EE9700150A - Stafülokinaasi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon - Google Patents

Stafülokinaasi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon

Info

Publication number
EE9700150A
EE9700150A EE9700150A EE9700150A EE9700150A EE 9700150 A EE9700150 A EE 9700150A EE 9700150 A EE9700150 A EE 9700150A EE 9700150 A EE9700150 A EE 9700150A EE 9700150 A EE9700150 A EE 9700150A
Authority
EE
Estonia
Prior art keywords
dna fragment
directed mutagenesis
staphylokinase
plasmid
host cell
Prior art date
Application number
EE9700150A
Other languages
English (en)
Estonian (et)
Inventor
Jos� Collen D�sir�
Original Assignee
Leuven Research & Development Vzw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP95200023A external-priority patent/EP0721982A1/de
Priority claimed from EP95201531A external-priority patent/EP0721013B1/de
Application filed by Leuven Research & Development Vzw filed Critical Leuven Research & Development Vzw
Publication of EE9700150A publication Critical patent/EE9700150A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EE9700150A 1995-01-06 1996-01-03 Stafülokinaasi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon EE9700150A (et)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP95200023A EP0721982A1 (de) 1995-01-06 1995-01-06 Neue staphylokinase Derivative
US08/371,505 US5695754A (en) 1995-01-06 1995-01-11 Staphylokinase derivatives
EP95201531A EP0721013B1 (de) 1995-01-06 1995-06-09 Neue staphylokinase Derivate
US49909295A 1995-07-06 1995-07-06
JP7299781A JPH08289790A (ja) 1995-01-06 1995-11-17 新規なスタフィロキナーゼ誘導体
PCT/EP1996/000081 WO1996021016A2 (en) 1995-01-06 1996-01-03 New staphylokinase derivatives

Publications (1)

Publication Number Publication Date
EE9700150A true EE9700150A (et) 1997-12-15

Family

ID=27514236

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700150A EE9700150A (et) 1995-01-06 1996-01-03 Stafülokinaasi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon

Country Status (22)

Country Link
EP (1) EP0793723B1 (de)
JP (1) JPH08289790A (de)
CN (1) CN1154729C (de)
AT (1) ATE306550T1 (de)
AU (1) AU705119B2 (de)
BG (1) BG64344B1 (de)
BR (1) BR9606724A (de)
CA (1) CA2206479A1 (de)
CZ (1) CZ290685B6 (de)
DE (1) DE69635269T2 (de)
EA (1) EA000121B1 (de)
EE (1) EE9700150A (de)
ES (1) ES2248805T3 (de)
FI (1) FI972862A (de)
HU (1) HUP9802915A3 (de)
NO (1) NO973083L (de)
NZ (1) NZ298801A (de)
PL (1) PL184348B1 (de)
RO (1) RO116969B1 (de)
SK (1) SK89297A3 (de)
TR (1) TR199700600T1 (de)
WO (1) WO1996021016A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951980A (en) * 1995-01-06 1999-09-14 Leuven Research & Development Vzw Identification, production and use of new staphylokinase derivatives with reduced immunogenicity
EP1277762B1 (de) * 1998-10-30 2008-03-26 Novozymes A/S Niedrigallergene Proteinvarianten
US6686164B1 (en) 1998-10-30 2004-02-03 Novozymes A/S Low allergenic protein variants
CN100342007C (zh) * 2000-01-28 2007-10-10 复旦大学 一种新型重组葡激酶及其制备方法
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU669149B2 (en) * 1991-12-30 1996-05-30 Thromb-X N.V. Expression signal-peptide-free staphylokinases

Also Published As

Publication number Publication date
HUP9802915A3 (en) 2001-02-28
WO1996021016A2 (en) 1996-07-11
ES2248805T3 (es) 2006-03-16
NO973083D0 (no) 1997-07-02
MX9705041A (es) 1998-07-31
EA000121B1 (ru) 1998-08-27
CZ210497A3 (en) 1997-11-12
EA199700073A1 (ru) 1997-12-30
TR199700600T1 (xx) 1998-01-21
NZ298801A (en) 2000-01-28
BG64344B1 (bg) 2004-10-29
SK89297A3 (en) 1998-05-06
AU4437796A (en) 1996-07-24
CN1168156A (zh) 1997-12-17
WO1996021016A3 (en) 1996-09-12
HUP9802915A2 (hu) 1999-03-29
AU705119B2 (en) 1999-05-13
ATE306550T1 (de) 2005-10-15
RO116969B1 (ro) 2001-08-30
PL321181A1 (en) 1997-11-24
PL184348B1 (pl) 2002-10-31
EP0793723B1 (de) 2005-10-12
NO973083L (no) 1997-08-04
FI972862A0 (fi) 1997-07-04
DE69635269D1 (de) 2006-02-23
DE69635269T2 (de) 2006-06-14
FI972862A (fi) 1997-09-03
CZ290685B6 (cs) 2002-09-11
EP0793723A2 (de) 1997-09-10
JPH08289790A (ja) 1996-11-05
BR9606724A (pt) 1998-01-13
BG101556A (en) 1998-02-27
CA2206479A1 (en) 1996-07-11
CN1154729C (zh) 2004-06-23

Similar Documents

Publication Publication Date Title
US5496924A (en) Fusion protein comprising an interleukin-2 fragment ballast portion
US5100784A (en) Process for the preparation of mature human serum albumin
EP0986644A1 (de) Herstellung von erythropoietin durch endogene genaktivierung mit viralen promotoren
DE69822251T2 (de) Verfahren zur Herstellung von mikrobieller Transglutaminase
DD264939A5 (de) Verfahren zur Herstellung einer Nucleinsäure
IE863334L (en) Fusion proteins with a eukaryotic ballast portion
JPS58224690A (ja) 動物インタ−フエロン
DE69028499T2 (de) Neues Verfahren zur Produktion von nichtfusioniertem Protein in E. coli
DE69010096T2 (de) Expression und Sekretion von reifem menschlichem beta-Interleukin-1 in Bacillus subtilis und Mittel und Verfahren zu deren Ausführung.
DE69118946T2 (de) Thermostabile Mutanten von neutraler Protease und Vorkehrungen zu deren Herstellung
WO1999040198A3 (en) Identification, production and use of staphylokinase derivatives with reduced immunogenicity and/or reduced clearance
EE9700150A (et) Stafülokinaasi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon
DE69022901T2 (de) Streptokinase-Proteine, entsprechende Gene, entsprechende Plasmide und Verfahren zu deren Herstellung.
DE3485923T2 (de) Dna-gen, verfahren zu seiner herstellung und dieses gen enthaltendes plasmid.
DD274053A5 (de) Verfahren zur Produktion eines menschlichen, einkettigen Plasminogenaktivators
JPH04228086A (ja) ストレプトミセスにおける外来タン白質の製造法
DE69017793T2 (de) Produktion von menschlichen Nervenwachstumsfaktoren.
DE3780199T2 (de) Modifiziertes enzym.
JP2637392B2 (ja) 遺伝子操作による生物活性β−NGFの生産方法
DE3877197T2 (de) Verfahren zur herstellung von hirudin.
DE69521281T2 (de) Verfahren zur Herstellung von menschlichem oder humanem Matrilysin mittels rekombinanter DNA.
WO2000061727A2 (de) Herstellung von pankreatischer procarboxypeptidase b, isoformen und muteinen davon und ihre verwendung
DE3900770A1 (de) Verfahren zur herstellung von pdgf-a und pdgf-aa
IE902832A1 (en) Dna fragment containing at least one protease gene, a¹cloning vector containing such a dna fragment, a host cell¹transformed with a cloning vector constructed in this¹manner, and also the proteases produced by, or products such¹as foodstuffs prepared with, such host cells
DE19860801A1 (de) Rekombinanter Wachstumsfaktor mit der biologischen Aktivität eines G-CSF (Granulocyte Colony Stimulating Factor)