ATE306550T1 - Neue staphylokinase derivate - Google Patents

Neue staphylokinase derivate

Info

Publication number
ATE306550T1
ATE306550T1 AT96900577T AT96900577T ATE306550T1 AT E306550 T1 ATE306550 T1 AT E306550T1 AT 96900577 T AT96900577 T AT 96900577T AT 96900577 T AT96900577 T AT 96900577T AT E306550 T1 ATE306550 T1 AT E306550T1
Authority
AT
Austria
Prior art keywords
dna fragment
directed mutagenesis
plasmid
host cell
staphylokinase
Prior art date
Application number
AT96900577T
Other languages
English (en)
Inventor
Desire Jose Collen
Original Assignee
Leuven Res & Dev V Z W
Desire Jose Collen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP95200023A external-priority patent/EP0721982A1/de
Priority claimed from EP95201531A external-priority patent/EP0721013B1/de
Application filed by Leuven Res & Dev V Z W, Desire Jose Collen filed Critical Leuven Res & Dev V Z W
Application granted granted Critical
Publication of ATE306550T1 publication Critical patent/ATE306550T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96900577T 1995-01-06 1996-01-03 Neue staphylokinase derivate ATE306550T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP95200023A EP0721982A1 (de) 1995-01-06 1995-01-06 Neue staphylokinase Derivative
US08/371,505 US5695754A (en) 1995-01-06 1995-01-11 Staphylokinase derivatives
EP95201531A EP0721013B1 (de) 1995-01-06 1995-06-09 Neue staphylokinase Derivate
US49909295A 1995-07-06 1995-07-06
JP7299781A JPH08289790A (ja) 1995-01-06 1995-11-17 新規なスタフィロキナーゼ誘導体
PCT/EP1996/000081 WO1996021016A2 (en) 1995-01-06 1996-01-03 New staphylokinase derivatives

Publications (1)

Publication Number Publication Date
ATE306550T1 true ATE306550T1 (de) 2005-10-15

Family

ID=27514236

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96900577T ATE306550T1 (de) 1995-01-06 1996-01-03 Neue staphylokinase derivate

Country Status (22)

Country Link
EP (1) EP0793723B1 (de)
JP (1) JPH08289790A (de)
CN (1) CN1154729C (de)
AT (1) ATE306550T1 (de)
AU (1) AU705119B2 (de)
BG (1) BG64344B1 (de)
BR (1) BR9606724A (de)
CA (1) CA2206479A1 (de)
CZ (1) CZ290685B6 (de)
DE (1) DE69635269T2 (de)
EA (1) EA000121B1 (de)
EE (1) EE9700150A (de)
ES (1) ES2248805T3 (de)
FI (1) FI972862A (de)
HU (1) HUP9802915A3 (de)
NO (1) NO973083L (de)
NZ (1) NZ298801A (de)
PL (1) PL184348B1 (de)
RO (1) RO116969B1 (de)
SK (1) SK89297A3 (de)
TR (1) TR199700600T1 (de)
WO (1) WO1996021016A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951980A (en) * 1995-01-06 1999-09-14 Leuven Research & Development Vzw Identification, production and use of new staphylokinase derivatives with reduced immunogenicity
EP1277762B1 (de) * 1998-10-30 2008-03-26 Novozymes A/S Niedrigallergene Proteinvarianten
US6686164B1 (en) 1998-10-30 2004-02-03 Novozymes A/S Low allergenic protein variants
CN100342007C (zh) * 2000-01-28 2007-10-10 复旦大学 一种新型重组葡激酶及其制备方法
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU669149B2 (en) * 1991-12-30 1996-05-30 Thromb-X N.V. Expression signal-peptide-free staphylokinases

Also Published As

Publication number Publication date
HUP9802915A3 (en) 2001-02-28
WO1996021016A2 (en) 1996-07-11
ES2248805T3 (es) 2006-03-16
NO973083D0 (no) 1997-07-02
MX9705041A (es) 1998-07-31
EA000121B1 (ru) 1998-08-27
CZ210497A3 (en) 1997-11-12
EA199700073A1 (ru) 1997-12-30
TR199700600T1 (xx) 1998-01-21
NZ298801A (en) 2000-01-28
BG64344B1 (bg) 2004-10-29
SK89297A3 (en) 1998-05-06
AU4437796A (en) 1996-07-24
CN1168156A (zh) 1997-12-17
WO1996021016A3 (en) 1996-09-12
HUP9802915A2 (hu) 1999-03-29
AU705119B2 (en) 1999-05-13
RO116969B1 (ro) 2001-08-30
PL321181A1 (en) 1997-11-24
PL184348B1 (pl) 2002-10-31
EP0793723B1 (de) 2005-10-12
NO973083L (no) 1997-08-04
FI972862A0 (fi) 1997-07-04
DE69635269D1 (de) 2006-02-23
DE69635269T2 (de) 2006-06-14
FI972862A (fi) 1997-09-03
CZ290685B6 (cs) 2002-09-11
EP0793723A2 (de) 1997-09-10
EE9700150A (et) 1997-12-15
JPH08289790A (ja) 1996-11-05
BR9606724A (pt) 1998-01-13
BG101556A (en) 1998-02-27
CA2206479A1 (en) 1996-07-11
CN1154729C (zh) 2004-06-23

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Legal Events

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