ES2003863B3 - Nueva preparacion farmaceutica con liberacion controlada de metoprolol, metodo para su fabricacion y uso de la nueva preparacion. - Google Patents
Nueva preparacion farmaceutica con liberacion controlada de metoprolol, metodo para su fabricacion y uso de la nueva preparacion.Info
- Publication number
- ES2003863B3 ES2003863B3 ES86850330T ES86850330T ES2003863B3 ES 2003863 B3 ES2003863 B3 ES 2003863B3 ES 86850330 T ES86850330 T ES 86850330T ES 86850330 T ES86850330 T ES 86850330T ES 2003863 B3 ES2003863 B3 ES 2003863B3
- Authority
- ES
- Spain
- Prior art keywords
- new
- preparation
- metoprolol
- controlled release
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PREPARACION DE LIBERACION CONTROLADA CONTIENE UN NUMERO DE GRANULOS DE SAL DE METOPROLOL COMO PRINCIPAL COMPONENTE SOLUBLE, UN METODO PARA LA PRODUCCION DEL MISMO Y SU USO EN EL TRATAMIENTO DE TRASTORNOS CARDIOVASCULARES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8504721A SE455836B (sv) | 1985-10-11 | 1985-10-11 | Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2003863A4 ES2003863A4 (es) | 1988-12-01 |
ES2003863B3 true ES2003863B3 (es) | 1992-01-16 |
Family
ID=20361706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES86850330T Expired - Lifetime ES2003863B3 (es) | 1985-10-11 | 1986-10-02 | Nueva preparacion farmaceutica con liberacion controlada de metoprolol, metodo para su fabricacion y uso de la nueva preparacion. |
Country Status (33)
Country | Link |
---|---|
US (1) | US4957745A (es) |
EP (1) | EP0220143B1 (es) |
JP (1) | JPH0759506B2 (es) |
KR (1) | KR940000100B1 (es) |
CN (1) | CN1023293C (es) |
AT (1) | ATE65391T1 (es) |
AU (1) | AU588630B2 (es) |
CY (1) | CY1616A (es) |
DD (1) | DD259789A5 (es) |
DE (2) | DE220143T1 (es) |
DK (1) | DK165939C (es) |
DZ (1) | DZ994A1 (es) |
ES (1) | ES2003863B3 (es) |
FI (1) | FI88579C (es) |
GB (1) | GB2181348B (es) |
GR (2) | GR890300059T1 (es) |
HK (1) | HK101791A (es) |
HU (1) | HU197839B (es) |
IE (1) | IE59053B1 (es) |
IS (1) | IS1529B (es) |
LT (2) | LT3951B (es) |
LV (3) | LV10913B (es) |
NO (1) | NO172276C (es) |
NZ (1) | NZ217696A (es) |
PH (1) | PH22277A (es) |
PL (1) | PL261802A1 (es) |
PT (1) | PT83509B (es) |
RU (1) | RU2072840C1 (es) |
SE (1) | SE455836B (es) |
SG (1) | SG95291G (es) |
SU (1) | SU1760969A3 (es) |
UA (2) | UA26211A (es) |
ZA (1) | ZA869860B (es) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8703881D0 (sv) * | 1987-10-08 | 1987-10-08 | Haessle Ab | New pharmaceutical preparation |
US4892739A (en) * | 1988-04-25 | 1990-01-09 | Ciba-Geigy Corporation | Osmotic continuous dispensing oral delivery system containing a pharmaceutically acceptable active agent having a improved core membrane adhesion properties |
US5268182A (en) * | 1988-06-24 | 1993-12-07 | Abbott Laboratories | Sustained-release drug dosage units of terazosin |
US5612059A (en) * | 1988-08-30 | 1997-03-18 | Pfizer Inc. | Use of asymmetric membranes in delivery devices |
US5084287A (en) * | 1990-03-15 | 1992-01-28 | Warner-Lambert Company | Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat |
CA2087435C (en) * | 1990-08-07 | 1998-05-05 | Scott Max Herbig | Use of interfacially-polymerized membranes in delivery devices |
EP0677291A3 (en) * | 1991-03-18 | 1996-08-07 | Sepracor Inc | Composition and method containing optically pure S-metoprolol. |
ES2073301T3 (es) * | 1991-05-20 | 1995-08-01 | Marion Laboratories Inc | Composicion multi-capa de liberacion controlada. |
IT1252185B (it) * | 1991-12-11 | 1995-06-05 | Therapicon Srl | Preparazioni farmaceutiche a liberazione programmata |
US7740881B1 (en) | 1993-07-01 | 2010-06-22 | Purdue Pharma Lp | Method of treating humans with opioid formulations having extended controlled release |
US5399358A (en) * | 1993-11-12 | 1995-03-21 | Edward Mendell Co., Inc. | Sustained release formulations for 24 hour release of metroprolol |
US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
SE9702338D0 (sv) * | 1997-06-18 | 1997-06-18 | Astra Ab | An analytical method and industrial process including the same |
SE9802537D0 (sv) * | 1998-07-13 | 1998-07-13 | Astra Ab | Method for controlling a coating process |
CA2346001C (en) * | 1998-10-01 | 2003-12-30 | Elan Pharma International, Limited | Controlled release nanoparticulate compositions |
US8293277B2 (en) | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
DE19848651C1 (de) * | 1998-10-22 | 2000-01-27 | Porsche Ag | Tülle für ein Kabelbündel |
US7459283B2 (en) | 2002-02-04 | 2008-12-02 | Elan Pharma International Limited | Nanoparticulate compositions having lysozyme as a surface stabilizer |
AU764469B2 (en) | 1999-01-29 | 2003-08-21 | Disphar International B.V. | Pharmaceutical compositions |
FR2802424B1 (fr) * | 1999-12-17 | 2002-02-15 | Adir | Comprime matriciel permettant la liberation prolongee de trimetazidine apres administration par voie orale |
US7198795B2 (en) | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
GB0025208D0 (en) | 2000-10-13 | 2000-11-29 | Euro Celtique Sa | Delayed release pharmaceutical formulations |
SE0100200D0 (sv) * | 2001-01-24 | 2001-01-24 | Astrazeneca Ab | New film coating |
US6610326B2 (en) * | 2001-02-16 | 2003-08-26 | Andrx Corporation | Divalproex sodium tablets |
US20040105886A1 (en) * | 2001-02-16 | 2004-06-03 | Chih-Ming Chen | Divalproex sodium tablets |
SE0100824D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method III to obtain microparticles |
US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
DE60202662T2 (de) * | 2001-12-19 | 2006-01-05 | Astrazeneca Ab | NEUE FILMBESCHICHTUNG enthaltend ein Äthylacrylate/Methylmethacrylate-copolymer und Polyvinylacetat |
MXPA04009701A (es) * | 2002-04-05 | 2005-05-27 | Penwest Pharmaceuticals Co | Formulaciones de metoprolol de liberacion sostenida. |
SE0201110D0 (sv) * | 2002-04-12 | 2002-04-12 | Astrazeneca Ab | New film coating |
US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
US7217300B2 (en) | 2003-06-27 | 2007-05-15 | Delphi Technologies, Inc. | Method and apparatus for gasketing a fuel cell |
US7314640B2 (en) * | 2003-07-11 | 2008-01-01 | Mongkol Sriwongjanya | Formulation and process for drug loaded cores |
US20050032879A1 (en) * | 2003-08-07 | 2005-02-10 | Temple Okarter | Formulations and use of a beta-blocker and an ACE-inhibitor for the treatment of cardiovascular diseases |
US20060003001A1 (en) * | 2004-02-11 | 2006-01-05 | John Devane | Chronotherapeutic compositions and methods of their use |
US20060105044A1 (en) | 2004-05-20 | 2006-05-18 | Singh Bramah N | Sustained release formulations of sotalol |
US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
NZ728442A (en) | 2004-10-21 | 2018-05-25 | Adare Pharmaceuticals Inc | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US8920837B2 (en) | 2005-07-01 | 2014-12-30 | Rubicon Research Private Limited | Sustained release dosage form |
US20070009589A1 (en) * | 2005-07-07 | 2007-01-11 | Kandarapu Raghupathi | Extended release compositions |
WO2007010501A2 (en) * | 2005-07-22 | 2007-01-25 | Ranbaxy Laboratories Limited | A pharmaceutical composition comprising a combination of beta blocker and an ace inhibitor |
US20070053983A1 (en) * | 2005-09-06 | 2007-03-08 | Girish Jain | Extended release compositions of metoprolol succinate |
US20070092573A1 (en) * | 2005-10-24 | 2007-04-26 | Laxminarayan Joshi | Stabilized extended release pharmaceutical compositions comprising a beta-adrenoreceptor antagonist |
DE102005060393A1 (de) | 2005-12-16 | 2007-06-21 | Add Advanced Drug Delivery Technologies Ltd. | Orales Präparat mit kontrollierter Freisetzung |
US8691272B2 (en) * | 2005-12-30 | 2014-04-08 | Intelgenx Corp. | Multilayer tablet |
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US20090068260A1 (en) * | 2006-02-24 | 2009-03-12 | Tomer Gold | Beta-1-selective adrenoceptor blocking agent compositions and methods for their preparation |
WO2008012346A1 (en) * | 2006-07-28 | 2008-01-31 | Farmaprojects, S. A. | Extended release pharmaceutical formulation of metoprolol and process for its preparation |
US20080107726A1 (en) * | 2006-11-01 | 2008-05-08 | Pramod Kharwade | Compositions comprising beta-adrenergic receptor antagonists and diuretics |
US20080187579A1 (en) * | 2007-02-01 | 2008-08-07 | Pavan Bhat | Extended-release dosage form |
EP2120881B1 (en) * | 2007-02-23 | 2019-08-07 | Glatt Air Techniques, Inc. | Method of determining the weight of the coating to be applied to form a controlled release dosage form |
PL2255791T3 (pl) * | 2009-04-03 | 2012-05-31 | Zakl Farmaceutyczne Polpharma Sa | Kompozycja farmaceutyczna o przedłużonym uwalnianiu zawierająca bursztynian metoprololu |
MX2012006240A (es) | 2009-12-02 | 2012-10-03 | Aptalis Pharma Ltd | Microcapsulas de fexofenadina y composiciones que contienen las mismas. |
US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
CN102670539A (zh) * | 2011-03-14 | 2012-09-19 | 北京天衡药物研究院 | 琥珀酸美托洛尔渗透泵控释片 |
BR112015018895A2 (pt) | 2013-02-13 | 2017-07-18 | Evonik Roehm Gmbh | composição farmacêutica multiparticulada compreendendo uma multiplicidade de dois tipos de pelotas |
US9849093B2 (en) * | 2013-03-15 | 2017-12-26 | Cape Spear Pharmaceuticals, Ltd. | Compositions and methods for administration to subjects with dysphagia |
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AU1873783A (en) * | 1982-10-08 | 1984-04-12 | Verex Laboratories Inc. | Constant release formulation |
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SE457505B (sv) * | 1984-01-10 | 1989-01-09 | Lejus Medical Ab | Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning |
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-
1985
- 1985-10-11 SE SE8504721A patent/SE455836B/sv not_active IP Right Cessation
-
1986
- 1986-09-09 ZA ZA869860A patent/ZA869860B/xx unknown
- 1986-09-18 IE IE249286A patent/IE59053B1/en not_active IP Right Cessation
- 1986-09-25 GB GB8623048A patent/GB2181348B/en not_active Expired
- 1986-09-25 PH PH34289A patent/PH22277A/en unknown
- 1986-09-26 AU AU63171/86A patent/AU588630B2/en not_active Expired
- 1986-09-26 NZ NZ217696A patent/NZ217696A/xx unknown
- 1986-10-02 EP EP86850330A patent/EP0220143B1/en not_active Expired - Lifetime
- 1986-10-02 DE DE198686850330T patent/DE220143T1/de active Pending
- 1986-10-02 AT AT86850330T patent/ATE65391T1/de not_active IP Right Cessation
- 1986-10-02 ES ES86850330T patent/ES2003863B3/es not_active Expired - Lifetime
- 1986-10-02 DE DE8686850330T patent/DE3680450D1/de not_active Expired - Lifetime
- 1986-10-07 DK DK478186A patent/DK165939C/da not_active IP Right Cessation
- 1986-10-07 NO NO863997A patent/NO172276C/no unknown
- 1986-10-08 DZ DZ860208A patent/DZ994A1/fr active
- 1986-10-09 PT PT83509A patent/PT83509B/pt unknown
- 1986-10-09 JP JP61239424A patent/JPH0759506B2/ja not_active Expired - Lifetime
- 1986-10-10 HU HU864249A patent/HU197839B/hu unknown
- 1986-10-10 IS IS3151A patent/IS1529B/is unknown
- 1986-10-10 SU SU864028342A patent/SU1760969A3/ru active
- 1986-10-10 KR KR1019860008481A patent/KR940000100B1/ko not_active IP Right Cessation
- 1986-10-10 FI FI864108A patent/FI88579C/fi not_active IP Right Cessation
- 1986-10-10 DD DD86295170A patent/DD259789A5/de unknown
- 1986-10-10 PL PL1986261802A patent/PL261802A1/xx unknown
- 1986-10-10 UA UA4028342A patent/UA26211A/uk unknown
- 1986-10-11 CN CN86106588A patent/CN1023293C/zh not_active Expired - Lifetime
-
1989
- 1989-02-14 US US07/310,489 patent/US4957745A/en not_active Expired - Lifetime
- 1989-06-22 GR GR89300059T patent/GR890300059T1/el unknown
-
1991
- 1991-08-19 GR GR91401214T patent/GR3002571T3/el unknown
- 1991-09-10 UA UA5001493A patent/UA39162C2/uk unknown
- 1991-09-10 RU SU915001493A patent/RU2072840C1/ru active
- 1991-11-08 SG SG952/91A patent/SG95291G/en unknown
- 1991-12-12 HK HK1017/91A patent/HK101791A/xx not_active IP Right Cessation
-
1992
- 1992-07-10 CY CY1616A patent/CY1616A/xx unknown
-
1993
- 1993-06-28 LV LVP-93-685A patent/LV10913B/en unknown
- 1993-06-30 LV LV930884A patent/LV10914A/xx unknown
- 1993-12-28 LT LTIP1679A patent/LT3951B/lt not_active IP Right Cessation
- 1993-12-28 LT LTIP1680A patent/LTIP1680A/xx not_active Application Discontinuation
-
1996
- 1996-07-17 LV LV960258A patent/LV5751B4/xx unknown
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