EP0135177A3 - Benzocycloalkane derivatives - Google Patents

Benzocycloalkane derivatives Download PDF

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Publication number
EP0135177A3
EP0135177A3 EP84110139A EP84110139A EP0135177A3 EP 0135177 A3 EP0135177 A3 EP 0135177A3 EP 84110139 A EP84110139 A EP 84110139A EP 84110139 A EP84110139 A EP 84110139A EP 0135177 A3 EP0135177 A3 EP 0135177A3
Authority
EP
European Patent Office
Prior art keywords
benzocycloalkane
derivatives
benzocycloalkane derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP84110139A
Other versions
EP0135177A2 (en
EP0135177B1 (en
Inventor
Munefumi C/O Daiichi Seiyaku Research Lab. Kanao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58155561A external-priority patent/JPS6048972A/en
Priority claimed from JP10227884A external-priority patent/JPS60246380A/en
Priority claimed from JP59112438A external-priority patent/JPS60255774A/en
Priority claimed from JP12055784A external-priority patent/JPS611661A/en
Priority claimed from JP59139525A external-priority patent/JPS6118770A/en
Priority claimed from JP59147252A external-priority patent/JPH062745B2/en
Priority to AT84110139T priority Critical patent/ATE48416T1/en
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of EP0135177A2 publication Critical patent/EP0135177A2/en
Publication of EP0135177A3 publication Critical patent/EP0135177A3/en
Publication of EP0135177B1 publication Critical patent/EP0135177B1/en
Application granted granted Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/34—Monohydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/36—Unsaturated compounds containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
EP84110139A 1983-08-25 1984-08-24 Benzocycloalkane derivatives Expired EP0135177B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT84110139T ATE48416T1 (en) 1983-08-25 1984-08-24 BENZOCYCLOALKALINE DERIVATIVES.

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP155561/83 1983-08-25
JP58155561A JPS6048972A (en) 1983-08-25 1983-08-25 Tetrahydronaphthalene derivative
JP10227884A JPS60246380A (en) 1984-05-21 1984-05-21 Tetrahydronaphthalene derivative
JP102278/84 1984-05-21
JP112438/84 1984-06-01
JP59112438A JPS60255774A (en) 1984-06-01 1984-06-01 Tetrahydronaphthalene derivative
JP12055784A JPS611661A (en) 1984-06-12 1984-06-12 Pyridine derivative
JP120557/84 1984-06-12
JP139525/84 1984-07-05
JP59139525A JPS6118770A (en) 1984-07-05 1984-07-05 Tetrahydronaphthalene derivative
JP147252/84 1984-07-16
JP59147252A JPH062745B2 (en) 1984-07-16 1984-07-16 Indane derivative

Publications (3)

Publication Number Publication Date
EP0135177A2 EP0135177A2 (en) 1985-03-27
EP0135177A3 true EP0135177A3 (en) 1986-07-16
EP0135177B1 EP0135177B1 (en) 1989-12-06

Family

ID=27552134

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84110139A Expired EP0135177B1 (en) 1983-08-25 1984-08-24 Benzocycloalkane derivatives

Country Status (9)

Country Link
US (2) US4665188A (en)
EP (1) EP0135177B1 (en)
KR (1) KR910008349B1 (en)
AU (1) AU547979B2 (en)
CA (1) CA1253866A (en)
DE (1) DE3480652D1 (en)
IE (1) IE58352B1 (en)
PH (1) PH22076A (en)
YU (1) YU43583B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3508905A1 (en) * 1985-03-13 1986-09-18 Hoechst Ag, 6230 Frankfurt NEW IMIDAZOLYL COMPOUNDS AND METHOD FOR THEIR PRODUCTION
JPS63501215A (en) * 1985-10-30 1988-05-12 ジ・アップジョン・カンパニー 3'-pyridinylalkylindene- and 3'-pyridinylalkylindole-2-carboxylic acids and homologues
ZA884053B (en) * 1987-06-10 1989-02-22 Daiichi Seiyaku Co Treating agents for renal diseases
IL86846A (en) * 1987-07-01 1992-03-29 Daiichi Seiyaku Co Pharmaceutical compositions for preventing and treating heart failure containing indane or naphthalene carboxylic acids
CA1314224C (en) * 1987-07-07 1993-03-09 Shinichiro Ashida Antidiabetic agent
US5166169A (en) * 1988-06-17 1992-11-24 Daiichi Pharmaceutical Co., Ltd. Treating agent for peripheral circulatory disturbances
IL91542A0 (en) * 1988-10-06 1990-04-29 Erba Carlo Spa N-imidazolyl-and n-imidazolyl-methyl derivatives of substituted bicyclic compounds,their preparation and pharmaceutical compositions containing them
US5354770A (en) * 1989-02-27 1994-10-11 Daiichi Pharmaceutical Co., Ltd. Using imidazolyl tetrahydronaphthalene carboxylic acids to inhibit restenosis
ZA901416B (en) * 1989-02-27 1990-12-28 Daiichi Seiyaku Co Post-ptca restenosis inhibitor
US5183886A (en) * 1989-05-22 1993-02-02 Mitsubishi Kasei Corporation Process for preparation of crystalline oxytitanium phthalocyanine showing A,B or C form
US5272264A (en) * 1989-05-22 1993-12-21 Mitsubishi Kasei Corporation Process for preparation of crystalline oxytitanium phthalocyanine
GB9027258D0 (en) * 1990-12-17 1991-02-06 Erba Carlo Spa Pyridyl derivatives of substituted bicyclic compounds and process for their preparation
GB9102862D0 (en) * 1991-02-11 1991-03-27 Erba Carlo Spa N-imidazolyl derivatives of substituted or alkoxymino tetrahydronaphthalenes and chromans
US5344836A (en) * 1991-11-11 1994-09-06 Ono Pharmaceutical Co., Ltd. Fused benzeneoxyacetic acid derivatives
FR2711139B1 (en) * 1993-10-15 1995-12-01 Adir New 1,2,3,4-tetrahydronaphthalene derivatives, process for their preparation and pharmaceutical compositions containing them.
US5559248A (en) * 1995-04-05 1996-09-24 Bristol-Myers Squibb Co. Retinoid-like heterocycles
CA2298527A1 (en) * 1997-10-02 1999-04-15 Yukijirushi Nyugyo Kabushiki Kaisha Novel dihydronaphthalene compounds and process for producing the same
US6559157B2 (en) 1997-10-02 2003-05-06 Daiichi Pharmaceutical Co., Ltd. Dihydronaphthalene compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2129090A1 (en) * 1970-06-12 1971-12-16 Science Union et Cie , Societe Fran caise de Recherche Medicale, Suresnes (Frankreich) New thiazolylbenzoic acid derivatives and processes for their preparation
EP0003560A2 (en) * 1978-02-01 1979-08-22 The Wellcome Foundation Limited Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations
FR2445319A1 (en) * 1978-12-28 1980-07-25 Ono Pharmaceutical Co PYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0073663A2 (en) * 1981-08-26 1983-03-09 Pfizer Limited Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
GB2122997A (en) * 1982-07-05 1984-01-25 Erba Farmitalia Imidazoles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK471479A (en) * 1978-12-13 1980-06-14 Pfizer PROCEDURE FOR PREPARING IMIDAZOLD DERIVATIVES AND SALTS THEREOF
ES8503669A1 (en) * 1982-07-05 1985-03-01 Erba Farmitalia N-Imidazolyl derivatives containing naphthalene or indene nucleus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2129090A1 (en) * 1970-06-12 1971-12-16 Science Union et Cie , Societe Fran caise de Recherche Medicale, Suresnes (Frankreich) New thiazolylbenzoic acid derivatives and processes for their preparation
EP0003560A2 (en) * 1978-02-01 1979-08-22 The Wellcome Foundation Limited Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations
FR2445319A1 (en) * 1978-12-28 1980-07-25 Ono Pharmaceutical Co PYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0073663A2 (en) * 1981-08-26 1983-03-09 Pfizer Limited Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
GB2122997A (en) * 1982-07-05 1984-01-25 Erba Farmitalia Imidazoles

Also Published As

Publication number Publication date
IE58352B1 (en) 1993-09-08
US4777257A (en) 1988-10-11
KR910008349B1 (en) 1991-10-12
YU144784A (en) 1987-02-28
EP0135177A2 (en) 1985-03-27
DE3480652D1 (en) 1990-01-11
AU547979B2 (en) 1985-11-14
IE842170L (en) 1985-02-25
US4665188A (en) 1987-05-12
YU43583B (en) 1989-08-31
CA1253866A (en) 1989-05-09
PH22076A (en) 1988-05-20
AU3238184A (en) 1985-02-28
KR850001905A (en) 1985-04-10
EP0135177B1 (en) 1989-12-06

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