AU3635793A - Pyrazolopyrimidin derivatives as angiotensin II receptor antagonists - Google Patents

Pyrazolopyrimidin derivatives as angiotensin II receptor antagonists

Info

Publication number
AU3635793A
AU3635793A AU36357/93A AU3635793A AU3635793A AU 3635793 A AU3635793 A AU 3635793A AU 36357/93 A AU36357/93 A AU 36357/93A AU 3635793 A AU3635793 A AU 3635793A AU 3635793 A AU3635793 A AU 3635793A
Authority
AU
Australia
Prior art keywords
derivatives
pyrazolopyrimidin
angiotensin
receptor antagonists
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU36357/93A
Other versions
AU668139B2 (en
Inventor
Nicole Bru-Magniez
Timur Gungor
Jean-Marie Teulon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UPSA SAS
Original Assignee
UNION PHARMA SCIENT APPL
UPSA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9202109A external-priority patent/FR2687676B1/en
Application filed by UNION PHARMA SCIENT APPL, UPSA SAS filed Critical UNION PHARMA SCIENT APPL
Publication of AU3635793A publication Critical patent/AU3635793A/en
Application granted granted Critical
Publication of AU668139B2 publication Critical patent/AU668139B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

The present invention relates to derivatives having the formula (I) and their tautomeric forms, as well as addition salts thereof and therapeutical utilization particularly for the treatment and prevention of cardiovascular diseases particularly for the treatment of hypertension, cardiac insufficiency, arterial wall diseases particularly atherosclerosis.
AU36357/93A 1992-02-24 1993-02-18 Pyrazolopyrimidin derivatives as angiotensin II receptor antagonists Expired AU668139B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9202109A FR2687676B1 (en) 1992-02-24 1992-02-24 NOVEL ANGIOTENSIN II RECEPTOR ANTAGONIST POLYAZAINDENES DERIVATIVES; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR9202109 1992-02-24
FR9205417 1992-04-30
FR9205417A FR2687677B1 (en) 1992-02-24 1992-04-30 NOVEL ANGIOTENSIN II RECEPTOR ANTAGONIST POLYAZAINDENES DERIVATIVES; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
PCT/FR1993/000160 WO1993017023A1 (en) 1992-02-24 1993-02-18 Pyrazolopyrimidin derivatives as angiotensin ii receptor antagonists

Publications (2)

Publication Number Publication Date
AU3635793A true AU3635793A (en) 1993-09-13
AU668139B2 AU668139B2 (en) 1996-04-26

Family

ID=26229283

Family Applications (2)

Application Number Title Priority Date Filing Date
AU36357/93A Expired AU668139B2 (en) 1992-02-24 1993-02-18 Pyrazolopyrimidin derivatives as angiotensin II receptor antagonists
AU36358/93A Expired AU668544B2 (en) 1992-02-24 1993-02-18 Triazolopyrimidin derivatives as antiotensin II receptor antagonists

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU36358/93A Expired AU668544B2 (en) 1992-02-24 1993-02-18 Triazolopyrimidin derivatives as antiotensin II receptor antagonists

Country Status (19)

Country Link
EP (2) EP0628045A1 (en)
JP (2) JP3372040B2 (en)
KR (2) KR100272922B1 (en)
AT (1) ATE179979T1 (en)
AU (2) AU668139B2 (en)
CA (2) CA2128871A1 (en)
CZ (2) CZ204594A3 (en)
DE (1) DE69324910T2 (en)
EE (2) EE03045B1 (en)
ES (1) ES2133390T3 (en)
FI (2) FI943807A (en)
FR (1) FR2687677B1 (en)
HU (2) HU220392B (en)
MD (2) MD553G2 (en)
NZ (2) NZ249509A (en)
RU (1) RU2116308C1 (en)
SK (2) SK99894A3 (en)
TW (2) TW222275B (en)
WO (2) WO1993017024A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389632A (en) * 1992-02-24 1995-02-14 Laboratoires Upsa Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists
IT1263804B (en) * 1993-01-22 1996-09-03 Luso Farmaco Inst PYRIMIDINONIC DERIVATIVES MELT WITH NITROGEN HETEROCYCLES ACTIVATED IN II ANTAGONIST
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
JP2008538759A (en) * 2005-04-25 2008-11-06 ビーエーエスエフ ソシエタス・ヨーロピア Use of 5-alkyl-6-phenylalkyl-7-aminoazolopyrimidines, novel azolopyrimidines, processes for their preparation, and compositions containing them
WO2008003753A1 (en) * 2006-07-07 2008-01-10 Biovitrum Ab (Publ) Pyrazolo [1,5-a] pyrimidine analogs for use as inhibitors of stearoyl-coa desaturase (scd) activity
DE102006039255A1 (en) * 2006-08-17 2008-02-21 Bayer Cropscience Ag Insecticidal heterocyclic carboxylic acid derivatives
MX2011008058A (en) * 2009-01-30 2011-09-01 Takeda Pharmaceutical Fused ring compound and use thereof.
SG189086A1 (en) 2010-09-27 2013-05-31 Proximagen Ltd 7-hydroxy-pyrazolo[1,5-a] pyrimidine compounds and their use as ccr2 receptor antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them
JPH05505609A (en) * 1990-03-30 1993-08-19 メルク・エンド・カムパニー・インコーポレーテツド Substituted pyrimidines, pyrimidinones and pyridrimidines
FR2678618B1 (en) * 1991-07-05 1993-11-05 Upsa Laboratoires NOVEL TRIAZOLO PYRIMIDINE DERIVATIVES ANTIAGONISTS OF ANGIOTENSIN II RECEPTORS; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Also Published As

Publication number Publication date
WO1993017023A1 (en) 1993-09-02
CZ204494A3 (en) 1994-12-15
WO1993017024A1 (en) 1993-09-02
ATE179979T1 (en) 1999-05-15
MD554G2 (en) 1997-01-31
HU9402430D0 (en) 1994-10-28
SK280343B6 (en) 1999-12-10
JPH07504177A (en) 1995-05-11
FI943808A (en) 1994-10-24
FI943807A0 (en) 1994-08-19
RU94040854A (en) 1996-08-10
CA2128876A1 (en) 1993-09-02
EP0628046B1 (en) 1999-05-12
EE03045B1 (en) 1997-10-15
JPH07504178A (en) 1995-05-11
SK99894A3 (en) 1995-04-12
RU2116308C1 (en) 1998-07-27
NZ249509A (en) 1996-06-25
MD553F1 (en) 1996-05-31
EP0628046A1 (en) 1994-12-14
HUT70953A (en) 1995-11-28
HU9402429D0 (en) 1994-10-28
CZ282075B6 (en) 1997-05-14
KR950700302A (en) 1995-01-16
DE69324910T2 (en) 1999-10-21
FR2687677B1 (en) 1996-10-11
CA2128876C (en) 2004-02-03
FI943807A (en) 1994-10-24
SK99794A3 (en) 1995-04-12
NZ249508A (en) 1996-07-26
JP3372040B2 (en) 2003-01-27
ES2133390T3 (en) 1999-09-16
EP0628045A1 (en) 1994-12-14
MD553G2 (en) 1996-12-31
TW222275B (en) 1994-04-11
AU3635893A (en) 1993-09-13
CA2128871A1 (en) 1993-09-02
KR100272922B1 (en) 2001-02-01
TW221438B (en) 1994-03-01
EE03046B1 (en) 1997-10-15
HUT70949A (en) 1995-11-28
KR950700303A (en) 1995-01-16
FI943808A0 (en) 1994-08-19
CZ204594A3 (en) 1994-12-15
MD554F1 (en) 1996-05-31
HU220392B (en) 2002-01-28
AU668544B2 (en) 1996-05-09
FR2687677A1 (en) 1993-08-27
AU668139B2 (en) 1996-04-26
DE69324910D1 (en) 1999-06-17

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