EP0000574A1 - Benzimidazoles substitués en position 2, procédé de préparation et leur utilisation pour préparer des médicaments - Google Patents

Benzimidazoles substitués en position 2, procédé de préparation et leur utilisation pour préparer des médicaments Download PDF

Info

Publication number
EP0000574A1
EP0000574A1 EP78100489A EP78100489A EP0000574A1 EP 0000574 A1 EP0000574 A1 EP 0000574A1 EP 78100489 A EP78100489 A EP 78100489A EP 78100489 A EP78100489 A EP 78100489A EP 0000574 A1 EP0000574 A1 EP 0000574A1
Authority
EP
European Patent Office
Prior art keywords
carbon atoms
formula
lower alkyl
group
benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP78100489A
Other languages
German (de)
English (en)
Other versions
EP0000574B1 (fr
Inventor
Ernst Dr. Habicht
Pier Giorgio Dr. Ferrini
Alfred Dr. Sallmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU77CI1761A external-priority patent/HU180700B/hu
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of EP0000574A1 publication Critical patent/EP0000574A1/fr
Application granted granted Critical
Publication of EP0000574B1 publication Critical patent/EP0000574B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP78100489A 1977-08-01 1978-07-24 Benzimidazoles substitués en position 2, procédé de préparation et leur utilisation pour préparer des médicaments Expired EP0000574B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU77CI1761A HU180700B (en) 1976-08-27 1977-08-01 Process for producing acylized benzimidasole derivatives
HUCI001761 1977-08-01
CH209478 1978-02-27
CH2094/78 1978-02-27

Publications (2)

Publication Number Publication Date
EP0000574A1 true EP0000574A1 (fr) 1979-02-07
EP0000574B1 EP0000574B1 (fr) 1982-08-04

Family

ID=25689497

Family Applications (1)

Application Number Title Priority Date Filing Date
EP78100489A Expired EP0000574B1 (fr) 1977-08-01 1978-07-24 Benzimidazoles substitués en position 2, procédé de préparation et leur utilisation pour préparer des médicaments

Country Status (19)

Country Link
US (1) US4323688A (fr)
EP (1) EP0000574B1 (fr)
JP (1) JPS5427565A (fr)
AR (4) AR227125A1 (fr)
AT (1) AT364830B (fr)
AU (1) AU523324B2 (fr)
CA (1) CA1109072A (fr)
DD (1) DD138318A5 (fr)
DE (1) DE2861987D1 (fr)
DK (1) DK339578A (fr)
ES (1) ES472208A1 (fr)
FI (1) FI68231C (fr)
GR (1) GR77614B (fr)
IE (1) IE47285B1 (fr)
IL (1) IL55253A (fr)
NO (1) NO150082C (fr)
NZ (1) NZ188006A (fr)
PL (1) PL208772A1 (fr)
PT (1) PT68365A (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014469A2 (fr) * 1979-02-09 1980-08-20 Ciba-Geigy Ag Dérivés de benzimidazol-2-yl comme médicaments, leur utilisation et compositions pharmaceutiques les contenant
US4323688A (en) * 1977-08-01 1982-04-06 Ciba-Geigy Corporation Benzimidazole-2-carboxylic acid and derivatives thereof
EP0070531A2 (fr) * 1981-07-20 1983-01-26 Rorer International (Overseas) Inc. Tétrahydronaphthoxazoles

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH356460A (de) * 1956-10-30 1961-08-31 Gruenenthal Chemie Verfahren zur Herstellung von neuen Derivaten des Benzimidazols
CH356461A (de) * 1956-10-30 1961-08-31 Gruenenthal Chemie Verfahren zur Herstellung von neuen Derivaten des Benzimidazols
CH362411A (de) * 1956-10-30 1962-06-15 Gruenenthal Chemie Verfahren zur Herstellung von neuen Derivaten des Benzimidazols

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB243766A (en) * 1924-12-01 1926-07-29 Bayer Ag Process for the manufacture of benzimidazoles
US2053822A (en) * 1933-12-15 1936-09-08 Soc Of Chemical Ind Alkylated imidazoles of high molecular weight and process of making same
GB766749A (en) 1954-01-11 1957-01-23 Aschaffenburger Zellstoffwerke Benzimidazole cobalamines and process for their preparation and separation
US2876233A (en) * 1956-10-29 1959-03-03 Gruenenthal Chemie 1-(p-halobenzyl)-2-methyl benzimidazoles and salts
US3325271A (en) * 1963-07-17 1967-06-13 United States Borax Chem Herbicidal composition and method employing substituted benzimidazoles
US3318889A (en) * 1963-10-14 1967-05-09 S B Penick & Company 2-benzimidazole carbamates
DE2014293A1 (de) * 1969-03-29 1970-10-08 Fisons Ltd., Felixstowe, Suffolk (Grossbritannien) Substituierte Benzimidazole und Verfahren zu ihrer Herstellung und Verwendung
CH528514A (de) * 1969-05-22 1972-09-30 Bayer Ag Verfahren zur Herstellung von Acylimidazolen
US3661925A (en) * 1970-05-15 1972-05-09 American Home Prod Process for the preparation of 2-benzimidazolecarboxamides
FR2115067B1 (fr) * 1970-11-27 1974-03-22 Delalande Sa
EP0000574B1 (fr) * 1977-08-01 1982-08-04 Ciba-Geigy Ag Benzimidazoles substitués en position 2, procédé de préparation et leur utilisation pour préparer des médicaments

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH356460A (de) * 1956-10-30 1961-08-31 Gruenenthal Chemie Verfahren zur Herstellung von neuen Derivaten des Benzimidazols
CH356461A (de) * 1956-10-30 1961-08-31 Gruenenthal Chemie Verfahren zur Herstellung von neuen Derivaten des Benzimidazols
CH362411A (de) * 1956-10-30 1962-06-15 Gruenenthal Chemie Verfahren zur Herstellung von neuen Derivaten des Benzimidazols

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4323688A (en) * 1977-08-01 1982-04-06 Ciba-Geigy Corporation Benzimidazole-2-carboxylic acid and derivatives thereof
EP0014469A2 (fr) * 1979-02-09 1980-08-20 Ciba-Geigy Ag Dérivés de benzimidazol-2-yl comme médicaments, leur utilisation et compositions pharmaceutiques les contenant
EP0014469A3 (fr) * 1979-02-09 1980-09-03 Ciba-Geigy Ag Dérivés de benzimidazol-2-yl comme médicaments, leur utilisation et compositions pharmaceutiques les contenant
EP0070531A2 (fr) * 1981-07-20 1983-01-26 Rorer International (Overseas) Inc. Tétrahydronaphthoxazoles
EP0070531A3 (en) * 1981-07-20 1984-03-07 Usv Pharmaceutical Corporation Tetrahydronaphthoxazoles

Also Published As

Publication number Publication date
IL55253A (en) 1982-04-30
FI68231B (fi) 1985-04-30
NO150082B (no) 1984-05-07
FI68231C (fi) 1985-08-12
AR231636A1 (es) 1985-01-31
GR77614B (fr) 1984-09-25
ATA553978A (de) 1981-04-15
JPS5427565A (en) 1979-03-01
AR228023A1 (es) 1983-01-14
DK339578A (da) 1979-02-02
NO782615L (no) 1979-02-02
IE781545L (en) 1979-02-01
ES472208A1 (es) 1979-03-16
NZ188006A (en) 1981-11-19
AU3847878A (en) 1980-02-07
AU523324B2 (en) 1982-07-22
CA1109072A (fr) 1981-09-15
AT364830B (de) 1981-11-25
AR227125A1 (es) 1982-09-30
FI782348A (fi) 1979-02-02
PT68365A (de) 1978-08-01
DD138318A5 (de) 1979-10-24
PL208772A1 (pl) 1979-06-04
AR223196A1 (es) 1981-07-31
NO150082C (no) 1984-08-15
US4323688A (en) 1982-04-06
IE47285B1 (en) 1984-02-08
DE2861987D1 (en) 1982-09-30
EP0000574B1 (fr) 1982-08-04
IL55253A0 (en) 1978-09-29

Similar Documents

Publication Publication Date Title
CH529115A (de) Verfahren zur Herstellung von neuen Benzolsulfonylharnstoffen
DE2428486A1 (de) Azapurinone
DE2418344A1 (de) Derivate von 3-nitrocumarinen enthaltende arzneimittel, neue 3-nitrocumarine und verfahren zu ihrer herstellung
DE2635326A1 (de) Benzimidazol-carbamate
EP0539329A1 (fr) Acétylène composés, utiles comme antagonistes de leukotriènes
AT371460B (de) Verfahren zur herstellung neuer benzopyranderivate und ihrer salze
DE2737462A1 (de) Verfahren zur herstellung von acylierten heterocyclylcarbonsaeuren
DE1493672C3 (de) Verfahren zur Herstellung von Benzolsulfonylharnstoffen
EP0000574B1 (fr) Benzimidazoles substitués en position 2, procédé de préparation et leur utilisation pour préparer des médicaments
EP0455596B1 (fr) Indoles substitués
EP0072960A2 (fr) Composés 1,5-diphénylpyrazolin-3-one, ainsi qu'un procédé et produits intermédiaires pour leur fabrication et médicaments contenant ces composés
DE2337068A1 (de) 1-benzylindenylsaeuren
EP0000488A1 (fr) Dérivés de 3-oxalylamino-4-oxo-4H-1-benzopyranes, procédé pour leur préparation et leur utilisation pharmaceutique
DE2832309C2 (fr)
DE2448387A1 (de) Isocumarin-derivate enthaltende arzneimittel, neue isocumarin-derivate und verfahren zu ihrer herstellung
DE2217329A1 (de) Benzofuranderivate
CH516593A (de) Verfahren zur Herstellung von neuen Estern von a-Aminobenzyl-penicillin
AT375350B (de) Verfahren zur herstellung neuer substituierter heterocyclylverbindungen und ihrer salze
EP0113911B1 (fr) Pyrido-triazoloquinazolines, leur préparation et utilisation
AT375928B (de) Verfahren zur herstellung neuer substituierter heterocyclylverbindungen und ihrer salze
AT374462B (de) Verfahren zur herstellung neuer benz-acylbenzimidazol-2-derivate und deren salze
AT374465B (de) Verfahren zur herstellung neuer benz-acylbenzimidazol-2-derivate und ihrer salze
DE2360355B2 (de) KCyanophenoxy)-2-hydroxy-3- [2-(5-1Htetrazolyl)-chromonyloxy] - propane
DE3445011A1 (de) Neues anilinderivat, verfahren zu seiner herstellung und seine verwendung
DE2319280A1 (de) 1-substituierte pyrazolone-(5), verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): BE CH DE FR GB LU NL SE

17P Request for examination filed
GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Designated state(s): BE CH DE FR GB LU NL SE

REF Corresponds to:

Ref document number: 2861987

Country of ref document: DE

Date of ref document: 19820930

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 19830628

Year of fee payment: 6

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19830731

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 19840608

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19840625

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 19840630

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 19840803

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 19840930

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 19850731

Year of fee payment: 8

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Effective date: 19860725

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Effective date: 19860731

Ref country code: BE

Effective date: 19860731

BERE Be: lapsed

Owner name: CIBA-GEIGY A.G.

Effective date: 19860731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Effective date: 19870201

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19870331

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Effective date: 19870401

GBPC Gb: european patent ceased through non-payment of renewal fee
REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Effective date: 19881117

EUG Se: european patent has lapsed

Ref document number: 78100489.0

Effective date: 19870518

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT