DE69113049T2 - Varianten des gewebeplasminogenaktivators mit vermindertem abbau. - Google Patents

Varianten des gewebeplasminogenaktivators mit vermindertem abbau.

Info

Publication number
DE69113049T2
DE69113049T2 DE69113049T DE69113049T DE69113049T2 DE 69113049 T2 DE69113049 T2 DE 69113049T2 DE 69113049 T DE69113049 T DE 69113049T DE 69113049 T DE69113049 T DE 69113049T DE 69113049 T2 DE69113049 T2 DE 69113049T2
Authority
DE
Germany
Prior art keywords
variants
plasminogen activator
tissue plasminogen
kringle
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69113049T
Other languages
English (en)
Other versions
DE69113049D1 (de
Inventor
Bruce Keyt
Mark Zoller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69113049D1 publication Critical patent/DE69113049D1/de
Publication of DE69113049T2 publication Critical patent/DE69113049T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69113049T 1990-07-31 1991-07-30 Varianten des gewebeplasminogenaktivators mit vermindertem abbau. Expired - Lifetime DE69113049T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56051590A 1990-07-31 1990-07-31
PCT/US1991/005418 WO1992002612A2 (en) 1990-07-31 1991-07-30 Tissue plasminogen activator variants with decreased clearance

Publications (2)

Publication Number Publication Date
DE69113049D1 DE69113049D1 (de) 1995-10-19
DE69113049T2 true DE69113049T2 (de) 1996-04-04

Family

ID=24238122

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69113049T Expired - Lifetime DE69113049T2 (de) 1990-07-31 1991-07-30 Varianten des gewebeplasminogenaktivators mit vermindertem abbau.

Country Status (8)

Country Link
EP (1) EP0542869B1 (de)
JP (1) JP3126381B2 (de)
AT (1) ATE127839T1 (de)
AU (1) AU645344B2 (de)
CA (1) CA2086835C (de)
DE (1) DE69113049T2 (de)
DK (1) DK0542869T3 (de)
WO (1) WO1992002612A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5156969A (en) * 1988-09-02 1992-10-20 Genentech Inc. Tissue plasminogen activator variant with deletion of amino acids 466-470 having fibrin specific properties
PT786257E (pt) * 1992-06-03 2003-12-31 Genentech Inc Variantes de glicosilacao do activador de plasminogenio tissular com propriedades terapeuticas meloradas
US6355255B1 (en) 1998-12-07 2002-03-12 Regents Of The University Of Minnesota Streptococcal C5a peptidase vaccine
EP2356135B1 (de) 2008-11-05 2017-10-25 Wyeth LLC Immunogene multikomponentenzusammensetzung zur prävention einer erkrankung mit beta-hämolytischen streptokokken (bhs)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7090887A (en) * 1986-04-02 1987-10-08 Beecham Group Plc Plasminogen activators modified in first kringle domain
JPH084501B2 (ja) * 1987-03-20 1996-01-24 エーザイ株式会社 糖鎖に関する変異ｔＰＡ
JPH03500002A (ja) * 1987-07-06 1991-01-10 ジェネティックス・インスチチュート・インコーポレーテッド 新規な血栓崩壊蛋白
IL88247A0 (en) * 1987-11-06 1989-06-30 Genentech Inc Novel human tissue-type plasminogen activator variant
IL90146A (en) * 1988-05-20 1994-10-07 Genentech Inc Glycosylation derivatives of tissue plasminogen activator
DE3825253A1 (de) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-pa-derivat und seine herstellung

Also Published As

Publication number Publication date
EP0542869B1 (de) 1995-09-13
CA2086835C (en) 2002-04-02
WO1992002612A3 (en) 1992-03-19
JPH05509229A (ja) 1993-12-22
AU8418791A (en) 1992-03-02
CA2086835A1 (en) 1992-02-01
DE69113049D1 (de) 1995-10-19
DK0542869T3 (da) 1996-02-05
ATE127839T1 (de) 1995-09-15
WO1992002612A2 (en) 1992-02-20
JP3126381B2 (ja) 2001-01-22
AU645344B2 (en) 1994-01-13
EP0542869A1 (de) 1993-05-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition