EE03561B1 - L(-)-karnitiini stabiilsete mittehügroskoopsete soolade valmistamismeetod - Google Patents
L(-)-karnitiini stabiilsete mittehügroskoopsete soolade valmistamismeetodInfo
- Publication number
- EE03561B1 EE03561B1 EEP199900361A EEP9900361A EE03561B1 EE 03561 B1 EE03561 B1 EE 03561B1 EE P199900361 A EEP199900361 A EE P199900361A EE P9900361 A EEP9900361 A EE P9900361A EE 03561 B1 EE03561 B1 EE 03561B1
- Authority
- EE
- Estonia
- Prior art keywords
- carnitine
- preparation
- hygroscopic salts
- stable non
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI000409A IT1289974B1 (it) | 1997-02-25 | 1997-02-25 | Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine |
PCT/EP1998/001039 WO1998038157A1 (en) | 1997-02-25 | 1998-02-24 | Process for the preparation of stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9900361A EE9900361A (et) | 2000-04-17 |
EE03561B1 true EE03561B1 (et) | 2001-12-17 |
Family
ID=11376175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP199900361A EE03561B1 (et) | 1997-02-25 | 1998-02-24 | L(-)-karnitiini stabiilsete mittehügroskoopsete soolade valmistamismeetod |
Country Status (25)
Country | Link |
---|---|
US (1) | US6271258B1 (pt) |
EP (1) | EP1019362B1 (pt) |
JP (1) | JP2001513096A (pt) |
KR (1) | KR100538788B1 (pt) |
CN (1) | CN1248967A (pt) |
AT (1) | ATE222233T1 (pt) |
AU (1) | AU724276B2 (pt) |
BR (1) | BR9807761A (pt) |
CA (1) | CA2281630C (pt) |
CZ (1) | CZ290893B6 (pt) |
DE (1) | DE69807245T2 (pt) |
DK (1) | DK1019362T3 (pt) |
EE (1) | EE03561B1 (pt) |
ES (1) | ES2182290T3 (pt) |
HU (1) | HUP0001674A3 (pt) |
IL (1) | IL131256A (pt) |
IS (1) | IS5160A (pt) |
IT (1) | IT1289974B1 (pt) |
NO (1) | NO994110L (pt) |
NZ (1) | NZ337188A (pt) |
PL (1) | PL188762B1 (pt) |
PT (1) | PT1019362E (pt) |
SK (1) | SK115399A3 (pt) |
TR (1) | TR199902043T2 (pt) |
WO (1) | WO1998038157A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1312018B1 (it) * | 1999-03-19 | 2002-04-04 | Fassi Aldo | Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina. |
KR100461572B1 (ko) * | 1999-03-27 | 2004-12-14 | 삼성정밀화학 주식회사 | L-카르니틴 칼슘 염과 이의 제조방법 |
KR100827900B1 (ko) * | 1999-09-03 | 2008-05-07 | 시그마-타우 헬스사이언스 에스.피.에이 | 초미세 l-카르니틴, 그의 제조 방법, 그를 함유하는조성물 및 그를 이용하는 방법 |
IT1316988B1 (it) * | 2000-02-10 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Procedimento migliorato di preparazione industriale di mucati dellal-carnitina e di alcanoil l-carnitine. |
IT1317013B1 (it) * | 2000-04-12 | 2003-05-26 | Biosalts Srl | Sostanze dolcificanti, particolarmente per il caffe' ed il the'. |
ITRM20020055A1 (it) * | 2002-02-04 | 2003-08-04 | Aldo Fassi | Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti |
KR101327700B1 (ko) * | 2005-07-05 | 2013-11-11 | 론자 아게 | 건조 카르니틴 분말 또는 과립을 제조하는 분무-건조 방법 |
US7523176B2 (en) * | 2005-08-02 | 2009-04-21 | International Business Machines Corporation | Method, apparatus, and computer program product for reconfiguring a storage area network to support the execution of an application automatically upon execution of the application |
US20070243211A1 (en) * | 2005-11-07 | 2007-10-18 | Jaffe Russell M | Compositions for regulating metabolic disorders and methods of use thereof |
CN101209975B (zh) * | 2006-12-29 | 2010-12-01 | 沈阳科硕营养科技有限公司 | 左旋肉碱富马酸钙及其制备方法与用途 |
JP2011068563A (ja) * | 2008-09-09 | 2011-04-07 | Mitsubishi Rayon Co Ltd | カルニチンフマル酸塩及びその製造方法 |
KR101291186B1 (ko) * | 2010-07-23 | 2013-09-13 | 주식회사 셀트리온제약 | L-카르니틴 1,5-나프탈렌다이설폰산염 및 이를 포함하는 약제학적 조성물 |
EP2425834A1 (en) * | 2010-09-06 | 2012-03-07 | Lonza Ltd. | Process for the production of l-carnitine tartrate |
CN108383741A (zh) * | 2018-03-16 | 2018-08-10 | 开原亨泰化工有限公司 | 一种制备左旋肉碱成盐的新方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU549565B2 (en) * | 1983-11-02 | 1986-01-30 | Pirrel S.p.A | L (-) carnotine hydrochloride and l (-) carnotine inner salt |
EP0150688B1 (en) * | 1983-12-28 | 1987-04-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
US5073376A (en) * | 1989-12-22 | 1991-12-17 | Lonza Ltd. | Preparations containing l-carnitine |
DE4111913A1 (de) * | 1991-04-12 | 1992-10-15 | Degussa | Verfahren zur herstellung von l-carnitin aus d,l-carnitinnitrilsalzen |
CH682485A5 (de) * | 1991-08-13 | 1993-09-30 | Lonza Ag | Verfahren zur Herstellung optisch aktiver Carbonsäuren durch Racematspaltung. |
TW397686B (en) * | 1993-08-11 | 2000-07-11 | Takeda Chemical Industries Ltd | Antacid compositions and pharmaceutical compositions |
IT1272290B (it) * | 1994-06-20 | 1997-06-16 | Avantgarde Spa | Sale della l-carnitina e composizioni farmaceutiche che lo contengono per il trattamento di affezioni cutanee |
IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
DK0914315T3 (da) * | 1996-05-31 | 2001-06-05 | Sigma Tau Ind Farmaceuti | Stabile, ikke-hygroskopiske salte af L(-)-carnitin og alkanoyl-L(-)-carnitiner, fremgangsmåde til fremstilling af sådanne salte og faste sammensætninger indeholdende sådanne salte til oral indgivelse |
-
1997
- 1997-02-25 IT IT97MI000409A patent/IT1289974B1/it active IP Right Grant
-
1998
- 1998-02-24 CA CA002281630A patent/CA2281630C/en not_active Expired - Fee Related
- 1998-02-24 DK DK98913582T patent/DK1019362T3/da active
- 1998-02-24 TR TR1999/02043T patent/TR199902043T2/xx unknown
- 1998-02-24 HU HU0001674A patent/HUP0001674A3/hu unknown
- 1998-02-24 CN CN98802829A patent/CN1248967A/zh active Pending
- 1998-02-24 US US09/355,804 patent/US6271258B1/en not_active Expired - Fee Related
- 1998-02-24 EP EP98913582A patent/EP1019362B1/en not_active Expired - Lifetime
- 1998-02-24 DE DE69807245T patent/DE69807245T2/de not_active Expired - Fee Related
- 1998-02-24 CZ CZ19993028A patent/CZ290893B6/cs not_active IP Right Cessation
- 1998-02-24 EE EEP199900361A patent/EE03561B1/xx not_active IP Right Cessation
- 1998-02-24 ES ES98913582T patent/ES2182290T3/es not_active Expired - Lifetime
- 1998-02-24 IL IL13125698A patent/IL131256A/xx not_active IP Right Cessation
- 1998-02-24 AT AT98913582T patent/ATE222233T1/de not_active IP Right Cessation
- 1998-02-24 JP JP53728998A patent/JP2001513096A/ja not_active Ceased
- 1998-02-24 BR BR9807761A patent/BR9807761A/pt not_active IP Right Cessation
- 1998-02-24 SK SK1153-99A patent/SK115399A3/sk unknown
- 1998-02-24 KR KR10-1999-7007778A patent/KR100538788B1/ko not_active IP Right Cessation
- 1998-02-24 WO PCT/EP1998/001039 patent/WO1998038157A1/en active IP Right Grant
- 1998-02-24 PT PT98913582T patent/PT1019362E/pt unknown
- 1998-02-24 PL PL98335350A patent/PL188762B1/pl not_active IP Right Cessation
- 1998-02-24 AU AU68229/98A patent/AU724276B2/en not_active Ceased
- 1998-02-24 NZ NZ337188A patent/NZ337188A/xx unknown
-
1999
- 1999-08-20 IS IS5160A patent/IS5160A/is unknown
- 1999-08-25 NO NO994110A patent/NO994110L/no not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20021231 |
|
MM4A | Lapsed by not paying the annual fees |
Effective date: 20030224 |