-fenilacetico, processo para a sua preparacao e sua utilizacao em composicoes farmaceuticas para aplicacao topica
DK0622372T3 (da) Hidtil ukendt forbindelse, Leustroducsin H, dens fremstilling og dens terapeutiske anvendelse
DK0533132T3 (da) Fremgangsmåde til oxidation af hydroxymethylpyridinderivater til pyridincarboxylsyrederivater
FR2664597B1 (fr) Procede de preparation de sulfonylpristinamycine iib.
GB1303256A (es)
DK1405843T3 (da) Fremgangsmåde til fremstilling af aminostilbenderivater
ES2128972B1 (es) Proceso para producir el acido (+)2-(4-(2-oxociclopentilmetil)fenil) propionico y sus sales

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 619809

Country of ref document: ES