DK165687A - Modificeret fibrinolytisk enzym - Google Patents
Modificeret fibrinolytisk enzymInfo
- Publication number
- DK165687A DK165687A DK165687A DK165687A DK165687A DK 165687 A DK165687 A DK 165687A DK 165687 A DK165687 A DK 165687A DK 165687 A DK165687 A DK 165687A DK 165687 A DK165687 A DK 165687A
- Authority
- DK
- Denmark
- Prior art keywords
- enzym
- fibrinolytic
- modified
- modified fibrinolytic
- fibrinolytic enzym
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868608019A GB8608019D0 (en) | 1986-04-02 | 1986-04-02 | Compounds |
GB878704078A GB8704078D0 (en) | 1987-02-21 | 1987-02-21 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DK165687D0 DK165687D0 (da) | 1987-04-01 |
DK165687A true DK165687A (da) | 1987-10-03 |
Family
ID=26290572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK165687A DK165687A (da) | 1986-04-02 | 1987-04-01 | Modificeret fibrinolytisk enzym |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0241209A1 (da) |
DK (1) | DK165687A (da) |
PT (1) | PT84589B (da) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5756093A (en) * | 1985-04-22 | 1998-05-26 | Genentech, Inc. | Tissue plasminogen activator variants |
US5736134A (en) * | 1985-04-22 | 1998-04-07 | Genentech, In.C | Tissue plasminogen activator variants |
US5714372A (en) * | 1985-04-22 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator variants |
US5580559A (en) * | 1986-12-05 | 1996-12-03 | Ciba-Geigy Corporation | Hybrid plasminogen activator |
US5242819A (en) * | 1986-12-05 | 1993-09-07 | Ciba-Geigy Corporation | DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase |
GB8701811D0 (en) * | 1987-01-28 | 1987-03-04 | Beecham Group Plc | Compounds |
GB2200640B (en) * | 1987-01-30 | 1991-07-10 | American Home Prod | Des-epidermal growth factor plasminogen activators |
US5346824A (en) * | 1988-05-20 | 1994-09-13 | Genentech, Inc. | DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof |
US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
GB8815135D0 (en) * | 1988-06-24 | 1988-08-03 | British Bio Technology | Proteins & nucleic acids |
US5258180A (en) * | 1988-09-02 | 1993-11-02 | Genetech, Inc. | Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US5108901A (en) * | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
SE462829B (sv) * | 1989-01-10 | 1990-09-10 | Kabigen Ab | Trombolytiskt aktiva kompositioner innehaallande en modifierad plasminogenaktivator av vaevnadstyp samt en normal human t-pa, streptokinas eller humant urokinas |
US5087572A (en) * | 1989-12-01 | 1992-02-11 | Genentech, Inc. | Dna encoding human plasminogen modified at the cleavage site |
US5190756A (en) * | 1989-12-01 | 1993-03-02 | Genentech, Inc. | Methods and materials for expression of human plasminogen variant |
NZ246432A (en) * | 1991-12-16 | 1996-06-25 | Genentech Inc | Fibrin-specific t-pa with a point mutation at position 276, vector cell cultures |
ES2203668T3 (es) * | 1992-06-03 | 2004-04-16 | Genentech, Inc. | Variantes de glicosilacion del activador de plasminogeno de tejido con propiedades terapeuticas mejoradas. |
US6706504B1 (en) | 1996-11-12 | 2004-03-16 | The Scripps Research Institute | Tissue type plasminogen activator (t-PA) variants: compositions and methods of use |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR241654A1 (es) * | 1982-05-05 | 1992-10-30 | Genentech Inc | Procedimiento para producir activador de plasminogeno de tejido humano. |
US4753879A (en) * | 1984-08-27 | 1988-06-28 | Biogen N.V. | Modified tissue plasminogen activators |
EP0201153A3 (en) * | 1985-02-09 | 1987-10-07 | Beecham Group Plc | Modified enzyme and process for its preparation |
EP0207589A1 (en) * | 1985-04-03 | 1987-01-07 | Beecham Group Plc | Fibrinolytic enzyme |
FR2581652B1 (fr) * | 1985-04-22 | 1989-12-22 | Genentech Inc | Nouveaux mutants de l'activateur tissulaire du plasminogene humain |
-
1987
- 1987-03-31 PT PT8458987A patent/PT84589B/pt unknown
- 1987-04-01 DK DK165687A patent/DK165687A/da not_active IP Right Cessation
- 1987-04-01 EP EP87302836A patent/EP0241209A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
PT84589B (en) | 1989-05-09 |
PT84589A (en) | 1987-04-01 |
EP0241209A1 (en) | 1987-10-14 |
DK165687D0 (da) | 1987-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment | ||
PUP | Patent expired |