CA2206479A1 - New staphylokinase derivatives - Google Patents

New staphylokinase derivatives

Info

Publication number
CA2206479A1
CA2206479A1 CA002206479A CA2206479A CA2206479A1 CA 2206479 A1 CA2206479 A1 CA 2206479A1 CA 002206479 A CA002206479 A CA 002206479A CA 2206479 A CA2206479 A CA 2206479A CA 2206479 A1 CA2206479 A1 CA 2206479A1
Authority
CA
Canada
Prior art keywords
staphylokinase
sakstar
derivatives
amino acid
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002206479A
Other languages
English (en)
French (fr)
Inventor
Desire Jose Collen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP95200023A external-priority patent/EP0721982A1/de
Priority claimed from EP95201531A external-priority patent/EP0721013B1/de
Application filed by Individual filed Critical Individual
Publication of CA2206479A1 publication Critical patent/CA2206479A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002206479A 1995-01-06 1996-01-03 New staphylokinase derivatives Abandoned CA2206479A1 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
EP95200023A EP0721982A1 (de) 1995-01-06 1995-01-06 Neue staphylokinase Derivative
EP95200023.0 1995-01-06
US08/371,505 1995-01-11
US08/371,505 US5695754A (en) 1995-01-06 1995-01-11 Staphylokinase derivatives
EP95201531.1 1995-06-09
EP95201531A EP0721013B1 (de) 1995-01-06 1995-06-09 Neue staphylokinase Derivate
US49909295A 1995-07-06 1995-07-06
US08/499,092 1995-07-06
JP7299781A JPH08289790A (ja) 1995-01-06 1995-11-17 新規なスタフィロキナーゼ誘導体
JP7/299781 1995-11-17

Publications (1)

Publication Number Publication Date
CA2206479A1 true CA2206479A1 (en) 1996-07-11

Family

ID=27514236

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002206479A Abandoned CA2206479A1 (en) 1995-01-06 1996-01-03 New staphylokinase derivatives

Country Status (22)

Country Link
EP (1) EP0793723B1 (de)
JP (1) JPH08289790A (de)
CN (1) CN1154729C (de)
AT (1) ATE306550T1 (de)
AU (1) AU705119B2 (de)
BG (1) BG64344B1 (de)
BR (1) BR9606724A (de)
CA (1) CA2206479A1 (de)
CZ (1) CZ290685B6 (de)
DE (1) DE69635269T2 (de)
EA (1) EA000121B1 (de)
EE (1) EE9700150A (de)
ES (1) ES2248805T3 (de)
FI (1) FI972862A (de)
HU (1) HUP9802915A3 (de)
NO (1) NO973083L (de)
NZ (1) NZ298801A (de)
PL (1) PL184348B1 (de)
RO (1) RO116969B1 (de)
SK (1) SK89297A3 (de)
TR (1) TR199700600T1 (de)
WO (1) WO1996021016A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951980A (en) * 1995-01-06 1999-09-14 Leuven Research & Development Vzw Identification, production and use of new staphylokinase derivatives with reduced immunogenicity
EP1277762B1 (de) * 1998-10-30 2008-03-26 Novozymes A/S Niedrigallergene Proteinvarianten
US6686164B1 (en) 1998-10-30 2004-02-03 Novozymes A/S Low allergenic protein variants
CN100342007C (zh) * 2000-01-28 2007-10-10 复旦大学 一种新型重组葡激酶及其制备方法
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0621899B1 (de) * 1991-12-30 1996-06-19 Medac Gesellschaft für klinische Spezialpräparate mbH Expression signalpeptid-freier staphylokinasen

Also Published As

Publication number Publication date
JPH08289790A (ja) 1996-11-05
PL184348B1 (pl) 2002-10-31
EE9700150A (et) 1997-12-15
NO973083D0 (no) 1997-07-02
EP0793723B1 (de) 2005-10-12
AU705119B2 (en) 1999-05-13
CZ290685B6 (cs) 2002-09-11
AU4437796A (en) 1996-07-24
ES2248805T3 (es) 2006-03-16
EP0793723A2 (de) 1997-09-10
HUP9802915A3 (en) 2001-02-28
ATE306550T1 (de) 2005-10-15
DE69635269T2 (de) 2006-06-14
BR9606724A (pt) 1998-01-13
CN1154729C (zh) 2004-06-23
MX9705041A (es) 1998-07-31
NZ298801A (en) 2000-01-28
NO973083L (no) 1997-08-04
WO1996021016A2 (en) 1996-07-11
EA199700073A1 (ru) 1997-12-30
DE69635269D1 (de) 2006-02-23
SK89297A3 (en) 1998-05-06
TR199700600T1 (xx) 1998-01-21
CN1168156A (zh) 1997-12-17
FI972862A (fi) 1997-09-03
PL321181A1 (en) 1997-11-24
BG64344B1 (bg) 2004-10-29
RO116969B1 (ro) 2001-08-30
WO1996021016A3 (en) 1996-09-12
HUP9802915A2 (hu) 1999-03-29
CZ210497A3 (en) 1997-11-12
FI972862A0 (fi) 1997-07-04
EA000121B1 (ru) 1998-08-27
BG101556A (en) 1998-02-27

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Collen Staphylokinase: a potent, uniquely fibrin-selective thrombolytic agent
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US20090087421A1 (en) Novel Recombinant Staphylokinase Derivatives and the Preparations and Applications thereof
EP1053330B1 (de) Identifizierung, produktion und verwendung von staphylokinase derivaten mit reduzierter immunogenizität und/oder reduzierter 'clearance'
US5695754A (en) Staphylokinase derivatives
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US9518255B2 (en) Mutants of staphylokinase carrying amino and carboxy-terminal extensions for polyethylene glycol conjugation
EP0721013B1 (de) Neue staphylokinase Derivate
US6902733B2 (en) Staphylokinase derivatives with polyethyleneglycol
JP3399963B2 (ja) 新規スタフィロキナーゼ誘導体
MXPA97005041A (en) New derivatives of estafilocin
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AU2003248284A1 (en) Identification, production and use of staphylokinase derivatives with reduced immunogenicity and/or reduced clearance

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued