DE3780199T2 - Modifiziertes enzym. - Google Patents

Modifiziertes enzym.

Info

Publication number
DE3780199T2
DE3780199T2 DE8787302837T DE3780199T DE3780199T2 DE 3780199 T2 DE3780199 T2 DE 3780199T2 DE 8787302837 T DE8787302837 T DE 8787302837T DE 3780199 T DE3780199 T DE 3780199T DE 3780199 T2 DE3780199 T2 DE 3780199T2
Authority
DE
Germany
Prior art keywords
modified enzyme
enzyme
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787302837T
Other languages
English (en)
Other versions
DE3780199D1 (de
Inventor
Michael Joseph Beecham Browne
Jeffery Hugh Beecham Robinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3780199D1 publication Critical patent/DE3780199D1/de
Publication of DE3780199T2 publication Critical patent/DE3780199T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE8787302837T 1986-04-02 1987-04-01 Modifiziertes enzym. Expired - Fee Related DE3780199T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868608020A GB8608020D0 (en) 1986-04-02 1986-04-02 Compounds

Publications (2)

Publication Number Publication Date
DE3780199D1 DE3780199D1 (de) 1992-08-13
DE3780199T2 true DE3780199T2 (de) 1993-01-21

Family

ID=10595544

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787302837T Expired - Fee Related DE3780199T2 (de) 1986-04-02 1987-04-01 Modifiziertes enzym.

Country Status (11)

Country Link
EP (1) EP0241210B1 (de)
JP (1) JPS62289181A (de)
AU (1) AU602681B2 (de)
DE (1) DE3780199T2 (de)
DK (1) DK165887A (de)
ES (1) ES2042553T3 (de)
GB (1) GB8608020D0 (de)
GR (1) GR3005571T3 (de)
NZ (1) NZ219828A (de)
PT (1) PT84590B (de)
ZA (1) ZA872334B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005822A1 (en) * 1987-01-30 1988-08-11 American Home Products Corporation Des-epidermal growth factor plasminogen activators
EP0292009A1 (de) * 1987-05-22 1988-11-23 Zymogenetics, Inc. Fibrinolytische Proteine
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
EP0340573A3 (de) * 1988-04-30 1990-05-30 BASF Aktiengesellschaft Neue Proteine, ihre Herstellung und Verwendung
DE3836200A1 (de) * 1988-10-24 1990-04-26 Boehringer Mannheim Gmbh Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)
DE4123845A1 (de) * 1991-07-18 1993-01-21 Boehringer Mannheim Gmbh Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
AU7090787A (en) * 1986-02-19 1987-10-08 Beecham Group Plc Tissue plasminogen activator
PT84588B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
PT84587B (pt) * 1986-04-02 1989-11-30 Beecham Group Plc Processo para preparacao de uma enzima fibrinolitica

Also Published As

Publication number Publication date
ES2042553T3 (es) 1993-12-16
AU7090587A (en) 1987-10-08
PT84590A (en) 1987-04-01
EP0241210A1 (de) 1987-10-14
DK165887A (da) 1987-10-02
PT84590B (pt) 1989-11-30
GR3005571T3 (de) 1993-06-07
AU602681B2 (en) 1990-10-25
DK165887D0 (da) 1987-04-01
NZ219828A (en) 1990-08-28
JPS62289181A (ja) 1987-12-16
ZA872334B (en) 1987-12-30
EP0241210B1 (de) 1992-07-08
GB8608020D0 (en) 1986-05-08
DE3780199D1 (de) 1992-08-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee