NO160002B - Analogifremgangsmaate ved fremstilling av terapeutisk aktive naftalener og benzokondenserte heterocykler. - Google Patents
Analogifremgangsmaate ved fremstilling av terapeutisk aktive naftalener og benzokondenserte heterocykler. Download PDFInfo
- Publication number
- NO160002B NO160002B NO822882A NO822882A NO160002B NO 160002 B NO160002 B NO 160002B NO 822882 A NO822882 A NO 822882A NO 822882 A NO822882 A NO 822882A NO 160002 B NO160002 B NO 160002B
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- Norway
- Prior art keywords
- groove
- alkyl
- benzo
- preparation
- therapeutically active
- Prior art date
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- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 title 2
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010069102 Thromboxane-A synthase Proteins 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 3
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
Classifications
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- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
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Description
Byggekloss.
Den foreliggende oppfinnelse angår en byggekloss, fortrinnsvis
av plast, med underskårne noter som ved den flate som noten er åpen ut mot, danner lepper, og med knaster som har et mellom leppene passende halsparti og et hodeparti som passer inn i notene. Disse noter og knaster tjener til forbindelse mellom byggeklossene for dannelse av leketoymodeller.
Byggeklosser av denne art er kjent. Forbindelsestappene har som regel et tverrsnitt som motsvarer tverrsnittet av de underskårne noter. Ved innskyvning av en slik forbindelsestapp i en not vil så-
ledes hele nottverrsnittet være utfylt av forbindelsestapperi <y>om
således med sin ytterflate ligger fullstendig an mot veggene av noten. Som folge av denne beroring på alle sider og den derav folgende store friksjon, er det vanskelig å skyve forbindelsestappene inn i notene. Enda vanskeligere er det imidlertid senere å forskyve en forbindelsestapp som allerede er satt inn i en not. Ved forskyvningen må nemlig forst hvilefriksjoneh overvinnes, noe som krever en hoyere kraft enn til overvinnelse av den lavere glidéfriksjon som opptrer, ved den etter-følgende glidning. Som folge av den derved opptredende "stick-slip-effekt" er det spesielt for et barn i en alder av 4 - 5 år praktisk talt umulig å forskyve forbindelsestappen til et noyaktig bestemt sted i området for noten for på denne måte å oppnå en bestemt stilling av byggeklossene i forhold til hinannen.
Hensikten med den foreliggende oppfinnelse er derfor å utforme forbindelsestappen slik at de nettopp nevnte ulemper ikke lenger opptrer.
Ifolge oppfinnelsen blir dette oppnådd ved at knastene og notene er slik avpasset at en knast bare i området ved sin hals ligger tett an mot veggene av noten.
Ved denne utformning vil tappen bare berore veggene av noten over et lite område, mens den forovrig ikke berorer notveggen. Frik-sjonen er dermed redusert til et minstemål, og det er på denne måte ikke bare mulig lett å fore en forbindelsestapp inn i en not, men også lett å forskyve forbindelsestappen på en byggekloss i noten i en annen byggekloss.
Ved utforelsen ifolge oppfinnelsen er det imidlertid også mulig å unngå den ellers ugunstige virkning av den volumforstorrelse som byggeklosser av plast er utsatt for som folge av absorbsjon av
fuktighet. Til tross for hoy presisjon kan nemlig dimensjonene ikke holdes innenfor så små toleranser at der på den ene side kan oppnås en jevn forskyvning og på den annen side pasningen av forbindelsestappen i noten blir tilstrekkelig. Alt etter fuktigheten i den luft som omgir byggedélene, vil nemlig disses dimensjoner forandres. Ved gjenstanden ifolge oppfinnelsen kan imidlertid materialet i forbindelsestappen unnvike i retningen for notens dybde når tappen sveller opp, idet tappen her ikke ligger an mot notveggen.
På tegningen er der vist et utforelseseksempel på oppfinnelsen. Den viste byggekloss 11 har en underskåret not 12 som har sirkelformet tverrsnitt og danner lepper 12a. Tverrsnittet av noten 12 er således utvidet bak leppene 12a. Leppene vil kunne utfores fjær-ende, og fjærvirkningen kan forhoyes ved hjelp av innsnitt 13 i klossen
11. En annen byggekloss 14 bærer en underskåret forbindelsesknast 15
på sin ene endeflate. Halsen 15a av knasten er tynnere enn det utenfor-liggende hodeparti. Forbindelsestappen ligger bare an mot noten 12
i området for sitt halsparti. Over det ovrige område er der avstand mellom notveggene og forbindelsestappen. Selve halsen 15a kan forovrig være tynnere enn svarende til avstanden mellom leppene 12a, slik at knasten 15 bare vil ligge an mot notveggene på det til halsen grensende parti av knastens hodeparti.
Claims (1)
- Byggekloss med underskårne noter (12) som ved den flate som noten er åpen ut mot, danner lepper (12a), og med en knast (15) som har et mellom leppene passende halsparti (15a) og et hodeparti som passer inn i notene, karakterisert ved at knastene og notene er slik avpasset at en knast (15) bare i området ved sin hals (15a) ligger tett an mot veggene av noten (12).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8125976 | 1981-08-26 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO822882L NO822882L (no) | 1983-02-28 |
NO160002B true NO160002B (no) | 1988-11-21 |
NO160002C NO160002C (no) | 1989-03-01 |
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ID=10524165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO822882A NO160002C (no) | 1981-08-26 | 1982-08-25 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive naftalener og benzokondenserte heterocykler. |
Country Status (24)
Country | Link |
---|---|
US (2) | US4496572A (no) |
EP (1) | EP0073663B1 (no) |
JP (1) | JPS5852272A (no) |
KR (1) | KR870000902B1 (no) |
AT (1) | ATE20467T1 (no) |
AU (1) | AU532848B2 (no) |
CA (1) | CA1178964A (no) |
CS (1) | CS235023B2 (no) |
DD (2) | DD215546A5 (no) |
DE (1) | DE3271771D1 (no) |
DK (1) | DK378682A (no) |
ES (2) | ES8307749A1 (no) |
FI (1) | FI822943L (no) |
GR (1) | GR76864B (no) |
HU (1) | HU194867B (no) |
IE (1) | IE53739B1 (no) |
IL (1) | IL66620A0 (no) |
NO (1) | NO160002C (no) |
NZ (1) | NZ201690A (no) |
PL (2) | PL137940B1 (no) |
PT (1) | PT75462B (no) |
SU (2) | SU1217256A3 (no) |
YU (2) | YU191482A (no) |
ZA (1) | ZA825413B (no) |
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ES8503669A1 (es) * | 1982-07-05 | 1985-03-01 | Erba Farmitalia | Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos. |
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PH22076A (en) * | 1983-08-25 | 1988-05-20 | Daiichi Seiyaku Co | Benzocycloalkane derivative |
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US4933351A (en) * | 1983-10-31 | 1990-06-12 | Merck Frosst Canada, Inc. | Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis |
US4822803A (en) * | 1983-10-31 | 1989-04-18 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis |
US4695578A (en) * | 1984-01-25 | 1987-09-22 | Glaxo Group Limited | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
CA1250586A (en) * | 1984-02-02 | 1989-02-28 | Manuel Raga | 1h-imidazole derivatives and process for their production |
US5135943A (en) * | 1984-02-02 | 1992-08-04 | Ferrer Internacional S.A. | 1H-imidazole derivative compounds and pharmaceutical compositions containing the same |
US5087638A (en) * | 1984-06-20 | 1992-02-11 | Merck Frosst Canada, Inc. | Benzofuran derivatives |
JPS6132198A (ja) * | 1984-07-25 | 1986-02-14 | セコム株式会社 | モ−ド切替装置 |
US4609733A (en) * | 1984-12-27 | 1986-09-02 | Ciba-Geigy Corporation | 3-keto-substituted-N-pyridylindoles |
JPS61183586A (ja) * | 1985-02-07 | 1986-08-16 | 三菱電機株式会社 | 通行制御装置 |
DE3508905A1 (de) * | 1985-03-13 | 1986-09-18 | Hoechst Ag, 6230 Frankfurt | Neue imidazolylverbindungen und verfahren zu ihrer herstellung |
DE3508903A1 (de) * | 1985-03-13 | 1986-09-18 | Hoechst Ag, 6230 Frankfurt | Neue 3-pyridylmethylnaphtylderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4731364A (en) * | 1985-08-12 | 1988-03-15 | Schering Corporation | Dihydrobenzo(B)thiophenes and pharmaceutical compositions thereof useful as antifungals |
JPS6267082A (ja) * | 1985-09-20 | 1987-03-26 | Sankyo Co Ltd | チアナフテン類 |
KR920002129B1 (ko) * | 1986-01-27 | 1992-03-12 | 상꾜 가부시끼가이샤 | 티아나프텐 유도체의 제조방법 |
US4808581A (en) * | 1986-03-17 | 1989-02-28 | Glaxo Group Limited | Imidazolyl- indolylpropanones as 5-HT3 receptor antagonists |
IT1216256B (it) * | 1986-08-13 | 1990-02-22 | Menarini Sas | (benzofuran-2-il) imidazoli, con attivita' farmacologica,loro sali e procedimenti di fabbricazione relativi. |
GB8623819D0 (en) * | 1986-10-03 | 1986-11-05 | Glaxo Group Ltd | Heterocyclic compounds |
US4766127A (en) * | 1987-02-10 | 1988-08-23 | Syntex (U.S.A.) Inc. | 2-(3-pyridylmethyl)naphthalene-6-carboxylic acid as a thromboxane synthetase inhibitor |
GB8726505D0 (en) * | 1987-11-12 | 1987-12-16 | Ici Plc | Naphtho(2 1-b)furan derivatives |
JPS63290877A (ja) * | 1988-04-15 | 1988-11-28 | Sankyo Co Ltd | チアナフテン誘導体 |
JPH0262332U (no) * | 1988-10-31 | 1990-05-09 | ||
WO1990012009A1 (fr) * | 1989-03-31 | 1990-10-18 | Kyoto Pharmaceutical Industries, Ltd. | Nouveaux derives d'imidazole, leur production, et leurs emplois comme medicaments |
AU7124691A (en) * | 1990-02-27 | 1991-08-29 | Ciba-Geigy Ag | Benzofurans |
EP0457716A1 (de) * | 1990-04-20 | 1991-11-21 | Ciba-Geigy Ag | Naphthalinderivate |
TW224461B (no) * | 1990-09-18 | 1994-06-01 | Ciba Geigy Ag | |
GB9101375D0 (en) * | 1991-01-22 | 1991-03-06 | Erba Carlo Spa | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohepht(b)indole |
GB9108811D0 (en) * | 1991-04-24 | 1991-06-12 | Erba Carlo Spa | N-imidazolyl derivatives of substituted indole |
JP3042156B2 (ja) * | 1992-02-20 | 2000-05-15 | 田辺製薬株式会社 | ナフタレン誘導体、その製法及びその合成中間体 |
EP0597112A4 (en) * | 1992-03-27 | 1994-06-22 | Kyoto Pharma Ind | Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor. |
US5538973A (en) * | 1992-03-27 | 1996-07-23 | Kyoto Pharmaceutical Industries, Ltd. | Imidazole derivative, pharmaceutical use thereof, and intermediate therefor |
GB9317764D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
GB9319100D0 (en) * | 1993-09-15 | 1993-11-03 | Pfizer Ltd | 3-(3-pyridinyl)h-indoles |
DE19532311A1 (de) * | 1995-09-01 | 1997-03-06 | Basf Ag | Benzoylderivate |
US6559157B2 (en) | 1997-10-02 | 2003-05-06 | Daiichi Pharmaceutical Co., Ltd. | Dihydronaphthalene compounds |
ES2218853T3 (es) * | 1997-10-02 | 2004-11-16 | Daiichi Pharmaceutical Co., Ltd. | Nuevos compuestos de dihidronaftaleno y procesos para la obtencion de los mismos. |
US6329369B1 (en) | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
US6841684B2 (en) | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
ZA9811672B (en) * | 1997-12-19 | 2000-06-19 | Lilly Co Eli | Hypoglycemic imidazoline compounds. |
TWI240723B (en) | 2001-06-20 | 2005-10-01 | Wyeth Corp | Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
PL368129A1 (en) | 2001-08-09 | 2005-03-21 | Ono Pharmaceutical Co, Ltd. | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
AU2003224257A1 (en) * | 2002-04-09 | 2003-10-27 | Astex Technology Limited | Heterocyclic compounds and their use as modulators of p38 map kinase |
US20040009976A1 (en) * | 2002-04-30 | 2004-01-15 | Kumiko Takeuchi | Hypoglycemic imidazoline compounds |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
DK1718608T3 (da) | 2004-02-20 | 2013-10-14 | Boehringer Ingelheim Int | Virale polymeraseinhibitorer |
CA2618682C (en) | 2005-08-12 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2007096362A1 (en) * | 2006-02-21 | 2007-08-30 | Trigen Limited | Heterocyclic compounds and their use in the treatment of cardiovascular disease |
CN101535298A (zh) * | 2006-11-16 | 2009-09-16 | 弗·哈夫曼-拉罗切有限公司 | 取代的4-咪唑类化合物 |
US20120058105A1 (en) | 2008-06-27 | 2012-03-08 | Martin Kean Chong Ng | Method of treatment of vascular complications |
TW201128812A (en) | 2009-12-01 | 2011-08-16 | Lg Innotek Co Ltd | Light emitting device |
AR080865A1 (es) | 2010-03-31 | 2012-05-16 | Array Biopharma Inc | Derivados de espirotetrahidronaftaleno, composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos para tratar enfermedades neurodegenerativas,tal como alzheimer. |
WO2016004513A1 (en) * | 2014-07-11 | 2016-01-14 | Simon Fraser University | Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods |
CN107531679B (zh) * | 2016-03-18 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 芳香酰胺类衍生物、其制备方法及其在医药上的应用 |
EP3585809A4 (en) | 2017-01-30 | 2021-02-24 | Western New England University | THIOLISOMERASE INHIBITORS AND USES THEREOF |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
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GB1333471A (en) * | 1971-01-27 | 1973-10-10 | Labaz | Imidazoline derivatives and process for preparing the same |
GB1436771A (en) * | 1973-02-16 | 1976-05-26 | Labaz | Indole derivatives and process for preparing the same |
FR2272081A1 (en) * | 1974-05-22 | 1975-12-19 | Labaz | Anti-inflammatory indolylpyridylketones prepn. - from 2-alkyl (or aryl) indole and pyridine carboxylic acid chlorides |
ES456283A1 (es) * | 1977-02-25 | 1978-04-01 | Made Labor Sa | Un procedimiento para la obetencion de 2,5-dimetil-benzo (b)tieno (2,3-f) morfano. |
DE2862340D1 (en) * | 1978-02-01 | 1983-11-24 | Wellcome Found | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof |
EP0003901B1 (en) * | 1978-02-24 | 1981-08-05 | Pfizer Limited | 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them |
GB2028317B (en) * | 1978-08-15 | 1982-11-10 | Pfizer Ltd | 2-(imidazol-1-ylmethyl)-pyridine and -quinoline thromboxane synthetase inhibitors |
DK151884C (da) * | 1979-03-07 | 1988-06-13 | Pfizer | Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
GB2045244B (en) * | 1979-03-07 | 1983-01-26 | Pfizer Ltd | 3-1-(imidazolylalkyl) indoles |
GR75101B (no) * | 1980-10-23 | 1984-07-13 | Pfizer |
-
1982
- 1982-07-28 ZA ZA825413A patent/ZA825413B/xx unknown
- 1982-08-09 US US06/406,140 patent/US4496572A/en not_active Expired - Fee Related
- 1982-08-23 CA CA000409929A patent/CA1178964A/en not_active Expired
- 1982-08-23 IL IL66620A patent/IL66620A0/xx not_active IP Right Cessation
- 1982-08-24 DD DD82255302A patent/DD215546A5/de not_active IP Right Cessation
- 1982-08-24 DD DD82242756A patent/DD206378A5/de not_active IP Right Cessation
- 1982-08-24 GR GR69094A patent/GR76864B/el unknown
- 1982-08-24 FI FI822943A patent/FI822943L/fi not_active Application Discontinuation
- 1982-08-24 DK DK378682A patent/DK378682A/da not_active Application Discontinuation
- 1982-08-24 ES ES515195A patent/ES8307749A1/es not_active Expired
- 1982-08-24 NZ NZ201690A patent/NZ201690A/en unknown
- 1982-08-25 HU HU822745A patent/HU194867B/hu not_active IP Right Cessation
- 1982-08-25 PT PT75462A patent/PT75462B/pt not_active IP Right Cessation
- 1982-08-25 YU YU01914/82A patent/YU191482A/xx unknown
- 1982-08-25 NO NO822882A patent/NO160002C/no unknown
- 1982-08-25 AU AU87599/82A patent/AU532848B2/en not_active Ceased
- 1982-08-25 SU SU823486394A patent/SU1217256A3/ru active
- 1982-08-25 IE IE2052/82A patent/IE53739B1/en not_active IP Right Cessation
- 1982-08-25 CS CS826196A patent/CS235023B2/cs unknown
- 1982-08-25 KR KR8203824A patent/KR870000902B1/ko active
- 1982-08-26 DE DE8282304528T patent/DE3271771D1/de not_active Expired
- 1982-08-26 AT AT82304528T patent/ATE20467T1/de not_active IP Right Cessation
- 1982-08-26 PL PL1982238048A patent/PL137940B1/pl unknown
- 1982-08-26 PL PL1982244112A patent/PL138849B1/pl unknown
- 1982-08-26 JP JP57148485A patent/JPS5852272A/ja active Granted
- 1982-08-26 EP EP82304528A patent/EP0073663B1/en not_active Expired
-
1983
- 1983-05-13 ES ES522383A patent/ES8505659A1/es not_active Expired
- 1983-06-16 SU SU833605461A patent/SU1194278A3/ru active
-
1984
- 1984-10-22 YU YU01801/84A patent/YU180184A/xx unknown
- 1984-10-22 US US06/663,244 patent/US4590200A/en not_active Expired - Lifetime
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