EP2922509A1 - Schleuse zur fixierung eines harnkatheters - Google Patents

Schleuse zur fixierung eines harnkatheters

Info

Publication number
EP2922509A1
EP2922509A1 EP13857538.6A EP13857538A EP2922509A1 EP 2922509 A1 EP2922509 A1 EP 2922509A1 EP 13857538 A EP13857538 A EP 13857538A EP 2922509 A1 EP2922509 A1 EP 2922509A1
Authority
EP
European Patent Office
Prior art keywords
catheter
aperture
sheath
shaft
urinary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13857538.6A
Other languages
English (en)
French (fr)
Other versions
EP2922509A4 (de
EP2922509B1 (de
Inventor
Anthony J. Conway
Sarah L. Grinde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CR Bard Inc
Original Assignee
CR Bard Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CR Bard Inc filed Critical CR Bard Inc
Publication of EP2922509A1 publication Critical patent/EP2922509A1/de
Publication of EP2922509A4 publication Critical patent/EP2922509A4/de
Application granted granted Critical
Publication of EP2922509B1 publication Critical patent/EP2922509B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02—Holding devices, e.g. on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02—Holding devices, e.g. on the body
    • A61M2025/0213—Holding devices, e.g. on the body where the catheter is attached by means specifically adapted to a part of the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/16—Male reproductive, genital organs
    • A61M2210/167—Penis

Definitions

  • the present invention relates to a device that secures a straight or Foley catheter in the urinary tract of a male subject.
  • the device includes a portion that can be coupled to the subject's penis and a portion that can be coupled to the straight or Foley catheter.
  • the present invention also relates to methods of making and using this device and to assemblies including the device and a straight or Foley catheter.
  • the present invention includes a catheter retention sheath.
  • the catheter retention sheath can include a sheath configured to fit over a penis.
  • the sheath can include a catheter retainer, which can be configured to couple to a shaft of a urinary catheter.
  • the catheter retainer can define an aperture.
  • a first portion of the aperture can be configured to allow axial movement of the shaft of the urinary catheter through the aperture.
  • a second portion of the aperture can be configured to retain the shaft of the urinary catheter.
  • the present invention includes a method of catheterizing a subject.
  • This method can include providing a catheter retention sheath.
  • This catheter retention sheath can include a catheter retainer configured to couple to a shaft of a urinary catheter.
  • the catheter retainer can define an aperture.
  • a first portion of the aperture can be configured to allow axial movement of the shaft of the urinary catheter through the aperture.
  • a second portion of the aperture can be configured to retain the shaft of the urinary catheter.
  • This method also includes inserting a shaft of a urinary catheter into the first portion of the aperture, inserting a portion of the shaft of the urinary catheter into a subject's urethra, and urging the shaft of the urinary catheter from the first portion of the aperture into the second portion of the aperture.
  • the present invention includes a method of making a catheter retention sheath.
  • This method includes applying silicone rubber to a portion of a mandrel and forming an aperture in the silicone rubber.
  • a first portion of the aperture can be configured to allow axial movement of the shaft of the urinary catheter through the aperture.
  • a second portion of the aperture can be configured to retain the shaft of the urinary catheter.
  • This method also includes curing the silicone rubber to form the catheter retention sheath defining the aperture.
  • the present invention includes a catheter system.
  • the catheter system includes a urinary catheter having a shaft and the present catheter retention sheath.
  • Figure 1 schematically represents an embodiment of a catheter system according to the present invention and including an embodiment of the present catheter retainer and a urinary catheter including a shaft.
  • Figure 2 schematically represents an embodiment of the present catheter retainer.
  • Figure 3 schematically represents an embodiment of the present tube showing an embodiment of a lumen and of a slit.
  • Figure 4 schematically represents an embodiment of a catheter system according to the present invention and including an embodiment of the present catheter retainer and a urinary catheter including a shaft.
  • the urinary catheter is shown in an embodiment of the catheter retention opening.
  • Figure 5 schematically represents a cross-sectional view of the present catheter retention sheath including a rolled-up sheath portion.
  • Figure 6 schematically represents an embodiment of the present catheter retainer including a tab-shaped transition section that defines the openings.
  • the present invention relates to a device that secures a urinary catheter (e.g., a straight or Foley catheter) in the urinary tract of a male subject.
  • the device includes a portion that can be coupled to the subject's penis and a portion that can be coupled to the straight or Foley catheter.
  • the portion that can be coupled to the subject's penis can be in the form of a sheath or condom configured to fit a penis, e.g., a normal, flaccid penis.
  • the device including the sheath or condom portion and the portion that couples to the urinary catheter can be referred to as a catheter retention sheath.
  • the portion of the catheter retention sheath that couples to the urinary catheter can define an aperture with two portions.
  • a first portion of the aperture is configured so that the urinary catheter can move freely (at least in the direction of the axis of its shaft) through this first portion.
  • This first portion of the aperture can be larger than the outside diameter of a shaft of the urinary catheter and can allow the urinary catheter into and through the sheath or condom portion.
  • a second portion of the aperture can be configured to restrict motion of the urinary catheter.
  • this second portion of the aperture can, in a relaxed state, be approximately the same size as or smaller than the outside diameter of the shaft of the urinary catheter.
  • the urinary catheter can be lodged in this second portion of the aperture and its motion restricted with respect to the sheath and the subject (at least in the direction of the axis of its shaft).
  • the portion of the catheter retention sheath that couples to the urinary catheter can include a neck portion that defines part or all of the second portion of the aperture.
  • This neck portion can include, for example, a tube with a slit along it that is coupled to the sheath portion.
  • the present invention includes a catheter retention sheath.
  • the catheter retention sheath can include a sheath configured to fit over a penis.
  • the sheath can include a catheter retainer, which can be configured to couple to a shaft of a urinary catheter.
  • the catheter retainer can define an aperture.
  • a first portion of the aperture can be configured to allow axial movement of the shaft of the urinary catheter through the aperture.
  • a second portion of the aperture can be configured to retain the shaft of the urinary catheter.
  • the first portion of the aperture is larger than the outside diameter of a shaft of the urinary catheter.
  • the first portion of the aperture can be configured to allow the urinary catheter into and through the sheath or condom portion of the catheter retention sheath.
  • the second portion of the aperture is configured to immobilize the urinary catheter in the sheath.
  • the second portion of the aperture is configured to restrict motion of the urinary catheter with respect to the subject's penis and bladder.
  • the second portion of the aperture is, in a relaxed state, approximately the same size as or smaller than the outside diameter of the shaft of the urinary catheter.
  • the catheter retainer defines a slit that couples the first portion of the aperture to the second portion of the aperture.
  • the present catheter retention sheath includes a neck portion that defines part or all of the second portion of the aperture.
  • the neck portion includes a tube coupled to the sheath, the tube defining an axial slit.
  • the catheter retainer includes an integral conical portion of thicker material that defines part or all of the second portion of the aperture.
  • the present catheter retention sheath can be employed with any of a variety of urinary catheters. Suitable urinary catheters include a straight catheter and a Foley catheter.
  • the sheath includes an inner surface and an outer surface, the inner surface including an adhesive configured to adhere to the penis.
  • the sheath can include a tubular sleeve member of resilient material rolled outwardly upon itself, the sleeve member having an outer surface and an inner surface. The outer surface of the sleeve member can contact a layer of adhesive and the layer of adhesive can contact the inner surface of the sleeve member.
  • the adhesive includes or is a hydrocolloid composition.
  • the adhesive composition is between the inner and outer surfaces of one or more consecutive rolls so that the adhesive is covered by the inner surface when the sheath is in rolled up condition.
  • the present catheter retention sheath includes an adhesive band made of resilient material and configured to retain the sheath on the penis.
  • the catheter retention sheath is made of a composition including silicone.
  • the catheter retention sheath can be made of silicone rubber.
  • the catheter retention sheath consists of silicone rubber.
  • the present invention includes a catheter system.
  • the catheter system includes a urinary catheter having a shaft and the present catheter retention sheath.
  • FIG. 1 schematically illustrates an embodiment of a catheter retention sheath according to the present invention and a straight urinary catheter.
  • Catheter retainer 1 includes a sleeve 3, a tube 5, and a transition section 7 between the sleeve 3 and tube 5.
  • Sleeve 3 is illustrated in its rolled configuration.
  • Transition section 7 defines catheter access opening 9, which is configured to allow movement of a straight urinary catheter 11.
  • straight urinary catheter 11 is shown protruding through catheter access opening 9 in a configuration suitable, for example, for insertion into a subject.
  • Tube 5 defines catheter retention opening (shown in Figures 2 and 3), which is configured to reduce movement of or to immobilize straight urinary catheter 11.
  • FIG. 1 schematically illustrates another view of the catheter retainer 1 of
  • FIG. 1 and showing tube 5, catheter access opening 9, and slit 13, which is defined by tube 5.
  • Slit 13 and a lumen (shown in Figure 3) of tube 5 form catheter retention opening 15.
  • Figure 3 schematically illustrates tube 5 showing lumen 17 and slit 13, which form catheter retention opening 15.
  • Figure 4 schematically illustrates an embodiment of catheter retainer 1 with a straight urinary catheter in catheter retention opening 15 defined by tube 5.
  • Straight urinary catheter 11 can be urged into lumen 17 from catheter access opening 9.
  • the straight urinary catheter 11 has been inserted into the subject's urethra before it is positioned in the catheter retention opening.
  • Sleeve 3 is not shown in Figure 4, but could be in its rolled configuration when the straight urinary catheter 11 is being inserted into the subject's urethra and then unrolled onto the subject's penis after insertion.
  • FIG. 5 schematically illustrates features of an embodiment of catheter retainer 1 without showing straight urinary catheter 11, access opening 9, or slit 13.
  • catheter retainer 1 has a unitary construction which includes a sleeve 3, a tube 5, and a transition section 7 between the sleeve 3 and tube 5.
  • Catheter retainer 1 can be made of silicone rubber.
  • Catheter retainer 1 has an inner surface 19 and an outer surface 21. Following manufacture and during pre-use storage, catheter retainer 1 can be in a pre-use configuration as shown in Figure 1, wherein a first portion 23 of sleeve 3 is rolled up on itself so that except as indicated hereinafter inner surface 19 is rolled up against and comes into contact with outer surface 21.
  • Adhesive layer 25 Interposed between most of inner surface 19 and outer surface 21 of sleeve 3 can be an adhesive layer 25.
  • Adhesive layer 25 adheres to inner surface 19 and does not adhere to outer surface 21 when sleeve 3 is unrolled. The reason for such phenomenon is discussed in more detail hereinafter.
  • Adhesive layer 25 can also include a second portion 27 formed on a significant portion of transition section 7. First portion 29 and second portion 27 of adhesive layer 25 can be contiguous as transition section 7 changes form to sleeve 3.
  • Sleeve 3 can be formed as a cylinder having a diameter appropriate for a limp penis.
  • Sleeve 3 can have a length of about 1 to about 5 inches.
  • the length of sleeve 3 can be selected to be long enough to provide sufficient fastening adhesion between first portion 23 of the adhesive layer 25 on the inside surface of the sleeve 3 and the penile shaft, but not so long so that the sleeve 3 cannot be completely unrolled when a recessed penis is pulled outwardly to expose the total length of penile shaft with respect to pelvic skin.
  • First portion 29 can include all of the inner surface of sleeve 22 except an adhesive-free band 31 on the inner surface of sleeve 3 adjacent its open end. Band 31 can provide a loose end for a practitioner or user of the device to grasp and begin to roll sleeve 3 back on itself or otherwise to remove an installed catheter retainer 1.
  • Transition section 7 provides a reduction in diameter from sleeve 3 to tube 5.
  • Second portion 27 to which adhesive can be applied contiguously with the hydrocolloid on first portion 29 includes most of the cone portion of transition section 7.
  • second portion 27 can provide an advantageously large adhesive surface within transition section 7 to contact and adhere to the glans penis.
  • an apex portion 33, which connects with and opens to tube 5, is free of adhesive.
  • Sleeve 3 can be rolled in the pre-use configuration. Hence, second portion 27 on the inside surface 19 of transition section 7 may be exposed (although the entire catheter retainer 1 can be appropriately protected in a package).
  • Sleeve 3 and transition section 7 can have a thickness which allows them to be conformed to the shape of the penis as the adhesive adheres to the penis.
  • Tube 5 has a greater thickness so as to retain its shape and provide for suitable retention of straight urinary catheter 11.
  • Tube 5 can be configured to provide a structure that retains its shape (e.g., doesn't collapse) when formed in a smaller diameter section 35 and a larger diameter section 37.
  • the device can include an optional short transitional neck 39 extends between sections 35 and 37.
  • a narrow portion of the cone-shape of transition section 7 can extend between larger diameter section 37 and the rest of transition section 7 so as to provide a short portion of greater thickness leading to the larger portion of transition section 7 having a thinner thickness.
  • Adhesive layer 25 does not adhere to the outer surface 21 when sleeve 3 is unrolled.
  • Adhesive layer 25 can be simply adhered to inner surface 19 or alternatively bonded to the inner surface 19 by a catalyzed process, for example, a vulcanizing process, in which constituents within the adhesive composition are cross-linked to constituents within the silicone rubber which is formed from an unvulcanized silicone rubber solution overcoat layer during the vulcanizing process. Once the adhesive layer 25 is adhered or bonded to the inner surface 19 and the outer surface is formed (e.g., according to a process described hereinafter), adhesive no longer irreversibly adheres to outer surface 21.
  • Figure 6 schematically illustrates an embodiment of the present catheter retainer 1 in which a tab- shaped transition section 7 defines catheter access opening 9 and catheter retention opening 15.
  • the catheter retainer can have of any of a variety of configurations with a tubular sleeve or a sheath that fits over a penis.
  • the tubular sleeve or the sheath can be made of a resilient material (e.g., silicone rubber) and can have an inner surface and an outer surface.
  • the present catheter retainer includes a sheath sized for fitting about a normal, flaccid penis.
  • the sheath can include a flexibly cylindrical member rolled outwardly upon itself forming consecutively larger rolls.
  • This cylindrical member can have adhesive composition between consecutive rolls.
  • the outer surface of the cylindrical member can release the adhesive composition when the member is unrolled and inner surface of the cylindrical member retains the adhesive when the member is unrolled.
  • the sheath may be stored with the adhesive composition protected between consecutive rolls of the member and used by unrolling the member onto a penis allowing the adhesive to release from the outer surface and allowing the adhesive to adhere to the inner surface and the penis.
  • the adhesive composition can be on a portion of the inner surface.
  • the tubular sleeve or the sheath can be rolled up upon itself. In the rolled up configuration, the tubular sleeve or sheath can isolate the adhesive composition from the surroundings.
  • the adhesive composition can be between layers of the rolled sleeve or sheath.
  • the outer surface of the sleeve or sheath can contact the layer of adhesive composition and the layer of adhesive composition can contact the inner surface of the sleeve or sheath.
  • the adhesive composition can be between the inner and outer surfaces of one or more consecutive rolls so that the adhesive is covered by the inner surface when the sheath is rolled up.
  • the adhesive composition is in the form of a layer that is directly and non-releasably bonded to a portion of the inner surface.
  • the adhesive composition can releasably contact one or more portions of the outer surface.
  • the inner surface of the silicone rubber sheath can be rolled up upon the outer surface.
  • the layer of adhesive composition on the portion of the inner surface comes into releasable contact with one or more portions of the outer surface.
  • the adhesive composition on the outer surface can then release from the outer surface with which it has come into contact, while remaining bonded to the inner surface, when the silicone rubber sheath is forcibly unrolled.
  • the adhesive can be or can include a hydrocolloid composition or adhesive.
  • the hydrocolloid can have (strong) adhesive properties and compatibility with both skin and catheter materials.
  • the hydrocolloid composition can include an acrylic pressure sensitive adhesive, a polyacrylic acid polymer, and, optionally, a neutralizes
  • the polyacrylic acid polymer can be a cross-linked polyacrylic acid polymer. Such a crosslinked polymer can provide efficient rheology modification and enhanced self-wetting.
  • Suitable polyacrylic acid polymers include that sold under the trade name CARBOPOL ULTREZ 10 NF® by Lubrizol, Cleveland, Ohio.
  • Suitable neutralizers include amines, such as an aminomethyl propanol.
  • Suitable amino methyl propanols include that sold under the trade name AMP-
  • the commercial product includes 93-97 wt-% 2-amino-2-methyl-l -propanol and about 5% water.
  • the amounts of neutralizer listed in the present application can be multiplied by, for example, about 0.93, about 0.97, or about 0.93 to about 0.97 to account for the level of active in the commercial product.
  • the amount of neutralizer listed in the present application refers to a neutralizer stock solution that includes about 93-97 wt-% 2-amino-2-methyl-l- propanol.
  • the hydrocolloid prep composition can include about 90 to about 99.99 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent); about 0.01 to about 10 wt-% (e.g., about 0.5 wt-%) polyacrylic acid polymer; and, optionally, about 0.01 to about 5 wt-% (e.g., about 0.5 wt-%) neutralizer.
  • acrylic pressure sensitive adhesive and solvent about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent
  • about 0.01 to about 10 wt-% e.g., about 0.5 wt-%) polyacrylic acid polymer
  • about 0.01 to about 5 wt-% e.g., about 0.5 wt-%) neutralizer.
  • the hydrocolloid prep composition can include about 90 to about 99.99 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent); and about 0.01 to about 10 wt-% of polyacrylic acid polymer and neutralizer; the neutralizer and polyacrylic acid polymer being in a ratio of about 0.9 to about 1 (e.g., 0.9: 1).
  • the amount of neutralizer can be just sufficient to neutralize the polyacrylic acid polymer without adding additional basicity to a mixture of the polyacrylic acid and the neutralizer.
  • the neutralizer and polyacrylic acid polymer are in a ratio of 0.7-0.99:0.95-1.2 (e.g., 0.9: 1).
  • the hydrocolloid adhesive composition can include about 55 to about 99.98 wt-% of acrylic pressure sensitive adhesive; about 0.02 to about 30 wt-% polyacrylic acid polymer; and, optionally, about 0.02 to about 15 wt-% neutralizer.
  • the hydrocolloid prep composition can include about 90 to about 99.99 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent); about 0.01 to about 10 wt-% (e.g., about 0.5 wt-%) polyacrylic acid polymer; and, optionally, about 0.01 to about 5 wt-% (e.g., about 0.5 wt-%) neutralizer.
  • acrylic pressure sensitive adhesive and solvent about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent
  • about 0.01 to about 10 wt-% e.g., about 0.5 wt-%) polyacrylic acid polymer
  • about 0.01 to about 5 wt-% e.g., about 0.5 wt-%) neutralizer.
  • the hydrocolloid prep composition can include about 90 to about 99.99 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent); about 0.01 to about 10 wt-% (e.g., about 0.5 wt- %) polyacrylic acid polymer; and about 0.01 to about 5 wt-% (e.g., about 0.5 wt-%) neutralizer.
  • the hydrocolloid prep composition can include about 96 to about 99.6 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt- % solids (e.g., the adhesive composition) the remainder being solvent); about 0.2 to about 2 wt-% polyacrylic acid polymer; and about 0.2 to about 2 wt-% neutralizer.
  • the hydrocolloid prep composition can include about 98 to about 99.4 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent); about 0.3 to about 1 wt-% polyacrylic acid polymer; and about 0.3 to about 1 wt-% neutralizer.
  • the hydrocolloid prep composition can include about 99 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent); about 0.5 wt-% polyacrylic acid polymer; and about 0.5 wt-% neutralizer.
  • the hydrocolloid prep composition can include about 90 to about 99.99 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt- % solids (e.g., the adhesive composition) the remainder being solvent).
  • the hydrocolloid prep composition can include about 96 to about 99.6 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent).
  • the hydrocolloid prep composition can include about 98 to about 99.4 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent).
  • the hydrocolloid prep composition can include about 99 wt-% of acrylic pressure sensitive adhesive and solvent (about 35 to about 45 wt-% solids (e.g., the adhesive composition) the remainder being solvent).
  • the hydrocolloid prep composition can include about 0.01 to about 10 wt-% (e.g., about 0.5 wt-%) polyacrylic acid polymer. In an embodiment, the hydrocolloid prep composition can include about 0.2 to about 2 wt-% polyacrylic acid polymer. In an embodiment, the hydrocoUoid prep composition can include about 0.3 to about 1 wt-% polyacrylic acid polymer. In an embodiment, the hydrocoUoid prep composition can include about 0.5 wt-% polyacrylic acid polymer.
  • the hydrocoUoid prep composition includes no added neutralizer. In an embodiment, the hydrocoUoid prep composition includes no neutralizer. In an embodiment, the hydrocoUoid prep composition can include about 0.01 to about 5 wt-% (e.g., about 0.5 wt-%) neutralizer. In an embodiment, the hydrocoUoid prep composition can include about 0.2 to about 2 wt-% neutralizer. In an embodiment, the hydrocoUoid prep composition can include about 0.3 to about 1 wt-% neutralizer. In an embodiment, the hydrocoUoid prep composition can include about 0.5 wt-% neutralizer.
  • the hydrocoUoid adhesive composition can include about 55 to about 99.98 wt-% of acrylic pressure sensitive adhesive; about 0.02 to about 30 wt-% polyacrylic acid polymer; and, optionally, about 0.02 to about 15 wt-% neutralizer.
  • the hydrocoUoid adhesive composition can include about 55 to about 99.96 wt-% of acrylic pressure sensitive adhesive; about 0.02 to about 30 wt-% polyacrylic acid polymer; and about 0.02 to about 15 wt-% neutralizer.
  • the hydrocoUoid composition can include about 90 to about 99.4 wt-% of acrylic pressure sensitive adhesive; about 0.3 to about 5 wt-% polyacrylic acid polymer; and about 0.3 to about 5 wt-% neutralizer. In an embodiment, the hydrocoUoid composition can include about 94 to about 99 wt-% acrylic pressure sensitive adhesive; about 0.5 to about 3 wt-% polyacrylic acid polymer; and about 0.5 to about 3 wt-% neutralizer. In an embodiment, the hydrocoUoid composition can include about 97 to about 98 wt-% of acrylic pressure sensitive adhesive; about 1 to about 1.5 wt-% polyacrylic acid polymer; and about 1 to about 1.5 wt-% neutralizer.
  • the hydrocoUoid composition can include about 97 wt-% of acrylic pressure sensitive adhesive; about 1.5 wt-% polyacrylic acid polymer; and about 1.5 wt-% neutralizer. In an embodiment, the hydrocoUoid composition can include about 98 wt-% of acrylic pressure sensitive adhesive; about 1 wt-% polyacrylic acid polymer; and about 1 wt-% neutralizer.
  • the hydrocoUoid adhesive composition can include about 55 to about 99.98 wt-% of acrylic pressure sensitive adhesive. In an embodiment, the hydrocoUoid adhesive composition can include about 55 to about 99.96 wt-% of acrylic pressure sensitive adhesive. In an embodiment, the hydrocoUoid composition can include about 90 to about 99.4 wt-% of acrylic pressure sensitive adhesive. In an embodiment, the hydrocoUoid composition can include about 94 to about 99 wt-% acrylic pressure sensitive adhesive. In an embodiment, the hydrocoUoid composition can include about 97 to about 98 wt-% of acrylic pressure sensitive adhesive. In an embodiment, the hydrocoUoid composition can include about 97 wt-% of acrylic pressure sensitive adhesive. In an embodiment, the hydrocoUoid composition can include about 98 wt-% of acrylic pressure sensitive adhesive.
  • the hydrocoUoid adhesive composition can include about 0.02 to about 30 wt-% polyacrylic acid polymer. In an embodiment, the hydrocoUoid composition can include about 0.02 to about 30 wt-% polyacrylic acid polymer. In an embodiment, the hydrocoUoid composition can include about 0.3 to about 5 wt-% polyacrylic acid polymer. In an embodiment, the hydrocoUoid composition can include about 0.5 to about 3 wt-% polyacrylic acid polymer. In an embodiment, the hydrocoUoid composition can include about 1 to about 1.5 wt-% polyacrylic acid polymer. In an embodiment, the hydrocoUoid composition can include about 1.5 wt-% polyacrylic acid polymer. In an embodiment, the hydrocoUoid composition can include about 1 wt-% polyacrylic acid polymer.
  • the hydrocoUoid adhesive composition can include about 0.02 to about 15 wt-% neutralizer. In an embodiment, the hydrocoUoid composition can include about 0.02 to about 15 wt-% neutralizer. In an embodiment, the hydrocoUoid composition can include about 0.3 to about 5 wt-% neutralizer. In an embodiment, the hydrocoUoid composition can include about 0.5 to about 3 wt-% neutralizer. In an embodiment, the hydrocoUoid composition can include about 1 to about 1.5 wt-% neutralizer. In an embodiment, the hydrocoUoid composition can include about 1.5 wt-% neutralizer. In an embodiment, the hydrocoUoid composition can include about 1 wt-% neutralizer.
  • the hydrocoUoid can include a bioadhesive.
  • suitable bioadhesives include poly(isobutylene) and acrylic adhesives.
  • the hydrocoUoid can be intimately mixed with the bioadhesive to produce an integral material.
  • hydrocolloids include natural gums, such as plant exudates
  • hydrocolloid (gum arabic, ghatti, karaya, and tragacanth); plant seed gums (guar, locust bean and acacia), seaweed extracts (agar, algin, alginate salts and carrageenin), cereal gums (starches and modified starches), fermentation or microbial gums (dextran and xanthan gum), modified celluloses (hydroxymethylcellulose, microcrystalline cellulose and carboxymethylcellulose) pectin, gelatin, casein and synthetic gums (polyvinylpyrrolidone, low methoxyl pectin, propylene glycol alginates, carboxymethyl locust bean gum and carboxymethyl guar gum) and water-swellable or hydratable hydrocoUoids.
  • hydrocolloid is used regardless of the state of hydration.
  • Hydrocolloid compositions can include a variety of components.
  • a hydrocolloid composition can contain, for example, an adhesive base, a gelling agent, an absorptive agent, a setting agent, an anti-microbial agent, or a mixture thereof.
  • Suitable adhesive bases include polyisobutylenes and acrylics, both of which possess the desirable characteristics of biocompatibility and strong adhesiveness for skin and catheter materials.
  • Other suitable adhesive bases include any of a variety of non-toxic polymers, for example, styrene, butadiene, styrene isoprene block copolymers, urethanes, silicones, styrene butadiene copolymers, methyl acrylate copolymers, acrylic acid, polyacrylates, and blends or copolymers thereof.
  • Suitable bases include bioadhesives for application to the epithelium that can be compatible with mucosal surfaces and exposed dermis.
  • a polyisobutylene PIB
  • a suitable type is a hot-melt, solvent-free compound with a high molecular weight (“MW”).
  • MW molecular weight
  • An example of an acceptable high MW polyisobutylene is "VISTANEX® L-140” available from Exxon Corp. and having a MW in the range of from 117,000 to 135,000 daltons.
  • the composition can include a low MW polyisobutylene, such as "VISTANEX® LMH", with a MW in the range of from 11,600 to 12,300 daltons.
  • the composition can include a high MW acrylic adhesive, such as "HRJ-4326", with a MW in the range of 105,000 to 125,00 daltons, available from Schenectedy International, Inc., of Schenectedy N.Y.
  • the composition can include a lower MW acrylic adhesive, such as "HRJ- 10753", with a MW in the range of 81,000-91,000 daltons, also available from Schenectedy International, Inc.
  • the adhesive base makes up about 20 to about 60 wt- of the hydrocolloid composition.
  • bioadhesive as used herein means an adhesive that adheres to or, for example, can strongly attach to a biological surface such as skin or mucosal tissue. Suitable bioadhesives include those that can maintain adhesion in moist or wet in vivo or in vitro environments. The strength of adherence of a hydrocolloid composition to a surface can be measured by standard tests for measuring the force, e.g. in dynes per square centimeter, as disclosed in U.S. Pat. No. 4,615,697.
  • Suitable gel agents include biocompatible compounds which, when exposed to water or aqueous solutions, form a solid gel, gelatin or highly viscous liquid.
  • Suitable gel agents include sodium alginate, pectin, gelatin and agar.
  • Suitable absorptive agents include calcium silicate, and natural or synthetic polysaccharides.
  • Suitable polysaccharides include cellulose derivatives such as methylcellulose, cellulose acetate, carboxymethylcellulose, hydroxyethylcellulose and the like.
  • Certain absorptive agents possess the capability to absorb and hold water or aqueous fluids in a colloidal mass. In a typical hydrated colloidal mass, the absorbed water or aqueous fluid may weigh many times the weight of the absorptive agent.
  • These absorptive agents include polysaccharides such as, karaya gum, tragacanth gum, pectin, guar gum, cellulose, and cellulose derivatives such as methyl cellulose, propyl cellulose, cellulose acetate and the like, along with other substances known for use in forming a solid colloid that can adhere to skin and mucosa, used alone or in combination with various adhesive bases.
  • Suitable absorptive agents include those prepared optionally from partially esterified polyacrylic acid polymers, including but not limited to, polyacrylic acid polymers lightly crosslinked with a polyalkenyl polyether such as those commercially available from B. F. Goodrich, Cincinnati, Ohio, under the trademarks "CARBOPOL® 934", “CARBOPOL® 934P”, “CARBOPOL® 940” and “CARBOPOL® 941.”
  • Additional suitable absorptive agents include hydrophilic polysaccharide gums such as natural plant exudates, including karaya gum, ghatti gum, tragacanth gum, xanthan gum, jaraya gum and the like, as well as seed gums such as guar gum, locust bean gum, psillium seed gum and the like.
  • Setting agents suitable for the compositions include calcium salts such as calcium chloride, calcium phosphate and calcium sulphate. The corresponding magnesium salts may also be useful as setting agents.
  • Anti-microbial agents that can be employed in the hydrocoUoid composition include an anti-fungal agent (e.g., magnesium borate) and other known topical anti-microbial agents, including bacitracin zinc, povidone iodine, benzalkonium chloride, neomycin sulfate, polymyxin B sulfate, silver sulfadiazine and mupirocin.
  • an anti-fungal agent e.g., magnesium borate
  • other known topical anti-microbial agents including bacitracin zinc, povidone iodine, benzalkonium chloride, neomycin sulfate, polymyxin B sulfate, silver sulfadiazine and mupirocin.
  • the present invention can include a sheath including a hydrocoUoid silicone composition.
  • a hydrocoUoid silicone composition can include silicone rubber, a polyacrylic acid polymer, and, optionally, a neutralizer.
  • the hydrocoUoid composition can be a component of the adhesive layer, of one or more silicone rubber layers, or of both adhesive and silicone rubber layers.
  • the present catheter retainer can include a sleeve or sheath made of a hydrocoUoid silicone composition.
  • the present catheter retainer can include a sleeve or sheath including a layer of hydrocoUoid silicone composition disposed under the adhesive.
  • the hydrocoUoid silicone composition beneath the adhesive can increase user comfort, for example, when removing the condom catheter.
  • the hydrocoUoid silicone composition beneath the adhesive can reduce maceration of tissue (e.g., skin) to which the adhesive adheres.
  • At least a portion of the resilient material can include a hydrocoUoid.
  • both the adhesive and at least a portion of the resilient material include a hydrocoUoid.
  • the tubular sleeve or the sheath can be made of a resilient material (e.g., silicone rubber, a hydrocoUoid silicone composition, or layers of both) and can have an inner surface and an outer surface.
  • a resilient material e.g., silicone rubber, a hydrocoUoid silicone composition, or layers of both
  • the method can include applying a hydrocoUoid silicone composition to the mandrel and over an adhesive composition; and curing the silicone rubber to form a condom catheter comprising a layer of hydrocoUoid adhesive composition, a hydrocoUoid silicone composition, or both; and removing the condom catheter from the mandrel.
  • catheter retainer 1 can be made of silicone rubber (e.g., the present hydrocoUoid silicone composition).
  • catheter retainer 1 can be made by combining two or more layers of a silicone rubber solution or of separate silicone rubber solutions.
  • one solution can be a silicone rubber solution and another solution can be a solution of a hydrocolloid silicone composition.
  • the present invention includes a method of catheterizing a subject.
  • This method can include providing a catheter retention sheath.
  • This catheter retention sheath can include a catheter retainer configured to couple to a shaft of a urinary catheter.
  • the catheter retainer can define an aperture.
  • a first portion of the aperture can be configured to allow axial movement of the shaft of the urinary catheter through the aperture.
  • a second portion of the aperture can be configured to retain the shaft of the urinary catheter.
  • This method also includes inserting a shaft of a urinary catheter into the first portion of the aperture, inserting a portion of the shaft of the urinary catheter into a subject's urethra, and urging the shaft of the urinary catheter from the first portion of the aperture into the second portion of the aperture.
  • the present invention includes a method of making a catheter retention sheath.
  • This method includes applying silicone rubber to a portion of a mandrel and forming an aperture in the silicone rubber.
  • a first portion of the aperture can be configured to allow axial movement of the shaft of the urinary catheter through the aperture.
  • a second portion of the aperture can be configured to retain the shaft of the urinary catheter.
  • This method also includes curing the silicone rubber to form the catheter retention sheath defining the aperture.

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EP13857538.6A 2012-11-20 2013-11-20 Schleuse zur fixierung eines harnkatheters Active EP2922509B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/682,406 US10092728B2 (en) 2012-11-20 2012-11-20 Sheath for securing urinary catheter
PCT/US2013/071046 WO2014081853A1 (en) 2012-11-20 2013-11-20 Sheath for securing urinary catheter

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EP2922509A1 true EP2922509A1 (de) 2015-09-30
EP2922509A4 EP2922509A4 (de) 2016-07-20
EP2922509B1 EP2922509B1 (de) 2021-03-03

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EP (1) EP2922509B1 (de)
JP (1) JP6316837B2 (de)
CN (1) CN104812339B (de)
BR (1) BR112015011239A2 (de)
CA (1) CA2887790C (de)
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JP2015534899A (ja) 2015-12-07
MX362377B (es) 2019-01-14
CA2887790C (en) 2020-03-24
CA2887790A1 (en) 2014-05-30
BR112015011239A2 (pt) 2017-07-11
EP2922509A4 (de) 2016-07-20
CN104812339A (zh) 2015-07-29
JP6316837B2 (ja) 2018-04-25
US20140142554A1 (en) 2014-05-22
US10092728B2 (en) 2018-10-09
CN104812339B (zh) 2018-04-10
ES2864698T3 (es) 2021-10-14
WO2014081853A1 (en) 2014-05-30
MX2015006058A (es) 2015-08-07
EP2922509B1 (de) 2021-03-03

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