EE05202B1 - Antitrombootilise toimega polüsahhariidid, millel on vähemalt üks kovalentne side biotiini v?i biotiini derivaadiga - Google Patents

Antitrombootilise toimega polüsahhariidid, millel on vähemalt üks kovalentne side biotiini v?i biotiini derivaadiga

Info

Publication number
EE05202B1
EE05202B1 EEP200300114A EEP200300114A EE05202B1 EE 05202 B1 EE05202 B1 EE 05202B1 EE P200300114 A EEP200300114 A EE P200300114A EE P200300114 A EEP200300114 A EE P200300114A EE 05202 B1 EE05202 B1 EE 05202B1
Authority
EE
Estonia
Prior art keywords
biotin
polysaccharides
covalent bond
antithrombotic activity
derivative
Prior art date
Application number
EEP200300114A
Other languages
English (en)
Estonian (et)
Inventor
Duchaussoy Philippe
Herbert Jean-Marc
Petitou Maurice
Savi Pierre
Original Assignee
Sanofi-Synthlabo
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthlabo, Akzo Nobel N.V. filed Critical Sanofi-Synthlabo
Publication of EE200300114A publication Critical patent/EE200300114A/xx
Publication of EE05202B1 publication Critical patent/EE05202B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
EEP200300114A 2000-09-22 2001-09-20 Antitrombootilise toimega polüsahhariidid, millel on vähemalt üks kovalentne side biotiini v?i biotiini derivaadiga EE05202B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0012094A FR2814463B1 (fr) 2000-09-22 2000-09-22 Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
PCT/FR2001/002918 WO2002024754A1 (fr) 2000-09-22 2001-09-20 Polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine

Publications (2)

Publication Number Publication Date
EE200300114A EE200300114A (et) 2005-02-15
EE05202B1 true EE05202B1 (et) 2009-08-17

Family

ID=8854579

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300114A EE05202B1 (et) 2000-09-22 2001-09-20 Antitrombootilise toimega polüsahhariidid, millel on vähemalt üks kovalentne side biotiini v?i biotiini derivaadiga

Country Status (39)

Country Link
US (3) US6844329B2 (cs)
EP (1) EP1322673B1 (cs)
JP (2) JP5016778B2 (cs)
KR (2) KR20080049139A (cs)
CN (1) CN1235914C (cs)
AR (1) AR030774A1 (cs)
AT (1) ATE374215T1 (cs)
AU (2) AU9196001A (cs)
BG (1) BG66191B1 (cs)
BR (1) BR0114007A (cs)
CA (1) CA2418815C (cs)
CY (1) CY1108076T1 (cs)
CZ (1) CZ300856B6 (cs)
DE (1) DE60130669T2 (cs)
DK (1) DK1322673T3 (cs)
EA (1) EA005133B1 (cs)
EC (1) ECSP034514A (cs)
EE (1) EE05202B1 (cs)
ES (1) ES2292625T3 (cs)
FR (1) FR2814463B1 (cs)
GE (1) GEP20053616B (cs)
HR (1) HRP20030219B1 (cs)
HU (2) HU1400034D0 (cs)
IL (2) IL154848A0 (cs)
IS (1) IS2550B (cs)
ME (2) ME00080B (cs)
MX (1) MXPA03002483A (cs)
NO (2) NO332905B1 (cs)
NZ (1) NZ524472A (cs)
PE (1) PE20020471A1 (cs)
PL (1) PL206727B1 (cs)
PT (1) PT1322673E (cs)
RS (1) RS50730B (cs)
SI (1) SI1322673T1 (cs)
SK (2) SK287218B6 (cs)
TW (1) TWI308153B (cs)
UA (1) UA79736C2 (cs)
WO (1) WO2002024754A1 (cs)
ZA (1) ZA200301692B (cs)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
UA94593C2 (ru) * 2005-10-10 2011-05-25 Н.В. Органон Антитромбозные двойные ингибиторы с биотиновой меткой
EP1991271B1 (en) * 2005-10-10 2011-03-09 N.V. Organon Anticoagulant antithrombotic dual inhibitors comprising a biotin label
CN1317035C (zh) * 2005-10-24 2007-05-23 天津大学 基于酰肼基的微粒表面多重生物功能因子组装方法
EP1886696A1 (en) * 2006-08-03 2008-02-13 Endotis Pharma Conjugates of antithrombin binding oligosaccharide derivatives and therapeutic proteins
FR2912409B1 (fr) * 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
TW201006479A (en) * 2008-07-18 2010-02-16 Sanofi Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
EP2145624A1 (en) 2008-07-18 2010-01-20 Sanofi-Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
EP2233143A1 (en) 2009-03-24 2010-09-29 Sanofi-Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
FR2935386B1 (fr) * 2008-08-26 2010-09-10 Sanofi Aventis Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
CA2735983A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
AU2009335709A1 (en) 2008-12-19 2011-07-14 Supernus Pharmaceuticals, Inc. Method of treatment of aggression
FR2952935B1 (fr) * 2009-11-20 2011-12-02 Sanofi Aventis Procede de preparation du n-biotinyl-6-aminocaproate de n succinimidyle
WO2011073408A2 (en) 2009-12-18 2011-06-23 Endotis Pharma Pharmaceutical oral dosage form containing a synthetic oligosaccharide
CZ302510B6 (cs) * 2010-03-29 2011-06-22 Univerzita Palackého v Olomouci Efektivní zpusob biotinylace sloucenin s karboxylovou skupinou pomocí syntézy na pevné fázi pro potreby afinitní chromatografie
CZ302669B6 (cs) * 2010-03-29 2011-08-24 Univerzita Palackého v Olomouci Efektivní zpusob biotinylace aminosloucenin pomocí syntézy na pevné fázi pro potreby afinitní chromatografie
EP2552423B1 (en) 2010-03-31 2017-07-12 Supernus Pharmaceuticals, Inc. Stabilized formulations of cns compounds
FR2964660B1 (fr) * 2010-09-10 2012-09-28 Sanofi Aventis Nouveaux polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
EP2614089A1 (fr) 2010-09-10 2013-07-17 Sanofi-Aventis Polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
EP2484366A1 (en) 2011-02-07 2012-08-08 Sanofi Idrabiotaparinux for the treatment of pulmonary embolism and for the secondary prevention of venous thromboembolic events
CA2839139A1 (en) 2011-06-17 2012-12-20 Carbomimetics Synthetic pentasaccharides having short half-life and high activity
WO2014078394A1 (en) * 2012-11-13 2014-05-22 Supernus Pharmaceuticals, Inc. Method of treatment of aggression
WO2015195404A1 (en) 2014-06-20 2015-12-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for detection of an analyte by movement of tethered microparticles
WO2016205239A1 (en) 2015-06-15 2016-12-22 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Non-hormonal mammalian sperm decoy contraception based on the n-terminus of the zp2 protein
CN110234600B (zh) 2016-10-21 2023-03-21 美国政府(由卫生和人类服务部的部长所代表) 分子纳米标签
CN108976318B (zh) * 2017-06-01 2021-03-30 首都医科大学 单-6-(生物素酰胺基)-6-脱氧-β-环糊精及其制备方法和应用
WO2019133727A1 (en) 2017-12-29 2019-07-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Universal influenza virus probe set for enrichment of any influenza virus nucleic acid
AU2020310172A1 (en) 2019-07-09 2022-03-03 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
WO2021075165A1 (ja) * 2019-10-17 2021-04-22 株式会社オートネットワーク技術研究所 配線モジュール
WO2022056078A1 (en) 2020-09-11 2022-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rnase h-assisted detection assay for rna (radar)
WO2024191684A1 (en) 2023-03-10 2024-09-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Detection of hepatitis c virus ribonucleic acid from whole blood using reverse transcription loop-mediated isothermal amplification

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960884A (en) * 1974-04-24 1976-06-01 Sergei Ivanovich Zavyalov Method of preparing racemic biotin
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
US20010023288A1 (en) * 1999-07-07 2001-09-20 Wilbur D. Scott Trifunctional reagent for conjugation to a biomolecule
FR2751334B1 (fr) * 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
FR2773804B1 (fr) * 1998-01-19 2000-02-18 Sanofi Sa Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant
GB2335490B (en) * 1998-03-20 2003-05-14 Ortho Clinical Diagnostics An assay surface that permits an analyte releasiing step
AU8366398A (en) * 1998-07-07 2000-01-24 Department Of Radiation Oncology University Of Washington Trifunctional reagent for conjugation to a biomolecule
WO2000006608A1 (fr) 1998-07-31 2000-02-10 Seikagaku Corporation Nouveau glycosaminoglycan et compositions medicamenteuses le contenant
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine

Also Published As

Publication number Publication date
HUP0303551A3 (en) 2004-03-29
US20110144042A1 (en) 2011-06-16
DE60130669T2 (de) 2008-07-17
EP1322673A1 (fr) 2003-07-02
WO2002024754A8 (fr) 2003-07-03
CN1235914C (zh) 2006-01-11
JP5016778B2 (ja) 2012-09-05
JP2012131809A (ja) 2012-07-12
BG107650A (bg) 2003-11-28
YU19703A (sh) 2006-05-25
NO20031295L (no) 2003-05-22
ME00080B (me) 2010-10-10
IS2550B (is) 2009-10-15
US6844329B2 (en) 2005-01-18
PE20020471A1 (es) 2002-06-01
DK1322673T3 (da) 2008-01-14
DE60130669D1 (de) 2007-11-08
CY1108076T1 (el) 2014-02-12
NZ524472A (en) 2004-10-29
KR100891388B1 (ko) 2009-04-02
PL206727B1 (pl) 2010-09-30
NO20110401L (no) 2003-05-22
ZA200301692B (en) 2004-03-01
CA2418815C (en) 2011-05-10
EA200300237A1 (ru) 2003-08-28
GEP20053616B (en) 2005-09-26
FR2814463B1 (fr) 2002-11-15
PT1322673E (pt) 2007-12-03
SI1322673T1 (sl) 2008-02-29
BG66191B1 (bg) 2011-12-30
KR20030055269A (ko) 2003-07-02
JP2004509902A (ja) 2004-04-02
HUP0303551A2 (hu) 2004-03-01
NO20031295D0 (no) 2003-03-20
CZ2003814A3 (cs) 2003-06-18
CN1466594A (zh) 2004-01-07
RS50730B (sr) 2010-08-31
PL363368A1 (en) 2004-11-15
ECSP034514A (es) 2003-04-25
AU2001291960B2 (en) 2007-03-01
US20060160768A1 (en) 2006-07-20
US7943595B2 (en) 2011-05-17
SK287054B6 (sk) 2009-10-07
WO2002024754A1 (fr) 2002-03-28
ATE374215T1 (de) 2007-10-15
NO332905B1 (no) 2013-01-28
FR2814463A1 (fr) 2002-03-29
HRP20030219A2 (en) 2003-06-30
AU9196001A (en) 2002-04-02
KR20080049139A (ko) 2008-06-03
EE200300114A (et) 2005-02-15
US20040024197A1 (en) 2004-02-05
IS6733A (is) 2003-02-28
MEP23608A (bs) 2010-06-10
US8318696B2 (en) 2012-11-27
EA005133B1 (ru) 2004-12-30
MXPA03002483A (es) 2004-05-24
IL154848A (en) 2010-11-30
IL154848A0 (en) 2003-10-31
AU2001291960C1 (en) 2009-10-08
BR0114007A (pt) 2003-08-12
SK3562003A3 (en) 2003-11-04
TWI308153B (en) 2009-04-01
HU1400034D0 (hu) 2004-03-01
SK287218B6 (sk) 2010-03-08
AR030774A1 (es) 2003-09-03
UA79736C2 (uk) 2007-07-25
HRP20030219B1 (hr) 2011-10-31
EP1322673B1 (fr) 2007-09-26
ES2292625T3 (es) 2008-03-16
CA2418815A1 (en) 2002-03-28
HK1053316A1 (zh) 2003-10-17
CZ300856B6 (cs) 2009-08-26

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Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20160920