MD553G2 - New purarolopirimidine derivatives, antagonists of angiotensine II receptors, methods of preparation thereof, pharmaceutical compositions thereof - Google Patents

New purarolopirimidine derivatives, antagonists of angiotensine II receptors, methods of preparation thereof, pharmaceutical compositions thereof

Info

Publication number
MD553G2
MD553G2 MD95-0085A MD950085A MD553G2 MD 553 G2 MD553 G2 MD 553G2 MD 950085 A MD950085 A MD 950085A MD 553 G2 MD553 G2 MD 553G2
Authority
MD
Moldova
Prior art keywords
derivatives
purarolopirimidine
angiotensine
antagonists
receptors
Prior art date
Application number
MD95-0085A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD553F1 (en
Inventor
Nicole Bru-Magniez
Timur Gungor
Jean-Marie Teulon
Original Assignee
Laboratoires Upsa, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9202109A external-priority patent/FR2687676B1/en
Application filed by Laboratoires Upsa, S.A. filed Critical Laboratoires Upsa, S.A.
Publication of MD553F1 publication Critical patent/MD553F1/en
Publication of MD553G2 publication Critical patent/MD553G2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to the derivatives of formula:and to its tautomeric forms, as well as to its addition salts, and to its utilization in therapy, particularly for trectment and prophilexis of cardiovascular affections, especially hypertensiv treatment, cardiac insufficency, affections of arterial walle, aspectally of atherosclerosis.
MD95-0085A 1992-02-24 1994-12-30 New purarolopirimidine derivatives, antagonists of angiotensine II receptors, methods of preparation thereof, pharmaceutical compositions thereof MD553G2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9202109A FR2687676B1 (en) 1992-02-24 1992-02-24 NOVEL ANGIOTENSIN II RECEPTOR ANTAGONIST POLYAZAINDENES DERIVATIVES; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR9205417A FR2687677B1 (en) 1992-02-24 1992-04-30 NOVEL ANGIOTENSIN II RECEPTOR ANTAGONIST POLYAZAINDENES DERIVATIVES; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Publications (2)

Publication Number Publication Date
MD553F1 MD553F1 (en) 1996-05-31
MD553G2 true MD553G2 (en) 1996-12-31

Family

ID=26229283

Family Applications (2)

Application Number Title Priority Date Filing Date
MD95-0085A MD553G2 (en) 1992-02-24 1994-12-30 New purarolopirimidine derivatives, antagonists of angiotensine II receptors, methods of preparation thereof, pharmaceutical compositions thereof
MD95-0112A MD554G2 (en) 1992-02-24 1994-12-30 New triazolpirimidine derivatives, antagonists of andtomensine II receptors, methods of preparation thereof, pharmaceutical compositions thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
MD95-0112A MD554G2 (en) 1992-02-24 1994-12-30 New triazolpirimidine derivatives, antagonists of andtomensine II receptors, methods of preparation thereof, pharmaceutical compositions thereof

Country Status (19)

Country Link
EP (2) EP0628046B1 (en)
JP (2) JP3372040B2 (en)
KR (2) KR100272922B1 (en)
AT (1) ATE179979T1 (en)
AU (2) AU668544B2 (en)
CA (2) CA2128871A1 (en)
CZ (2) CZ204594A3 (en)
DE (1) DE69324910T2 (en)
EE (2) EE03045B1 (en)
ES (1) ES2133390T3 (en)
FI (2) FI943808A (en)
FR (1) FR2687677B1 (en)
HU (2) HU220392B (en)
MD (2) MD553G2 (en)
NZ (2) NZ249509A (en)
RU (1) RU2116308C1 (en)
SK (2) SK280343B6 (en)
TW (2) TW222275B (en)
WO (2) WO1993017023A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389632A (en) * 1992-02-24 1995-02-14 Laboratoires Upsa Pyrazolopyrimidine derivatives which are angiotensin II receptor antagonists
IT1263804B (en) * 1993-01-22 1996-09-03 Luso Farmaco Inst PYRIMIDINONIC DERIVATIVES MELT WITH NITROGEN HETEROCYCLES ACTIVATED IN II ANTAGONIST
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
US20080188494A1 (en) * 2005-04-25 2008-08-07 Basf Aktiengesellschaft Use Of 5-Alkyl-6-Phenylalkyl-7-Aminoazolopyrimidines, Novel Azolopyrimidines, Processes For Their Preparation And Compositions Comprising Them
WO2008003753A1 (en) * 2006-07-07 2008-01-10 Biovitrum Ab (Publ) Pyrazolo [1,5-a] pyrimidine analogs for use as inhibitors of stearoyl-coa desaturase (scd) activity
DE102006039255A1 (en) * 2006-08-17 2008-02-21 Bayer Cropscience Ag Insecticidal heterocyclic carboxylic acid derivatives
MA33071B1 (en) * 2009-01-30 2012-02-01 Takeda Pharmaceutical Composite of intensive nucleus and its use
JP2013538838A (en) 2010-09-27 2013-10-17 プロクシマゲン リミテッド 7-Hydroxy-pyrazolo [1,5-A] pyrimidine compounds and their use as CCR2 receptor antagonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015209A1 (en) * 1990-03-30 1991-10-17 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them
FR2678618B1 (en) * 1991-07-05 1993-11-05 Upsa Laboratoires NOVEL TRIAZOLO PYRIMIDINE DERIVATIVES ANTIAGONISTS OF ANGIOTENSIN II RECEPTORS; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015209A1 (en) * 1990-03-30 1991-10-17 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines

Also Published As

Publication number Publication date
HU9402429D0 (en) 1994-10-28
AU668544B2 (en) 1996-05-09
KR100272922B1 (en) 2001-02-01
JP3372040B2 (en) 2003-01-27
EE03046B1 (en) 1997-10-15
JPH07504177A (en) 1995-05-11
JPH07504178A (en) 1995-05-11
WO1993017023A1 (en) 1993-09-02
FR2687677A1 (en) 1993-08-27
FI943807A0 (en) 1994-08-19
DE69324910T2 (en) 1999-10-21
SK99894A3 (en) 1995-04-12
AU668139B2 (en) 1996-04-26
HUT70949A (en) 1995-11-28
FI943808A0 (en) 1994-08-19
EP0628046A1 (en) 1994-12-14
NZ249508A (en) 1996-07-26
HUT70953A (en) 1995-11-28
ATE179979T1 (en) 1999-05-15
CA2128876A1 (en) 1993-09-02
RU94040854A (en) 1996-08-10
KR950700302A (en) 1995-01-16
TW222275B (en) 1994-04-11
CZ282075B6 (en) 1997-05-14
NZ249509A (en) 1996-06-25
FI943808A (en) 1994-10-24
EP0628046B1 (en) 1999-05-12
DE69324910D1 (en) 1999-06-17
KR950700303A (en) 1995-01-16
HU220392B (en) 2002-01-28
HU9402430D0 (en) 1994-10-28
FR2687677B1 (en) 1996-10-11
CA2128876C (en) 2004-02-03
CA2128871A1 (en) 1993-09-02
FI943807A (en) 1994-10-24
AU3635793A (en) 1993-09-13
EP0628045A1 (en) 1994-12-14
MD554F1 (en) 1996-05-31
AU3635893A (en) 1993-09-13
MD554G2 (en) 1997-01-31
EE03045B1 (en) 1997-10-15
ES2133390T3 (en) 1999-09-16
CZ204494A3 (en) 1994-12-15
WO1993017024A1 (en) 1993-09-02
MD553F1 (en) 1996-05-31
SK99794A3 (en) 1995-04-12
SK280343B6 (en) 1999-12-10
RU2116308C1 (en) 1998-07-27
TW221438B (en) 1994-03-01
CZ204594A3 (en) 1994-12-15

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Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20141230

MK4A Patent for invention expired