EP0083617A1 - Appareil pour la mesure du temps de coagulation du sang et procede pour saisir et mesurer le temps - Google Patents
Appareil pour la mesure du temps de coagulation du sang et procede pour saisir et mesurer le tempsInfo
- Publication number
- EP0083617A1 EP0083617A1 EP82902153A EP82902153A EP0083617A1 EP 0083617 A1 EP0083617 A1 EP 0083617A1 EP 82902153 A EP82902153 A EP 82902153A EP 82902153 A EP82902153 A EP 82902153A EP 0083617 A1 EP0083617 A1 EP 0083617A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- measuring
- light
- cuvette
- block
- microprocessor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
- B01F35/42—Clamping or holding arrangements for mounting receptacles on mixing devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
Abstract
L'appareil comprend une cuvette de mesure faisant partie d'un bloc de mesure pouvant être maintenu à une température modérée, un dispositif d'agitation, un dispositif optique de mesure de la turbidité. Il présente une combinaison des caractères suivants: Le dispositif d'agitation (16) est du type magnétique en soi connu; il est placé dans le bloc de mesure (11), au-dessous du canal (8) de réception de la cuvette de mesure (17). Un agitateur, constitué par une bille de métal (23), est disposé dans la cuvette de mesure (17). Il est mis en mouvement par effet magnétique au moyen du dispositif d'agitation (16). La cuvette de mesure (17) est maintenue dans le canal de mesure (8) au moyen d'un dispositif de blocage (18). Elle est disposée dans la trajectoire du faisceau lumineux (32) d'un dispositif de détection optique (13) dont la source de lumière (15) est alimentée par une tension de service au moins égale à la moitié de la tension nominale. Le récepteur de lumière (14) est relié à un indicateur de la valeur mesurée (27). Le bloc de mesure à température modérée peut aussi comprendre un bloc de cuvettes amovible (39) muni de plusieurs canaux (8, 8a) pour plusieurs cuvettes de mesure (17). A chaque cuvette de mesure (17) disposée dans son canal (8a) est associé un détecteur particulier du dispositif de détection optique (13). Celui-ci est relié à un microprocesseur (43) ou analogue, pouvant être actioné au moyen d'un organe de commande (44) et qui est relié à un dispositif de sortie des données. Ce dispositif de sortie des données peut être une imprimante (31) et/ou un écran d'affichage (46).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813127560 DE3127560A1 (de) | 1981-07-11 | 1981-07-11 | Geraet zum erfassen und messen der blutgerinnungszeit mit einem zur aufnahme der messkuevette dienenden temperierbaren metallblock, einer ruehreinrichtung und einer lichtoptischen truebungsmesseinrichtung |
DE3127560 | 1981-07-11 | ||
DE3145692A DE3145692C3 (de) | 1981-11-19 | 1981-11-19 | Verfahren zum Erfassen und Messen der Blutgerinnungszeit und Gerät zur Durchführung des Verfahrens |
DE3145692 | 1981-11-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0083617A1 true EP0083617A1 (fr) | 1983-07-20 |
Family
ID=25794533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP82902153A Withdrawn EP0083617A1 (fr) | 1981-07-11 | 1982-07-02 | Appareil pour la mesure du temps de coagulation du sang et procede pour saisir et mesurer le temps |
Country Status (4)
Country | Link |
---|---|
US (1) | US4876069A (fr) |
EP (1) | EP0083617A1 (fr) |
JP (1) | JPS58501096A (fr) |
WO (1) | WO1983000228A1 (fr) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1178901B (it) * | 1984-03-22 | 1987-09-16 | Irfin S P A | Procedimento per il recupero selettivo dei materiali costituenti cascami di cavi elettrici isolati |
DE3587510T2 (de) * | 1984-06-27 | 1994-03-03 | Wako Pure Chem Ind Ltd | Gerät zur Messung von Endotoxin. |
US5144139A (en) * | 1985-08-05 | 1992-09-01 | Biotrack, Inc. | Capillary flow device |
US5204525A (en) * | 1985-08-05 | 1993-04-20 | Biotrack | Capillary flow device |
US5164598A (en) * | 1985-08-05 | 1992-11-17 | Biotrack | Capillary flow device |
US5140161A (en) * | 1985-08-05 | 1992-08-18 | Biotrack | Capillary flow device |
US5272092A (en) * | 1987-11-12 | 1993-12-21 | Hitachi, Ltd. | Method for analyzing a reaction solution |
US5298224A (en) * | 1988-01-14 | 1994-03-29 | Novo Nordisk A/S | Apparatus for determination of the coagulation time of a blood sample |
IT1224861B (it) * | 1988-07-29 | 1990-10-24 | Menarini Sas | Analizzatore per la determinazione del gruppo abo e fenotipo |
DE3837078A1 (de) * | 1988-10-31 | 1990-05-03 | Holger Behnk | Verfahren und vorrichtung zum untersuchen und messen der blutgerinnungszeit |
US5007740A (en) * | 1989-03-30 | 1991-04-16 | The Foxboro Company | Optical probe for fluid light transmission properties |
DE4113330A1 (de) * | 1991-04-24 | 1992-10-29 | Amelung Gmbh Heinrich | Vorrichtung zur photometrischen bestimmung des gerinnungsverhaltens von blut, blutplasma oder dergleichen |
DE4117583A1 (de) * | 1991-05-29 | 1992-12-03 | Helmut Prof Dr Orth | Geraet zur messung der blutsenkung |
US5314826A (en) * | 1991-08-23 | 1994-05-24 | Medtronic Hemotec, Inc. | Platelet activation and function evaluation technique |
US5416575A (en) * | 1991-11-18 | 1995-05-16 | Schwartz; Mark | Method and system for calibrating an optical density measurement apparatus |
US5222808A (en) * | 1992-04-10 | 1993-06-29 | Biotrack, Inc. | Capillary mixing device |
WO1993025902A1 (fr) * | 1992-06-09 | 1993-12-23 | Medical Devices Corporation | Procede et appareil optiques d'analyse hemostatique du sang |
US5526111A (en) * | 1993-08-31 | 1996-06-11 | Boehringer Mannheim Corporation | Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control |
US5841023A (en) * | 1993-08-31 | 1998-11-24 | Boehringer Mannheim Corporation | Magnet for medical instrument |
US5522255A (en) | 1993-08-31 | 1996-06-04 | Boehringer Mannheim Corporation | Fluid dose, flow and coagulation sensor for medical instrument |
DE4339328C1 (de) * | 1993-11-19 | 1995-02-23 | Janke & Kunkel Kg | Verfahren und Vorrichtung zum Erkennen der Viskositätsänderung eines mittels Magnetrührer gerührten Mediums |
US5589394A (en) * | 1994-08-01 | 1996-12-31 | Abbott Laboratories | Cell suspension preparation apparatus and method |
US5529391A (en) * | 1994-09-22 | 1996-06-25 | Duke University | Magnetic stirring and heating/cooling apparatus |
FR2733835B1 (fr) * | 1995-05-03 | 1997-07-18 | Hycel Groupe Lisabio | Procede et dispositif de detection du point de lyse de globules rouges |
US5629209A (en) * | 1995-10-19 | 1997-05-13 | Braun, Sr.; Walter J. | Method and apparatus for detecting viscosity changes in fluids |
US5854423A (en) * | 1996-03-20 | 1998-12-29 | Venegas; Jose G. | Apparatus and method for assessment of visco-elasticity and shear adherence strength properties of blood clots |
US5925319A (en) | 1996-04-30 | 1999-07-20 | Medtronic, Inc. | Test cartridge for evaluating blood platelet functionality |
AU6681298A (en) * | 1997-03-05 | 1998-09-22 | Diametrics | Method and apparatus for measurement of whole blood coagulation parameters |
US6177283B1 (en) * | 1997-05-28 | 2001-01-23 | Flexsite Diagnostics, Inc. | Diagnostic assay |
US6265223B1 (en) | 1997-05-28 | 2001-07-24 | Flexsite Diagnostics, Inc. | Diagnostic assay |
US5899567A (en) * | 1997-09-23 | 1999-05-04 | Morris, Jr.; Joseph E. | Magnetic synchronized stirring and heating test apparatus |
EP0970742A3 (fr) * | 1998-07-09 | 2002-01-23 | Ral Tecnica para el Laboratorio, S.A. | Dispositif d'agitation amélioré |
US6382827B1 (en) * | 2000-11-01 | 2002-05-07 | Dade Behring Inc. | Method and apparatus for mixing liquid solutions using a rotating magnet to generate a stirring vortex action |
US6467946B1 (en) * | 2001-04-24 | 2002-10-22 | Dade Microscan Inc. | Method and apparatus for mixing liquid samples in a container using rotating magnetic fields |
JP4334171B2 (ja) * | 2001-12-03 | 2009-09-30 | シスメックス株式会社 | 血液凝固反応解析方法 |
DE50204937D1 (de) * | 2002-02-14 | 2005-12-22 | Emz Hanauer Gmbh & Co Kgaa | Trübungssensoren mit angepasster Übertragungscharakteristik und Verfahren zum Herstellen derselben |
WO2003083489A1 (fr) * | 2002-03-25 | 2003-10-09 | Vector Ii, Inc. | Systeme conçu pour realiser des dosages de coagulation sanguine et mesurer les temps de coagulation sanguine |
US7291310B2 (en) * | 2002-12-17 | 2007-11-06 | The Regents Of The University Of Michigan | Microsystem for determining clotting time of blood and low-cost, single-use device for use therein |
EP1544596B1 (fr) * | 2003-12-17 | 2016-11-23 | Boehringer Ingelheim microParts GmbH | Méthode et appareil de détermination de la viscosité |
ATE532058T1 (de) | 2004-05-17 | 2011-11-15 | Medtronic Inc | Point-of-care-heparinbestimmungssystem |
US7484880B2 (en) * | 2005-06-24 | 2009-02-03 | V & P Scientific, Inc. | Vortex stirring of vessels in a two-dimensional array |
GB2432667A (en) * | 2005-09-06 | 2007-05-30 | Gwernafalau Gyfyngedig | Apparatus and method for the separation of material from biological samples |
US7963733B2 (en) * | 2008-10-01 | 2011-06-21 | Perfect Systems, Llc | Apparatus for and a method of binding of a perfect bound book |
US8398297B2 (en) | 2009-08-13 | 2013-03-19 | General Electric Company | Electromagnetic stirring apparatus |
JP5533589B2 (ja) * | 2010-11-22 | 2014-06-25 | セイコーエプソン株式会社 | 流体噴射装置とその流体撹拌方法、及び流体貯溜装置とその流体撹拌方法 |
CN102565317B (zh) * | 2010-12-24 | 2013-08-14 | 北京普利生仪器有限公司 | 一种凝血因子和d-二聚体的测定方法 |
EP2581744A1 (fr) | 2011-10-14 | 2013-04-17 | Koninklijke Philips Electronics N.V. | Procédé de détection de l'activité de coagulation et de biomarqueurs |
EP2770318B1 (fr) | 2013-02-21 | 2018-03-21 | Roche Diagniostics GmbH | Procédé et appareil de détection de caillots dans un liquide et système d'automatisation de laboratoire |
FR3038526A1 (fr) * | 2015-07-06 | 2017-01-13 | Provaine | Systeme de fabrication d'une formulation |
US10701765B2 (en) | 2015-08-26 | 2020-06-30 | Bernard Robert McKellar | Flexible convertible hotplate adapter for rounded vessels and objects |
US10953376B2 (en) * | 2015-09-03 | 2021-03-23 | Tetracore, Inc. | Device and method for mixing and bubble removal |
US11105723B2 (en) * | 2016-08-22 | 2021-08-31 | Commonwealth Scientific And Industrial Research Organisation | Automatic sedimentation and separation curve generator |
CN115248318B (zh) * | 2022-09-21 | 2022-12-13 | 南京颐兰贝生物科技有限责任公司 | 一种凝血分析仪的检测方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2516965A (en) * | 1947-06-27 | 1950-08-01 | Frank G Dresser | Support for burettes and the like |
US3488156A (en) * | 1966-02-23 | 1970-01-06 | Lab Line Biomedical Products I | Automatic agglutinometer |
JPS5014919B1 (fr) * | 1968-06-17 | 1975-05-31 | ||
US3550619A (en) * | 1968-06-21 | 1970-12-29 | Becton Dickinson Co | Tubing holder |
US3593568A (en) * | 1969-04-01 | 1971-07-20 | Bio Dynamics Inc | Prothrombin time measuring apparatus with means to start the timer in response to the initial decrement of optical transmissivity |
US3967934A (en) * | 1969-06-13 | 1976-07-06 | Baxter Laboratories, Inc. | Prothrombin timer |
US3595531A (en) * | 1969-11-04 | 1971-07-27 | Dow Chemical Co | Mixer apparatus |
BE789878A (nl) * | 1971-12-14 | 1973-02-01 | I C N Tracerlab N V | Cassette voor het opnemen van monsterbuizen |
US3833864A (en) * | 1972-11-30 | 1974-09-03 | R Kiess | Digital direct reading colorimeter |
US3905769A (en) * | 1974-02-28 | 1975-09-16 | Bagley Wallace E | Method and apparatus for measuring prothrombin time and the like |
US3914773A (en) * | 1974-04-05 | 1975-10-21 | Harold W Harrower | Recording device |
US4135818A (en) * | 1975-01-22 | 1979-01-23 | Bio/Data Corporation | Platelet aggregation monitoring device |
FR2318421A1 (fr) * | 1975-07-16 | 1977-02-11 | Girolami Antoine | Procede et appareil de mesure du temps de variation de l'etat physique d'un corps ou milieu |
CH586901A5 (fr) * | 1975-09-22 | 1977-04-15 | Contraves Ag | |
US4274744A (en) * | 1978-11-21 | 1981-06-23 | Medico Electronic, Inc. | Direct reading digital colorimeter |
-
1982
- 1982-07-02 WO PCT/DE1982/000137 patent/WO1983000228A1/fr unknown
- 1982-07-02 EP EP82902153A patent/EP0083617A1/fr not_active Withdrawn
- 1982-07-02 JP JP57502175A patent/JPS58501096A/ja active Granted
-
1986
- 1986-10-27 US US06/924,155 patent/US4876069A/en not_active Expired - Lifetime
Non-Patent Citations (1)
Title |
---|
See references of WO8300228A1 * |
Also Published As
Publication number | Publication date |
---|---|
US4876069A (en) | 1989-10-24 |
WO1983000228A1 (fr) | 1983-01-20 |
JPH0246110B2 (fr) | 1990-10-12 |
JPS58501096A (ja) | 1983-07-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Designated state(s): FR |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19830919 |