EE03046B1 - Triazolopyrimidine Derivatives of Angiotensin II Receptor Antagonists, Method for Their Preparation and Formulations - Google Patents

Triazolopyrimidine Derivatives of Angiotensin II Receptor Antagonists, Method for Their Preparation and Formulations

Info

Publication number
EE03046B1
EE03046B1 EE9400441A EE9400441A EE03046B1 EE 03046 B1 EE03046 B1 EE 03046B1 EE 9400441 A EE9400441 A EE 9400441A EE 9400441 A EE9400441 A EE 9400441A EE 03046 B1 EE03046 B1 EE 03046B1
Authority
EE
Estonia
Prior art keywords
angiotensin
formulations
preparation
receptor antagonists
triazolopyrimidine derivatives
Prior art date
Application number
EE9400441A
Other languages
Estonian (et)
Inventor
Bru-Magniez Nicole
G�ngor Timur
Teulon Jean-Marie
Original Assignee
Laboratoires Upsa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9202109A external-priority patent/FR2687676B1/en
Application filed by Laboratoires Upsa filed Critical Laboratoires Upsa
Publication of EE03046B1 publication Critical patent/EE03046B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to derivatives having the formula (I) and their tautomeric forms, as well as addition salts thereof and therapeutical utilization particularly for the treatment and prevention of cardiovascular diseases particularly for the treatment of hypertension, cardiac insufficiency, arterial wall diseases particularly atherosclerosis.
EE9400441A 1992-02-24 1994-11-22 Triazolopyrimidine Derivatives of Angiotensin II Receptor Antagonists, Method for Their Preparation and Formulations EE03046B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9202109A FR2687676B1 (en) 1992-02-24 1992-02-24 NOVEL ANGIOTENSIN II RECEPTOR ANTAGONIST POLYAZAINDENES DERIVATIVES; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR9205417A FR2687677B1 (en) 1992-02-24 1992-04-30 NOVEL ANGIOTENSIN II RECEPTOR ANTAGONIST POLYAZAINDENES DERIVATIVES; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
PCT/FR1993/000161 WO1993017024A1 (en) 1992-02-24 1993-02-18 Triazolopyrimidin derivatives as antiotensin ii receptor antagonists

Publications (1)

Publication Number Publication Date
EE03046B1 true EE03046B1 (en) 1997-10-15

Family

ID=26229283

Family Applications (2)

Application Number Title Priority Date Filing Date
EE9400440A EE03045B1 (en) 1992-02-24 1994-11-22 Pyrazolopyrimidine Derivatives of Angiotensin II Receptor Antagonists, Method for Their Preparation and Formulations
EE9400441A EE03046B1 (en) 1992-02-24 1994-11-22 Triazolopyrimidine Derivatives of Angiotensin II Receptor Antagonists, Method for Their Preparation and Formulations

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EE9400440A EE03045B1 (en) 1992-02-24 1994-11-22 Pyrazolopyrimidine Derivatives of Angiotensin II Receptor Antagonists, Method for Their Preparation and Formulations

Country Status (19)

Country Link
EP (2) EP0628046B1 (en)
JP (2) JP3372040B2 (en)
KR (2) KR100272922B1 (en)
AT (1) ATE179979T1 (en)
AU (2) AU668544B2 (en)
CA (2) CA2128871A1 (en)
CZ (2) CZ204594A3 (en)
DE (1) DE69324910T2 (en)
EE (2) EE03045B1 (en)
ES (1) ES2133390T3 (en)
FI (2) FI943808A (en)
FR (1) FR2687677B1 (en)
HU (2) HU220392B (en)
MD (2) MD553G2 (en)
NZ (2) NZ249509A (en)
RU (1) RU2116308C1 (en)
SK (2) SK280343B6 (en)
TW (2) TW222275B (en)
WO (2) WO1993017023A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389632A (en) * 1992-02-24 1995-02-14 Laboratoires Upsa Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists
IT1263804B (en) * 1993-01-22 1996-09-03 Luso Farmaco Inst PYRIMIDINONIC DERIVATIVES MELT WITH NITROGEN HETEROCYCLES ACTIVATED IN II ANTAGONIST
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
US20080188494A1 (en) * 2005-04-25 2008-08-07 Basf Aktiengesellschaft Use Of 5-Alkyl-6-Phenylalkyl-7-Aminoazolopyrimidines, Novel Azolopyrimidines, Processes For Their Preparation And Compositions Comprising Them
WO2008003753A1 (en) * 2006-07-07 2008-01-10 Biovitrum Ab (Publ) Pyrazolo [1,5-a] pyrimidine analogs for use as inhibitors of stearoyl-coa desaturase (scd) activity
DE102006039255A1 (en) * 2006-08-17 2008-02-21 Bayer Cropscience Ag Insecticidal heterocyclic carboxylic acid derivatives
MA33071B1 (en) * 2009-01-30 2012-02-01 Takeda Pharmaceutical Composite of intensive nucleus and its use
JP2013538838A (en) 2010-09-27 2013-10-17 プロクシマゲン リミテッド 7-Hydroxy-pyrazolo [1,5-A] pyrimidine compounds and their use as CCR2 receptor antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them
EP0522038A4 (en) * 1990-03-30 1993-05-26 Merck & Co. Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines
FR2678618B1 (en) * 1991-07-05 1993-11-05 Upsa Laboratoires NOVEL TRIAZOLO PYRIMIDINE DERIVATIVES ANTIAGONISTS OF ANGIOTENSIN II RECEPTORS; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Also Published As

Publication number Publication date
HU9402429D0 (en) 1994-10-28
AU668544B2 (en) 1996-05-09
KR100272922B1 (en) 2001-02-01
JP3372040B2 (en) 2003-01-27
JPH07504177A (en) 1995-05-11
JPH07504178A (en) 1995-05-11
WO1993017023A1 (en) 1993-09-02
FR2687677A1 (en) 1993-08-27
FI943807A0 (en) 1994-08-19
DE69324910T2 (en) 1999-10-21
SK99894A3 (en) 1995-04-12
AU668139B2 (en) 1996-04-26
HUT70949A (en) 1995-11-28
FI943808A0 (en) 1994-08-19
EP0628046A1 (en) 1994-12-14
NZ249508A (en) 1996-07-26
HUT70953A (en) 1995-11-28
ATE179979T1 (en) 1999-05-15
CA2128876A1 (en) 1993-09-02
RU94040854A (en) 1996-08-10
KR950700302A (en) 1995-01-16
TW222275B (en) 1994-04-11
CZ282075B6 (en) 1997-05-14
MD553G2 (en) 1996-12-31
NZ249509A (en) 1996-06-25
FI943808A (en) 1994-10-24
EP0628046B1 (en) 1999-05-12
DE69324910D1 (en) 1999-06-17
KR950700303A (en) 1995-01-16
HU220392B (en) 2002-01-28
HU9402430D0 (en) 1994-10-28
FR2687677B1 (en) 1996-10-11
CA2128876C (en) 2004-02-03
CA2128871A1 (en) 1993-09-02
FI943807A (en) 1994-10-24
AU3635793A (en) 1993-09-13
EP0628045A1 (en) 1994-12-14
MD554F1 (en) 1996-05-31
AU3635893A (en) 1993-09-13
MD554G2 (en) 1997-01-31
EE03045B1 (en) 1997-10-15
ES2133390T3 (en) 1999-09-16
CZ204494A3 (en) 1994-12-15
WO1993017024A1 (en) 1993-09-02
MD553F1 (en) 1996-05-31
SK99794A3 (en) 1995-04-12
SK280343B6 (en) 1999-12-10
RU2116308C1 (en) 1998-07-27
TW221438B (en) 1994-03-01
CZ204594A3 (en) 1994-12-15

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20021231

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KB4A Valid patent at the end of a year

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Effective date: 20091231

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Effective date: 20101231