DK165787A - Modificeret fibrinolytisk enzym - Google Patents

Modificeret fibrinolytisk enzym

Info

Publication number
DK165787A
DK165787A DK165787A DK165787A DK165787A DK 165787 A DK165787 A DK 165787A DK 165787 A DK165787 A DK 165787A DK 165787 A DK165787 A DK 165787A DK 165787 A DK165787 A DK 165787A
Authority
DK
Denmark
Prior art keywords
enzym
fibrinolytic
modified
modified fibrinolytic
fibrinolytic enzym
Prior art date
Application number
DK165787A
Other languages
English (en)
Other versions
DK165787D0 (da
Inventor
Michael Joseph Browne
Jeffery Hugh Robinson
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868608016A external-priority patent/GB8608016D0/en
Priority claimed from GB868608017A external-priority patent/GB8608017D0/en
Priority claimed from GB868621868A external-priority patent/GB8621868D0/en
Priority claimed from GB878704077A external-priority patent/GB8704077D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of DK165787D0 publication Critical patent/DK165787D0/da
Publication of DK165787A publication Critical patent/DK165787A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK165787A 1986-04-02 1987-04-01 Modificeret fibrinolytisk enzym DK165787A (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB868608016A GB8608016D0 (en) 1986-04-02 1986-04-02 Compounds
GB868608017A GB8608017D0 (en) 1986-04-02 1986-04-02 Compounds
GB868621868A GB8621868D0 (en) 1986-09-11 1986-09-11 Compounds
GB878704077A GB8704077D0 (en) 1987-02-21 1987-02-21 Compounds

Publications (2)

Publication Number Publication Date
DK165787D0 DK165787D0 (da) 1987-04-01
DK165787A true DK165787A (da) 1987-10-03

Family

ID=27449752

Family Applications (1)

Application Number Title Priority Date Filing Date
DK165787A DK165787A (da) 1986-04-02 1987-04-01 Modificeret fibrinolytisk enzym

Country Status (4)

Country Link
EP (1) EP0241208A1 (da)
AU (1) AU7090887A (da)
DK (1) DK165787A (da)
PT (1) PT84588B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608020D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
IE880255L (en) * 1987-01-30 1988-07-30 American Home Prod Des-epidermal growth factor activators.
FI882628A (fi) * 1987-06-04 1988-12-05 Zymogenetics Inc T-pa mutaterad genom remplacering av en region bestaoende av tre disulfidbindningar (kringle).
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
JP2534332B2 (ja) * 1987-10-29 1996-09-11 山之内製薬株式会社 ポリペプチド化合物
AU618039B2 (en) * 1987-10-29 1991-12-12 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
EP0386240B1 (en) * 1987-10-29 1995-07-19 Yamanouchi Pharmaceutical Co. Ltd. Novel polypeptide compounds
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE3830734A1 (de) * 1988-09-09 1990-03-22 Basf Ag Neue polypeptide, ihre herstellung und verwendung
DE68922859T2 (de) * 1988-10-27 1995-09-21 Tno Trombolytischer wirkstoff mit modifikation der domäne der kringle.
WO1991015235A1 (en) * 1990-03-30 1991-10-17 Survival Technology, Inc. t-PA ENHANCER PROFILE
US5246850A (en) * 1990-07-31 1993-09-21 Genentech, Inc. DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
DE69113049T2 (de) * 1990-07-31 1996-04-04 Genentech, Inc., South San Francisco, Calif. Varianten des gewebeplasminogenaktivators mit vermindertem abbau.
DE69312493T2 (de) * 1992-06-03 1998-01-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79202B (da) * 1982-05-05 1984-10-22 Genentech Inc
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
PT82326B (pt) * 1985-04-04 1988-10-14 Beecham Group Plc Processo para a preparacao de activador de plasminogenio de tipo tissular fibrinoliticamente activo
HU206520B (en) * 1985-04-22 1992-11-30 Genentech Inc Process for producing new human tissue plasminogen activator /tpa/ mutants and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PT84588A (en) 1987-04-01
PT84588B (en) 1989-05-09
AU7090887A (en) 1987-10-08
DK165787D0 (da) 1987-04-01
EP0241208A1 (en) 1987-10-14

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Legal Events

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