EE03526B1 - Leukotrieen-antagonistliku toimega bensopüraanderivaadid, nende valmistamismeetod ja kasutamine - Google Patents

Leukotrieen-antagonistliku toimega bensopüraanderivaadid, nende valmistamismeetod ja kasutamine

Info

Publication number
EE03526B1
EE03526B1 EE9800318A EE9800318A EE03526B1 EE 03526 B1 EE03526 B1 EE 03526B1 EE 9800318 A EE9800318 A EE 9800318A EE 9800318 A EE9800318 A EE 9800318A EE 03526 B1 EE03526 B1 EE 03526B1
Authority
EE
Estonia
Prior art keywords
pct
compounds
preparation
antagonist activity
leukotriene antagonist
Prior art date
Application number
EE9800318A
Other languages
English (en)
Estonian (et)
Other versions
EE9800318A (et
Inventor
Carganico Germano
Mauleon Casellas David
Pascual Avellana Jaime
Garcia Perez Luisa
Palomer Benet Albert
Original Assignee
Laboratorios Menarini S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini S.A. filed Critical Laboratorios Menarini S.A.
Publication of EE9800318A publication Critical patent/EE9800318A/xx
Publication of EE03526B1 publication Critical patent/EE03526B1/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
EE9800318A 1996-03-21 1997-03-20 Leukotrieen-antagonistliku toimega bensopüraanderivaadid, nende valmistamismeetod ja kasutamine EE03526B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009600682A ES2127106B1 (es) 1996-03-21 1996-03-21 Derivados benzopiranicos con accion antagonista de los leucotrienos, procedimiento para su preparacion y utilizacion de los mismos.
PCT/EP1997/001418 WO1997034885A1 (en) 1996-03-21 1997-03-20 Benzopyran derivatives having leukotriene-antagonistic action

Publications (2)

Publication Number Publication Date
EE9800318A EE9800318A (et) 1999-04-15
EE03526B1 true EE03526B1 (et) 2001-10-15

Family

ID=8294261

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800318A EE03526B1 (et) 1996-03-21 1997-03-20 Leukotrieen-antagonistliku toimega bensopüraanderivaadid, nende valmistamismeetod ja kasutamine

Country Status (31)

Country Link
US (1) US5990142A (hu)
EP (1) EP0888327B1 (hu)
JP (1) JP3914575B2 (hu)
KR (1) KR100378892B1 (hu)
CN (1) CN1182129C (hu)
AT (1) ATE219073T1 (hu)
AU (1) AU707282B2 (hu)
BG (1) BG63433B1 (hu)
BR (1) BR9708215A (hu)
CA (1) CA2249402C (hu)
CU (1) CU22777A3 (hu)
CZ (1) CZ296260B6 (hu)
DE (1) DE69713300T2 (hu)
DK (1) DK0888327T3 (hu)
EA (1) EA001680B1 (hu)
EE (1) EE03526B1 (hu)
ES (2) ES2127106B1 (hu)
GE (1) GEP20012416B (hu)
HK (1) HK1018701A1 (hu)
HU (1) HUP9901326A3 (hu)
IL (1) IL126296A (hu)
NO (1) NO319612B1 (hu)
NZ (1) NZ331953A (hu)
PL (1) PL189562B1 (hu)
PT (1) PT888327E (hu)
RS (1) RS49588B (hu)
SI (1) SI0888327T1 (hu)
SK (1) SK282979B6 (hu)
TR (1) TR199801857T2 (hu)
UA (1) UA65535C2 (hu)
WO (1) WO1997034885A1 (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7001723B1 (en) 1999-11-24 2006-02-21 The Research Foundation Of State University Of New York Catalytic RNAs with aminoacylation activity
AU2003213136A1 (en) * 2002-02-15 2003-09-09 The Research Foundation Of State University Of New York At Buffalo RIBOZYMES WITH BROAD tRNA AMINOACYLATION ACTIVITY
JP2006508180A (ja) * 2002-10-17 2006-03-09 デコード ジェネティクス イーエッチエフ. 心筋梗塞に対する感受性遺伝子;治療の方法
US7851486B2 (en) 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
CA2580584C (en) 2003-09-19 2015-07-28 Galileo Pharmaceuticals, Inc. Use of alpha-tocotrienol for treatment of mitochondrial diseases
CA2554696C (en) 2004-02-13 2009-06-30 Warner-Lambert Company Llc Androgen receptor modulators
CN100475781C (zh) * 2004-02-13 2009-04-08 沃尼尔·朗伯有限责任公司 雄激素受体调节剂
US7507860B2 (en) 2004-04-13 2009-03-24 Pfizer Inc. Androgen modulators
MXPA06015169A (es) * 2004-07-08 2007-08-21 Warner Lambert Co Moduladores de androgenos.
WO2006018732A1 (en) * 2004-08-18 2006-02-23 Warner-Lambert Company Llc Androgen modulators
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
US20090170886A1 (en) * 2005-08-08 2009-07-02 Pfizer Inc Androgen modulators
EP1964916B1 (en) * 2005-12-06 2012-08-01 The University of Tokyo Multi-purpose acylation catalayst and use thereof
ITMI20061606A1 (it) * 2006-08-09 2008-02-10 Dipharma Spa Procedimento per la preparazione di composti nitrilici
CN102304052A (zh) * 2011-07-28 2012-01-04 浙江大学 一种制备5-溴-2-羟基-3-硝基苯乙酮的方法
CN103980257B (zh) * 2014-05-28 2016-04-27 苏州开元民生科技股份有限公司 8-硝基-2-四氮唑基-4-羰基苯并吡喃的合成方法
CN104402711A (zh) * 2014-11-12 2015-03-11 平湖优康药物研发有限公司 一种抗哮喘药物普伦斯特中间体的合成工艺
CN113651788B (zh) * 2021-09-16 2023-11-21 东华理工大学 一种3-胺烷基色酮化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977162A (en) * 1989-07-13 1990-12-11 Rorer Pharmaceutical Corporation Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments
JPH0395144A (ja) * 1989-08-04 1991-04-19 Ono Pharmaceut Co Ltd アミノフェノール誘導体の製造方法

Also Published As

Publication number Publication date
KR100378892B1 (ko) 2005-11-14
EE9800318A (et) 1999-04-15
EA001680B1 (ru) 2001-06-25
NO319612B1 (no) 2005-08-29
AU707282B2 (en) 1999-07-08
BG63433B1 (bg) 2002-01-31
EP0888327A1 (en) 1999-01-07
JP3914575B2 (ja) 2007-05-16
EP0888327B1 (en) 2002-06-12
BR9708215A (pt) 2000-01-04
IL126296A (en) 2002-08-14
NZ331953A (en) 1999-03-29
CZ299598A3 (cs) 1999-03-17
CU22777A3 (es) 2002-07-24
JP2000506878A (ja) 2000-06-06
RS49588B (sr) 2007-06-04
UA65535C2 (en) 2004-04-15
NO984330D0 (no) 1998-09-17
PL329027A1 (en) 1999-03-01
CN1182129C (zh) 2004-12-29
NO984330L (no) 1998-10-09
SK127298A3 (en) 1999-03-12
DK0888327T3 (da) 2002-09-16
ES2127106A1 (es) 1999-04-01
CA2249402A1 (en) 1997-09-25
US5990142A (en) 1999-11-23
PT888327E (pt) 2002-11-29
AU2158797A (en) 1997-10-10
PL189562B1 (pl) 2005-08-31
CN1214048A (zh) 1999-04-14
IL126296A0 (en) 1999-05-09
ATE219073T1 (de) 2002-06-15
HUP9901326A2 (hu) 1999-08-30
YU40798A (en) 1999-11-22
KR20000064682A (ko) 2000-11-06
TR199801857T2 (xx) 1998-12-21
SK282979B6 (sk) 2003-01-09
HUP9901326A3 (en) 2000-12-28
EA199800738A1 (ru) 1999-06-24
GEP20012416B (en) 2001-04-25
CA2249402C (en) 2006-10-24
ES2176719T3 (es) 2002-12-01
DE69713300T2 (de) 2002-09-26
DE69713300D1 (de) 2002-07-18
WO1997034885A1 (en) 1997-09-25
CZ296260B6 (cs) 2006-02-15
HK1018701A1 (en) 1999-12-30
ES2127106B1 (es) 1999-11-16
BG102775A (en) 1999-08-31
SI0888327T1 (en) 2002-10-31

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