EG14592A - Process for preparing of 9-aminoalkylfluorenes useful as antiarrhythmic agents - Google Patents

Process for preparing of 9-aminoalkylfluorenes useful as antiarrhythmic agents

Info

Publication number
EG14592A
EG14592A EG80144A EG14480A EG14592A EG 14592 A EG14592 A EG 14592A EG 80144 A EG80144 A EG 80144A EG 14480 A EG14480 A EG 14480A EG 14592 A EG14592 A EG 14592A
Authority
EG
Egypt
Prior art keywords
aminoalkylfluorenes
preparing
useful
antiarrhythmic agents
antiarrhythmic
Prior art date
Application number
EG80144A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of EG14592A publication Critical patent/EG14592A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/10—Impermeable to liquids, e.g. waterproof; Liquid-repellent
    • A41D31/102—Waterproof and breathable
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/18—Elastic
    • A41D31/185—Elastic using layered materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Textile Engineering (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EG80144A 1979-03-12 1980-03-11 Process for preparing of 9-aminoalkylfluorenes useful as antiarrhythmic agents EG14592A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1953379A 1979-03-12 1979-03-12

Publications (1)

Publication Number Publication Date
EG14592A true EG14592A (en) 1985-03-31

Family

ID=21793707

Family Applications (1)

Application Number Title Priority Date Filing Date
EG80144A EG14592A (en) 1979-03-12 1980-03-11 Process for preparing of 9-aminoalkylfluorenes useful as antiarrhythmic agents

Country Status (40)

Country Link
US (1) US4277495A (de)
EP (1) EP0018076B1 (de)
JP (1) JPS55124743A (de)
KR (2) KR840000279B1 (de)
AR (6) AR228851A1 (de)
AT (4) AT370407B (de)
AU (1) AU527992B2 (de)
BE (1) BE882166A (de)
CA (1) CA1136624A (de)
CH (1) CH643234A5 (de)
CS (4) CS214700B2 (de)
CY (1) CY1345A (de)
DD (1) DD149511A5 (de)
DE (1) DE3064872D1 (de)
DK (1) DK158658C (de)
EG (1) EG14592A (de)
ES (5) ES8104186A1 (de)
FI (3) FI67211C (de)
FR (2) FR2460287A1 (de)
GB (1) GB2046257B (de)
GR (1) GR68035B (de)
GT (1) GT198062477A (de)
HK (1) HK101086A (de)
HU (1) HU179837B (de)
IE (1) IE49553B1 (de)
IL (1) IL59558A (de)
IT (1) IT1140772B (de)
LU (1) LU82236A1 (de)
MA (1) MA18763A1 (de)
MY (1) MY8700080A (de)
NZ (1) NZ193078A (de)
OA (1) OA06486A (de)
PH (1) PH15594A (de)
PL (1) PL122643B1 (de)
PT (1) PT70927A (de)
RO (2) RO79822A (de)
SG (1) SG72286G (de)
SU (2) SU1022656A3 (de)
YU (1) YU65680A (de)
ZA (1) ZA801422B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4212337A (en) * 1978-03-31 1980-07-15 Union Carbide Corporation Closure fastening device
US4452745A (en) * 1981-02-06 1984-06-05 Eli Lilly And Company 9-Aminoalkylfluorenes
US4484352A (en) * 1983-02-07 1984-11-20 Katzin Lawrence F Reclosable plastic bag
US4552982A (en) * 1983-08-01 1985-11-12 Eli Lilly And Company Synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorenes
US4508735A (en) * 1983-09-21 1985-04-02 Eli Lilly And Company Anti-arrhythmic N-alkanoylaminoalkyl fluorenes
US4585894A (en) * 1983-10-19 1986-04-29 Eli Lilly And Company Process for producing 9-carbamoyl fluorene derivatives
IL73261A (en) * 1983-10-19 1988-03-31 Lilly Co Eli Process for producing 9-carbamoyl-9-aminoalkyl fluorene derivatives,and certain intermediates thereof
US4486592A (en) * 1983-10-19 1984-12-04 Eli Lilly And Company 9-Carbamoylfluorene derivatives
DE3444837A1 (de) * 1984-12-08 1986-06-12 Basf Ag, 6700 Ludwigshafen 10,11-dihydro-5h-dibenzo(a,d)cycloheptadien- derivate, ihre herstellung und verwendung
GB9304189D0 (en) * 1993-03-02 1993-04-21 Sturmey Archer Ltd Epicyclic change speed gear hubs
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5631203A (en) * 1995-05-04 1997-05-20 Phillips Petroleum Company Metallocene compounds and preparation thereof containing terminal alkynes
PL328094A1 (en) * 1996-01-16 1999-01-04 Bristol Myers Squibb Co Conformingly restricted aromatic inhibitors triglycerides carrying chromosome protein and method of obtaining such inhibitors
US5760246A (en) 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB736372A (en) * 1953-05-06 1955-09-07 Miles Lab Fluorene derivatives
NL287095A (de) 1962-12-21 1965-02-25
FR1345419A (fr) * 1962-12-21 1963-12-06 Boehringer & Soehne Gmbh Procédé pour la préparation de dérivés basiques du fluorène et des sels de ces dérivés
DE1203253B (de) * 1963-02-09 1965-10-21 Boehringer & Soehne Gmbh Verfahren zur Herstellung basischer Fluorenderivate und ihrer Salze
FR1482727A (fr) * 1965-06-10 1967-05-26 Upjohn Co 9-(2-amino-1-méthyléthyl) fluoren-9-ols et leur procédé de fabrication
GB1211459A (en) * 1967-05-10 1970-11-04 Abbott Lab Hydroxy amines
US3660485A (en) * 1970-10-05 1972-05-02 Searle & Co Fluorene-9-carboxylic acid hydrazides
US3843657A (en) * 1972-12-08 1974-10-22 Searle & Co 9-dialkylamin oalkyl-n-substituted fluorene-9-carboxamides

Also Published As

Publication number Publication date
FI70006B (fi) 1986-01-31
ES497300A0 (es) 1982-01-01
AT368131B (de) 1982-09-10
KR840001836B1 (ko) 1984-10-22
KR840000279B1 (ko) 1984-03-13
ES497303A0 (es) 1982-01-01
FR2460287A1 (fr) 1981-01-23
FI840920A (fi) 1984-03-07
IT1140772B (it) 1986-10-10
ES497301A0 (es) 1982-01-01
ES489470A0 (es) 1981-04-16
ATA114181A (de) 1982-01-15
ES8201943A1 (es) 1982-01-01
MA18763A1 (fr) 1980-10-01
CS214699B2 (en) 1982-05-28
PL222600A1 (de) 1980-12-15
IL59558A0 (en) 1980-06-30
ES8104186A1 (es) 1981-04-16
FR2457278A1 (fr) 1980-12-19
GB2046257A (en) 1980-11-12
FI840921A (fi) 1984-03-07
SU1022656A3 (ru) 1983-06-07
ATA114081A (de) 1982-01-15
DK158658B (da) 1990-07-02
FR2460287B1 (de) 1983-03-11
CS214700B2 (en) 1982-05-28
GT198062477A (es) 1981-09-02
IE800494L (en) 1980-09-12
DD149511A5 (de) 1981-07-15
DK103380A (da) 1980-09-13
FI69299C (fi) 1986-01-10
GB2046257B (en) 1983-10-19
AR227318A1 (es) 1982-10-15
AR225526A1 (es) 1982-03-31
CY1345A (en) 1987-01-16
GR68035B (de) 1981-10-27
FI70006C (fi) 1986-09-12
NZ193078A (en) 1981-11-19
CH643234A5 (fr) 1984-05-30
IE49553B1 (en) 1985-10-30
BE882166A (fr) 1980-09-11
PH15594A (en) 1983-02-28
EP0018076B1 (de) 1983-09-21
JPS55124743A (en) 1980-09-26
JPS6314702B2 (de) 1988-04-01
RO85074A (ro) 1984-08-17
MY8700080A (en) 1987-12-31
EP0018076A1 (de) 1980-10-29
FI67211C (fi) 1985-02-11
FI67211B (fi) 1984-10-31
AR228851A1 (es) 1983-04-29
AT370407B (de) 1983-03-25
ATA113981A (de) 1982-01-15
FI840921A0 (fi) 1984-03-07
LU82236A1 (fr) 1980-06-06
AR229402A1 (es) 1983-08-15
FI800735A (fi) 1980-09-13
CS214696B2 (en) 1982-05-28
FR2457278B1 (de) 1984-06-29
ES8201945A1 (es) 1982-01-01
AT368125B (de) 1982-09-10
ES8201946A1 (es) 1982-01-01
IT8020502A0 (it) 1980-03-11
PL122643B1 (en) 1982-08-31
AR228059A1 (es) 1983-01-14
US4277495A (en) 1981-07-07
DK158658C (da) 1990-12-31
IL59558A (en) 1984-05-31
HU179837B (en) 1982-12-28
ES8201947A1 (es) 1982-01-01
SU1015820A3 (ru) 1983-04-30
ES497302A0 (es) 1982-01-01
HK101086A (en) 1987-01-02
OA06486A (fr) 1981-07-31
CA1136624A (en) 1982-11-30
AR230983A1 (es) 1984-08-31
PT70927A (en) 1980-04-01
AU527992B2 (en) 1983-03-31
YU65680A (en) 1983-02-28
ZA801422B (en) 1981-10-28
FI840920A0 (fi) 1984-03-07
DE3064872D1 (en) 1983-10-27
AU5630180A (en) 1980-09-18
KR830001860A (ko) 1983-05-19
RO79822A (ro) 1983-02-01
CS214698B2 (en) 1982-05-28
ATA134480A (de) 1982-08-15
SG72286G (en) 1987-03-27
FI69299B (fi) 1985-09-30
AT368130B (de) 1982-09-10

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