EP2978536B1 - Abstützungsvorrichtung für einen zentrifugiergutbehälter - Google Patents

Abstützungsvorrichtung für einen zentrifugiergutbehälter Download PDF

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Publication number
EP2978536B1
EP2978536B1 EP14715868.7A EP14715868A EP2978536B1 EP 2978536 B1 EP2978536 B1 EP 2978536B1 EP 14715868 A EP14715868 A EP 14715868A EP 2978536 B1 EP2978536 B1 EP 2978536B1
Authority
EP
European Patent Office
Prior art keywords
centrifuge container
plate
support device
centrifuge
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP14715868.7A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2978536A1 (de
Inventor
Klaus-Günter Eberle
Timo LIEBERMANN
Christoph Pabst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Andreas Hettich GmbH and Co KG
Original Assignee
Andreas Hettich GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andreas Hettich GmbH and Co KG filed Critical Andreas Hettich GmbH and Co KG
Publication of EP2978536A1 publication Critical patent/EP2978536A1/de
Application granted granted Critical
Publication of EP2978536B1 publication Critical patent/EP2978536B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B2005/0435—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with adapters for centrifuge tubes or bags

Definitions

  • the invention relates to a centrifuge container assembly comprising a support device and the use of a support device for a Zentrifugiergut actuallyer.
  • Zentrifugugen lifeern Zentrifugiergut capableer especially in the form of bags are often used and processed.
  • the shape of a centrifuge container, in particular a bag, inserted into the centrifuge container is influenced by the altered mass distribution.
  • pockets, wrinkles or the like can be formed by changing the position and shape of the bag already at the beginning of the centrifugation. A separation of Zentrifugierguts is then no longer completely possible.
  • the DE 72 19 685 U discloses a supporting device in the form of an air-filled support bag.
  • the US 4,447,220 discloses a pressure device for applying an increasing pressure during centrifugation to transfer blood between communicating blood bags.
  • the US 3,830,425 discloses a metal clip that can support a blood bag and moreover accommodate compensation weights.
  • the US 4,892,668 discloses a fluid-filled support member for a blood bag, wherein the fluid is displaced depending on the pressure exerted by the blood bag.
  • the US 6,159,321 US discloses a support device for a Zentrifugigut actuallyer, which consists of a flexible band which corresponds in height to a Zentrifugiergut employer and can be wound around the Zentrifugigut actually.
  • An adhesive mechanism allows both ends of the bath to be fixed against each other, providing support for the wrapped centrifuge container.
  • an adaptive support device is provided, which however has the disadvantage that the shape of a flexible container, for example a blood bag, can not be retained, whereby the separation result is adversely affected.
  • a support device which is used in addition to the Zentrifugiergut containing Zentrifugiergut considereder, in particular a bag in a centrifuge container.
  • the supporting device comprises a resilient plate, wherein the flexible plate is designed in material selection and dimensioning such that it causes by bending a restoring force, which aims to restore the plate to its original shape.
  • Material selection and dimensioning are further coordinated so that when bending around a bending axis, at least as far as possible, that the tangent planes include a bending angle between 0 ° and 90 ° at the edges parallel to the bending axis.
  • Zentrifugiergut examplesers Due to the resilient behavior of the beige-elastic plate, the original shape of Zentrifugiergut mattersers can be maintained under tension due to the restoring force generated by the support device.
  • the bending elasticity may be chosen so that two edges opposite the bending axis at the plate ends can be brought into contact.
  • the bending elasticity can also be chosen so that after bending the plate about a bending axis, the opposite surfaces can at least partially abut each other.
  • the plate can be inserted next to the Zentrifugiergut matterser in a centrifuge container so that by bending the plate on its bending axis this into a support region which rests against the bag and a Verspann Scheme which braces the plate against a centrifuge container wall is divided.
  • the clamping area which lies above a desired bending axis in a vertical not yet bent plate, be bent down so that the clamping area presses with the applied restoring force against the container wall.
  • the supporting region of the plate resting against the centrifuging container forms a wall which presses the centrifuging container against the centrifuge container wall or another supporting device.
  • the pressure arises in particular in the region of the bending axis.
  • the bending axis may preferably be chosen so that it lies at the upper end of the bag used.
  • the position of the bending axis and thus the division of the plate in bracing and support area can be freely selected with the device according to the invention. Due to the free choice of the bending axis, the support device can be easily adapted to different containers or bag sizes.
  • the choice of the height at which the bending axis should lie depends, on the one hand, on the size of the centrifuge container and, on the other hand, on its fill level. The choice of the height of the bending axis is of particular importance when connections are provided for the removal of the centrifuged contents.
  • a further embodiment of the invention provides that a handle device is arranged at one end of the plate. This is designed so that it facilitates access to the bent down in the direction of the centrifuge container bottom clamping region.
  • the handling device By means of the handling device, the tension of the flexurally elastic plate can be released in such a metered manner that it is possible to prevent the separating layers of the centrifuging material from breaking up.
  • the handle device is designed in the form of a tab.
  • This tab is preferably designed flexurally in shape and choice of material. Due to the flexibility of the tab, this can cling to the centrifuge container wall. It is fixed by the clamping force during centrifugation between supporting device and container wall, so that they can not slip onto the container bottom. As a result, the tab remains easily accessible even after completion of the centrifugation.
  • the plate is made of silicone. Silicone is particularly easy to clean, which plays a major role due to the possibility of contamination of the support device during centrifugation.
  • the plate may have a smooth, substantially non-porous surface to facilitate cleaning operations.
  • the plate is longer than the height of Zentrifugiergut examplesers. It has been found that a supernatant of more than one third of the bag length is particularly advantageous.
  • the plate is preferably chosen so that it is as thin as possible, and yet has a thickness sufficient to ensure sufficient restoring force for holding the bag before and after centrifugation. This is particularly well fulfilled in a thickness range of 0.5 cm to 2 cm.
  • the thickness of the plate can be between 0.2 cm and 0.5 cm, so move in a range between 0.2 cm and 2 cm.
  • a centrifuge container arrangement which comprises a centrifuge container and a supporting device described above.
  • a support device can be introduced permanently or detachably into the centrifuge container.
  • the support device is inserted next to the Zentrifugiergut matterser in the centrifuge container.
  • a tensioning of Zentrifugiergut mattersers compared to the centrifuge container is carried out as described above.
  • the centrifuge container arrangement may preferably be chosen such that the width of the plate corresponds at most to the maximum width or diameter of the centrifuge container. This ensures that a bending of the support device is excluded about the longitudinal axis, and the support areas of the plate can rest against the container in its entire width.
  • the length of the plate is selected such that it projects beyond the height of the centrifuge container space by at least one third. This simplifies the handling when folding the Verspann Schemes and guarantees that a bending axis at the level of the upper edge of the centrifuge container can be realized while providing a sufficient clamping force.
  • the plate is inserted parallel to the Zentrifugiergut actually in the centrifuge container, whereupon an upper clamping area about a bending axis which is substantially parallel to the container bottom, is bent away from the bag.
  • a support takes place on the voltage applied to the bag support area.
  • Fig. 1 shows a centrifuge container assembly 10, comprising a centrifuge container 12 and a support device 14.
  • the support device 14 also includes a flexurally elastic plate 16 and a flexurally elastic flap 18 integrally formed at its end.
  • a centrifuge container assembly 10 in which a blood bag 20 inserted into a centrifuge container 12 can be supported by a support device 14 introduced vertically into the centrifuge container 12.
  • the support device 14 comprises a flexurally elastic silicone plate 16, which has a length which corresponds to twice the height of the centrifuge container 12.
  • a tab 18 made of plastic is attached at the upper end of the silicone plate 16. Blood bag 20 and supporting device 14 are introduced into the centrifuge container such that the blood bag 20 is inserted between the silicone plate 16 and the inner wall of the centrifuge container 12.
  • Fig. 2 shows in a next step, as the vertically mounted support device 14, which is arranged in parallel next to the blood container 20 in parallel, is bent about a bending axis A.
  • the bending axis A separates the silicone plate 16 into a support region 16a and a clamping region 16b.
  • the clamping region 16b presses against the wall of the centrifuge container 12 facing away from the blood bag 20 and thereby in particular braces the upper region of the blood bag 20 and presses it against the bag-side centrifuge container wall. Due to the flexurally elastic configuration of the silicone plate 16, a pressure is exerted over the entire blood bag 20. However, the largest contact force is in the area of the bending axis A. This ensures that above all the connections of the blood bag 20 are kept stable in the upper region of the centrifuge container 12.
  • the flexurally elastic tab 18 is shown. Due to the flexurally elastic configuration of the tab 18, it is not displaced during the centrifugation in the direction of the container bottom, but remains easily accessible even after centrifugation. As in Fig. 2 the pressure range is approximately at the level of the bending axis A and thus are the connections of the blood bag 20 sets above the container edge. The applied tension by the restoring force can also support the present blood bag 20 under the influence of the centrifugal forces.
  • Fig. 3 shows a plan view of the centrifuge container 12 with the clamped blood bag 20, the support device 14, wherein the position of the bending axis A of the plate 16 can be seen particularly well.
  • Fig. 4 shows a perspective view of a supporting device 14 according to the invention, wherein this comprises a flexurally elastic plate 16 and a flexurally elastic tab 18.
  • the plate 16 is made of silicone, wherein the tab 18 is formed of a thin polyethylene or polyurethane strip.
  • Fig. 5a shows a schematic sectional view of two centrifuge containers, each with a blood bag 20, which is clamped between two plates 16 respectively.
  • the plates 16 are arranged so that they rest with their support region 16a respectively on the blood bag 20 and with their bracing 16b are supported against the centrifuge container wall.
  • Fig. 5b 2 shows a schematic sectional view of two centrifuge containers, each with one blood bag 20.
  • the blood bag 20 is supported by two plates 16 such that a first plate 16 with its support region 16a is arranged on the blood bag 20, and with its clamping region 16b against the support region 16a of a second Plate presses.
  • This second plate 16 braced with its clamping area 16b again against the centrifuge container wall.

Landscapes

  • Centrifugal Separators (AREA)
  • External Artificial Organs (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
EP14715868.7A 2013-03-27 2014-03-27 Abstützungsvorrichtung für einen zentrifugiergutbehälter Active EP2978536B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102013103153.6A DE102013103153B4 (de) 2013-03-27 2013-03-27 Abstützungsvorrichtung für einen Zentrifugiergutbehälter
PCT/EP2014/056208 WO2014154827A1 (de) 2013-03-27 2014-03-27 Abstützungsvorrichtung für einen zentrifugiergutbehälter

Publications (2)

Publication Number Publication Date
EP2978536A1 EP2978536A1 (de) 2016-02-03
EP2978536B1 true EP2978536B1 (de) 2018-07-04

Family

ID=50442493

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14715868.7A Active EP2978536B1 (de) 2013-03-27 2014-03-27 Abstützungsvorrichtung für einen zentrifugiergutbehälter

Country Status (6)

Country Link
US (1) US10232375B2 (zh)
EP (1) EP2978536B1 (zh)
JP (1) JP6285535B2 (zh)
CN (1) CN105073267B (zh)
DE (1) DE102013103153B4 (zh)
WO (1) WO2014154827A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107433231A (zh) * 2016-05-26 2017-12-05 上海安亭科学仪器厂 一种大容量离心杯

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2142737C3 (de) * 1971-08-26 1974-01-31 Heraeus-Christ Gmbh, 3360 Osterode Schwenkbecher zum Zentrifugieren von Blutbeuteln
DE7219685U (de) * 1972-05-26 1975-02-27 Biotest Serum Institut Gmbh Stützbeutel für ein Verfahren zum Zentrifugieren von Beuteln für Blut und Blutderivate
BE794143A (fr) * 1972-09-07 1973-05-16 American Hospital Supply Corp Assemblage de rotor de centrifugeuse
EP0026417B1 (de) 1979-09-22 1983-12-14 Firma Andreas Hettich Zentrifuge mit Blutbeutelsystem zur Trennung von Blutkomponenten
JPS61200867A (ja) * 1985-03-01 1986-09-05 Kawasumi Lab Inc 血液バツグの遠心分離方法
US4892668A (en) 1988-10-05 1990-01-09 Engineering & Research Associates, Inc. Blood collection bag support
AUPN883396A0 (en) * 1996-03-21 1996-04-18 Australian Red Cross Society (Western Australian Division) Centrifugation support
CN2257742Y (zh) * 1996-05-31 1997-07-16 李家洲 多级污水分离器
US6325775B1 (en) * 1999-09-03 2001-12-04 Baxter International Inc. Self-contained, transportable blood processsing device
US6602180B2 (en) * 2000-04-04 2003-08-05 Fleetguard, Inc. Self-driven centrifuge with vane module
CN2644003Y (zh) * 2003-06-13 2004-09-29 李军掴 一种离心无压式滤油机
DE202005015644U1 (de) 2005-10-06 2007-02-15 Andreas Hettich Gmbh & Co. Kg Zentrifugenbecher mit Halterung für Blutbeutel
JP2011050579A (ja) * 2009-09-02 2011-03-17 Terumo Corp 医療用バッグ装着具
WO2011065716A2 (ko) * 2009-11-26 2011-06-03 Bang Sang-Bae 접이형 도마
WO2012149641A1 (en) * 2011-05-05 2012-11-08 Stemcell Technologies Inc. Method and insert for density gradient separation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
WO2014154827A1 (de) 2014-10-02
US20160016173A1 (en) 2016-01-21
EP2978536A1 (de) 2016-02-03
CN105073267A (zh) 2015-11-18
US10232375B2 (en) 2019-03-19
JP6285535B2 (ja) 2018-02-28
JP2016518971A (ja) 2016-06-30
DE102013103153B4 (de) 2016-09-08
DE102013103153A1 (de) 2014-10-02
CN105073267B (zh) 2018-11-30

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