PT84588B - Process for preparing a fibrinolytic enzyme - Google Patents

Process for preparing a fibrinolytic enzyme

Info

Publication number
PT84588B
PT84588B PT8458887A PT8458887A PT84588B PT 84588 B PT84588 B PT 84588B PT 8458887 A PT8458887 A PT 8458887A PT 8458887 A PT8458887 A PT 8458887A PT 84588 B PT84588 B PT 84588B
Authority
PT
Portugal
Prior art keywords
preparing
fibrinolytic enzyme
fibrinolytic
enzyme
Prior art date
Application number
PT8458887A
Other languages
English (en)
Other versions
PT84588A (en
Inventor
Michael Joseph Browne
Jeffery Hugh Robinson
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868608017A external-priority patent/GB8608017D0/en
Priority claimed from GB868608016A external-priority patent/GB8608016D0/en
Priority claimed from GB868621868A external-priority patent/GB8621868D0/en
Priority claimed from GB878704077A external-priority patent/GB8704077D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of PT84588A publication Critical patent/PT84588A/pt
Publication of PT84588B publication Critical patent/PT84588B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT8458887A 1986-04-02 1987-03-31 Process for preparing a fibrinolytic enzyme PT84588B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB868608017A GB8608017D0 (en) 1986-04-02 1986-04-02 Compounds
GB868608016A GB8608016D0 (en) 1986-04-02 1986-04-02 Compounds
GB868621868A GB8621868D0 (en) 1986-09-11 1986-09-11 Compounds
GB878704077A GB8704077D0 (en) 1987-02-21 1987-02-21 Compounds

Publications (2)

Publication Number Publication Date
PT84588A PT84588A (en) 1987-04-01
PT84588B true PT84588B (en) 1989-05-09

Family

ID=27449752

Family Applications (1)

Application Number Title Priority Date Filing Date
PT8458887A PT84588B (en) 1986-04-02 1987-03-31 Process for preparing a fibrinolytic enzyme

Country Status (4)

Country Link
EP (1) EP0241208A1 (pt)
AU (1) AU7090887A (pt)
DK (1) DK165787A (pt)
PT (1) PT84588B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608020D0 (en) * 1986-04-02 1986-05-08 Beecham Group Plc Compounds
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
EP0299053A1 (en) * 1987-01-30 1989-01-18 American Home Products Corporation Des-epidermal growth factor plasminogen activators
ES2058180T3 (es) * 1987-06-04 1994-11-01 Zymogenetics Inc T-pa mutante con reemplazo de kringle.
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it
AU618039B2 (en) * 1987-10-29 1991-12-12 Yamanouchi Pharmaceutical Co., Ltd. Novel polypeptide compounds
EP0386240B1 (en) * 1987-10-29 1995-07-19 Yamanouchi Pharmaceutical Co. Ltd. Novel polypeptide compounds
JP2534332B2 (ja) * 1987-10-29 1996-09-11 山之内製薬株式会社 ポリペプチド化合物
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE3830734A1 (de) * 1988-09-09 1990-03-22 Basf Ag Neue polypeptide, ihre herstellung und verwendung
EP0440709B1 (en) * 1988-10-27 1995-05-24 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Thrombolytic agents with modified kringle domains
WO1991015235A1 (en) * 1990-03-30 1991-10-17 Survival Technology, Inc. t-PA ENHANCER PROFILE
US5246850A (en) * 1990-07-31 1993-09-21 Genentech, Inc. DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
WO1992002612A2 (en) * 1990-07-31 1992-02-20 Genentech, Inc. Tissue plasminogen activator variants with decreased clearance
AU664469B2 (en) * 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
NZ215660A (en) * 1985-04-04 1990-03-27 Beecham Group Plc Tissue plasminogen activator modified in the growth factor domain
IL78571A (en) * 1985-04-22 1991-06-30 Genentech Inc Human tissue plasminogen activator mutants resistant to enzymatic cleavage resulting in two-chain form

Also Published As

Publication number Publication date
EP0241208A1 (en) 1987-10-14
AU7090887A (en) 1987-10-08
PT84588A (en) 1987-04-01
DK165787A (da) 1987-10-03
DK165787D0 (da) 1987-04-01

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