WO1992020651A3 - N-(heteroaryl)-imidazolyl-alkenoic acids - Google Patents

N-(heteroaryl)-imidazolyl-alkenoic acids Download PDF

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Publication number
WO1992020651A3
WO1992020651A3 PCT/US1992/004071 US9204071W WO9220651A3 WO 1992020651 A3 WO1992020651 A3 WO 1992020651A3 US 9204071 W US9204071 W US 9204071W WO 9220651 A3 WO9220651 A3 WO 9220651A3
Authority
WO
WIPO (PCT)
Prior art keywords
imidazolyl
heteroaryl
alkenoic acids
angiotensin
antagonists
Prior art date
Application number
PCT/US1992/004071
Other languages
French (fr)
Other versions
WO1992020651A2 (en
Inventor
Gerald Robert Girard
David Taylor Hill
Joseph Weinstock
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Priority to US08/150,018 priority Critical patent/US5447949A/en
Priority to JP5500202A priority patent/JPH06507899A/en
Publication of WO1992020651A2 publication Critical patent/WO1992020651A2/en
Publication of WO1992020651A3 publication Critical patent/WO1992020651A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Angiotensin II receptor antagonists having formula (I) which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.
PCT/US1992/004071 1991-05-15 1992-05-14 N-(heteroaryl)-imidazolyl-alkenoic acids WO1992020651A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US08/150,018 US5447949A (en) 1991-05-15 1992-05-14 N-(heteroaryl) imidazolyl-alkenoic acids having angiotension II receptor antagonist activity
JP5500202A JPH06507899A (en) 1991-05-15 1992-05-14 Compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9110532.0 1991-05-15
GB919110532A GB9110532D0 (en) 1991-05-15 1991-05-15 Chemical compounds

Publications (2)

Publication Number Publication Date
WO1992020651A2 WO1992020651A2 (en) 1992-11-26
WO1992020651A3 true WO1992020651A3 (en) 1993-02-18

Family

ID=10695047

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/004071 WO1992020651A2 (en) 1991-05-15 1992-05-14 N-(heteroaryl)-imidazolyl-alkenoic acids

Country Status (11)

Country Link
EP (1) EP0585383A4 (en)
JP (1) JPH06507899A (en)
AU (1) AU2156192A (en)
GB (1) GB9110532D0 (en)
IE (1) IE921539A1 (en)
MX (1) MX9202262A (en)
NZ (1) NZ242734A (en)
PT (1) PT100491A (en)
TW (1) TW211010B (en)
WO (1) WO1992020651A2 (en)
ZA (1) ZA923496B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395847A (en) * 1993-12-02 1995-03-07 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
KR100587187B1 (en) * 1997-10-29 2006-10-24 론자 아게 Process for the preparation of formylimidazoles
KR100567183B1 (en) * 1997-11-14 2006-06-13 론자 아게 How to prepare formyl imidazole
JP2000053651A (en) * 1998-06-18 2000-02-22 Lonza Ag Production of formylimidazoles
SE9903028D0 (en) 1999-08-27 1999-08-27 Astra Ab New use
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2170930B3 (en) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
BRPI0817860A2 (en) * 2007-10-22 2019-09-24 Orchid Res Laboratories Limited histone deacetylase inhibitors
JP2011522828A (en) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0403159A2 (en) * 1989-06-14 1990-12-19 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
EP0425211A1 (en) * 1989-10-25 1991-05-02 Smithkline Beecham Corporation Substituted 5-((tetrazolyl)alkenyl)-imidazoles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0403159A2 (en) * 1989-06-14 1990-12-19 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
EP0425211A1 (en) * 1989-10-25 1991-05-02 Smithkline Beecham Corporation Substituted 5-((tetrazolyl)alkenyl)-imidazoles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Med. Chem., Vol. 34, No. 4, 1991, WEINSTOCK et al., "1-(Carboxybenzyl) imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists", pp. 1514-1517. *
See also references of EP0585383A4 *

Also Published As

Publication number Publication date
MX9202262A (en) 1992-11-01
IE921539A1 (en) 1992-11-18
GB9110532D0 (en) 1991-07-03
ZA923496B (en) 1993-04-28
EP0585383A4 (en) 1994-08-17
AU2156192A (en) 1992-12-30
WO1992020651A2 (en) 1992-11-26
JPH06507899A (en) 1994-09-08
TW211010B (en) 1993-08-11
NZ242734A (en) 1995-04-27
EP0585383A1 (en) 1994-03-09
PT100491A (en) 1993-09-30

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