NO160002B - Analogifremgangsmaate ved fremstilling av terapeutisk aktive naftalener og benzokondenserte heterocykler. - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive naftalener og benzokondenserte heterocykler. Download PDF

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Publication number
NO160002B
NO160002B NO822882A NO822882A NO160002B NO 160002 B NO160002 B NO 160002B NO 822882 A NO822882 A NO 822882A NO 822882 A NO822882 A NO 822882A NO 160002 B NO160002 B NO 160002B
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groove
alkyl
benzo
preparation
therapeutically active
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NO822882A
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NO822882L (no
NO160002C (no
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Peter Edward Cross
Roger Peter Dickinson
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Pfizer
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Publication of NO822882L publication Critical patent/NO822882L/no
Publication of NO160002B publication Critical patent/NO160002B/no
Publication of NO160002C publication Critical patent/NO160002C/no

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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Description

Byggekloss.
Den foreliggende oppfinnelse angår en byggekloss, fortrinnsvis
av plast, med underskårne noter som ved den flate som noten er åpen ut mot, danner lepper, og med knaster som har et mellom leppene passende halsparti og et hodeparti som passer inn i notene. Disse noter og knaster tjener til forbindelse mellom byggeklossene for dannelse av leketoymodeller.
Byggeklosser av denne art er kjent. Forbindelsestappene har som regel et tverrsnitt som motsvarer tverrsnittet av de underskårne noter. Ved innskyvning av en slik forbindelsestapp i en not vil så-
ledes hele nottverrsnittet være utfylt av forbindelsestapperi <y>om
således med sin ytterflate ligger fullstendig an mot veggene av noten. Som folge av denne beroring på alle sider og den derav folgende store friksjon, er det vanskelig å skyve forbindelsestappene inn i notene. Enda vanskeligere er det imidlertid senere å forskyve en forbindelsestapp som allerede er satt inn i en not. Ved forskyvningen må nemlig forst hvilefriksjoneh overvinnes, noe som krever en hoyere kraft enn til overvinnelse av den lavere glidéfriksjon som opptrer, ved den etter-følgende glidning. Som folge av den derved opptredende "stick-slip-effekt" er det spesielt for et barn i en alder av 4 - 5 år praktisk talt umulig å forskyve forbindelsestappen til et noyaktig bestemt sted i området for noten for på denne måte å oppnå en bestemt stilling av byggeklossene i forhold til hinannen.
Hensikten med den foreliggende oppfinnelse er derfor å utforme forbindelsestappen slik at de nettopp nevnte ulemper ikke lenger opptrer.
Ifolge oppfinnelsen blir dette oppnådd ved at knastene og notene er slik avpasset at en knast bare i området ved sin hals ligger tett an mot veggene av noten.
Ved denne utformning vil tappen bare berore veggene av noten over et lite område, mens den forovrig ikke berorer notveggen. Frik-sjonen er dermed redusert til et minstemål, og det er på denne måte ikke bare mulig lett å fore en forbindelsestapp inn i en not, men også lett å forskyve forbindelsestappen på en byggekloss i noten i en annen byggekloss.
Ved utforelsen ifolge oppfinnelsen er det imidlertid også mulig å unngå den ellers ugunstige virkning av den volumforstorrelse som byggeklosser av plast er utsatt for som folge av absorbsjon av
fuktighet. Til tross for hoy presisjon kan nemlig dimensjonene ikke holdes innenfor så små toleranser at der på den ene side kan oppnås en jevn forskyvning og på den annen side pasningen av forbindelsestappen i noten blir tilstrekkelig. Alt etter fuktigheten i den luft som omgir byggedélene, vil nemlig disses dimensjoner forandres. Ved gjenstanden ifolge oppfinnelsen kan imidlertid materialet i forbindelsestappen unnvike i retningen for notens dybde når tappen sveller opp, idet tappen her ikke ligger an mot notveggen.
På tegningen er der vist et utforelseseksempel på oppfinnelsen. Den viste byggekloss 11 har en underskåret not 12 som har sirkelformet tverrsnitt og danner lepper 12a. Tverrsnittet av noten 12 er således utvidet bak leppene 12a. Leppene vil kunne utfores fjær-ende, og fjærvirkningen kan forhoyes ved hjelp av innsnitt 13 i klossen
11. En annen byggekloss 14 bærer en underskåret forbindelsesknast 15
på sin ene endeflate. Halsen 15a av knasten er tynnere enn det utenfor-liggende hodeparti. Forbindelsestappen ligger bare an mot noten 12
i området for sitt halsparti. Over det ovrige område er der avstand mellom notveggene og forbindelsestappen. Selve halsen 15a kan forovrig være tynnere enn svarende til avstanden mellom leppene 12a, slik at knasten 15 bare vil ligge an mot notveggene på det til halsen grensende parti av knastens hodeparti.

Claims (1)

  1. Byggekloss med underskårne noter (12) som ved den flate som noten er åpen ut mot, danner lepper (12a), og med en knast (15) som har et mellom leppene passende halsparti (15a) og et hodeparti som passer inn i notene, karakterisert ved at knastene og notene er slik avpasset at en knast (15) bare i området ved sin hals (15a) ligger tett an mot veggene av noten (12).
NO822882A 1981-08-26 1982-08-25 Analogifremgangsmaate ved fremstilling av terapeutisk aktive naftalener og benzokondenserte heterocykler. NO160002C (no)

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GB8125976 1981-08-26

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NO822882L NO822882L (no) 1983-02-28
NO160002B true NO160002B (no) 1988-11-21
NO160002C NO160002C (no) 1989-03-01

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NO822882A NO160002C (no) 1981-08-26 1982-08-25 Analogifremgangsmaate ved fremstilling av terapeutisk aktive naftalener og benzokondenserte heterocykler.

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YU180184A (en) 1985-04-30
FI822943A0 (fi) 1982-08-24
NO822882L (no) 1983-02-28
ZA825413B (en) 1983-06-29
PT75462B (en) 1985-11-28
PL244112A1 (en) 1984-06-18
FI822943L (fi) 1983-02-27
JPS611067B2 (no) 1986-01-13
ES8307749A1 (es) 1983-08-16
IE822052L (en) 1983-02-26
ATE20467T1 (de) 1986-07-15
EP0073663A3 (en) 1983-04-13
EP0073663A2 (en) 1983-03-09
US4496572A (en) 1985-01-29
JPS5852272A (ja) 1983-03-28
PL137940B1 (en) 1986-08-30
AU532848B2 (en) 1983-10-13
EP0073663B1 (en) 1986-06-18
PL138849B1 (en) 1986-11-29
KR870000902B1 (ko) 1987-05-04
NZ201690A (en) 1985-08-16
IL66620A0 (en) 1982-12-31
PL238048A1 (en) 1984-02-13
US4590200A (en) 1986-05-20
FI822943A7 (fi) 1983-02-27
YU191482A (en) 1985-03-20
ES522383A0 (es) 1985-06-01
NO160002C (no) 1989-03-01
DK378682A (da) 1983-03-25
CS235023B2 (en) 1985-04-16
KR840001164A (ko) 1984-03-28
ES515195A0 (es) 1983-08-16
AU8759982A (en) 1983-03-24
SU1217256A3 (ru) 1986-03-07
IE53739B1 (en) 1989-02-01
DE3271771D1 (en) 1986-07-24
PT75462A (en) 1982-09-01
GR76864B (no) 1984-09-04
ES8505659A1 (es) 1985-06-01
SU1194278A3 (ru) 1985-11-23
CA1178964A (en) 1984-12-04
DD206378A5 (de) 1984-01-25
HU194867B (en) 1988-03-28
DD215546A5 (de) 1984-11-14

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