EP2978536B1 - Support device for a centrifuged-material-container - Google Patents

Support device for a centrifuged-material-container Download PDF

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Publication number
EP2978536B1
EP2978536B1 EP14715868.7A EP14715868A EP2978536B1 EP 2978536 B1 EP2978536 B1 EP 2978536B1 EP 14715868 A EP14715868 A EP 14715868A EP 2978536 B1 EP2978536 B1 EP 2978536B1
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EP
European Patent Office
Prior art keywords
centrifuge container
plate
support device
centrifuge
container
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EP14715868.7A
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German (de)
French (fr)
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EP2978536A1 (en
Inventor
Klaus-Günter Eberle
Timo LIEBERMANN
Christoph Pabst
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Andreas Hettich GmbH and Co KG
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Andreas Hettich GmbH and Co KG
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B2005/0435—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with adapters for centrifuge tubes or bags

Definitions

  • the invention relates to a centrifuge container assembly comprising a support device and the use of a support device for a Zentrifugiergut actuallyer.
  • Zentrifugugen lifeern Zentrifugiergut capableer especially in the form of bags are often used and processed.
  • the shape of a centrifuge container, in particular a bag, inserted into the centrifuge container is influenced by the altered mass distribution.
  • pockets, wrinkles or the like can be formed by changing the position and shape of the bag already at the beginning of the centrifugation. A separation of Zentrifugierguts is then no longer completely possible.
  • the DE 72 19 685 U discloses a supporting device in the form of an air-filled support bag.
  • the US 4,447,220 discloses a pressure device for applying an increasing pressure during centrifugation to transfer blood between communicating blood bags.
  • the US 3,830,425 discloses a metal clip that can support a blood bag and moreover accommodate compensation weights.
  • the US 4,892,668 discloses a fluid-filled support member for a blood bag, wherein the fluid is displaced depending on the pressure exerted by the blood bag.
  • the US 6,159,321 US discloses a support device for a Zentrifugigut actuallyer, which consists of a flexible band which corresponds in height to a Zentrifugiergut employer and can be wound around the Zentrifugigut actually.
  • An adhesive mechanism allows both ends of the bath to be fixed against each other, providing support for the wrapped centrifuge container.
  • an adaptive support device is provided, which however has the disadvantage that the shape of a flexible container, for example a blood bag, can not be retained, whereby the separation result is adversely affected.
  • a support device which is used in addition to the Zentrifugiergut containing Zentrifugiergut considereder, in particular a bag in a centrifuge container.
  • the supporting device comprises a resilient plate, wherein the flexible plate is designed in material selection and dimensioning such that it causes by bending a restoring force, which aims to restore the plate to its original shape.
  • Material selection and dimensioning are further coordinated so that when bending around a bending axis, at least as far as possible, that the tangent planes include a bending angle between 0 ° and 90 ° at the edges parallel to the bending axis.
  • Zentrifugiergut examplesers Due to the resilient behavior of the beige-elastic plate, the original shape of Zentrifugiergut mattersers can be maintained under tension due to the restoring force generated by the support device.
  • the bending elasticity may be chosen so that two edges opposite the bending axis at the plate ends can be brought into contact.
  • the bending elasticity can also be chosen so that after bending the plate about a bending axis, the opposite surfaces can at least partially abut each other.
  • the plate can be inserted next to the Zentrifugiergut matterser in a centrifuge container so that by bending the plate on its bending axis this into a support region which rests against the bag and a Verspann Scheme which braces the plate against a centrifuge container wall is divided.
  • the clamping area which lies above a desired bending axis in a vertical not yet bent plate, be bent down so that the clamping area presses with the applied restoring force against the container wall.
  • the supporting region of the plate resting against the centrifuging container forms a wall which presses the centrifuging container against the centrifuge container wall or another supporting device.
  • the pressure arises in particular in the region of the bending axis.
  • the bending axis may preferably be chosen so that it lies at the upper end of the bag used.
  • the position of the bending axis and thus the division of the plate in bracing and support area can be freely selected with the device according to the invention. Due to the free choice of the bending axis, the support device can be easily adapted to different containers or bag sizes.
  • the choice of the height at which the bending axis should lie depends, on the one hand, on the size of the centrifuge container and, on the other hand, on its fill level. The choice of the height of the bending axis is of particular importance when connections are provided for the removal of the centrifuged contents.
  • a further embodiment of the invention provides that a handle device is arranged at one end of the plate. This is designed so that it facilitates access to the bent down in the direction of the centrifuge container bottom clamping region.
  • the handling device By means of the handling device, the tension of the flexurally elastic plate can be released in such a metered manner that it is possible to prevent the separating layers of the centrifuging material from breaking up.
  • the handle device is designed in the form of a tab.
  • This tab is preferably designed flexurally in shape and choice of material. Due to the flexibility of the tab, this can cling to the centrifuge container wall. It is fixed by the clamping force during centrifugation between supporting device and container wall, so that they can not slip onto the container bottom. As a result, the tab remains easily accessible even after completion of the centrifugation.
  • the plate is made of silicone. Silicone is particularly easy to clean, which plays a major role due to the possibility of contamination of the support device during centrifugation.
  • the plate may have a smooth, substantially non-porous surface to facilitate cleaning operations.
  • the plate is longer than the height of Zentrifugiergut examplesers. It has been found that a supernatant of more than one third of the bag length is particularly advantageous.
  • the plate is preferably chosen so that it is as thin as possible, and yet has a thickness sufficient to ensure sufficient restoring force for holding the bag before and after centrifugation. This is particularly well fulfilled in a thickness range of 0.5 cm to 2 cm.
  • the thickness of the plate can be between 0.2 cm and 0.5 cm, so move in a range between 0.2 cm and 2 cm.
  • a centrifuge container arrangement which comprises a centrifuge container and a supporting device described above.
  • a support device can be introduced permanently or detachably into the centrifuge container.
  • the support device is inserted next to the Zentrifugiergut matterser in the centrifuge container.
  • a tensioning of Zentrifugiergut mattersers compared to the centrifuge container is carried out as described above.
  • the centrifuge container arrangement may preferably be chosen such that the width of the plate corresponds at most to the maximum width or diameter of the centrifuge container. This ensures that a bending of the support device is excluded about the longitudinal axis, and the support areas of the plate can rest against the container in its entire width.
  • the length of the plate is selected such that it projects beyond the height of the centrifuge container space by at least one third. This simplifies the handling when folding the Verspann Schemes and guarantees that a bending axis at the level of the upper edge of the centrifuge container can be realized while providing a sufficient clamping force.
  • the plate is inserted parallel to the Zentrifugiergut actually in the centrifuge container, whereupon an upper clamping area about a bending axis which is substantially parallel to the container bottom, is bent away from the bag.
  • a support takes place on the voltage applied to the bag support area.
  • Fig. 1 shows a centrifuge container assembly 10, comprising a centrifuge container 12 and a support device 14.
  • the support device 14 also includes a flexurally elastic plate 16 and a flexurally elastic flap 18 integrally formed at its end.
  • a centrifuge container assembly 10 in which a blood bag 20 inserted into a centrifuge container 12 can be supported by a support device 14 introduced vertically into the centrifuge container 12.
  • the support device 14 comprises a flexurally elastic silicone plate 16, which has a length which corresponds to twice the height of the centrifuge container 12.
  • a tab 18 made of plastic is attached at the upper end of the silicone plate 16. Blood bag 20 and supporting device 14 are introduced into the centrifuge container such that the blood bag 20 is inserted between the silicone plate 16 and the inner wall of the centrifuge container 12.
  • Fig. 2 shows in a next step, as the vertically mounted support device 14, which is arranged in parallel next to the blood container 20 in parallel, is bent about a bending axis A.
  • the bending axis A separates the silicone plate 16 into a support region 16a and a clamping region 16b.
  • the clamping region 16b presses against the wall of the centrifuge container 12 facing away from the blood bag 20 and thereby in particular braces the upper region of the blood bag 20 and presses it against the bag-side centrifuge container wall. Due to the flexurally elastic configuration of the silicone plate 16, a pressure is exerted over the entire blood bag 20. However, the largest contact force is in the area of the bending axis A. This ensures that above all the connections of the blood bag 20 are kept stable in the upper region of the centrifuge container 12.
  • the flexurally elastic tab 18 is shown. Due to the flexurally elastic configuration of the tab 18, it is not displaced during the centrifugation in the direction of the container bottom, but remains easily accessible even after centrifugation. As in Fig. 2 the pressure range is approximately at the level of the bending axis A and thus are the connections of the blood bag 20 sets above the container edge. The applied tension by the restoring force can also support the present blood bag 20 under the influence of the centrifugal forces.
  • Fig. 3 shows a plan view of the centrifuge container 12 with the clamped blood bag 20, the support device 14, wherein the position of the bending axis A of the plate 16 can be seen particularly well.
  • Fig. 4 shows a perspective view of a supporting device 14 according to the invention, wherein this comprises a flexurally elastic plate 16 and a flexurally elastic tab 18.
  • the plate 16 is made of silicone, wherein the tab 18 is formed of a thin polyethylene or polyurethane strip.
  • Fig. 5a shows a schematic sectional view of two centrifuge containers, each with a blood bag 20, which is clamped between two plates 16 respectively.
  • the plates 16 are arranged so that they rest with their support region 16a respectively on the blood bag 20 and with their bracing 16b are supported against the centrifuge container wall.
  • Fig. 5b 2 shows a schematic sectional view of two centrifuge containers, each with one blood bag 20.
  • the blood bag 20 is supported by two plates 16 such that a first plate 16 with its support region 16a is arranged on the blood bag 20, and with its clamping region 16b against the support region 16a of a second Plate presses.
  • This second plate 16 braced with its clamping area 16b again against the centrifuge container wall.

Landscapes

  • Centrifugal Separators (AREA)
  • External Artificial Organs (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Description

Die Erfindung betrifft eine Zentrifugenbehälteranordnung umfassend eine Abstützvorrichtung und die Verwendung einer Abstützungsvorrichtung für einen Zentrifugiergutbehälter.
In Zentrifugenbehältern werden oftmals Zentrifugiergutbehälter, insbesondere in Form von Beuteln, eingesetzt und verarbeitet. Während der Zentrifugation wird dabei die Form eines in den Zentrifugenbehälter eingesetzten Zentrifugiergutbehälters, insbesondere eines Beutels, durch die veränderte Massenverteilung beeinflusst. Dies führt dazu, dass Taschen, Falten oder Ähnliches durch die Veränderung der Lage und der Form des Beutels bereits zu Beginn der Zentrifugation entstehen können. Eine Auftrennung des Zentrifugierguts ist dann nicht mehr vollständig möglich.
Auch bei einer Entnahme des deformierten Beutels ergeben sich Schwierigkeiten, da eine Auflösung der Taschen zu einem Aufbruch der durch die Zentrifugation gewonnenen Trennschichten führen kann. Diese Probleme spielen besonders bei der Zentrifugation und der Analyse von Blut eine große Rolle. Die DE 72 19 685 U offenbart eine Abstützvorrichtung in Form eines luftgefüllten Stützbeutels.
Die US 4 447 220 offenbart eine Druckvorrichtung zur Aufbringung eines ansteigenden Drucks während der Zentrifugation, um Blut zwischen kommunizierenden Blutbeuteln zu übertragen.
Die US 3 830 425 offenbart eine Metallklammer, die einen Blutbeutel stützen kann und überdies Kompensationsgewichte aufnehmen kann.The invention relates to a centrifuge container assembly comprising a support device and the use of a support device for a Zentrifugiergutbehälter.
Zentrifugugenbehältern Zentrifugiergutbehälter, especially in the form of bags are often used and processed. During centrifugation, the shape of a centrifuge container, in particular a bag, inserted into the centrifuge container is influenced by the altered mass distribution. As a result, pockets, wrinkles or the like can be formed by changing the position and shape of the bag already at the beginning of the centrifugation. A separation of Zentrifugierguts is then no longer completely possible.
Even with a removal of the deformed bag difficulties arise because a resolution of the pockets can lead to a departure of the separation layers obtained by the centrifugation. These problems are particularly important in the centrifugation and analysis of blood. The DE 72 19 685 U discloses a supporting device in the form of an air-filled support bag.
The US 4,447,220 discloses a pressure device for applying an increasing pressure during centrifugation to transfer blood between communicating blood bags.
The US 3,830,425 discloses a metal clip that can support a blood bag and moreover accommodate compensation weights.

Die US 4 892 668 offenbart ein fluidgefülltes Stützelement für einen Blutbeutel, wobei das Fluid abhängig von dem durch den Blutbeutel ausgeübten Druck verdrängt wird.The US 4,892,668 discloses a fluid-filled support member for a blood bag, wherein the fluid is displaced depending on the pressure exerted by the blood bag.

In der DE 20 2005 015 644 U1 ist ein Zentrifugenbecher beschrieben, der eine Halterung am Deckel aufweist, die zum Einklemmen eines Blutbeutels an seinem oberen Rand dient. Dazu werden Anschlüsse des Blutbeutels aufgenommen. Durch diese Halterung ist eine spezifizierte Halterung eines Blutbeutels möglich.In the DE 20 2005 015 644 U1 a centrifuge bowl is described which has a holder on the lid, which serves to clamp a blood bag at its upper edge. For this purpose, connections of the blood bag are recorded. By this holder, a specified holder of a blood bag is possible.

Die US 6,159,321 US offenbart eine Stützvorrichtung für einen Zentrifugiergutbehälter, der aus einem flexiblen Band besteht, das in seiner Höhe einem Zentrifugiergutbehälter entspricht und um den Zentrifugiergutbehälter gewickelt werden kann. Durch einen Haftmechanismus können beide Enden des Badnes gegeneinander fixiert werden, wodurch eine Stützung für den eingewickelten Zentrifugiergutbehälter bereitgestellt wird. Dadurch wird eine anpassungsfähige Stützvorrichtung bereitgestellt, die jedoch den Nachteil hat, dass die Form eines flexibeln Behältnisses, beispielsweise eines Blutbeutels nicht beibehalten werden kann, wodurch das Trennergebnis negativ beeinflusst wird.The US 6,159,321 US discloses a support device for a Zentrifugigutbehälter, which consists of a flexible band which corresponds in height to a Zentrifugiergutbehälter and can be wound around the Zentrifugigutbehälter. An adhesive mechanism allows both ends of the bath to be fixed against each other, providing support for the wrapped centrifuge container. Thereby, an adaptive support device is provided, which however has the disadvantage that the shape of a flexible container, for example a blood bag, can not be retained, whereby the separation result is adversely affected.

Es ist daher Aufgabe der Erfindung, eine Vorrichtung anzugeben, die unter Vermeidung oben genannter Nachteile eine Lagerung eines Zentrifugiergutbehälters im Zentrifugenbehälter variabel und an unterschiedliche Zentrifugiergutbehälter anpassbar ermöglicht.It is therefore an object of the invention to provide a device which, while avoiding the above-mentioned disadvantages, enables a storage of a centrifuge container in the centrifuge container to be variable and adaptable to different centrifuge containers.

Diese Aufgabe wird erfindungsgemäß durch die Merkmale der Ansprüche 1 und 10 gelöst.This object is achieved by the features of claims 1 and 10.

So wird eine Abstützvorrichtung bereitgestellt, welche neben dem das Zentrifugiergut beinhaltenden Zentrifugiergutbehälter, insbesondere einen Beutel, in einen Zentrifugenbehälter eingesetzt wird. Erfindungsgemäß umfasst die Abstützvorrichtung eine elastische Platte, wobei die biegsame Platte in Materialwahl und Dimensionierung derart ausgelegt ist, dass diese durch Verbiegen eine Rückstellkraft hervorruft, die eine Rückstellung der Platte in ihre ursprüngliche Form anstrebt. Materialwahl und Dimensionierung sind weiter so aufeinander abgestimmt, dass bei Biegung um eine Biegeachse, wenigstens soweit ermöglicht wird, dass die Tangentialebenen an den zur Biegeachse parallelen Kanten einen Biegewinkel zwischen 0° und 90° einschließen.Thus, a support device is provided which is used in addition to the Zentrifugiergut containing Zentrifugiergutbehälter, in particular a bag in a centrifuge container. According to the invention, the supporting device comprises a resilient plate, wherein the flexible plate is designed in material selection and dimensioning such that it causes by bending a restoring force, which aims to restore the plate to its original shape. Material selection and dimensioning are further coordinated so that when bending around a bending axis, at least as far as possible, that the tangent planes include a bending angle between 0 ° and 90 ° at the edges parallel to the bending axis.

Durch das federnde Verhalten der beigeelastischen Platte kann die ursprüngliche Form des Zentrifugiergutbehälters auch unter Verspannung aufgrund der durch die Abstützvorrichtung erzeugten Rückstellkraft beibehalten werden.Due to the resilient behavior of the beige-elastic plate, the original shape of Zentrifugiergutbehälters can be maintained under tension due to the restoring force generated by the support device.

Vorzugsweise kann die Biegeelastizität so gewählt sein, dass zwei parallel zur Biegeachse an den Plattenenden gegenüberliegende Kanten in Berührung gebracht werden können. Die Biegeelastizität kann auch so gewählt sein, dass nach Umbiegen der Platte um eine Biegeachse die gegenüberliegenden Flächen wenigstens teilweise aneinander liegen können.Preferably, the bending elasticity may be chosen so that two edges opposite the bending axis at the plate ends can be brought into contact. The bending elasticity can also be chosen so that after bending the plate about a bending axis, the opposite surfaces can at least partially abut each other.

Aufgrund der Biegeelastizität kann die Platte neben den Zentrifugiergutbehälter in einen Zentrifugenbehälter so eingesetzt werden, dass durch Umbiegen der Platte an ihrer Biegeachse diese in einen Stützbereich, der am Beutel anliegt und einen Verspannbereich, der die Platte gegen eine Zentrifugenbehälterwand verspannt, eingeteilt wird.Due to the flexural elasticity, the plate can be inserted next to the Zentrifugiergutbehälter in a centrifuge container so that by bending the plate on its bending axis this into a support region which rests against the bag and a Verspannbereich which braces the plate against a centrifuge container wall is divided.

So kann der Verspannbereich, welcher bei einer vertikal eingesetzten noch nicht umgebogenen Platte oberhalb einer angestrebten Biegeachse liegt, so nach unten umgebogen werden, dass der Verspannbereich mit der aufgebrachten Rückstellkraft gegen die Behälterwand drückt. Dadurch bildet der am Zentrifugiergutbehälter anliegende Stützbereich der Platte eine Wand, die den Zentrifugiergutbehälter gegen die Zentrifugenbehälterwand oder eine weitere Abstützvorrichtung drückt. Der Druck entsteht insbesondere im Bereich der Biegeachse. Die Biegeachse kann vorzugsweise so gewählt werden, dass diese am oberen Ende des eingesetzten Beutels liegt. Dadurch wird eine aufrechte Fixierung des Zentrifugiergutbehälters im Zentrifugenbehälter auch während der Zentrifugation gewährleistet. Dadurch wird eine Faltenbildung effektiv verhindert.Thus, the clamping area, which lies above a desired bending axis in a vertical not yet bent plate, be bent down so that the clamping area presses with the applied restoring force against the container wall. As a result, the supporting region of the plate resting against the centrifuging container forms a wall which presses the centrifuging container against the centrifuge container wall or another supporting device. The pressure arises in particular in the region of the bending axis. The bending axis may preferably be chosen so that it lies at the upper end of the bag used. As a result, an upright fixation of the Zentrifugiergutbehälters is ensured in the centrifuge container during centrifugation. This effectively prevents wrinkling.

Die Lage der Biegeachse und damit die Einteilung der Platte in Verspann- und Stützbereich ist mit der erfindungsgemäßen Vorrichtung frei wählbar. Durch die freie Wahl der Biegeachse kann die Abstützungsvorrichtung problemlos an unterschiedliche Behälter bzw. Beutelgrößen angepasst werden. Die Wahl, auf welcher Höhe die Biegeachse liegen soll, ist zum einen von der Größe des Zentrifugiergutbehälters und zum anderen von seinem Füllstand abhängig. Die Wahl der Höhe der Biegeachse ist dann von besonderer Bedeutung, wenn Anschlüsse für die Entnahme des zentrifugierten Inhalts vorgesehen sind. Durch die erfindungsgemäße Abstützvorrichtung kann ein variabler Einsatz für viele unterschiedliche Zentrifugiergutbehälterformen gewährleistet werden.The position of the bending axis and thus the division of the plate in bracing and support area can be freely selected with the device according to the invention. Due to the free choice of the bending axis, the support device can be easily adapted to different containers or bag sizes. The choice of the height at which the bending axis should lie depends, on the one hand, on the size of the centrifuge container and, on the other hand, on its fill level. The choice of the height of the bending axis is of particular importance when connections are provided for the removal of the centrifuged contents. By the supporting device according to the invention, a variable use can be ensured for many different Zentrifugiergutbehälterformen.

Eine weitere Ausführungsform der Erfindung sieht vor, dass an einem Ende der Platte eine Handhabeeinrichtung angeordnet ist. Diese ist derart ausgestaltet, dass sie den Zugriff auf den nach unten in Richtung des Zentrifugenbehälterbodens umgebogenen Verspannbereich erleichtert. Durch die Handhabeeinrichtung kann die Verspannung der biegeelastischen Platte so dosiert gelöst werden, dass ein Aufbrechen der Trennschichten des Zentrifugierguts vermieden werden kann.A further embodiment of the invention provides that a handle device is arranged at one end of the plate. This is designed so that it facilitates access to the bent down in the direction of the centrifuge container bottom clamping region. By means of the handling device, the tension of the flexurally elastic plate can be released in such a metered manner that it is possible to prevent the separating layers of the centrifuging material from breaking up.

Vorzugsweise ist die Handhabeeinrichtung in Form einer Lasche ausgebildet. Diese Lasche ist in ihrer Form und Materialwahl vorzugsweise biegeelastisch gestaltet. Durch die Biegsamkeit der Lasche kann sich diese an die Zentrifugenbehälterwand anschmiegen. Sie wird durch die Spannkraft während der Zentrifugation zwischen Abstützvorrichtung und Behälterwand fixiert, so dass sie nicht auf den Behälterboden rutschen kann. Dadurch bleibt die Lasche auch nach Beendigung der Zentrifugation noch leicht zugänglich.Preferably, the handle device is designed in the form of a tab. This tab is preferably designed flexurally in shape and choice of material. Due to the flexibility of the tab, this can cling to the centrifuge container wall. It is fixed by the clamping force during centrifugation between supporting device and container wall, so that they can not slip onto the container bottom. As a result, the tab remains easily accessible even after completion of the centrifugation.

Eine günstige Materialwahl für die erfindungsgemäße Abstützvorrichtung ist Kunststoff, da auf diese Weise problemlos die biegeelastischen Eigenschaften der Platte erreicht werden können. In einer besonders vorteilhaften Ausführungsform ist die Platte aus Silikon hergestellt. Silikon ist besonders leicht zu reinigen, was aufgrund der Kontaminationsmöglichkeit der Abstützungsvorrichtung während der Zentrifugation eine große Rolle spielt. Die Platte kann insbesondere eine glatte im Wesentlichen porenfreie Oberfläche aufweisen, um Reinigungsvorgänge zu erleichtern.A favorable choice of material for the supporting device according to the invention is plastic, since in this way easily the bending elastic properties of the plate can be achieved. In a particularly advantageous embodiment, the plate is made of silicone. Silicone is particularly easy to clean, which plays a major role due to the possibility of contamination of the support device during centrifugation. In particular, the plate may have a smooth, substantially non-porous surface to facilitate cleaning operations.

Vorzugsweise ist die Platte länger als die Höhe des Zentrifugiergutbehälters. Es hat sich herausgestellt, dass ein Überstand von mehr als einem Drittel der Beutellänge besonders vorteilhaft ist.Preferably, the plate is longer than the height of Zentrifugiergutbehälters. It has been found that a supernatant of more than one third of the bag length is particularly advantageous.

Für gängige Zentrifugiergutbehälter, insbesondere Blutbeutel, entspricht dies einer Länge der Platte von etwa 20 cm.For common Zentrifugiergutbehälter, especially blood bags, this corresponds to a length of the plate of about 20 cm.

In der Stärke ist die Platte vorzugsweise so gewählt, dass diese möglichst dünn ist, und dennoch eine ausreichende Dicke aufweist, um eine ausreichende Rückstellkraft zur Halterung des Beutels vor und nach der Zentrifugation zu gewährleisten. Dies ist in einem Stärkenbereich von 0,5 cm bis 2 cm besonders gut erfüllt. Die Stärke der Platte kann zwischen 0,2 cm und 0,5 cm liegen, also sich in einem Bereich zwischen 0,2 cm und 2 cm bewegen.In thickness, the plate is preferably chosen so that it is as thin as possible, and yet has a thickness sufficient to ensure sufficient restoring force for holding the bag before and after centrifugation. This is particularly well fulfilled in a thickness range of 0.5 cm to 2 cm. The thickness of the plate can be between 0.2 cm and 0.5 cm, so move in a range between 0.2 cm and 2 cm.

Erfindungsgemäß ist eine Zentrifugenbehälteranordnung vorgesehen, welche einen Zentrifugenbehälter und eine vorangehend beschriebene Abstützvorrichtung umfasst. In einer solchen Zentrifugenbehälteranordnung ist in den Zentrifugenbehälter eine solche Abstützvorrichtung fest oder lösbar einbringbar. Die Abstützvorrichtung wird neben dem Zentrifugiergutbehälter in den Zentrifugenbehälter eingesetzt. Eine Verspannung des Zentrifugiergutbehälters gegenüber dem Zentrifugenbehälter erfolgt wie zuvor beschrieben.According to the invention, a centrifuge container arrangement is provided which comprises a centrifuge container and a supporting device described above. In such a centrifuge container arrangement, such a support device can be introduced permanently or detachably into the centrifuge container. The support device is inserted next to the Zentrifugiergutbehälter in the centrifuge container. A tensioning of Zentrifugiergutbehälters compared to the centrifuge container is carried out as described above.

Die Zentrifugenbehälteranordnung kann vorzugsweise so gewählt werden, dass die Breite der Platte höchstens der maximalen Breite bzw. Durchmessers des Zentrifugenbehälters entspricht. Dadurch wird gewährleistet, dass ein Verbiegen der Abstützvorrichtung um die Längsachse ausgeschlossen ist, und der Stützbereiche der Platte in seiner ganzen Breite am Behältnis anliegen kann.The centrifuge container arrangement may preferably be chosen such that the width of the plate corresponds at most to the maximum width or diameter of the centrifuge container. This ensures that a bending of the support device is excluded about the longitudinal axis, and the support areas of the plate can rest against the container in its entire width.

In einer Weiterbildung der Zentrifugenbehälteranordnung ist die Länge der Platte so gewählt, dass diese die Höhe des Zentrifugenbehälterraums um wenigstens ein Drittel überragt. Dies vereinfacht die Handhabung beim Einklappen des Verspannbereichs und garantiert, dass auch eine Biegeachse auf Höhe der Oberkante des Zentrifugenbehälters unter Bereitstellung einer ausreichenden Spannkraft realisierbar ist.In a development of the centrifuge container arrangement, the length of the plate is selected such that it projects beyond the height of the centrifuge container space by at least one third. This simplifies the handling when folding the Verspannbereichs and guarantees that a bending axis at the level of the upper edge of the centrifuge container can be realized while providing a sufficient clamping force.

Ferner ist die Verwendung einer zuvor beschriebenen Abstützvorrichtung zur Abstützung eines Behältnisses in einem Zentrifugenbehälter Gegenstand der Erfindung.Furthermore, the use of a previously described supporting device for supporting a container in a centrifuge container is the subject of the invention.

Gemäß einer vorteilhaften Verwendungsmöglichkeit wird die Platte parallel zum Zentrifugiergutbehälter in den Zentrifugenbehälter eingesetzt, woraufhin ein oberer Verspannbereich um eine Biegeachse, die im Wesentlichen parallel zum Behälterboden verläuft, von dem Beutel weggebogen wird. Dadurch erfolgt eine Abstützung an dem am Beutel anliegenden Stützbereich.According to an advantageous possibility of use, the plate is inserted parallel to the Zentrifugiergutbehälter in the centrifuge container, whereupon an upper clamping area about a bending axis which is substantially parallel to the container bottom, is bent away from the bag. As a result, a support takes place on the voltage applied to the bag support area.

Weitere Vorteile, Merkmale und Anwendungsmöglichkeiten der vorliegenden Erfindung ergeben sich aus der nachfolgenden Beschreibung in Verbindung mit den in den Zeichnungen dargestellten Ausführungsbeispielen.Further advantages, features and possible applications of the present invention will become apparent from the following description in conjunction with the embodiments illustrated in the drawings.

In der Beschreibung, in den Ansprüchen und in der Zeichnung werden die in der unten aufgeführten Liste der Bezugszeichen verwendeten Begriffe und zugeordneten Bezugszeichen verwendet. In der Zeichnung bedeutet:

Fig. 1
eine Zentrifugenbehälteranordnung;
Fig. 2
eine vertikal eingebrachte Abstützvorrichtung;
Fig. 3
eine Draufsicht auf den Zentrifugenbehälter;
Fig. 4
eine perspektivische Ansicht einer erfindungsgemäßen Abstützvorrichtung;
Fig. 5a
eine schematische Schnittansicht von Zentrifugenbehältern mit je zwei erfindungsgemäßen Abstützvorrichtungen, und
Fig. 5b
eine schematische Schnittansicht von Zentrifugenbehältern mit je zwei erfindungsgemäßen Abstützvorrichtungen.
In the description, the claims, and the drawing, the terms and associated reference numerals used in the list of reference numerals below are used. In the drawing:
Fig. 1
a centrifuge container assembly;
Fig. 2
a vertically mounted support device;
Fig. 3
a plan view of the centrifuge container;
Fig. 4
a perspective view of a supporting device according to the invention;
Fig. 5a
a schematic sectional view of centrifuge containers, each with two supporting devices according to the invention, and
Fig. 5b
a schematic sectional view of centrifuge containers, each with two supporting devices according to the invention.

Fig. 1 zeigt eine Zentrifugenbehälteranordnung 10, umfassend einen Zentrifugenbehälter 12 und eine Abstützvorrichtung 14. Die Abstützvorrichtung 14 umfasst zudem eine biegeelastische Platte 16 sowie eine an ihrem Ende angeformte biegeelastische Lasche 18. Fig. 1 shows a centrifuge container assembly 10, comprising a centrifuge container 12 and a support device 14. The support device 14 also includes a flexurally elastic plate 16 and a flexurally elastic flap 18 integrally formed at its end.

In Fig. 1 ist eine Zentrifugenbehälteranordnung 10 gezeigt, in welcher ein in einen Zentrifugenbehälter 12 eingesetzter Blutbeutel 20 durch eine vertikal in den Zentrifugenbehälter 12 eingebrachte Abstützvorrichtung 14 abgestützt werden kann. Die Abstützvorrichtung 14 umfasst eine biegeelastische Silikonplatte 16, die eine Länge aufweist, die der doppelten Höhe des Zentrifugenbehälters 12 entspricht. Am oberen Ende der Silikonplatte 16 ist eine Lasche 18 aus Kunststoff angebracht. Blutbeutel 20 und Abstützvorrichtung 14 sind derart in den Zentrifugenbehälter eingebracht, dass der Blutbeutel 20 zwischen der Silikonplatte 16 und der inneren Wand des Zentrifugenbehälters 12 eingebracht ist.In Fig. 1 a centrifuge container assembly 10 is shown, in which a blood bag 20 inserted into a centrifuge container 12 can be supported by a support device 14 introduced vertically into the centrifuge container 12. The support device 14 comprises a flexurally elastic silicone plate 16, which has a length which corresponds to twice the height of the centrifuge container 12. At the upper end of the silicone plate 16, a tab 18 made of plastic is attached. Blood bag 20 and supporting device 14 are introduced into the centrifuge container such that the blood bag 20 is inserted between the silicone plate 16 and the inner wall of the centrifuge container 12.

Fig. 2 zeigt in einem nächsten Schritt, wie die vertikal eingebrachte Abstützvorrichtung 14, die neben dem Blutbehälter 20 parallel angeordnet ist, um eine Biegeachse A gebogen wird. Die Biegeachse A trennt die Silikonplatte 16 in einen Stützbereich 16a und einen Verspannbereich 16b. Der Verspannbereich 16b drückt gegen die vom Blutbeutel 20 abgewandte Wand des Zentrifugenbehälters 12 und verspannt dadurch insbesondere den oberen Bereich des Blutbeutels 20 und drückt diesen gegen die beutelseitige Zentrifugenbehälterwand. Aufgrund der biegeelastischen Ausgestaltung der Silikonplatte 16 wird ein Druck über den gesamten Blutbeutel 20 ausgeübt. Die größte Anpresskraft liegt jedoch im Bereich der Biegeachse A vor. Dies sorgt dafür, dass vor allem die Anschlüsse des Blutbeutels 20 stabil im oberen Bereich des Zentrifugenbehälters 12 gehalten werden. Fig. 2 shows in a next step, as the vertically mounted support device 14, which is arranged in parallel next to the blood container 20 in parallel, is bent about a bending axis A. The bending axis A separates the silicone plate 16 into a support region 16a and a clamping region 16b. The clamping region 16b presses against the wall of the centrifuge container 12 facing away from the blood bag 20 and thereby in particular braces the upper region of the blood bag 20 and presses it against the bag-side centrifuge container wall. Due to the flexurally elastic configuration of the silicone plate 16, a pressure is exerted over the entire blood bag 20. However, the largest contact force is in the area of the bending axis A. This ensures that above all the connections of the blood bag 20 are kept stable in the upper region of the centrifuge container 12.

Zudem ist die biegeelastische Lasche 18 dargestellt. Durch die biegeelastische Ausgestaltung der Lasche 18 wird diese nicht während der Zentrifugation in Richtung des Behälterbodens verdrückt, sondern bleibt auch nach der Zentrifugation gut erreichbar. Wie in Fig. 2 gut zu erkennen liegt der Andrückbereich in etwa auf Höhe der Biegeachse A und dadurch sind die Anschlüsse des Blutbeutels 20 oberhalb der Behälterkante festlegt. Die aufgebrachte Spannung durch die Rückstellkraft kann den vorliegenden Blutbeutel 20 auch unter Einfluss der Zentrifugationskräfte stützen.In addition, the flexurally elastic tab 18 is shown. Due to the flexurally elastic configuration of the tab 18, it is not displaced during the centrifugation in the direction of the container bottom, but remains easily accessible even after centrifugation. As in Fig. 2 the pressure range is approximately at the level of the bending axis A and thus are the connections of the blood bag 20 sets above the container edge. The applied tension by the restoring force can also support the present blood bag 20 under the influence of the centrifugal forces.

Fig. 3 zeigt eine Draufsicht auf den Zentrifugenbehälter 12 mit dem eingeklemmten Blutbeutel 20, der Abstützvorrichtung 14, wobei besonders gut die Lage der Biegeachse A der Platte 16 zu erkennen ist. Fig. 3 shows a plan view of the centrifuge container 12 with the clamped blood bag 20, the support device 14, wherein the position of the bending axis A of the plate 16 can be seen particularly well.

Fig. 4 zeigt eine perspektivische Ansicht einer erfindungsgemäßen Abstützvorrichtung 14, wobei diese eine biegeelastische Platte 16 sowie eine biegeelastische Lasche 18 umfasst. Die Platte 16 ist aus Silikon hergestellt, wobei die Lasche 18 aus einem dünnen Polyethylen- oder Polyurethanstreifen gebildet ist. Fig. 4 shows a perspective view of a supporting device 14 according to the invention, wherein this comprises a flexurally elastic plate 16 and a flexurally elastic tab 18. The plate 16 is made of silicone, wherein the tab 18 is formed of a thin polyethylene or polyurethane strip.

Fig. 5a zeigt eine schematische Schnittansicht von zwei Zentrifugenbehältern mit je einem Blutbeutel 20, der jeweils zwischen zwei Platten 16 eingeklemmt ist. Die Platten 16 sind so angeordnet, dass diese mit ihrem Stützbereich 16a jeweils am Blutbeutel 20 anliegen und mit ihrem Verspannbereich 16b sich gegen die Zentrifugenbehälterwand abstützen. Fig. 5a shows a schematic sectional view of two centrifuge containers, each with a blood bag 20, which is clamped between two plates 16 respectively. The plates 16 are arranged so that they rest with their support region 16a respectively on the blood bag 20 and with their bracing 16b are supported against the centrifuge container wall.

Fig. 5b zeigt eine schematische Schnittansicht von zwei Zentrifugenbehältern mit je einem Blutbeutel 20. Der Blutbeutel 20 wird von zwei Platten 16 derart gestützt, dass eine erste Platte 16 mit ihrem Stützbereich 16a am Blutbeutel 20 angeordnet ist, und mit ihrem Verspannbereich 16b gegen den Stützbereich 16a einer zweiten Platte drückt. Diese zweite Platte 16 verspannt sich mit ihrem Verspannbereich 16b wiederum gegen die Zentrifugenbehälterwand. Auf diese Weise kann durch die Verwendung der erfindungsgemäßen Abstützvorrichtung auf einfache Weise unterschiedlichen Ausdehnungen von Zentrifugiergutbehältern und Zentrifugenbehältern flexibel Rechnung getragen werden. Fig. 5b 2 shows a schematic sectional view of two centrifuge containers, each with one blood bag 20. The blood bag 20 is supported by two plates 16 such that a first plate 16 with its support region 16a is arranged on the blood bag 20, and with its clamping region 16b against the support region 16a of a second Plate presses. This second plate 16 braced with its clamping area 16b again against the centrifuge container wall. In this way, by the use of the supporting device according to the invention in a simple manner different dimensions of Zentrifugiergutbehältern and centrifuge containers are flexibly taken into account.

BezugszeichenlisteLIST OF REFERENCE NUMBERS

1010
ZentrifugenbehälteranordnungCentrifuges container arrangement
1212
Zentrifugenbehältercentrifuge container
1414
AbstützvorrichtungSupport device
1616
Silikonplattesilicone plate
16a16a
Stützbereichsupport area
16b16b
VerspannbereichVerspannbereich
1818
Lascheflap
2020
Blutbeutelblood bags
AA
Biegeachsebending axis

Claims (15)

  1. Centrifuge container assembly (10), comprising a centrifuge container (12) and at least one support device (14) for supporting a container (20) for centrifuged material that holds material to be centrifuged contained in a centrifuge container (12), characterized in that the support device (14) comprises a flexible plate (16) which, when bent, causes a restoring force to be generated, wherein the material and dimensions of the plate (16) have been chosen so as to allow flexible bending at least to such an extent that its two ends will make contact, wherein the support device (14) is of a width that maximally corresponds the maximum width of the receiving space for the centrifuge container (12).
  2. Centrifuge container assembly (10) according to claim 1, characterized in that the support device (14) has a handle means provided at one end of the plate.
  3. Centrifuge container assembly (10) according to claim 1 or 2, characterized in that the height of the plate (16) is at least one third higher than the height of the centrifuge container (12).
  4. Centrifuge container assembly (10) according to one of claims 1 to 3, characterized in that the plate (16) is made of plastic, in particular of silicone.
  5. Centrifuge container assembly (10) according to one of claims 1 to 4, characterized in that the plate (16) is of a thickness of between 0.5 cm and 2 cm.
  6. Centrifuge container assembly (10) according to one of claims 1 to 5, characterized in that the plate (16) is of a length of at least 20 cm.
  7. Centrifuge container assembly (10) according to one of claims 2 to 7, characterized in that the handle means is designed as a tab (18).
  8. Centrifuge container assembly (10) according to one of claims 2 to 7, characterized in that the tab (18) is flexible.
  9. Centrifuge container assembly (10) according to one of claims 8 to 9, characterized in that the tab (18) is of a width of between 1 cm and 2 cm and of a thickness of approx. 1mm.
  10. Use of a support device (14) for supporting a container (20) for material to be centrifuged that holds material to be centrifuged contained in a centrifuge container (12), which support device (14) comprises a flexible plate (16) which, when bent, generates a restoring force, wherein the material and dimensions of the plate (16) have been chosen so as to allow flexible bending at least to such an extent that its two ends will make contact, in a centrifuge container (12) during centrifugation.
  11. Use according to claim 10, characterized in that at least one support device (14) is inserted in the centrifuge container (12) and then an upper bending portion is bent away from the likewise inserted container (20) for material to be centrifuged, about a bending axis (A) which extends essentially in parallel to the container base.
  12. Use according to claim 11, characterized in that the support device (14) has a handle means provided at one end of the plate.
  13. Use according to claim 12, characterized in that the handle means is designed as a tab (18).
  14. Use according to claim 13, characterized in that the tab (18) is flexible.
  15. Use according to one of claims 13 or 14, characterized in that the tab (18) is of a width of between 1 cm and 2 cm and of a thickness of approx. 1 mm.
EP14715868.7A 2013-03-27 2014-03-27 Support device for a centrifuged-material-container Active EP2978536B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102013103153.6A DE102013103153B4 (en) 2013-03-27 2013-03-27 Support device for a Zentrifugigutbehälter
PCT/EP2014/056208 WO2014154827A1 (en) 2013-03-27 2014-03-27 Support device for a centrifuged-material-container

Publications (2)

Publication Number Publication Date
EP2978536A1 EP2978536A1 (en) 2016-02-03
EP2978536B1 true EP2978536B1 (en) 2018-07-04

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EP14715868.7A Active EP2978536B1 (en) 2013-03-27 2014-03-27 Support device for a centrifuged-material-container

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US (1) US10232375B2 (en)
EP (1) EP2978536B1 (en)
JP (1) JP6285535B2 (en)
CN (1) CN105073267B (en)
DE (1) DE102013103153B4 (en)
WO (1) WO2014154827A1 (en)

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CN107433231A (en) * 2016-05-26 2017-12-05 上海安亭科学仪器厂 A kind of Large Copacity Centrifuge Cup
DE102019109749A1 (en) * 2019-04-12 2020-10-15 Lmb Technologie Gmbh Blood separation device

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DE7219685U (en) 1972-05-26 1975-02-27 Biotest Serum Institut Gmbh Support bag for a method of centrifuging bags for blood and blood derivatives
BE794143A (en) * 1972-09-07 1973-05-16 American Hospital Supply Corp CENTRIFUGE ROTOR ASSEMBLY
EP0026417B1 (en) 1979-09-22 1983-12-14 Firma Andreas Hettich Centrifuge with system of bloodbag for the separation of blood components
JPS61200867A (en) * 1985-03-01 1986-09-05 Kawasumi Lab Inc Centrifugal separation of blood bag
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AUPN883396A0 (en) * 1996-03-21 1996-04-18 Australian Red Cross Society (Western Australian Division) Centrifugation support
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US20160016173A1 (en) 2016-01-21
US10232375B2 (en) 2019-03-19
JP6285535B2 (en) 2018-02-28
CN105073267A (en) 2015-11-18
JP2016518971A (en) 2016-06-30
CN105073267B (en) 2018-11-30
WO2014154827A1 (en) 2014-10-02
EP2978536A1 (en) 2016-02-03
DE102013103153B4 (en) 2016-09-08
DE102013103153A1 (en) 2014-10-02

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