MD553G2 - Derivaţi noi ai pirazolopirimidinelor, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice care le conţin - Google Patents

Derivaţi noi ai pirazolopirimidinelor, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice care le conţin

Info

Publication number
MD553G2
MD553G2 MD95-0085A MD950085A MD553G2 MD 553 G2 MD553 G2 MD 553G2 MD 950085 A MD950085 A MD 950085A MD 553 G2 MD553 G2 MD 553G2
Authority
MD
Moldova
Prior art keywords
derivatives
purarolopirimidine
angiotensine
antagonists
receptors
Prior art date
Application number
MD95-0085A
Other languages
English (en)
Russian (ru)
Other versions
MD553F1 (ro
Inventor
Nicole Bru-Magniez
Timur Gungor
Jean-Marie Teulon
Original Assignee
Laboratoires Upsa, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9202109A external-priority patent/FR2687676B1/fr
Application filed by Laboratoires Upsa, S.A. filed Critical Laboratoires Upsa, S.A.
Publication of MD553F1 publication Critical patent/MD553F1/ro
Publication of MD553G2 publication Critical patent/MD553G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Invenţia se referă la derivaţii cu formula:şi la formele lor tautomere, precum şi la sărurile lor aditive şi la utilizarea lor în terapie, în special, pentru tratarea şi prevenirea afecţiunilor cardiovasculare, în particular, pentru tratamentul hipertensiunii, insuficienţei cardiace, afecţiunilor peretelui arterial, în special, al aterosclerozei.
MD95-0085A 1992-02-24 1994-12-30 Derivaţi noi ai pirazolopirimidinelor, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice care le conţin MD553G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9202109A FR2687676B1 (fr) 1992-02-24 1992-02-24 Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
FR9205417A FR2687677B1 (fr) 1992-02-24 1992-04-30 Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant.

Publications (2)

Publication Number Publication Date
MD553F1 MD553F1 (ro) 1996-05-31
MD553G2 true MD553G2 (ro) 1996-12-31

Family

ID=26229283

Family Applications (2)

Application Number Title Priority Date Filing Date
MD95-0112A MD554G2 (ro) 1992-02-24 1994-12-30 Derivaţi noi ai triazolpirimidinelor, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice care le conţin
MD95-0085A MD553G2 (ro) 1992-02-24 1994-12-30 Derivaţi noi ai pirazolopirimidinelor, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice care le conţin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MD95-0112A MD554G2 (ro) 1992-02-24 1994-12-30 Derivaţi noi ai triazolpirimidinelor, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice care le conţin

Country Status (19)

Country Link
EP (2) EP0628046B1 (ro)
JP (2) JP3372040B2 (ro)
KR (2) KR100272922B1 (ro)
AT (1) ATE179979T1 (ro)
AU (2) AU668139B2 (ro)
CA (2) CA2128876C (ro)
CZ (2) CZ282075B6 (ro)
DE (1) DE69324910T2 (ro)
EE (2) EE03046B1 (ro)
ES (1) ES2133390T3 (ro)
FI (2) FI943807A7 (ro)
FR (1) FR2687677B1 (ro)
HU (2) HU220392B (ro)
MD (2) MD554G2 (ro)
NZ (2) NZ249508A (ro)
RU (1) RU2116308C1 (ro)
SK (2) SK99894A3 (ro)
TW (2) TW221438B (ro)
WO (2) WO1993017023A1 (ro)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389632A (en) * 1992-02-24 1995-02-14 Laboratoires Upsa Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists
IT1263804B (it) * 1993-01-22 1996-09-03 Luso Farmaco Inst Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
TWI334868B (en) * 2003-06-03 2010-12-21 Nippon Kayaku Kk [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof
WO2006114405A2 (de) * 2005-04-25 2006-11-02 Basf Aktiengesellschaft Verwendung von 5-alkyl-6-phenylalkyl-7-amino-azolopyrimidinen, neue azolopyrimidine, verfahren zu ihrer herstellung und sie enthaltende mittel
WO2008003753A1 (en) * 2006-07-07 2008-01-10 Biovitrum Ab (Publ) Pyrazolo [1,5-a] pyrimidine analogs for use as inhibitors of stearoyl-coa desaturase (scd) activity
DE102006039255A1 (de) * 2006-08-17 2008-02-21 Bayer Cropscience Ag Insektizide heterocyclische Carbonsäurederivate
MX2011008058A (es) * 2009-01-30 2011-09-01 Takeda Pharmaceutical Compuesto de anillo fusionado y su uso.
BR112013008695A2 (pt) 2010-09-27 2016-06-21 Proximagen Ltd compostos de 7-hidróxi-pirazol[1,5-a] pirimidina e seu uso como antagonistas do receptor ccr2

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015209A1 (en) * 1990-03-30 1991-10-17 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
FR2678618B1 (fr) * 1991-07-05 1993-11-05 Upsa Laboratoires Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015209A1 (en) * 1990-03-30 1991-10-17 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines

Also Published As

Publication number Publication date
JPH07504178A (ja) 1995-05-11
MD553F1 (ro) 1996-05-31
JP3372040B2 (ja) 2003-01-27
FI943808A7 (fi) 1994-10-24
MD554F1 (ro) 1996-05-31
AU3635893A (en) 1993-09-13
EE03046B1 (et) 1997-10-15
HUT70953A (en) 1995-11-28
WO1993017024A1 (fr) 1993-09-02
KR950700303A (ko) 1995-01-16
ES2133390T3 (es) 1999-09-16
AU668544B2 (en) 1996-05-09
FR2687677B1 (fr) 1996-10-11
WO1993017023A1 (fr) 1993-09-02
DE69324910D1 (de) 1999-06-17
TW222275B (ro) 1994-04-11
HU9402429D0 (en) 1994-10-28
HU220392B (hu) 2002-01-28
JPH07504177A (ja) 1995-05-11
ATE179979T1 (de) 1999-05-15
CA2128876C (en) 2004-02-03
NZ249509A (en) 1996-06-25
NZ249508A (en) 1996-07-26
EP0628046B1 (fr) 1999-05-12
FI943807L (fi) 1994-10-24
AU3635793A (en) 1993-09-13
KR100272922B1 (ko) 2001-02-01
RU2116308C1 (ru) 1998-07-27
FR2687677A1 (fr) 1993-08-27
FI943807A7 (fi) 1994-10-24
DE69324910T2 (de) 1999-10-21
EP0628045A1 (fr) 1994-12-14
RU94040854A (ru) 1996-08-10
HU9402430D0 (en) 1994-10-28
TW221438B (ro) 1994-03-01
FI943808A0 (fi) 1994-08-19
SK280343B6 (sk) 1999-12-10
CA2128871A1 (en) 1993-09-02
SK99894A3 (en) 1995-04-12
AU668139B2 (en) 1996-04-26
CZ282075B6 (cs) 1997-05-14
CZ204594A3 (en) 1994-12-15
KR950700302A (ko) 1995-01-16
CZ204494A3 (en) 1994-12-15
CA2128876A1 (en) 1993-09-02
EP0628046A1 (fr) 1994-12-14
MD554G2 (ro) 1997-01-31
FI943807A0 (fi) 1994-08-19
HUT70949A (en) 1995-11-28
SK99794A3 (en) 1995-04-12
EE03045B1 (et) 1997-10-15
FI943808L (fi) 1994-10-24

Similar Documents

Publication Publication Date Title
BG103417A (en) Condensed pyrimidine bicyclic derivatives
MY133732A (en) Sulfonylcarboxamide derivatives, process for their preparation and their use as medicines
BR0014178A (pt) Derivados de ácido dicarboxìlico com propriedades farmacêuticas
GB9202791D0 (en) Compounds
UA34416C2 (uk) Похідні хроману, активні стосовно 5-нт рецептора, спосіб їх одержання та проміжні сполуки
RU94042907A (ru) Производные имидазопиридина, способ их получения, фармацевтическая композиция и способ ее получения
MD523G2 (ro) Derivaţi noi ai triazolpirimidinei, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
MD553G2 (ro) Derivaţi noi ai pirazolopirimidinelor, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice care le conţin
ATE219073T1 (de) Benzopyran derivate mit leukotrien- antagonistischer wirkung
RU94038256A (ru) Производные пиразолопиримидина, способ их получения, фармацевтические композиции на их основе
MD502G2 (ro) Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
PL344056A1 (en) Piperididinyl and n-amidinopiperidinyl derivatives
AU2003226765A8 (en) Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents
MXPA02002007A (es) Compuestos de bencimidazol sustituidos con alcoxi, preparaciones farmaceuticas que contienen los mismos, metodos para usarlos.
SE0004462D0 (sv) Novel method and use
MXPA02012574A (es) Uso novedoso de los antagonistas ii de angiotensina.
IL149544A0 (en) N-ACYLPYRROLIDIN-2-YLALKYLBENZAMIDINE DERIVATIVES AS INHIBITORS OF FACTOR Xa
TR200201503T2 (tr) Heterosiklik türevler.
IL160604A0 (en) C2-disubstituted indan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals
SE9802207D0 (sv) Novel compounds
GEP20053513B (en) 2-Aminocarbonyl-9H-Purine Derivatives
FR2804867B1 (fr) Application de derives de xanthine pour la preparation d'un medicament destine a la prevention ou au traitement de l'osteoporose

Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20141230

MK4A Patent for invention expired