EP0073663A2 - Inhibiteurs de tromboxanne synthétase, procédés par leur préparation, et compositions pharmazeutiques les contenant - Google Patents

Inhibiteurs de tromboxanne synthétase, procédés par leur préparation, et compositions pharmazeutiques les contenant Download PDF

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EP0073663A2
EP0073663A2 EP82304528A EP82304528A EP0073663A2 EP 0073663 A2 EP0073663 A2 EP 0073663A2 EP 82304528 A EP82304528 A EP 82304528A EP 82304528 A EP82304528 A EP 82304528A EP 0073663 A2 EP0073663 A2 EP 0073663A2
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alkyl
formula
compound
thiophene
carboxylic acid
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EP0073663A3 (en
EP0073663B1 (fr
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Peter Edward Cross
Roger Peter Dickinson
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Pfizer Ltd
Pfizer Corp
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Pfizer Ltd
Pfizer Corp
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Definitions

  • This invention relates to certain naphthalenes and benzo-fused heterocycles, namely benzothiophenes, benzofurans and indoles, which are substituted by a; carboxy, lower alkoxycarbonyl or carbamoyl group.
  • Such compounds are able to selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacyclin synthetase or cyclooxygenase enzymes.
  • the compounds are thus useful as therapeutic agents, for example, in the treatment of thrombosis, ischaemic heart disease, stroke, transient ischaemic attack, migraine, peripheral vascular disease, the vascular complications of diabetes, cancer and endotoxin shock.
  • Alkyl groups of 3 or 4 carbon atoms may be straight or branched chain.
  • R and R 1 are attached to a carbon atom of ring "B".
  • the invention also includes the novel intermediates of the formula:- where X, R and R 1 are as defined for formula (I) and the -CN group is attached to a carbon atom of ring "A".
  • the preferred alkyl groups are methyl and ethyl and the preferred alkylthio group is methylthio.
  • the compounds of the formula (1) can be prepared as follows:-(1)
  • the preferred metal salts of imidazole are the alkali metal and the silver salts.
  • the most preferred salt is the sodium salt, preparable from imidazole and sodium hydride.
  • Q is preferably Cl or Br.
  • the preferred additional base is NaHC0 3 (in this case up to a 10 x excess of imidazole is desirable).
  • Preferred solvents are DMF (when using NaH) and acetone (when using NaHC0 3 ).
  • the reaction proceeds to completion at room temperature, although in some cases heating, e.g. up to 100°C and occasionally at reflux, is necessary to-accelerate the reaction, which is generally complete in 12 hours or less.
  • the product can be isolated and purified by conventional procedures.
  • the above process can be carried out using -CN in place of the -COO(C 1 -C 4 alkyl) substituent, followed by converting -CN conventionally to -COOH or -CONH 2 .
  • nitriles are generally obtained by treatment of the corresponding -Br compounds with CuCN/DMF at reflux, e.g. as follows:-
  • the acids can be prepared by the acidic (e.g. HC1) or basic (e.g. KOH) hydrolysis of the corresponding esters in a conventional manner.
  • reaction of the esters with ammonia produces the amides, which can also be prepared by reaction of the corresponding acids with carbonyl di-imidazole or thionyl chloride, and then with ammonia.
  • KOH usually hydrolyses both the -N.Ac and ester groups.
  • NH 3 /EtOH usually just hydrolyses the -N.Ac group.
  • This reaction can also be carried out using compounds in which the -COO(C 1 -C 4 alkyl) group is replaced by Br or CN.
  • Typical alkylating agents are alkyl halides and dialkyl sulphates.
  • reaction can be carried out using -Br or -CN in place of -CO 2 (C 1 -C 4 alkyl), etc., as mentioned in (a) above.
  • the indole ester in DMF is stirred with sodium hydride at room temperature (R.T.) for about 30 minutes and then a solution of dimethyl sulphate in DMF is added and the resulting mixture is stirred at room temperature for up to about 24 hours.
  • the product can then be isolated and purified conventionally.
  • the first stage is the Mannich reaction. It may be carried out conventionally, and, as in (a) and (b) above, starting materials having -Br or -CN can be used, followed by conversion of Br to CN, and hydrolysis of -CN to -COOR conventionally.
  • carbinol precursor may also be used as the substrate.
  • the -Br group may be converted to -CN and then to -CONH 2 , -COOH or -COO(C 1 C 4 alkyl) conventionally.
  • the preferred alkali metal salt is the sodium salt, obtainable from the hydroxypyridine and sodium; hydride.
  • a suitable organic solvent e.g. DMF
  • heating at up to 100°C may in some cases be necessary, and again the product can be isolated and purified by conventional procedures.
  • reaction can also be carried out with -Br or -CN in place of -CO 2 (C 1 -C 4 alkyl), etc., as mentioned in (4a).
  • the reaction can generally be carried out by stirring the reaction mixture at room temperature for a few hours, although in some cases heating at up to 100°C may be necessary, the preferred base/solvent combination being sodium hydride/dimethoxyethane, and again the product can be isolated and pruified by conventional procedures.
  • the reaction is generally complete in 24 hours or less.
  • starting materials in which -CO 2 (C 1 -C 4 alkyl) is replaced by -Br or -CN, or in which X is -N(acetyl), etc. can be used.
  • the phosphorus-containing starting materials are obtainable conventionally, e.g. by the reaction of the corresponding chloromethyl compound with triethyl phosphite under reflux for about 3 hours.
  • the -CN function introduced by the CuCN can be converted to -CONH 2 .
  • pyridylmethyl group may be introduced directly via a Grignard intermediates
  • carbinol precursor may also be used as the substrate.
  • R 1 is preferably not alkyl.
  • Y 1 Br,CN,CO 2 (C 1 -C 4 alkyl)
  • R - halogen, especially Br or Cl
  • R - halogen, especially Br or Cl
  • salts can be prepared by conventional procedures, e.g. by reacting an organic solution of the compound with an organic solution of a suitable acid to obtain an acid addition salt either by precipitation, or by evaporation of the solution.
  • an organic solution of the compound e.g., a suitable acid
  • an acid addition salt either by precipitation, or by evaporation of the solution.
  • ester starting materials often the acid used will cause hydrolysis to the free acid in addition to salt formation.
  • the starting materials used in the previous.routes are either known compounds or can be prepared by procedures analogous to thosa of the prior art.
  • the compounds of formula (I) and their pharmaceutically acceptable salts have been found to selectively inhibit the action of the thromboxane synthetase enzyme without significantly affecting the action of the prostacyclin synthetase or cyclooxygenase enzymes.
  • the compounds are of value in the treatment of a variety of clinical conditions which are characterised by an imbalance of prostacyclin/thromboxane A 2 .
  • these conditions include thrombosis, ischaemic heart disease, stroke, transient ischaemic attack, migraine, peripheral vascular disease, cancer, the vascular complications of diabetes and endotoxin shock.
  • Prostacyclin for instance is a powerful vasodilator and inhibitor of platelet aggregation, and in this last respect is the most potent endogenous substance so far discovered.
  • the prostacyclin synthetase enzyme is located in the endothelial layer of the vasculature, and may be fed by endoperoxides released by blood platelets coming into contact with the vessel wall.
  • the prostacyclin thus produced is important for prevention of platelet deposition on vessel walls.
  • Thromboxane A 2 is synthesised by the thromboxane synthetase enzyme which is located in, for example, the blood platelets. Thromboxane A 2 is a powerful vasoconstrictor and pro-aggregatory substance. As such its actions are in direct opposition to those of prostacyclin. If, for any reason, prostacyclin formation by the vasculature is impaired, then the endoperoxides produced by platelets coming into contact with the vessel wall are converted into thromboxane, but are not converted effectively into prostacyclin (Lancet, 1977, 18, Prostaglandins, 1978, 13, 3).
  • Another area where a PGI 2 /TxA 2 imbalance is considered to be a contributory factor is that of migraine.
  • the migraine headache is associated with changes in intra and extracerebral blood flow, in particular a pre-headache reduction of cerebral blood flow followed by dilatation in both vascular areas during the headache phase.
  • Diabetic patients Abnormalities of platelet behaviour have been reported in patients with diabetes mellitus (Metabolism, 1979, 28, 394, Lancet, 1978 (i) 235). Diabetic patients are known to be particularly susceptible to microvascular complications, atherosclerosis and thrombosis and platelet hyper-reactivity has been suggested as the cause of such angiopathy. Diabetic platelets produce elevated amounts of T X B 2 and malondialdehyde (Symposium "Diabetes and Thrombosis - Implications for Therapy", Leeds U.K., April 1979).
  • TxA 2 -synthetase inhibitor could therefore find clinical utility in preventing these vascular complications.
  • Aspirin and most other non-steroidal anti-inflammatory drugs inhibit the cyclo-oxygenase enzyme. The effect of this is to shut down the production of the PGG 2 /H 2 endoperoxides and by so doing to reduce both the prostacyclin and thromboxane A2 levels. Aspirin and aspirin-like drugs have been evaluated clinically for prevention of stroke and heart attack (New England and J. Med. 1978, 299, 53, B.M.J., 1978, 1188, Stroke, 1977, 8, 301).
  • Shock caused by bacterial endotoxins is associated with thrombocytopaenia, disseminated intravascular coagulation, lysosomal labilisation and pulmonary and mesenteric vasoconstriction.
  • plasma thromboxane levels have been shown to rise markedly.
  • Administration of imidazole TxA 2 synthetase inhibitors to experimental animals prior to endotoxin resulted in a decrease in symptoms of shock and a markedly increased survival rate (Prostaglandins and Medicine, 4, 215, (1980) Circulation Res., 46, 854 (1980)).
  • Ram seminal vesicle microsomes (Biochtmistry, 1971, 10, 2372) are incubated with arachidonic acid (100 ⁇ M:I min.:22°) to produce PGH 2 and aliquots of the reaction mixture injected into a stream of Krebs-bicarbonate at 37°C (containing a mixture of antagonists (Nature, 1978, 218, 1135) and indomethacin (Brit. J. Pharmacol., 1972, 45, 451) which is superfusing a spirally-cut rabbit aorta strip (Nature, 1969, 223, 29).
  • the ability of a compound to inhibit the enzyme is measured by comparing the increase in isometric tension produced by PGH 2 in the absence of the test compound, and following pre-incubation of the enzyme with the test compound for 5 minutes (Agents and Actions, 1981, 11, 274).
  • Pig aorta microsomes (Nature, 1976, 263, 663) are incubated (30 sec.; 22°C) with PGH 2 produced as in 1 and the reaction terminated with 5 volumes of ethanol.
  • PGI 2 production is assessed by measuring its stable breakdown product, 6-keto PGF 1 ⁇ , using a specific radioimmunoassay.
  • PGI 2 production can be completely inhibited by pre-incubation of the enzyme with the selective PGI 2 synthetase inhibitor, 15-hydroperoxyarachidonic acid (Prostaglandins, 1976, 12, 715). The test compound is pre-incubated with the enzyme for 5 minutes, and its ability to prevent the production of PGI 2 (6-keto PGF 1 ⁇ ) is measured.
  • test compound is pre-incubated with enzyme for 5 minutes, and its ability to inhibit the thromboxane syntehtase-enzyme is measured as reduction of the TxA 2 (TxB 2 ) production.
  • the method of Patrono et al is adapted to study the generation of TxB 2 is whole blood samples removed from animals prior to and following drug treatment. Briefly, blood samples are taken into glass tubes and allowed to clot at 37°C. Serum is separated by centrifugation and the samples stored at -40°C until assayed for TxB 2 , when appropriate dilutions of ethanol deproteinised samples are analysed by RIA. This technique is used in experiments with the test compounds to determine intravenous potency in anaesthetised rabbits:-Anaesthetised Rabbits
  • mice Male New Zealand white rabbits (2.6-5.6 kg) are anaesthetised with sodium pentobarbitone (30 mg/kg i.v.) followed by urethane (500 mg/kg i.p.). After cannulation of the trachea, a carotid artery is catheterised for collection of blood samples. The catheter is kept patent by slow infusion (0.2 ml/minute) of sterile saline. Control carotid arterial blood samples are taken 30 and 5 minutes prior to administration of the test compound or vehicle (0.9% w/v NaCl, 0.2 ml/kg) via a marginal ear vein. Three groups of rabbits are used. The first group receive 0.03 mg/kg of the test compound followed, one hour later, by 0.1 mg/kg.
  • the second group receive 0.3 mg/kg, followed by 1 mg/kg.
  • the third group receive vehicle, followed one hour later by a further vehicle injection.
  • Carotid arterial blood samples are taken i5 and 45 minutes after all doses.
  • a 1 ml blood sample is taken into a glass test tube, without anticoagulant, for TxB 2 determination.
  • the blood sample is allowed to clot during a two hour incubation at 37°C (which preliminary experiments had shown to give maximum TxB 2 production) and the serum obtained by centrifugation. Serum samples are then processed through the TxB 2 RIA after deproteinisation with ethanol and dilution with Isogel Tris buffer.
  • Intravenous injection of arachidonic acid causes death in rabbits by causing platelet clumping and embolisation in the lungs.
  • both the clinically effective aspirin (Agents and Actions, 1977, 1, 481) and sulphinpyrazone (Pharmacology, 1976, 14, 522) protect the rabbit from the lethal effect of the injection.
  • Sulphinpyrazone has also been shown to prevent the aggregation of platelets in an extra corporeal loop of the abdominal aorta of rats in vivo (Thromb. Diathes. Haem., 1973, 30, 138.
  • the compounds can be administered orally in the form of tablets or capsules containing a unit dose of the compound together with such excipients as maize starch, calcium carbonate, dicalcium phosphate, alginic acid, lactose, magnesium stearate, "Primogel” (Trade Mark) or talc.
  • the tablets are typically prepared by granulating the ingredients together and compressing the resulting mixture to give tablets of the desired size.
  • Capsules are typically prepared by granulating the ingredients together and filling them into hard gelatine capsules of the appropriate size to contain the desired dosage.
  • the compounds can also be administered parenterally, for example by intramuscular, intravenous or subcutaneous injection.
  • parenteral administration they are best used in the form of a sterile aqueous solution which may contain other solutes such as tonic and pH adjusters.
  • the compounds may be added to distilled water and the pH adjusted to 3-6 using an acid such as citric, lactic or hydrochloric acid. Sufficient solutes such as dextrose or saline may be added to render the solution isotonic.
  • the resulting solution may then be sterilised and filled into sterile glass vials of an appropriate size to contain the desired volume of solution.
  • the compounds of the invention can also be administered by the infusion of a parenteral formulation as described above into a vein.
  • the daily dosage level of a compound of the formula (I) will be from 0.1 to 20 mg/kg per day for a typical adult patient (70 kg).
  • the daily dosage level of a compound of the formula (I) will be from 0.01 - 0.5 mg/kg. per day, for a typical adult patient.
  • tablets or capsules contain from 5 to 150 mg of the active compound for administration orally up to 3 times a day.
  • Dosage units for parenteral administration will contain from 0.5 - 35 mg of the active compound.
  • a typical vial would be a 10 ml vial containing 5 mg of the active compound in 6 - 10 ml of solution.
  • Hydrogen chloride gas was passed for 30 minutes through a mixture of 3-methylbenzo[b]thiophene-5-carboxylic acid ethyl ester (5.50 g), anhydrous zinc chloride (1.25 g) and paraformaldehyde (1.50 g) in chloroform (50 ml). The resulting mixture was stirred for 8 hours and then the chloroform solution was decanted off from the gummy residue, washed well with water and dried (Na 2 SO 4 ). Evaporation of the solvent gave crude 2-chloromethyl-3-methyl- benzo[b]thiophene-5-carboxylic acid ethyl ester which was used directly in the next stage.
  • Hydrogen chloride was passed for 2 hours through a stirred mixture of 3-methylthiobenzo[b]thiophene-5-carboxylic acid ethyl ester (1.0 g), paraformaldehyde (0.24 g) and anhydrous zinc chloride (0.2 g) in chloroform (30 ml) at 0°C. The resulting mixture was stirred at room temperature for 18 hours and then washed with water. The organic layer was separated, dried (Na 2 SO 4 ) and evaporated to give an oil which was chromatographed on silica gel. Elution with toluene gave a solid which was crystallised from petrol (b.p. 60-80°) to give 2-chloromethyl-3-methylthiobenzo[b]thiophene-5-carboxylic acid ethyl ester (0.42 g), m.p. 95-96°.
  • the ether layer was extracted with concentrated hydrochloric acid (20 ml) and the acid extracts were combined and warmed to complete hydrolysis of the intermediate ketimine salt.
  • the solution was cooled and made alkaline with sodium hydroxide solution.
  • the mixture was extracted several times with ethyl acetate and the combined extracts were washed with water and dried (Na 2 S0 4 ). Evaporation of the solvent gave a solid which was chromatographed on silica gel. Elution with chloroform/petrol (b.p. 40-60°) (2:1) gave a solid which was crystallised from ethyl acetate/petrol (b.p. 40-60°) to give 6-bromo-3-methylbenzo[b]thien-2-yl pyrid-3-yl ketone (4.70 g), m.p. 110-111°.
  • Table 1 contains a list of carboxylic acids prepared by hydrolysis of the corresponding esters by the method of Example 3(v).
  • Methyl magnesium bromide (15 ml of a 3M solution in ether) was added dropwilse over 5 minutes to a stirred solution of 7-bromo-2-(3-pyridylmethyl)-l-tetralone (3.20 g) in dry tetrahydrofuran (50 ml). The resulting mixture was heated under reflux with stirring for 10 hours and then cooled. An excess of aqueous ammonium chloride solution was added and the mixture was extracted several times with ether. The combined ethereal extracts were dried (Na 2 S0 4 ) and evaporated. The residue was -chromatographed on silica gel.
  • a sample crystallised from methanol/ethyl acetate had m.p. 176-178°.
  • the hydrochloride was converted to the free base by dissolving in a small volume of water and adding a slight excess of a saturated aqueous solution of sodium bicarbonate. Ether extraction gave the free base as an oil.

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EP82304528A 1981-08-26 1982-08-26 Inhibiteurs de tromboxanne synthétase, procédés par leur préparation, et compositions pharmazeutiques les contenant Expired EP0073663B1 (fr)

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Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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EP0135177A2 (fr) * 1983-08-25 1985-03-27 Daiichi Seiyaku Co., Ltd. Dérivés de benzocycloalkanes
US4510149A (en) * 1982-07-05 1985-04-09 Farmitalia Carlo Erba S.P.A. N-Imidazolyl derivatives containing naphthalene or indene nucleus
EP0151477A2 (fr) * 1984-02-02 1985-08-14 Ferrer Internacional, S.A. Dérivés de 1H-imidazole, un procédé pour leur préparation et compositions pharmaceutiques les contenant
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
EP0194580A2 (fr) * 1985-03-13 1986-09-17 Hoechst Aktiengesellschaft Dérivés de l'imidazole et leur procédé de préparation
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US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
EP0240107A1 (fr) * 1986-01-28 1987-10-07 Sankyo Company Limited Dérivés de thianaphtène, leurs préparation et application
EP0257171A1 (fr) * 1986-08-13 1988-03-02 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Benzofuran-2-yl-imidazoles avec activité pharmaceutique, leurs sels et procédés relatifs pour leur préparation
US4808581A (en) * 1986-03-17 1989-02-28 Glaxo Group Limited Imidazolyl- indolylpropanones as 5-HT3 receptor antagonists
US4814344A (en) * 1986-10-03 1989-03-21 Glaxo Group Limited Indole derivatives
US4822803A (en) * 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
EP0316097A1 (fr) * 1987-11-12 1989-05-17 Imperial Chemical Industries Plc Dérivés de naphto(2,1-b)furane
US4933351A (en) * 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
WO1990012009A1 (fr) * 1989-03-31 1990-10-18 Kyoto Pharmaceutical Industries, Ltd. Nouveaux derives d'imidazole, leur production, et leurs emplois comme medicaments
EP0445073A1 (fr) * 1990-02-27 1991-09-04 Ciba-Geigy Ag Benzofurannes
US5087638A (en) * 1984-06-20 1992-02-11 Merck Frosst Canada, Inc. Benzofuran derivatives
EP0496237A2 (fr) * 1991-01-22 1992-07-29 PHARMACIA S.p.A. Dérivés N-imidazolyliques de tétrahydrocarbazole et cyclohept[b]-indole substitués
EP0510398A2 (fr) * 1991-04-24 1992-10-28 PHARMACIA S.p.A. Dérivés N-imidazolyle d'indoles substitués
US5206256A (en) * 1990-04-20 1993-04-27 Ciba-Geigy Corporation Naphthalene derivatives
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WO1995006046A1 (fr) * 1993-08-26 1995-03-02 Pfizer Limited Antagonistes de la thromboxane a2 derives d'un indole
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US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
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US6559157B2 (en) 1997-10-02 2003-05-06 Daiichi Pharmaceutical Co., Ltd. Dihydronaphthalene compounds
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2218098A1 (fr) * 1973-02-16 1974-09-13 Labaz
FR2272081A1 (en) * 1974-05-22 1975-12-19 Labaz Anti-inflammatory indolylpyridylketones prepn. - from 2-alkyl (or aryl) indole and pyridine carboxylic acid chlorides
EP0003901A2 (fr) * 1978-02-24 1979-09-05 Pfizer Limited 3-(Imidazol-1-ylalkyl)indoles, comme inhibiteurs sélectifs de la thromboxane synthétase, compositions pharmaceutiques les contenant et leurs procédés de préparation
GB2045244A (en) * 1979-03-07 1980-10-29 Pfizer Ltd 3-1-(Imidazolylalkyl) indoles
EP0050957A1 (fr) * 1980-10-23 1982-05-05 Pfizer Limited Composés hétérocycliques à effet inhibiteur sur la thromboxane synthétase, procédé pour leur préparation et compositions pharmaceutiques les contenant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1333471A (en) * 1971-01-27 1973-10-10 Labaz Imidazoline derivatives and process for preparing the same
ES456283A1 (es) * 1977-02-25 1978-04-01 Made Labor Sa Un procedimiento para la obetencion de 2,5-dimetil-benzo (b)tieno (2,3-f) morfano.
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
GB2028317B (en) * 1978-08-15 1982-11-10 Pfizer Ltd 2-(imidazol-1-ylmethyl)-pyridine and -quinoline thromboxane synthetase inhibitors
DK151884C (da) * 1979-03-07 1988-06-13 Pfizer Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2218098A1 (fr) * 1973-02-16 1974-09-13 Labaz
FR2272081A1 (en) * 1974-05-22 1975-12-19 Labaz Anti-inflammatory indolylpyridylketones prepn. - from 2-alkyl (or aryl) indole and pyridine carboxylic acid chlorides
EP0003901A2 (fr) * 1978-02-24 1979-09-05 Pfizer Limited 3-(Imidazol-1-ylalkyl)indoles, comme inhibiteurs sélectifs de la thromboxane synthétase, compositions pharmaceutiques les contenant et leurs procédés de préparation
GB2045244A (en) * 1979-03-07 1980-10-29 Pfizer Ltd 3-1-(Imidazolylalkyl) indoles
EP0050957A1 (fr) * 1980-10-23 1982-05-05 Pfizer Limited Composés hétérocycliques à effet inhibiteur sur la thromboxane synthétase, procédé pour leur préparation et compositions pharmaceutiques les contenant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALFRED BURGER, MEDICINAL CHEMISTRY, THIRD ED., PART I, WILEY-INTERSCIENCE, NEW YORK, pages 75-80 (1970) *

Cited By (58)

* Cited by examiner, † Cited by third party
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US4510149A (en) * 1982-07-05 1985-04-09 Farmitalia Carlo Erba S.P.A. N-Imidazolyl derivatives containing naphthalene or indene nucleus
US4602022A (en) * 1982-07-05 1986-07-22 Farmitalia Carlo Erba, S.P.A. N-imidazolyl derivatives of bicyclic compounds
EP0129051A2 (fr) * 1983-05-17 1984-12-27 Ciba-Geigy Ag Indoles substitués
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
EP0129051A3 (en) * 1983-05-17 1986-07-02 Ciba-Geigy Ag Substituted indoles
EP0135177A3 (en) * 1983-08-25 1986-07-16 Daiichi Seiyaku Co. Ltd. Benzocycloalkane derivatives
EP0135177A2 (fr) * 1983-08-25 1985-03-27 Daiichi Seiyaku Co., Ltd. Dérivés de benzocycloalkanes
US4822803A (en) * 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4933351A (en) * 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
EP0151477A2 (fr) * 1984-02-02 1985-08-14 Ferrer Internacional, S.A. Dérivés de 1H-imidazole, un procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0151477A3 (en) * 1984-02-02 1986-10-29 Ferrer Internacional, S.A. 1h-imidazole derivatives, a process for preparing them and pharmaceutical compositions containing them
US5087638A (en) * 1984-06-20 1992-02-11 Merck Frosst Canada, Inc. Benzofuran derivatives
US4609733A (en) * 1984-12-27 1986-09-02 Ciba-Geigy Corporation 3-keto-substituted-N-pyridylindoles
EP0194579A3 (en) * 1985-03-13 1987-09-30 Hoechst Aktiengesellschaft 3-pyridylmethylnaphthyl derivatives, process for their preparation and their use as medicaments
EP0194580A3 (en) * 1985-03-13 1987-07-22 Hoechst Aktiengesellschaft Imidazole derivatives and process for their preparation
US4778817A (en) * 1985-03-13 1988-10-18 Hoechst Aktiengesellschaft Naphthyl imidazolyl compounds and pharmaceutical compositions
EP0194580A2 (fr) * 1985-03-13 1986-09-17 Hoechst Aktiengesellschaft Dérivés de l'imidazole et leur procédé de préparation
EP0194579A2 (fr) * 1985-03-13 1986-09-17 Hoechst Aktiengesellschaft Dérivés 3-pyridylméthylnaphtyle, leur procédé de préparation et leur utilisation comme médicament
EP0240107A1 (fr) * 1986-01-28 1987-10-07 Sankyo Company Limited Dérivés de thianaphtène, leurs préparation et application
US4808581A (en) * 1986-03-17 1989-02-28 Glaxo Group Limited Imidazolyl- indolylpropanones as 5-HT3 receptor antagonists
EP0257171A1 (fr) * 1986-08-13 1988-03-02 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Benzofuran-2-yl-imidazoles avec activité pharmaceutique, leurs sels et procédés relatifs pour leur préparation
US4814344A (en) * 1986-10-03 1989-03-21 Glaxo Group Limited Indole derivatives
EP0316097A1 (fr) * 1987-11-12 1989-05-17 Imperial Chemical Industries Plc Dérivés de naphto(2,1-b)furane
WO1990012009A1 (fr) * 1989-03-31 1990-10-18 Kyoto Pharmaceutical Industries, Ltd. Nouveaux derives d'imidazole, leur production, et leurs emplois comme medicaments
EP0445073A1 (fr) * 1990-02-27 1991-09-04 Ciba-Geigy Ag Benzofurannes
US5206256A (en) * 1990-04-20 1993-04-27 Ciba-Geigy Corporation Naphthalene derivatives
US5246952A (en) * 1990-09-18 1993-09-21 Ciba-Geigy Corporation Heteroarylmethylbenzenes
US5378721A (en) * 1990-09-18 1995-01-03 Ciba-Geigy Corporation Heteroarylmethylbenzenes
EP0496237A2 (fr) * 1991-01-22 1992-07-29 PHARMACIA S.p.A. Dérivés N-imidazolyliques de tétrahydrocarbazole et cyclohept[b]-indole substitués
EP0496237A3 (en) * 1991-01-22 1992-12-09 Farmitalia Carlo Erba S.R.L. N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept(b)indole
EP0510398A2 (fr) * 1991-04-24 1992-10-28 PHARMACIA S.p.A. Dérivés N-imidazolyle d'indoles substitués
EP0510398A3 (en) * 1991-04-24 1993-01-13 Farmitalia Carlo Erba S.R.L. N-imidazolyl derivatives of substituted indole
EP0597112A1 (fr) * 1992-03-27 1994-05-18 Kyoto Pharmaceutical Industries, Ltd. Nouveau derive d'imidazole, son utilisation pharmaceutique, et intermediaire associe
EP0597112A4 (en) * 1992-03-27 1994-06-22 Kyoto Pharma Ind Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor.
US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
WO1995006046A1 (fr) * 1993-08-26 1995-03-02 Pfizer Limited Antagonistes de la thromboxane a2 derives d'un indole
US5744488A (en) * 1993-08-26 1998-04-28 Pfizer Inc. Indole derivatives thromboxane A2 antagonists
EP0643059A1 (fr) * 1993-09-15 1995-03-15 Pfizer Limited 3-(3-Pyridinyl)-1H-indoles comme inhibiteurs de thromboxane A2 synthétase
US6054414A (en) * 1995-09-01 2000-04-25 Basf Aktiengesellschaft Benzoyl derivatives
EP1028110A1 (fr) * 1997-10-02 2000-08-16 Yukijirushi Nyugyo Kabushiki Kaisha Nouveaux composes a base de dihydronaphtalene et leur procede de production
EP1028110A4 (fr) * 1997-10-02 2001-05-23 Yukijirushi Nyugyo Kabushiki K Nouveaux composes a base de dihydronaphtalene et leur procede de production
US6559157B2 (en) 1997-10-02 2003-05-06 Daiichi Pharmaceutical Co., Ltd. Dihydronaphthalene compounds
US7157486B2 (en) 2001-07-25 2007-01-02 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US7893084B2 (en) 2001-07-25 2011-02-22 Boehringer Ingelheim Canada Ltd. Viral polymerase inhibitors
US7576079B2 (en) 2001-07-25 2009-08-18 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
US7803944B2 (en) 2001-07-25 2010-09-28 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7491748B2 (en) 2001-08-09 2009-02-17 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
US7786161B2 (en) 2001-08-09 2010-08-31 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and pharmaceutical agent comprising the same as active ingredient
US7838537B2 (en) 2003-01-22 2010-11-23 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7888363B2 (en) 2003-01-22 2011-02-15 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7582770B2 (en) 2004-02-20 2009-09-01 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7879851B2 (en) 2004-02-20 2011-02-01 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8030309B2 (en) 2004-02-20 2011-10-04 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US8076365B2 (en) 2005-08-12 2011-12-13 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2007096362A1 (fr) * 2006-02-21 2007-08-30 Trigen Limited Composes heterocycliques et leur utilisation dans le traitement des maladies cardiovasculaires
WO2011123674A1 (fr) 2010-03-31 2011-10-06 Array Biopharma Inc. Composés pour traiter des maladies neurodégénératives
WO2016004513A1 (fr) * 2014-07-11 2016-01-14 Simon Fraser University Composés antibactériens modulateurs de la pyruvate kinase, compositions, utilisations et procédés associés

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PL138849B1 (en) 1986-11-29
HU194867B (en) 1988-03-28
CS235023B2 (en) 1985-04-16
FI822943A0 (fi) 1982-08-24
US4590200A (en) 1986-05-20
NO160002C (no) 1989-03-01
SU1217256A3 (ru) 1986-03-07
ES8505659A1 (es) 1985-06-01
ES522383A0 (es) 1985-06-01
IE822052L (en) 1983-02-26
DD215546A5 (de) 1984-11-14
PT75462A (en) 1982-09-01
JPS5852272A (ja) 1983-03-28
NZ201690A (en) 1985-08-16
JPS611067B2 (fr) 1986-01-13
YU191482A (en) 1985-03-20
PL137940B1 (en) 1986-08-30
EP0073663A3 (en) 1983-04-13
AU532848B2 (en) 1983-10-13
US4496572A (en) 1985-01-29
FI822943L (fi) 1983-02-27
NO822882L (no) 1983-02-28
ATE20467T1 (de) 1986-07-15
PT75462B (en) 1985-11-28
DD206378A5 (de) 1984-01-25
IE53739B1 (en) 1989-02-01
YU180184A (en) 1985-04-30
ZA825413B (en) 1983-06-29
KR840001164A (ko) 1984-03-28
DE3271771D1 (en) 1986-07-24
AU8759982A (en) 1983-03-24
ES8307749A1 (es) 1983-08-16
PL238048A1 (en) 1984-02-13
IL66620A0 (en) 1982-12-31
ES515195A0 (es) 1983-08-16
PL244112A1 (en) 1984-06-18
CA1178964A (fr) 1984-12-04
NO160002B (no) 1988-11-21
KR870000902B1 (ko) 1987-05-04
GR76864B (fr) 1984-09-04
EP0073663B1 (fr) 1986-06-18
DK378682A (da) 1983-03-25
SU1194278A3 (ru) 1985-11-23

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