EE200100335A - 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid - Google Patents

4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid

Info

Publication number
EE200100335A
EE200100335A EEP200100335A EEP200100335A EE200100335A EE 200100335 A EE200100335 A EE 200100335A EE P200100335 A EEP200100335 A EE P200100335A EE P200100335 A EEP200100335 A EE P200100335A EE 200100335 A EE200100335 A EE 200100335A
Authority
EE
Estonia
Prior art keywords
aminomethyl
intermediates
preparation
methods
pharmaceutical composition
Prior art date
Application number
EEP200100335A
Other languages
English (en)
Estonian (et)
Inventor
Ren Marie Andr Bosmans Jean-Paul
Louise Gabri�lle Meulemans Ann
Anna Jozef De Cleyn Michel
Jacobus Maria Gijsen Henricus
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200100335A publication Critical patent/EE200100335A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EEP200100335A 1998-12-22 1999-12-14 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid EE200100335A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204411 1998-12-22
PCT/EP1999/010064 WO2000037461A1 (en) 1998-12-22 1999-12-14 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders

Publications (1)

Publication Number Publication Date
EE200100335A true EE200100335A (et) 2002-08-15

Family

ID=8234539

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100335A EE200100335A (et) 1998-12-22 1999-12-14 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid

Country Status (34)

Country Link
US (2) US6544997B1 (ru)
EP (1) EP1140915B1 (ru)
JP (1) JP4615725B2 (ru)
KR (1) KR100633680B1 (ru)
CN (1) CN1150190C (ru)
AR (1) AR024240A1 (ru)
AT (1) ATE297917T1 (ru)
AU (1) AU770397B2 (ru)
BG (1) BG64953B1 (ru)
BR (1) BR9916491A (ru)
CA (1) CA2355857C (ru)
CZ (1) CZ300851B6 (ru)
DE (1) DE69925865T2 (ru)
DK (1) DK1140915T3 (ru)
EA (1) EA003608B1 (ru)
EE (1) EE200100335A (ru)
ES (1) ES2245131T3 (ru)
HK (1) HK1039114B (ru)
HR (1) HRP20010445A2 (ru)
HU (1) HUP0104838A3 (ru)
ID (1) ID28953A (ru)
IL (1) IL143858A (ru)
MY (1) MY121852A (ru)
NO (1) NO321324B1 (ru)
NZ (1) NZ512871A (ru)
PL (1) PL197409B1 (ru)
PT (1) PT1140915E (ru)
SI (1) SI1140915T1 (ru)
SK (1) SK285829B6 (ru)
TR (1) TR200101962T2 (ru)
TW (1) TW570920B (ru)
UA (1) UA71591C2 (ru)
WO (1) WO2000037461A1 (ru)
ZA (1) ZA200105135B (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002335161A1 (en) * 2002-09-12 2004-04-30 Nagase Chemtex Corporation Medicinal composition
WO2005003124A1 (en) * 2003-06-19 2005-01-13 Janssen Pharmaceutica N.V. Heterocyclic substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
US7652040B2 (en) 2003-06-19 2010-01-26 Janssen Pharmaceutica N.V. Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists
DE602004029888D1 (en) * 2003-06-19 2010-12-16 Janssen Pharmaceutica Nv Hydroxycarbonylphenyl substituierte 4-(aminomethyl)-piperidinbenzamide als 5ht4-antagonisten
PT1638959E (pt) * 2003-06-19 2007-12-12 Janssen Pharmaceutica Nv 4-(aminometil)piperidinobenzamidas antagonistas de 5ht4
JO2478B1 (en) * 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
SI1664036T1 (sl) * 2003-09-03 2012-03-30 Pfizer Spojine benzimidazolona z agnostično aktivnostjoreceptorja ht
CA2545092C (en) * 2003-11-24 2010-08-17 Pfizer Inc. Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
BRPI0512046A (pt) 2004-06-15 2008-02-06 Pfizer derivados de ácido benzimidazolona carboxìlico
US20060035890A1 (en) * 2004-08-10 2006-02-16 Amit Banerjee Compounds and methods for the treatment of ubiquitin conjugating disorders
ES2327142T3 (es) * 2004-11-05 2009-10-26 Theravance, Inc. Compuestos de quinolinona-carboxamida.
WO2006052640A1 (en) * 2004-11-05 2006-05-18 Theravance, Inc. 5-ht4 receptor agonist compounds
DE602005021696D1 (de) * 2004-12-22 2010-07-15 Theravance Inc Indazolcarbonsäureamidverbindungen
CA2599404A1 (en) * 2005-03-02 2006-09-08 Adam Goldblum Quinolinone compounds as 5-ht4 receptor agonists
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
CA3001857A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
AU2020311942A1 (en) 2019-07-11 2022-02-24 Praxis Precision Medicines, Inc. Formulations of T-type calcium channel modulators and methods of use thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5374637A (en) 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
PT100785A (pt) 1991-08-20 1994-04-29 Smithkline Beecham Plc Utilizacao de compostos, por exemplo indole-3-carboxilatos, para a producao de medicamentos, compostos ai utilizados e composicoes farmaceuticas que os contem.
US5580885A (en) * 1991-09-12 1996-12-03 Smithkline Beecham P.L.C. 5-HT4 receptor antagonists
EP0846694A1 (en) * 1992-01-23 1998-06-10 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
CA2129112A1 (en) * 1992-02-06 1993-08-19 Francis David King Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
GB9219163D0 (en) 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
EP0664805A1 (en) 1992-10-13 1995-08-02 Smithkline Beecham Plc Heterocyclic -esters or -amides used as 5-ht 4? receptor antagonists
KR950704328A (ko) * 1992-11-05 1995-11-17 데이비드 로버츠 5-HT₄ 수용체 길항제로서의 피페리딘 유도체(Piperidine Derivatives as 5-HT₄ Receptor Antagonists)
GB9301660D0 (en) 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
ES2103675B1 (es) * 1995-01-10 1998-07-01 Almirall Lab Nuevas piperidinas sustituidas.
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
WO1997029739A2 (en) * 1996-02-15 1997-08-21 Janssen Pharmaceutica N.V. Use of 5ht4 receptor antagonists for overcoming gastrointestinal effects of serotonin reuptake inhibitors
TW445263B (en) 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
TR200100698T2 (tr) * 1998-09-10 2001-07-23 F.Hoffmann-La Roche Ag 5-HT4 alıcı-Antagonistleri olarak Dihidrobenzodioksin Karboksamit ve Keton türevleri
DE10217868A1 (de) * 2002-04-22 2003-10-30 Jomed N V Ballon-Katheter

Also Published As

Publication number Publication date
CA2355857A1 (en) 2000-06-29
IL143858A0 (en) 2002-04-21
DE69925865D1 (de) 2005-07-21
HK1039114A1 (en) 2002-04-12
SK8592001A3 (en) 2002-02-05
HRP20010445A2 (en) 2002-06-30
CZ20012117A3 (cs) 2001-10-17
CA2355857C (en) 2008-10-28
KR100633680B1 (ko) 2006-10-11
ES2245131T3 (es) 2005-12-16
IL143858A (en) 2005-03-20
ID28953A (id) 2001-07-19
UA71591C2 (en) 2004-12-15
BG105571A (en) 2002-01-31
HUP0104838A3 (en) 2003-05-28
PT1140915E (pt) 2005-11-30
AR024240A1 (es) 2002-09-25
EA003608B1 (ru) 2003-06-26
US7205410B2 (en) 2007-04-17
TR200101962T2 (tr) 2002-04-22
SK285829B6 (sk) 2007-09-06
EA200100710A1 (ru) 2001-12-24
HUP0104838A2 (hu) 2002-07-29
NO20012858L (no) 2001-06-08
WO2000037461A1 (en) 2000-06-29
PL197409B1 (pl) 2008-03-31
JP4615725B2 (ja) 2011-01-19
ZA200105135B (en) 2002-06-21
EP1140915A1 (en) 2001-10-10
BG64953B1 (bg) 2006-10-31
CN1331690A (zh) 2002-01-16
US20030181456A1 (en) 2003-09-25
DK1140915T3 (da) 2005-10-10
HK1039114B (zh) 2005-08-19
AU2432800A (en) 2000-07-12
NO20012858D0 (no) 2001-06-08
BR9916491A (pt) 2001-09-04
DE69925865T2 (de) 2006-05-11
MY121852A (en) 2006-02-28
CN1150190C (zh) 2004-05-19
NZ512871A (en) 2002-11-26
TW570920B (en) 2004-01-11
US6544997B1 (en) 2003-04-08
JP2002533337A (ja) 2002-10-08
PL348417A1 (en) 2002-05-20
KR20010080293A (ko) 2001-08-22
SI1140915T1 (sl) 2005-12-31
ATE297917T1 (de) 2005-07-15
EP1140915B1 (en) 2005-06-15
AU770397B2 (en) 2004-02-19
NO321324B1 (no) 2006-04-24
CZ300851B6 (cs) 2009-08-26

Similar Documents

Publication Publication Date Title
EE200100335A (et) 4-(aminometüül)piperidiinbensamiidid, vaheühendid, farmatseutiline kompositsioon ja nende valmistamismeetodid
EE04178B1 (et) 3- või 4-asendatud 4-(aminometüül)piperidiini bitsüklilised bensamiidid, vaheühend ja farmatseutiline kompositsioon ning nende valmistamismeetodid
EE05104B1 (et) Asetidiini derivaadid, nende valmistamise meetodid ja farmatseutiline kompositsioon
EE05081B1 (et) Farmatseutilised kompositsioonid, mis sisaldavad 3-aminoasetidiini derivaate, 3-aminoasetidiini derivaadid ja nende valmistamise meetodid
NO20025450L (no) Ny farmasöytisk sammensetning
EE04464B1 (et) Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE200000319A (et) hGRF-PEG konjugaatide saitspetsiifiline valmistamismeetod, hGRF-PEG konjugaadid, nende vaheühendid, kasutamine ja farmatseutiline kompositsioon
EE9500064A (et) Asendatud 1H-imidasoolid, nende valmistamismeetodid ja farmatseutilised kompositsioonid
EE9900018A (et) Asendatud püridiinid, nende kasutamine ja farmatseutilised kompositsioonid
EE200300370A (et) Atsüülitud 6,7,8,9-tetrahüdro-5H-bensotsükloheptenüülamiinid, nende valmistamismeetod, kasutamine ja farmatseutiline preparaat
EE04915B1 (et) Kinuklidiinderivaadid, nende valmistamismeetod, vahehendid, farmatseutiline kompositsioon ja nende kasutamine
EE200300207A (et) Heterotsüklüülalküülpiperidiini derivaadid, nendevalmistamismeetodid ja farmatseutiline kompositsioon
DK199900554A (da) Paroxetinsalte, fremgangsmåde til fremstilling deraf, farmaceutiske præparater omfattende disse og anvendelser deraf
EE03688B1 (et) N-[4-(heteroarüülmetüül)fenüül]-heteroarüülamiinid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja meetod selle valmistamiseks
EE200300369A (et) Atsüülitud indanüülamiinid, nende valmistamismeetod, kasutamine ja farmatseutiline preparaat
FR2775596B1 (fr) Nouvelles compositions pharmaceutiques
EE04275B1 (et) Kinoliini derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutilised kompositsioonid
EE200000620A (et) 3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon
EE04717B1 (et) Indolüülpiperidiinühendid, nende valmistamismeetod, kompositsioon ja nende kasutamine
NO996115L (no) Azetidinylpropylpiperidin-derivater, intermediater og anvendelse som tachykinin-antagonister
EE04917B1 (et) Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine
EE04346B1 (et) Asoolid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
EE03996B1 (et) Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
EE200100173A (et) 2-fenüülpüraan-4-ooni derivaadid, nende valmistamismeetod ja kasutamine, vaheühendite kasutamine jafarmatseutiline kompositsioon
EE200300553A (et) Piperidiinkarboksamiidi derivaadid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid