ES2039522T3 - Procedimiento para preparar un nuevo benzotiazol. - Google Patents

Procedimiento para preparar un nuevo benzotiazol.

Info

Publication number
ES2039522T3
ES2039522T3 ES198888112722T ES88112722T ES2039522T3 ES 2039522 T3 ES2039522 T3 ES 2039522T3 ES 198888112722 T ES198888112722 T ES 198888112722T ES 88112722 T ES88112722 T ES 88112722T ES 2039522 T3 ES2039522 T3 ES 2039522T3
Authority
ES
Spain
Prior art keywords
benzotiazole
prepare
procedure
new
benzothiazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888112722T
Other languages
English (en)
Inventor
Atsushi Imamura
Noriyuki Hori
Tadayuki Saito
Noriyasu Nishimura
Masami Ohashi
Kohichiro Yoshino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Application granted granted Critical
Publication of ES2039522T3 publication Critical patent/ES2039522T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

UN BENZOTIAZOLE DE LA FORMULA SIGUIENTE (I) EN EL QUE R REPRESENTA UN GRUPO METIL, METOXI, CARBOXIL O METOCARBONIL. EL COMPONENTE ES UTIL PARA TRATAR ARTRITIS REUMATICA.
ES198888112722T 1987-08-07 1988-08-04 Procedimiento para preparar un nuevo benzotiazol. Expired - Lifetime ES2039522T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62198669A JPH0670025B2 (ja) 1987-08-07 1987-08-07 ベンゾチアゾ−ル誘導体および該化合物を有効成分とする抗リウマチ剤

Publications (1)

Publication Number Publication Date
ES2039522T3 true ES2039522T3 (es) 1993-10-01

Family

ID=16395075

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888112722T Expired - Lifetime ES2039522T3 (es) 1987-08-07 1988-08-04 Procedimiento para preparar un nuevo benzotiazol.

Country Status (8)

Country Link
US (1) US4910211A (es)
EP (1) EP0306708B1 (es)
JP (1) JPH0670025B2 (es)
KR (1) KR930009790B1 (es)
AT (1) ATE71372T1 (es)
DE (1) DE3867572D1 (es)
ES (1) ES2039522T3 (es)
GR (1) GR3004018T3 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428052A (en) * 1984-09-19 1995-06-27 Centre Internationale De Recherches Dermatologiques (C.I.R.D.) Aromatic heterocyclic derivatives and their therapeutic and cosmetic use
US5260295A (en) * 1984-09-19 1993-11-09 Centre International De Recherches Dermatologiques (C.I.R.D.) Aromatic heterocyclic derivatives and their therapeutic and cosmetic use
ATE159760T1 (de) * 1988-07-08 1997-11-15 Jbl Scient Inc Herstellung und verwendung von fluoreszierenden benzothiazolderivaten
US5254692A (en) * 1990-04-06 1993-10-19 Bayer Aktiengesellschaft 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US6372770B1 (en) 1994-10-12 2002-04-16 Euro-Celtique, S.A. Benzoxazoles
US5665737B1 (en) * 1994-10-12 1999-02-16 Euro Celtique Sa Substituted benzoxazoles
SK45497A3 (en) * 1994-10-12 1997-10-08 Euro Celtique Sa Benzoxazoles, pharmaceutical composition containing them and their use
WO1996018399A1 (en) * 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryl thioxanthines
AU4527996A (en) * 1994-12-13 1996-07-03 Euro-Celtique S.A. Trisubstituted thioxanthines
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US6013659A (en) * 1998-09-04 2000-01-11 University Of Pittsburgh Methods of reducing tumor colony number using novel benzothiazole compounds
WO2002051821A1 (en) * 2000-12-22 2002-07-04 Astrazeneca Ab Therapeutic compounds
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
EP1478631A1 (en) * 2001-11-28 2004-11-24 AstraZeneca AB Therapeutic compounds
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
AU2003208525B9 (en) * 2002-02-04 2009-08-27 Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda Amend the invention title to read Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
EP1487843A4 (en) 2002-03-20 2010-03-10 Metabolex Inc SUBSTITUTED PHENYLACETIC ACIDS
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US7199259B2 (en) 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
EP1675459A1 (en) * 2003-08-04 2006-07-05 Hemocorm Limited Use of boranocarbonates for the therapeutic delivery of carbon monoxide
CA2567437A1 (en) * 2004-05-25 2005-12-08 Metabolex, Inc. Substituted triazoles as modulators of ppar and methods of their preparation
JP2008500358A (ja) * 2004-05-25 2008-01-10 メタボレックス インコーポレーティッド Ｐｐａｒのモジュレーターとしての、二環式の置換されたトリアゾール、およびこれらの調製方法
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US7714131B2 (en) 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
WO2007073226A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda Method for treating a mammal by administration of a compound having the ability to release co
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
EP2699242B1 (en) 2011-04-19 2017-11-01 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
EP2734235B1 (en) 2011-07-21 2017-03-22 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof
WO2020142865A1 (zh) * 2019-01-07 2020-07-16 江苏凯迪恩医药科技有限公司 一种苯甲酰胺类化合物、中间体、制备方法及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2035757A1 (en) * 1969-02-25 1970-12-24 Roussel Uclaf Novel 4-carboxy-4,5,6,7-tetrahydro benzothia- - zole derivs
US3816443A (en) * 1972-02-17 1974-06-11 Merck & Co Inc 4-(benzothiazol-2-yl)fluoro phenyl-acetic acids
US3895028A (en) * 1972-09-12 1975-07-15 Tokyo Tanabe Co Alpha-(2-phenylbenzothiazol-5-yl)propionic acid
JPS59121704A (ja) * 1982-12-28 1984-07-13 三菱電線工業株式会社 耐水トリ−性電気絶縁性組成物

Also Published As

Publication number Publication date
GR3004018T3 (es) 1993-03-31
EP0306708A1 (en) 1989-03-15
EP0306708B1 (en) 1992-01-08
KR890003720A (ko) 1989-04-17
JPH0670025B2 (ja) 1994-09-07
DE3867572D1 (de) 1992-02-20
KR930009790B1 (ko) 1993-10-11
JPS6442476A (en) 1989-02-14
US4910211A (en) 1990-03-20
ATE71372T1 (de) 1992-01-15

Similar Documents

Publication Publication Date Title
ES2039522T3 (es) Procedimiento para preparar un nuevo benzotiazol.
ES2070660B1 (es) Un procedimiento para la preparacion de 2,5-damino-3-hidroxihexanos sustituidos, utiles como inhibidores de proteasas retrovirales.
DE69018908D1 (de) N-aryl und N-Heteroarylamide und Harnstoffderivate als Inhibitoren von Acyl-Coenzym A: Cholesterol-Acyl-Transferase.
PT1022274E (pt) Intermediarios para a preparacao de derivados de oxazolidinodiona e de tiazolidinodiona
NO914092L (no) Nye mercaptoacetylamid-derivater som er anvendbare som inhibitorer for enkefalinase og ace
NO941278L (no) Sykliske ureaer og analoger som er anvendbare som retrovirale proteaseinhibitorer
ATE6422T1 (de) 3-aryloxy-3-phenylpropylamine.
DK633088D0 (da) Hidtil ukendte forbindelser
NO934792L (no) Xantinderivater
ATE110725T1 (de) Organische salze von physostigminderivaten.
FI895046A0 (fi) 4-amino-3-acylkinolinderivat samt deras anvaendning saosom inhibitorer av sekretion av matsmaeltningsvaetskor.
SE8802412D0 (sv) Thiourea derivatives
ES2116313T3 (es) Composicion y metodo para inhibir las incrustaciones y la corrosion usando acidos naftilamino-policarboxilicos.
DE69126758D1 (de) Benzamid-Derivate
ES2099820T3 (es) Procedimiento para la preparacion de trans-piperidina-2,5-dicarboxilatos.
ES522418A0 (es) Un procedimiento para preparar -15-desoxiespergualina.
DE68923320D1 (de) Derivate von Aminsäuren.
ES2055128T3 (es) Procedimiento para la preparacion de diarilsulfuros o de diarilseleniuros.
DE3765030D1 (de) Substituierte isoquinolinderivate und antiulcusmittel.
DK0775692T3 (da) Guanidinomethylcyclohexancarboxylsyreesterderivater
MX9205408A (es) Metodo para tratar hipertension.
ATE145395T1 (de) 5-amino-2-phenoxysulfonanilid-derivate
ATE60048T1 (de) Aminoverbindungen und diese enthaltende fungizide.
DK656889D0 (da) Hidtil ukendte forbindelser
ES2056332T3 (es) (quinolin-2-il-metoxi)fenil-tioureas substituidas.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 306708

Country of ref document: ES