DK1322673T3 - Polysaccharider med antithrombotisk aktivitet, der omfatter mindst en kovalent binding til biotin eller et biotinderivat - Google Patents

Polysaccharider med antithrombotisk aktivitet, der omfatter mindst en kovalent binding til biotin eller et biotinderivat

Info

Publication number
DK1322673T3
DK1322673T3 DK01972171T DK01972171T DK1322673T3 DK 1322673 T3 DK1322673 T3 DK 1322673T3 DK 01972171 T DK01972171 T DK 01972171T DK 01972171 T DK01972171 T DK 01972171T DK 1322673 T3 DK1322673 T3 DK 1322673T3
Authority
DK
Denmark
Prior art keywords
biotin
polysaccharides
covalent bond
antithrombotic activity
derivative
Prior art date
Application number
DK01972171T
Other languages
Danish (da)
English (en)
Inventor
Philippe Duchaussoy
Jean-Marc Herbert
Maurice Petitou
Pierre Savi
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of DK1322673T3 publication Critical patent/DK1322673T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK01972171T 2000-09-22 2001-09-20 Polysaccharider med antithrombotisk aktivitet, der omfatter mindst en kovalent binding til biotin eller et biotinderivat DK1322673T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0012094A FR2814463B1 (fr) 2000-09-22 2000-09-22 Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
PCT/FR2001/002918 WO2002024754A1 (fr) 2000-09-22 2001-09-20 Polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine

Publications (1)

Publication Number Publication Date
DK1322673T3 true DK1322673T3 (da) 2008-01-14

Family

ID=8854579

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01972171T DK1322673T3 (da) 2000-09-22 2001-09-20 Polysaccharider med antithrombotisk aktivitet, der omfatter mindst en kovalent binding til biotin eller et biotinderivat

Country Status (39)

Country Link
US (3) US6844329B2 (cs)
EP (1) EP1322673B1 (cs)
JP (2) JP5016778B2 (cs)
KR (2) KR100891388B1 (cs)
CN (1) CN1235914C (cs)
AR (1) AR030774A1 (cs)
AT (1) ATE374215T1 (cs)
AU (2) AU2001291960C1 (cs)
BG (1) BG66191B1 (cs)
BR (1) BR0114007A (cs)
CA (1) CA2418815C (cs)
CY (1) CY1108076T1 (cs)
CZ (1) CZ300856B6 (cs)
DE (1) DE60130669T2 (cs)
DK (1) DK1322673T3 (cs)
EA (1) EA005133B1 (cs)
EC (1) ECSP034514A (cs)
EE (1) EE05202B1 (cs)
ES (1) ES2292625T3 (cs)
FR (1) FR2814463B1 (cs)
GE (1) GEP20053616B (cs)
HR (1) HRP20030219B1 (cs)
HU (2) HUP0303551A3 (cs)
IL (2) IL154848A0 (cs)
IS (1) IS2550B (cs)
ME (2) ME00080B (cs)
MX (1) MXPA03002483A (cs)
NO (2) NO332905B1 (cs)
NZ (1) NZ524472A (cs)
PE (1) PE20020471A1 (cs)
PL (1) PL206727B1 (cs)
PT (1) PT1322673E (cs)
RS (1) RS50730B (cs)
SI (1) SI1322673T1 (cs)
SK (2) SK287054B6 (cs)
TW (1) TWI308153B (cs)
UA (1) UA79736C2 (cs)
WO (1) WO2002024754A1 (cs)
ZA (1) ZA200301692B (cs)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
FR2874924B1 (fr) * 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
WO2007042469A2 (en) * 2005-10-10 2007-04-19 N.V. Organon Anticoagulant antithrombotic dual inhibitors comprising a biotin label
UA94593C2 (ru) * 2005-10-10 2011-05-25 Н.В. Органон Антитромбозные двойные ингибиторы с биотиновой меткой
CN1317035C (zh) * 2005-10-24 2007-05-23 天津大学 基于酰肼基的微粒表面多重生物功能因子组装方法
EP1886696A1 (en) * 2006-08-03 2008-02-13 Endotis Pharma Conjugates of antithrombin binding oligosaccharide derivatives and therapeutic proteins
FR2912409B1 (fr) * 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
TW201006479A (en) * 2008-07-18 2010-02-16 Sanofi Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
EP2145624A1 (en) 2008-07-18 2010-01-20 Sanofi-Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
EP2233143A1 (en) 2009-03-24 2010-09-29 Sanofi-Aventis Use of idrabiotaparinux for decreasing the incidence of bleedings during an antithrombotic treatment
FR2935386B1 (fr) * 2008-08-26 2010-09-10 Sanofi Aventis Nouveaux polysaccharides a activite antithrombotique comprenant une liaion covalente avec une chaine amine
WO2010029552A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
AU2009335709A1 (en) 2008-12-19 2011-07-14 Supernus Pharmaceuticals, Inc. Method of treatment of aggression
FR2952935B1 (fr) * 2009-11-20 2011-12-02 Sanofi Aventis Procede de preparation du n-biotinyl-6-aminocaproate de n succinimidyle
WO2011073408A2 (en) 2009-12-18 2011-06-23 Endotis Pharma Pharmaceutical oral dosage form containing a synthetic oligosaccharide
CZ302669B6 (cs) * 2010-03-29 2011-08-24 Univerzita Palackého v Olomouci Efektivní zpusob biotinylace aminosloucenin pomocí syntézy na pevné fázi pro potreby afinitní chromatografie
CZ302510B6 (cs) * 2010-03-29 2011-06-22 Univerzita Palackého v Olomouci Efektivní zpusob biotinylace sloucenin s karboxylovou skupinou pomocí syntézy na pevné fázi pro potreby afinitní chromatografie
MX2012010829A (es) 2010-03-31 2012-11-12 Supernus Pharmaceuticals Inc Formulaciones estabilizadas de compuesto para el sistema nervioso central.
FR2964660B1 (fr) * 2010-09-10 2012-09-28 Sanofi Aventis Nouveaux polysaccharides biotinyles a activite antithrombotique et presentant une stabilite metabolique amelioree
JP2013537181A (ja) * 2010-09-10 2013-09-30 サノフイ 抗血栓活性及び改善された代謝安定性を有するビオチン化多糖類
EP2484366A1 (en) 2011-02-07 2012-08-08 Sanofi Idrabiotaparinux for the treatment of pulmonary embolism and for the secondary prevention of venous thromboembolic events
ES2560467T3 (es) * 2011-06-17 2016-02-19 Carbomimetics Pentasacáridos sintéticos que tienen vida media corta y alta actividad
MX2015005937A (es) * 2012-11-13 2015-09-08 Supernus Pharmaceuticals Inc Metodo de tratamiento de la agresion.
WO2015195404A1 (en) 2014-06-20 2015-12-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for detection of an analyte by movement of tethered microparticles
WO2016205239A1 (en) 2015-06-15 2016-12-22 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Non-hormonal mammalian sperm decoy contraception based on the n-terminus of the zp2 protein
CN110234600B (zh) 2016-10-21 2023-03-21 美国政府(由卫生和人类服务部的部长所代表) 分子纳米标签
CN108976318B (zh) * 2017-06-01 2021-03-30 首都医科大学 单-6-(生物素酰胺基)-6-脱氧-β-环糊精及其制备方法和应用
WO2019133727A1 (en) 2017-12-29 2019-07-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Universal influenza virus probe set for enrichment of any influenza virus nucleic acid
WO2021007429A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
CN114556685B (zh) * 2019-10-17 2024-04-02 株式会社自动网络技术研究所 布线模块
WO2022056078A1 (en) 2020-09-11 2022-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rnase h-assisted detection assay for rna (radar)
WO2024191684A1 (en) 2023-03-10 2024-09-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Detection of hepatitis c virus ribonucleic acid from whole blood using reverse transcription loop-mediated isothermal amplification

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Publication number Priority date Publication date Assignee Title
US3960884A (en) * 1974-04-24 1976-06-01 Sergei Ivanovich Zavyalov Method of preparing racemic biotin
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
US20010023288A1 (en) * 1999-07-07 2001-09-20 Wilbur D. Scott Trifunctional reagent for conjugation to a biomolecule
FR2751334B1 (fr) * 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2773801B1 (fr) * 1998-01-19 2000-05-12 Sanofi Sa Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
FR2773804B1 (fr) * 1998-01-19 2000-02-18 Sanofi Sa Polysaccharides de synthese, procede pour leur preparation et compositions pharmaceutiques le contenant
GB2335490B (en) * 1998-03-20 2003-05-14 Ortho Clinical Diagnostics An assay surface that permits an analyte releasiing step
AU8366398A (en) * 1998-07-07 2000-01-24 Department Of Radiation Oncology University Of Washington Trifunctional reagent for conjugation to a biomolecule
ATE270677T1 (de) 1998-07-31 2004-07-15 Seikagaku Kogyo Co Ltd Neues glycosaminoglycan und dieses enthaltendes arzneimittel
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine

Also Published As

Publication number Publication date
AU2001291960B2 (en) 2007-03-01
PL363368A1 (en) 2004-11-15
NO20031295D0 (no) 2003-03-20
HUP0303551A2 (hu) 2004-03-01
JP2004509902A (ja) 2004-04-02
IL154848A (en) 2010-11-30
EA005133B1 (ru) 2004-12-30
EE200300114A (et) 2005-02-15
ECSP034514A (es) 2003-04-25
ZA200301692B (en) 2004-03-01
KR100891388B1 (ko) 2009-04-02
FR2814463A1 (fr) 2002-03-29
HU1400034D0 (hu) 2004-03-01
PL206727B1 (pl) 2010-09-30
WO2002024754A1 (fr) 2002-03-28
HRP20030219B1 (hr) 2011-10-31
HUP0303551A3 (en) 2004-03-29
JP2012131809A (ja) 2012-07-12
IS6733A (is) 2003-02-28
SI1322673T1 (sl) 2008-02-29
AU2001291960C1 (en) 2009-10-08
NO20031295L (no) 2003-05-22
PE20020471A1 (es) 2002-06-01
MEP23608A (bs) 2010-06-10
YU19703A (sh) 2006-05-25
NO20110401L (no) 2003-05-22
SK287054B6 (sk) 2009-10-07
UA79736C2 (uk) 2007-07-25
WO2002024754A8 (fr) 2003-07-03
EP1322673A1 (fr) 2003-07-02
MXPA03002483A (es) 2004-05-24
ES2292625T3 (es) 2008-03-16
CA2418815C (en) 2011-05-10
CY1108076T1 (el) 2014-02-12
BG107650A (bg) 2003-11-28
AU9196001A (en) 2002-04-02
IL154848A0 (en) 2003-10-31
EP1322673B1 (fr) 2007-09-26
EE05202B1 (et) 2009-08-17
CZ300856B6 (cs) 2009-08-26
DE60130669T2 (de) 2008-07-17
HK1053316A1 (zh) 2003-10-17
CA2418815A1 (en) 2002-03-28
AR030774A1 (es) 2003-09-03
HRP20030219A2 (en) 2003-06-30
RS50730B (sr) 2010-08-31
CN1235914C (zh) 2006-01-11
US7943595B2 (en) 2011-05-17
ME00080B (me) 2010-10-10
US20040024197A1 (en) 2004-02-05
US8318696B2 (en) 2012-11-27
ATE374215T1 (de) 2007-10-15
US6844329B2 (en) 2005-01-18
PT1322673E (pt) 2007-12-03
CN1466594A (zh) 2004-01-07
NO332905B1 (no) 2013-01-28
IS2550B (is) 2009-10-15
US20060160768A1 (en) 2006-07-20
GEP20053616B (en) 2005-09-26
CZ2003814A3 (cs) 2003-06-18
SK287218B6 (sk) 2010-03-08
US20110144042A1 (en) 2011-06-16
EA200300237A1 (ru) 2003-08-28
JP5016778B2 (ja) 2012-09-05
KR20080049139A (ko) 2008-06-03
BG66191B1 (bg) 2011-12-30
BR0114007A (pt) 2003-08-12
FR2814463B1 (fr) 2002-11-15
NZ524472A (en) 2004-10-29
SK3562003A3 (en) 2003-11-04
TWI308153B (en) 2009-04-01
KR20030055269A (ko) 2003-07-02
DE60130669D1 (de) 2007-11-08

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