CA2128876C - Triazolopyrimidine derivatives as angiotensin ii receptor antagonists - Google Patents

Abstract

The present invention relates to the deriva-tives of the formula

Description

-\
:1 ~ ~ ~ ,r1!
v.~U~) d °..' TRIAZOLOPYRIMIDIN DERIVATTVES AS ANGTOTENSIN II
RECEPTOR ANTAGONISTS
05 ..
The present invention relates, by way of novel products, to the triazolopyrimidine derivatives of general formula (I) below and their tautomeric forms and, where appropriate, their addition salts, in particular the pharmaceutically acceptable addition salts.
The compounds in question have a very valuable pharmacological profile insofar as they possess anta-gonistic properties towards the angiotensin II recep-tors, and antiproliferative properties. They are therefore particularly indicated for the treatment and prevention of cardiovascular diseases and in particular for the treatment of hypertension, for the treatment of cardiac insufficiency and for the treatment and preven-tion of diseases of the arterial wall, especially atherosclerosis.
The present invention further relates to the method of preparing said products and to their uses in therapeutics.
These triazolopyrimidine derivatives and their tautomeric forms have general formula (I):
R
X N \
Yw R ~R~
x Formula (I) In formula ( T ) i ~7 1~

- 2 - ~ ~. r-,~ ~.~ u; ~ ~~l - one of the radicals R1 and R2 is - a lower alkyl radical having 1 to 6 carbon atoms;
- an ether .radical of the formula -(CH2)pOR, in 05 which p is an integer from 1 to 6 and R is a lower alkyl radical having 1 to 6 carbon atoms or a benzyl radical; or - an alcohol radical of the formula -(CHZ)pOH, in which p is as defined above; and - the other radical R1 or R2 is - the hydrogen atom;
- a halogen atom;
- a lower alkyl radical having 1 to 6 carbon atoms: or - a radical selected from the group comprising the radicals N3, ORQ, SR4, NR5R6 and NH(CH2)n-NRSR6, in which:
RQ is - the hydrogen atom;
- a lower alkyl radical having 1 to 6 carbon atoms or a C3-C.,-cycloalkyl radical;
- a radical (CH2)m COOR', m being an integer from 1 to 4 and R' being the hydrogen atom or a lower alkyl radical having 1 to 6 carbon atoms; or - a radical ( CH2 ) m-O-R' , m and R' being as defined above;
R5 and R6, which are identical or different, are - the hydrogen atom: or - a lower alkyl radical having 1 to 6 carbon atoms or a C3-C.,-cycloalkyl radical; or R5 and R6, taken together with the nitrogen atom to wl2:ich they are attached, form a heterocycle selected from morpholine, pyrrolidine or piperidine;
and :'\
,n ~ ~ ~ ~ c~ '.) n is an integer from 1 to 4:
- X and Y, which are different, are - in one case the nitrogen atom: and - in the other case a group C-R." in which R
05 is - the hydrogen atom;
- a Lower alkyl radical having 1 to 6 carbon atoms or a C3-C~-cycloalkyl radical;
- a radical (CHZ)n~OH, in which n' is an integer from 0 to 4;
- a radical SR', R' being as defined above; or - a radical NR5R6, in which R5 and Rg, which are identical or different, are the hydrogen atom, a lower alkyl radical having 1 to 6 carbon atoms or a 63 C.,-cycloalkyl radical; and - R3 is a radical of the formula R" R"
R,~
R" ~ or ~z z in which:
- Z is CH or N or Z' is S or O;
- Ry1 is the hydrogen atom or a halogen atom:
and - R12 is a tptrazole radical, CN, COOH or CONH2.
The above-mentioned derivatives must also be considered in their tautomeric form.
In the case where RZ is an azide group, the compounds may be considered in the tricyclic tetrazolo-[1,5-c]-1,2,4-triazolo[1,5-a]pyrimidine form according to the equilibrium well known in the literature (cf.
Temple and Montgomery, J. Org. Chem., 30, 826 (1965)).

c ~~ :, n r7 ;~
1'J ~~

mhe above-mentioned derivatives can take the form of addition salts, in particular the pharmaceuti-cally acceptable addition salts.
Advantageously, the derivatives of the inven-05 tion have general formula (I) criven above in which:
- one of the radicals R1 and R' is - a lower alkyl radical having 1 to 6 carbon atoms;
- an ether radical of the formula -(CH2)pOR, in which p is an integer from 1 to 6 and R is a lower alkyl radical having 1 to 6 carbon atoms or a benzyl radical; or - an alcohol radical of the formula -(CH2)pOH, in which p is as defined above; and - the other radical R1 or R2 is - the hydrogen atom;
- a halogen atom;
- a lower alkyl radical having 1 to 6 carbon atoms; or - a radical selected from the group comprising the radicals N3 , OR4 , SRS,, , NR5R6 arid NH ( CH2 ),_,-NRSR6 , in which:
RQ is - the hydrogen atom; or - a radical -(CH2)m-O-R' in which m is an integer from 1 to 4 .and R' is a lower alkyl radical having 1 to 6 carbon atoms;
R5 and R6, which are identical or different, are - the hydrogen atom; or - a lower alkyl radical having 1 to 6 carbon atoms; or R5 and R6, taken together with the nitrogen atom to which they are attached, form a heterocycle selected from morpholine, pyrrolidine or piperidine;

,., .
-q . c . n > ~ '7 ~ ~F~~l) E ~) and n is an integer from 1 to 4:
- X and Y, which are different, are - in one case the nitrogen atom: and 05 - in the other case a group C-R~ in which R~ is - the hydrogen atoms - a lower alkyl radical having 1 to 6 carbon atoms;
- a radical (CHzJn~OH, in which n' is an integer from 0 to 4;
- a radical SR', R' being as defined above; or - a radical NR5R6 in which R5 and R6, which.
are identical or different, are the hydrogen atom or a lower alkyl radical having 1 to 6 carbon atoms: and - R3 is one of the following radicals:
N-N N-N
N'N ~ / HOOC / N~N ~ / N
H ~ ( ~ I H \ I
N-N
N-N N~N
H2NOC , N~N
H
~ I N
Br In the description and the claims, lower alkyl radical is understood as meaning a linear or branched hydrocarbon chain having from 1 to 6 carbon atoms. A
lower alkyl radical is for example a methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, hexyl or isohexyl radical.
C3-C~-Cycloalkyl radical is understood as meaning a saturated cyclic hydrocarbon radical, pre-rl .~ :~ n ~.~.~rl~~~~ v) ferably a cyclopropyl, cyclobutyl, cyclohexyl or cyclo-heptyl radical.
Halogen is understood as meaning a chlorine, bromine, iodine or fluorine atom.
05 In one embodiment, R1 is an n-propyl group.
In another embodiment, R1 is an N-diethylamino group.
In another embodiment, R1 is an n-butyl group.
In one embodiment, Rs is a hydroxyl group.
In another embodiment, RZ is an n-propyl group.
In another embodiment, R2 is an N-diethylamino group.
In one embodiment, R3 is a 2-(1H-tetrazol-5-yl)phenyl group.
In one embodiment, X is the nitrogen atom.
In one embodiment, Y is the group CH.
Tn another embodiment, Y is the group C-CH3.
In another embodiment, Y is the group C-NH2.
The particularly preferred compounds of the invention are selected from the products of the formu-lae JH

.. ~ ~ L r) ~' r ~ i7 l~
rN~

In general terms, the method of preparing the compounds of formula (I) comprises:
a) preparing a compound of formula («):
B
X N \
Y~ ~ i \
N N A ~ R, Formula (a) in which:
- X, Y and R3 are as defined above; and - A and B are in one case a hydroxyl group or a lower alkyl radical having 1 to 6 carbon atoms and in the other case a lower alkyl radical having 1 to 6 carbon atoms or an ether radical of the formula -(CH2)p-OR, in which p is an integer from 1 to 6 and H is a lower alkyl radical having 1 to 6 carbon atoms or a benzyl radical, by condensing a 3-amino-1,2,4-triazole of formula (II):

.:yes f~ ~ ~ ~
_ g _ ~NHZ
N I
N
R ~N.~
H

Formula (II) in which R~ is as defined above, with a derivative of formula (,B) Ra Formula (,B) in which R'1 is a lower alkyl radical having 1 to 6 carbon atoms or an ether radical of the formula -(CHZ)p-OR, in which p is an integer from 1 to 6 and R
is a lower alkyl radical having 1 to 6 carbon atoms or a benzyl radical, RS is a lower alkyl radical having 1 to 6 carbon atoms or a lower O-alkyl group having 1 to 6 carbon atoms, preferably methyl or ethyl, and R3 is as defined above, in an aprotic solvent such as dichloro- or trichloro benzene, or in an acid solvent such as acetic acid, or else in an alcohol in the presence of the corresponding sodium or potassium alcoholate, or else in pyridine or 2-methyl-5-ethylpyridine in the presence or absence of 4-dimethylaminopyridine, at a temperature of between 50 and 200°C;
b) if appropriate, protecting the group carried by R3 :7 ~-) n r ~~ Y,. b to -0~ ;_~

using a method known per se;
c) heating the derivative thus obtained from the deri-vative of formula (,e), when the latter is a ketoester, in an appropriate reagent such as, for example, POC13, 05 to convert the hydroxyl group represented by A or B to a chlorine atom;
d) heating this chlorinated derivative in the presence of a nucleophile containing nitrogen, oxygen or sulfur, under reflux in an alcohol or in an autoclave at 100°C, in the presence or absence of a base such as, for example, Na2C03, to give,a derivative of formula («) in which A and B have the same meanings as R1 and RZ res-pectively;
e) if appropriate, deprotecting the group carried by R3 ;
e1) converting this group to an acid group, for example by hydrolysis in the case where this group is a nit-rile; or ea) converting this group to a tetrazole group, for example, in the case where this group is a nitrile, by reaotion with a trialkyltin azide with heating in toluene or xylene, followed by a treatment with gaseous hydrochloric acid in tetrahydrofuran; or e3) converting this group to an amide group, for example, in the case where this group is a nitrile, by reaction with sulfuric acid, or by reaction with hydro gen peroxide, or else by reaction with polyphosphoric ;acid; and f) if appropriate, converting the resulting derivative to an addition salt, preferably a pharmaceutically acceptable addition salt.
According to the invention, it will be possible to synthesize the compounds of formula (I) in accor-dance with the following reaction sequence:
Methods known per se, such as, for example, the <~r, ~.~ ~ i ~j~i Claisen reaction or the method using Meldrum's acid, which methods can easily be found in the following literature references:
- HAUSER C.R.; SWAMER F.W.; ADAMS J.T.; Org. Reaction, 05 vol. VIII, 1954, 59-196, - HENNE A.L.; TEDDER J.M.; J. Chem. SOC., 1953, 3628, - BRESLOW D.S.: BAUMGARTEN E.; HAUSER C.R.; J. Am.
Chem. Soc., 1944, 66, 1286, - OIKAWA Y.; SUGANO K.; YONEMITSU O.; J. Org. Chem., 1978, 43(10), 2087-88, - WIERENGA W.; SKULNICK H.I.; J. Org. Chem., 1979, 44, 310, - HOUGHTON R.; LAPHAM D.; SYNTHESIS, 1982, 6, 451-2, - BRAM G.; VILKAS M.; Bull. Soc. Chim. France, 1964(5), 945-51, - BALYAKINA M.V.; ZHDANOVICH E.S.; PREOBRAZHENSKII
N.A.; Tr. Vses. Nauchn. Issled. Vitam in. Inst., 1961, 7, 8-16, - RENARD M.; MAQUINAY A.; Bull. Soc. Chim. Belg., 1946, 55, 98-105, - BRUCE F.W.; COOVER H.W.; J. Am. Chem. Soc., 1944, 66, 2092-94, and - EBY C.J. and HAUSER C.R.; J. Am. Chem. Soc., 1957, ?9, 723-5, will be used to prepare the compounds of formula (III):
R'; i -CHz C-R, O O
Formula (III) in which R'1 is a lower alkyl radical having 1 to 6 carbon atoms or an ether radical of the formula -(CH2)p-OR, in which p is an integer from 1 to 6 and R
is a lower alkyl radical having 1 to 6 carbon atoms or ~A ø tl !'? '1 n ~ .~ E:;~ a L) ~ ~_i a benzyl radical, and R8 is a lower alkyl radical having 1 to 6 carbon atoms or a lower O-alkyl group having 1 to 6 carbon atoms, preferably methyl or ethyl.
The compounds of the formula ~e Formula (V) :vill be obtained by benzylating the compounds of for-mula (III) with compounds of formula (IV):
W
I
CH, v o Formula (IV) in the presence of a base such as sodium or potassium carbonate in acetone,~a sodium or potassium alcoholate in an alcohol, or sodium or lithium hydride in solvents such as tetrahydrofuran, dioxane or dimethylformamide, for example, at a temperature of between 50 and 100°C, or else in the presence of one equivalent of lithium chloride or bromide and two equivalents of diisopropyl-ethylamine in tetrahydrofuran under reflux, according to the following reference:
- SUNG-EUN Y00; KYU YANG YI; Bull. Korean Chem. Soc., 1989, 10(1), 112.

iy.~.r~t ~.~ri These compounds of formula (V) can also be obtained by condensation of an aldehyde of formula (VI):

r j v Formula (VI) with the compounds of formula (III), followed by hydro-genation in the presence of a catalyst such as Raney nickel, palladium-on-charcoal or platinum oxide, in a solvent such as an alcohol or tetrahydrofuran, under pressure or at ordinary pressure if the substituents present allow it.
In more general terms, methods of preparing the compounds of formula (V) will be found in the following references:
- DURGESHWARI P.; CHAUDHURY N.D.; J. Ind. Chem. Soc., 1962, 39, 735-6, - HEINZ P.; KREGLEWSKI A.; J. Prakt. Chem., 1963, 21(3-4), 186-197, - ZAUGG H.E.; DUNNIGAN D.A.; MICHAELS R.J.; SWETT L.R.;
J. Org. Chem., 1961 , 26, 644-51, - KAGAN H.B.; HENG SUEN Y.; Bull. Soc. Chim. France, 1966(6), 1819-22, - RATHKE M. W . ; DEITCH J . ; Tetrahedron Lett . , 1971 ( 31 ) , 2953-6, BORRIES KUBEL; Liebigs Ann. Chem., 1980, 1392-1401, - MARQUET J.; MORENO-MAMAS M.; Chem. Lett., 1981, 2_, 173-6, - IOFFE T.; POPOV E.M.; VATSURO K.V.; TULIKOVA E.K.;

.. q c7 f~ ;~ r n ~- ~ r,, ~ ~1 ~ ~_~

KABACHNIK M.I.; Tetrahedron, 1962, 18, 923-940, and - SHEPHERD T.M.; Chem. Ind. (London), 1970, 17, 567.
In formula (IV), W is a halogen atom, prefer-ably chlorine or bromine.
05 In the same formula:
V can be a group Rg being a lower alkyl or benzyl radical, in which case the compounds of formula (IV) are prepared by reacting a magnesium compound of p-bromotoluene with a compound of the formula to give a compound of the formula which is then hydrolyzed to give the compound of the formula ~~'~~'~~3 Procedures for the three steps described above will be found in the following reference:
- MEYERS A.I.; MIHELICH E.D.; J. Am. Chem. Soc., 1975, 97, 7383.
The acid is then esterified with an alcohol of the formula RgOH, R9 being as defined above.
These derivatives are then brominated or chlorinated, for example with N-bromosuccinimide, N
chlorosuccinimide or bromine, in a solvent such as carbon tetrachloride, dibromoethane or dichloroethane, to give the compounds of formula (TV) in which V is the group R9GaOC
V can be the group NC \
in which case the compound ;~ rW ~~ r~ ~
~~JU

prepared above will be converted to the primary amide by reacting the acid chloride, obtained with thionyl chloride or phosphorus oxychloride, with aqueous ammo-nia, and this amide will be converted to the nitrite by reaction with phosphorus oxychloride in dimethylforma-mide or with thionyl chloride. Likewise, the compound CHI
N
'' I ~O
obtained above may be converted directly to tha carbo-nitrile derivative by treatment in pyridine in the presence of POC13. The resulting nitrite derivative of the formula 35 wall then be brominated or chlorinated under the same < j ';! '~ n Gv i~ L! ~ ~~' _ 1~ _ conditions as the above ester to give the compounds of formula (IV) in which V is the group NC
V can be a group N
NC
in which case the corresponding compounds of formula (IV) are synthesized in the following manner:
The magnesium compound BrMg ~ \ CH20CH3 prepared by a conventional Grignard reaction, is converted to the zinc derivative by reaction with zinc chloride. This zinc derivative is condensed with 2-chloronicotinonitrile, in the presence of [Ni(P~3)]2C12, to give the derivative of the formula N
CH30CH2 ~ \
NC~
This compound, treated with boron tribromide in chloro-form, will give the compounds of formula (IV) in which W is the bromine atom and V is the group c :l t r~

7 CO :' _ 1g - ~~a;.Ji.j '_~
N
r NC
05 V can be a group N
r R9 being as defined above, in which case the correspon-ding compounds of formula (IV) may be prepared from the nitrite prepared above of the formula NCr by conventional hydrolysis of the nitrite group fol-lowed by esterification of the acid obtained, or direct conversion of the nitrite group to the ester group by the methods known to those skilled in the art, followed by a treatment with boron tribromide in chloroform, to give the compounds of formula (IV) in which W is the bromine atom and V is the group N
R900C \
V can be a group r "1 1' ra L
- 19 ° <~~..c=di~~ ~'~
NC
05 in which case the corresponding compounds of formula (IV) are synthesized in the following manner:
The compound of the formula to CHs ~ ~ C=C-CHz -CH2 C I
CI
will be obtained from 4-chloro-4'-methylbutyrophenone of the formula CH3 ~ ~ OU-CH2 CH2 CH2 C I
the preparation of. which is described in Belgian patent 577,977 of 15th May 1959, CA : 54, 4629 c, by treatment with phosphorus oxychloride and dimethylformamide under the conditions described in the following reference:
- VOLODINA M.A.; TENENT'EV A.P.; KUDRYASHOVA V.A.;
KABOSHINA L.N.; Khim. Geterosikl. Soedim; 1967, 5-8.
This compound is then treated with sodium sulfide in a solvent such as tetrahydrofuran, under reflux, to give the derivative CH3 s 35 which is then converted in two steps to the nitrile r'.._~~) to derivative by dehydration of the oxime formed from the aldehyde and hydroxylamine. This dehydration may be carried out for example with acetic anhydride to give the nitrile compound CH3 i s S
NC
which may then be aromatized by treatment with bromine in carbon tetrachloride to give the compound s NC
This compound can then be chlorinated or bro minated with halogenating agents such as N-chlorosuc cinimide or N-bromosuccinimide, in a solvent such as carbon tetrachloride or dibromoethane, to give the compounds of formula (IV) in which V is the group S
V cam be a group S
3 s R900C

G2 ,.~ :J ,-1 ;1 r' 1~
~. iii i) ~) ~ ~'i R9 being as defined above, i:n which case the corres-ponding compounds of formula (IV) may be prepared from the nitrile prepared above of the formula os CH3 to by conventional hydrolysis of the nitrite group fol-lowed by esterification of the acid obtained, or direct conversion of the nitrite group to the ester group by the methods known to those skilled in the art, followed 15 by chlorination or bromination of the ester with N-chlorosuccinimide or N-bromosuccinimide, for example in carbon tetrachloride or dibromoethane, to give the com-pounds of formula (IV) in which W is the bromine atom or the chlorine atom and V is the group R90C!C
V can be a group O

R9 being as defined above, in which case the corres-ponding compounds of formula (IV) may be prepared by reacting the diazotized derivative of p-toluidine with 3-furoic acid to give the compounds of the formula h L

/ O

by the method described in the following literature reference:
- A. JURASEK et al., Collect. Czech. Chem. Commun., 1989, 54, 215.
This compound will then be esterified by 'the conventional methods known to those skilled in the art to give the compound C
in which R9 is as defined above, this derivative then being brominated or chlorinated by reaction with N-bromosuccinimide or N-chlorosuccinimide, for example in carbon tetrachloride or 1,2-dichloroethane, to give the derivative of formula (IV) in which W is the bromine atom or the chlorine atom and V is the group O O
/ or /
RsOOC R OOC Br (or C1) s V can be a group C ~ 4 i l'1 l,.' y. n - 23 - '' ~.r _~ i;. :J ~,', ~ t~
O
NC
05 in which case the acid r HOOC
prepared above will be converted to the acid chloride by reaction with thionyl chloride and then to the amide by reaction with ammonia. The amide obtained will be converted to the nitrile by reaction with phosphorus oxychloride in dimethylformamide to give the compounds of the formula 2o CH3 \
O
NC
This derivative will then be brominated or chlorinated by reaction with N-bromosuccinimide or N-chlorosuccinimide, for example in carbon tetrachloride or 1,2-dichloroethane, to give the compounds of formula (IV) in which W is the bromine atom or the chlorine atom and V is the group O O
or NC ~ NC ~ Br (or C1) r .1 4~ i) ;) ~'~ ~' _~" i;n U L) a ti In formula (V), R'1 and R8 are as defined above and V is as defined in formula (IV).
However, the compounds of formula (V) in which v is a group ,N ~ , / S . / o /
NC ~ I NC a NC ~ NC / orNC r Br will react with one equivalent of sodium azide in a solvent such as dimethylformamide, in the presence of an ammonium salt such as ammonium chloride, or by heating in toluene or xylene with a trialkyltin azide, to give the compounds of formula (V) in which V is the group N
Br N- N_ ~ N_ N_ 'N_ 2o N~N~NH N~~ ~NH~ N~~ ,NH N~~ ,NH N~~ ,NH
N N N N
In formula (VI), V is as defined in formula (IV), but this condensation method will only be used when V possesses a group unaffected by hydrogenation.
Thus reaction of a 3-amino-1,2,4-triazole of formula (II):
~NHZ
N

R~Ni H
Formula (TI) .\
C? ~ ~)r~7r~~!' / i s..~ ~ ;M ~~ ) E 3 in which R~ is as defined above (these products being commercially available or capable of being prepared by the methods described in the following literature references:
OS - HUFFMANN and SCHAEFER, J. of Org. Chem., 1963, 28, p.
1812-1816 and p. 1816-1821, - ALLEN.et al., J. of Org. Chem., 1959, 24, p. 793-796, and - Organic Synthesis Collective, volume 3, p. 95), with the compounds of formula (V), in which R'1 and R8 are as defined above and V is one of the following groups:
1s N-N
R900C / NC , N~N ~
\ ~ , \ ( , H \ ~ , 2o N-N
R900C / N NC / N N~N \ / N
I ~ \ I , H \ I ' N-N
2 s R9ppC N C
~ \S ~ ~ \S ' H ~S , ~/~
N-N
3o R9~C NC
i\ .~\ N i O ~ O ' H ~O

~) j n ~~ ,n r' n - ~ ~ ~, C) .) f ; ) N-N

w w , N w O ~ O O
H
05 Br ~r Sr where R9 is as defined above, will give the compounds of formulae (VIIa) and/or (VIIb):
R', R,o X N
W ~ ~ ~ ~ ~ Y~N~~/ R~~ \ V
N N R, V
Formula (VIIa) Formula (VIIb) and their tautomeric forms, in which R'1, X, Y and V
are as defined above and R1o is the hydroxyl group when the compounds of .formula (V) are p-ketoesters and a lower alkyl radical having 1 to 6 carbon atoms in the case where these same compounds of formula (V) are ,e-diketones, by condensation in an aprotic solvent such as dichloro- or trichloro-benzene, or in an acid solvent such as acetic acid, or else in an alcohol in the presence of the corresponding sodium or potassium alcoholate, or else in pyridine or 2-methyl-5-ethyl-pyridine in the presence or absence of 4-dimethylamino-pyridine, at a temperature of between 50° and 200°C.
In the case where V possesses a tetrazole group, the reaction temperatures should not exceed 140°C so as not to decompose the tetrazole.
The reactions of aminotriazoles or similar heteroaromatic amines with ,B-ketoesters and ,B-diketone derivatives are described well in the literature and, according to the operating conditions, the forms ;~ .ys n C~ r~ :'°
i.'., ::. ~w ~ ~~ 3 obtained are identified. Examples which may be cited are the studies by - J.A. VAN ALLAN et al., J. Org. Chem., p. 779 to p.
801 (1959), 05 and by - L.A. WILLIAMS, J. Chem. Soc., p. 1829 (1960), and - L.A. WILLIAMS, J. Chem. Soc., p. 3046 (1961).
Thus the compounds VIIa and VIIb will be iden-tified for separate treatment.
The Applicant has discovered, however, that 2-methyl-5-ethylpyridine, in the presence or absence of 4-dimethylaminopyridine, is a preferred solvent for orientating the reaction almost exclusively towards the formation of the derivatives of formula (VIIb); in fact, the temperature (170-180°C) and the pH which are necessary for this orientation can be achieved using this solvent.
If the derivatives of formulae (VIIa) and (VIIb) in which Rlo is a hydroxyl group are treated with a reagent such as P2S5 or Lawesson's reagent, the derivatives of formulae (VIIa) and (VIIb) in which the group R1o is a thiol will be obtained.
For example, if the derivatives of formulae (VIIa) and (VIIb) in which R1a is a hydroxyl group are heated in POC13, the derivatives of formulae (VIIIa) and (VIIIb):
Ci X N \ / X N \ /
Yw ~ ~ \
!~ , \ N N CI V
N N R, V
Formula (VIIIa) Formula (VIIIb) will be obtained, in which R'z, X, Y and V are as c~~ y;yr/;, ~..~...U'u' i ~_) _ 28 defined above.
Hydrogenation of the derivatives of formulae (VIIIa) and (VIIIb), in the presence of a catalyst such as palladium-on-charcoal, will make it possible to 05 replace the chlorine with a hydrogen atom, and the derivatives of formula (IX):
R, X N ~
N N R ! V
z Formula (IX) in which R1, R2, X, Y and V are as defined above, will be obtained by heating the derivatives of formulae (VIIIa) and (VIIIb), in the presence of a nucleophile containing nitrogen, oxygen or sulfur, under reflux in an alcohol , in the presence or absence of a base such as Na2C03, or in an autoclave at 100°C.
The derivatives of formulae (VIIa) and (VIIb) in which R'1 is the group (CHa)a0-benzyl, p being as defined above, may be hydrogenated in the presence of palladium-on-charcoal, in acetic acid, to give the compounds of formulae (VIIa) and (VIIb) in which R'1 is an alcohol group.
These triazolopyrimidines of formulae (VIIa) and (VIIb) may also be obtained by reacting the deriva-tives of formula (X):

iT~ '~ ~) () ~ >'~ n ~ ~,. r,. J ~? ~ ~:i R, N ~
NH,---NH N Fi2 'V

Formula (X) in which R1, RZ and V are as defined above, with:
- acids, acid chlorides or carboxylic acid esters, - isocyanates or isothiocyanates, - orthoesters, - carbonyldiimidazole or urea, potassium xanthogenate, carbon disulfide or an analogous reagent, by heating without a solvent or in a solvent such as N-methylpyrrolidone or an alcohol like ethanol or meth-oxyethanol, in the presence or absence of a base such as triethylamine, pyridine or 2-methyl-5-ethylpyridine.
Depending .on the operating conditions, especi ally the temperature and pH of the reaction, 1,2,4 triazolo[4,3-a]pyrimidine derivatives or their 3,2,4 triazolo[1,5-a]pyrimidine rearrangement products will be obtained.
The compounds of formula (X) can be obtained by any one of the known methods of synthesizing 2-hydra zinopyrimidines (cf.:~The Pyrimidines: The Chemistry of Heterocyclic Compounds: D.J. BROWN: Wiley Interscience 1970), especially by substituting the derivatives of formula (XI):
f ~\
.S :1 ~ r ~ n ~i ~ i;,r ~ l~ 1_7 R, CH,S \ N R2 V
OS
Formula ( 3tI ) in which Rl, R2 and V are as defined above, with hydrazine hydrate, for example.
The compounds of formula (XI) are obtained by condensing S-methylthiourea with the derivatives of formula (V), for example, or by any one of the methods of synthesizing 2-thiomethylpyrimidines which are known in the literature (cf.: The Pyrimidines, op. cit.).
The compounds of formula (IX) in which V
possesses an ester group COORS may be hydrolyzed in an acid or basic medium, or hydrogenated in the case where R9 is a benzyl, to give the compounds of formula (I) in which R3 possesses. an acid group.
The compounds of foxmula (IX} in which V
possesses a nitrite group will react with one equiva-lent of sodium azide in a solvent such as dimethyl-formamide, in the presence of an ammonium salt such as ammonium chloride, or by heating in toluene or xylene with a trialkyltin azide, for example trimethyltin or tributyltin azide, followed by an acid treatment, for example with gaseous hydrochloric acid in tetrahydro-furan, to give the compounds of general formula (I) in which R~ possesses a tetrazol-5-yl group.
These same compounds in which V possesses a nitrite group may be converted by reaction with sul furic acid, or by reaction with hydrogen peroxide, or else by reaction with polyphosphoric acid, to deriva tives of general formula (I) in which R3 possesses an amide group.

f7 ~ n ;
l~ ~ ~ J ~ ~ :_1 The derivatives in which V possesses a nitrile group or an amide group may also be converted by basic or acid hydrolysis to derivatives of general formula (I) in which R3 possesses an acid group.
05 It is possible to obtain addition salts of some of the compounds of formula (I), especially pharma-ceutically acceptable addition salts. In particular, when the compounds of formula (I) contain an acid or tetrazole group, there may be mentioned the salts of sodium, potassium, calcium, an amine such as dicyclo-hexylamine or an amino acid such as lysine. When they contain an amine group, there may be mentioned the salts of an inorganic or organic acid, such as, for example, the hydrochloride, methanesulfonate, acetate, maleate, succinate, fumarate, sulfate, lactate or citrate.
The novel compounds according to the invention possess remarkable pharmacological properties as angio-tensin II receptor antagonists and antiproliferatives and can be used in therapeutics for the treatment and prevention of cardiovascular diseases and in particular for the treatment of hypertension, cardiac insuffi-ciency and diseases of the arterial wall, especially atherosclerosis.
Thus the invention covers the pharmaceutical compositions which contain as the active principle the drugs consisting of a pharmaceutically effective amount of at least one compound of formula (I) as defined above, as well as one of its pharmaceutically accep table addition salts where appropriate.
These compositions can be administered by the buccal, rectal, parenteral, transdermal or ocular route.
These compositions can be solid or liquid and can take the pharmaceutical forms commonly used in :~ ' n n ;o ri~
a , ..
t~w~ aL (~ i) ~_.~ S ~_~

human medicine, such as, for example, simple or coated tablets, gelatin capsules, granules, suppositories, injectable preparations, transdermal systems and eye lotions. They are prepared by the customary methods.
05 In said compositions, the active principle, consisting of a pharmaceutically effective amount of at least one compound of formula (I) as defined above, or one of its pharmaceutically acceptable addition salts, can be incorporated with excipients normally employed in these pharmaceutical compositions, such as talc, gum arabic, lactose, starch, magnesium stearate, polyvidone, cellu-lose derivatives, cacao butter, semisynthetic glyce-rides, aqueous or non-aqueous vehicles, fats of animal or vegetable origin, glycols, various wetting agents, dispersants or emulsifiers, silicone gels, certain polymers or copolymers, preservatives, flavorings and colors.
The invention also covers a pharmaceutical com position with antagonistic activity towards angiotensin II receptors, and/or antiproliferative activity, which permits especially a favorable treatment or prevention of cardiovascular diseases, in particular hypertension, cardiac insufficiency and diseases of the arterial wall, especially atherosclerosis, said composition com-prising a pharmaceutically effective amount of at least one compound of formula (I) given above, or one of its pharmaceutically acceptable addition salts, which may be incorporated in a pharmaceutically acceptable excipient, vehicle or carrier.
The dosage varies especially according to the route of administration, the complaint treated and the subject in question.
For example, for an adult with an average weight of 60 to 70 kg, it can vary between 1 and 400 mg of active principle, administered orally in one or more r iv! l.W ,) ~ Lr daily doses, or from 0.01 to 50 mg, administered paren-terally in one or more daily doses.
The invention also covers a method of preparing a pharmaceutical composition, which comprises incor 05 porating a pharmaceutically effective amount of at least one compound of formula (I) as defined above, or one of its pharmaceutically acceptable addition salts, into a pharmaceutically acceptable excipient, vehicle or carrier. This pharmaceutical composition can be formulated as gelatin capsules or tablets containing from 1 to 400 mg of active principle, or as injectable preparations containing from 0.01 to 50 mg of active principle.
The invention also covers a method of therapeu tic treatment for mammals, which comprises adminis tering to this mammal a therapeutically effective amount of at least one compound of formula (I) as defined above, or one of its pharmaceutically accep table addition salts.
In animal therapeutics, the daily dose which can be used is normally between 1 and 100 mg per kg.
Further characteristics and advantages of the invention will be understood more clearly from the following description of some Preparatory Examples, which in no way imply a limitation but are given by way of illustration.
Example 1: Ethyl 3-oxohexanoate Formula (III): R'1 = n-propyl, RS = 0-ethyl 176 g of 2,2-dimethyl-4,6-dioxo-1,3-dioxane (Meldrum's acid) are dissolved in 550 ml of dichloro-methane and 188 ml of pyridine; the mixture is cooled to 5°C with a bath of water and ice arid 133 ml of .. ;) c/ fl ;l ~~ !~°
~a ~_ i,~ l) l~ s ~ !

butyryl chloride are added dro;pwise. When the addition is complete, the mixture is stirred for three hours at room temperature. The solution is washed with a dilute solution of hydrochloric acid, dried over magnesium 05 sulfate and evaporated under vacuum to give an oil.
This oil is dissolved in 700 ml of ethanol and the mixture is refluxed for six hours. The ethanol is evaporated off under vacuum and the residue obtained is distilled to give 145.4 g of ethyl 3-oxohexanoate in the form of an oil.
Boiling point (20 mm of mercury): 98°-100°C.
The compound of Example 2 was prepared by the procedure of Example 1.
Example 2: Ethyl 3-oxoheptanoate Formula (III): R'1 = n-butyl, RS = O-ethyl Boiling point (20 mm of mercury): 115°-120°C.
Example 3: Ethyl 4-benzyloxy-3-oxobutanoate Formula (III) : R'1 = CH2-O-CH2 l \ , R8 = O-ethyl 80 g of 60% NaH are added in portions to 800 ml of anhydrous THF. The medium is cooled to 10°C and maintained at this temperature. 500 ml of benzyl alcohol are then introduced dropwise. A solution of 65.8 g of ethyl 4-chloroacetoacetate in 200 ml of benzyl alcohol is then added. The mixture is stirred at room temperature for 20 h. It is neutralized by the w .~ r) n ;? r~
_R. ~H ~ l? s ,3 _ 35 _ slow addition of acetic acid (120 ml) while being cooled with an ice bath. The whole is then poured into a mixture of water and ice and extracted with ether.
The organic phase is washed with a solution of sodium 05 bicarbonate, dried over MgS04 and then concentrated to give an orange oil. The product is purified by two successive distillations to give a yellow oil.
Boiling point (under 0.05 mm of mercury): 126-132°C.
Exa~le 4: 4'-Bromomethyl-2-cyanobiphenyl CN
Formula (IV): W = Br, V =
a) Preparation of 2-cyano-4'-methylbiphenyl 563.8 g of (4'-methylbiphenyl-2-yl)carboxylic acid, prepared according to MEYERS A.I.p MIHELICH E.D.;
J. Am. Chem. Soc., 1975, 97(25), 7383, are added in small portions to 800 ml of thionyl chloride. The mix ture is refluxed for two hours. The thionyl chloride is concentrated under vacuum and the residue is poured into a 28% solution of ammonium hydroxide cooled beforehand with a bath of water and ice. The mixture is stirred for 30 minutes and the crystals obtained are filtered off, washed with water followed by ether and then dried to give 554.8 g of (4'-methylbiphenyl-2-yl)-carboxamide in the form of crystals melting at 128°-132°C. These crystals are taken up in 1300 ml of thionyl chloride and the mixture is refluxed for 3 hours and then concentrated under vacuum to give an orange oil. This is taken up in two liters of chloro-form and washed with water and the organic phase is ~ ,3 c? f> ;1 r~
i F.~~_I~UC~ i..3 then dried and concentrated to give 509.8 g of an oil, which, crystallizes from pentane to give 467.3 g of 2-cyano-4'-methylbiphenyl.
Melting point: 46°-48°C.

b) 4'-Bromomethyl-2-cyanobipheny~l 467.3 g of 2-cyano-4'-methylbiphenyl, prepared above, are dissolved in 4.7 1 of 1,2-dichloroethane in the presence of 467.3 g of N-bromosuccinimide and 9.3 g of benzoyl peroxide. The mixture is heated very gradually so as to have good control over the exo thermic effect. It is subsequently refluxed for 4 h, cooled to 50 ° C and then washed 3 times with hot water and dried and the organic phase is concentrated to give cream-colored crystals.
Recrystallization from isopropanol gives 451 g of white crystals of 4'-bromomethyl-2-cyanobiphenyl.
Melting point: 128°C.
xa ple 5: Ethyl 2-[(2'-cyanobiphenyl-4-yljmethyl]-3-oxohexanoate Formula (A): R'1 = n-propyl, RS = O-ethyl, CN
V =
23 g of ethyl 3-oxohexanoate, prepared in Example 1, are dissolved in 120 ml of tetrahydrofuran.
30.3 g of 4'-bromomethyl-2-cyanobiphenyl, prepared in Example 4, and 4.7 g of lithium chloride are added and the mixture is stirred at room temperature. 39 ml of diisopropylethylamine are than introduced dropwise, ~ n ;7 ~a , causing a slight exothermic effect. The mixture is subsequently stirred for three hours at room tempera-ture and 'then for ten hours under reflex. The solvents are evaporated off under vacuum and the residue is 05 taken up in water and then extracted with chloroform.
__ The organic phase is decanted and then washed with a dilute solution of hydrochloric acid, dried over mag nesium sulfate and evaporated under vacuum to give 38 g of an orange oil.
Purification by chromatography on silica gel (eluent: CHC1~) gives 32.3 g of ethyl 2-[(2'-cyano-biphenyl-4-yl)methyl]-3-oxohexanoate.
The compounds of Examples 6 to 10 are obtained by the procedure of Example 5 using the appropriate ,B
ketoester.
Example 6: Ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxoheptanoate Formula (V): R'1 = n-butyl, Rg = O-ethyl, GN
V =

Oil used as such in the next step.
Example 7: Ethyl 2-[(2'-cyanobiphenyi-4-yl)methyl]-3-oxobutanoate Formula (V): R'~ = methyl, Ra = O-ethyl, c .~ ,~ n p r ~ 1 ~.! U ~_, ~ : i V =

Yellow oil purified by chromatography on silica gel (eluent: chloroform 95%/ether 50).
Example 8: Ethyl 2-[(2'-cyanobiphenyl-~.-yl)methyl]-3-l0 oxopentanoate Formula (V): R'1 = ethyl, Rs = O-ethyl, 15 / ~N
V=
Oil purified by chromatography on silica geI
20 (eluent: CHC13 95o/ether 5%).
Example 9: Ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-4-methoxy-3-oxobutanoate 25 Formula (V): R'1 = methoxymethyl, R8 =
O-ethyl, CN
3G V =
Yellow oil purified by chromatography on silica gel (eluent: CHC13 95%/ether 5%).

~_~h Jt)~i Example 10: Ethyl 4-benzyloxy-2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxobutanoate 05 Formula (V) : R'1 = GH2-C~-CH2 , V = ~ , Ra = O-ethyl to s Oil purified by chromatography twice in succes-sion (eluents: chloroform, then cyclohexane 80%/ethyl acetate 20%).
Example 11: Ethyl 2-[4-(3-cyano-2-pyridyl)benzyl]-3-oxohexanoate 2o N , CN
Formula (V): R'1 = CHZ-CH'-CH3, V = I , R8 = O-ethyl a) Preparation of 4-bromobenzyl methyl ether A solution of sodium methylate, prepared from 11.8 g of sodium and 350 ml of methanol, is introduced dropwise into a suspension of 117.7 g of 4-bromobenzyl bromide in 350 ml of methanol. The mixture is stirred for 2 h at room temperature arid left to stand over night. The methanol is evaporated off, the residue is taken up in ether and the organic phase is washed with water and then dried and concentrated to give a yellow oil, which ~,s purified by distillation to give 102 g of bromobenzyl methyl ether as a colorless liquid.

i .) t.) ~ T~~ n i,r ~,) l ~ i l Boiling point under 17 mm of mercury: 112-114°C.
b) Synthesis of 3-cyano-2-(4-methoxymethylphenyllpyri-05 dine 2 g of the compound 4-bromobenzyl methyl ether, prepared above, are added to a suspension of 18 g of magnesium in 50 ml of anhydrous THF. The formation of the magnesium compound is initiated with a few crystals of iodine and, if necessary, by heating with a bath of warm water. A solution of 121.8 g of 4-bromobenzyl methyl ether in 200 ml of anhydrous THF is introduced dropwise so that the temperature does not exceed 40°C.
The components are reacted for 1 h at room temperature and 800 ml of a solution of zinc chloride in ether are then introduced under excess nitrogen pressure. A
white precipitate forms. The components are reacted for 1 h 30 min at room temperature. 800 mg of the coupling catalyst bis(triphenylphosphine)nickel(II) chloride, [NiP(phenyl)3]2C12, axe added and a solution of 76.9 g of 2-chloronicotinonitrile in 300 ml of THF
is then introduced. The mixture is stirred overnight at room temperature and concentrated under vacuum. The concentrate is taken up in a mixture of 1 1 of di-chloromethane, 1 1 of water and 1 1 of the disodium salt of EDTA. The emulsion is filtered on C~lite 545.
The organic phase is decanted, washed with water, dried and concentrated to give 133.6 g of an orange oil, which is purified by chromatography twice in succession (eluent: chloroform 95%/ether 5%). 69.4 g of 3-cyano-2-(4-methoxymethylphenyl)pyridine are thus isolated in the form of an orange oil, which crystallizes.
Melting point: 74°C.

c) Preparation of 3-cyano-2-(4-bromomethylphenyl~pyri-dine 05 N ,,,, C N
Formula (IV): W = Br, V =
s 69.4 g of 3-cyano-2-{4-methoxymethylphenyl)-pyridine, prepared in the previous step, are dissolved in 700 ml of chloroform stabilized with amylene. The solution is cooled to -10°C. A solution of 66 ml of BBr3 in 200 ml of chloroform stabilized with amylene is introduced dropwise so that the temperature does not exceed 5°C. The mixture is left for 1 h 30 min in an ice bath. It is hydrolyzed with ice and then with water. It is filtered and the suspension is taken up in a mixture of water and chloroform. After decanta-tion, the organic. phases are combined, dried and then concentrated to give 78.2 g of cream-colored crystals of 3-cyano-2-(4-bromomethylphenyl)pyridine.
Melting point: 118°C.
d) Preparation of ethyl 2-[4-(3-cyano-2-pyridvl)-benzylZ-3-oxohexanoate N , CN
Formula (V): R'1 = CH2-CH2-CH3, V =
~ s R8 = O-ethyl Following the procedure of Example 5, the expected derivative is obtained in the form of an orange oil, which is used as such in the next step.

'' -' c) ~) :l y~ n (; ~ ;,, J a ~ ~;

Example 12: Ethyl 2-(4-(3-cyano-2-thienyl)benzyl]-3-oxohexanoate o5 a C1V
Formula (V): R'1 = CHZ-CH2-CH3, V = S~ a R8 = O-ethyl a) Preparation of 4-chloro-1-(4-methylphenyl)butanone A mixture of 560 ml of 4-chlorobutyryl chloride and 550 ml of toluene is added dropwise to a suspension of 740 g of AlCl3 in 2 1 of dichloromethane, the tem-perature being maintained at between 10° and 15°C. The reaction mixture is stirred for 30 min at room tempera-ture and poured on to ice. After decantation, the organic phase is separated off and the aqueous phase is extracted with dichloromethane. The organic phases are combined, washed with water and then dried and concen-traced under vacuum to give 994.5 g of 4-chloro-1-(4-methylphenyl)butanone in the form of an oil, which is used in the next step without further purification.
b) Preparation of 3-chloro-2-_(2-chloroethyl~-3-(4-methylphenyl~,prop-2-en-1-al 390 ml of POC13 are introduced dropwise, at a temperature of between 7° and 12°C, into a solution of 352.5 g of 4-chloro-1-(4-methylphenyl)butanone, pre-pared above according to Example 12 a), in 450 ml of DMF. The temperature is raised gradually, in the first instance to 50°C over 2 h and then to 75°C over 45 min.
The mixture is poured on to ice and extracted three times with ether and the organic phases are combined, washed with water and then dried and evaporated to give 387.8 g of 3-chloro-2-(2-chloroethyl)-3-(4-methyl-;1 rs r y n /~J _~ Sw L) l1 , ~ 1.1 phenyl)prop-2-en-1-al in the form of an oil, which is used as such in the next step.
c) Preparation of 4~5-dihydro-3-formyl-2- 4-methyl-05 phenyl)thiophene A mixture of 200 g of 3-chloro-2-(2-chloro-ethyl)-3-(4-methylphenyl)prop-2-en-1-al, prepared in Example 12 b) , 2 . 2 1 of THF, 276. 5 g of Na2S ~ 9H20 and 373 ml of water is refluxed for 6 h. :It is concentra-ted under vacuum and the concentrate is taken up in water and extracted 3 times with ether. The organic phases are combined, washed with water, dried and concentrated to give 170.3 g of an oil, which crys-tallizes.
Melting point: below 50°C.
d) Preparation of 4,5-dihydro-3-formyl-2-(4-met ~~
phenyl)thiophene oxime 132.1 g of hydroxylamine hydrochloride are added in portions to a solution of 323.5 g of the aldehyde prepared according to 12 c) in 800 ml of ethanol. A solution of sodium carbonate, prepared from 100.5 g of NazC03 and 700 ml of water, is than added dropwise. The mixture is heated at 40°C for 5 min and the reaction is then left to proceed at room tempera-ture for 1 h. The mixture is cooled to 15°C and the solid is filtered off and washed with water and then with a mixture of isopropyl ether 50%/petroleum ether 50% to give 252 g of oxime. Extraction of the filtrate with dichloromethane gives a 2nd crop of 99 g of the expected oxime.
e) Preparation of 3-cyano-4~5-dihydro-2-(4-methyl-phenyllthiophene A salution of 171.8 g of the oxime prepared in ~~i , UU~ i Example 12 d) in 680 ml of acetic anhydride is refluxed for 3 h. It is concentrated to remove the excess anhydride and then distilled to give 115.3 g of nitrile derivative.
05 Boiling point under 0.05 mm of mercury: 140-150~C.
f) Preparation of 3-cyano-2-f4-methylphenyllthiophene 62 ml of bromine are introduced dropwise into a solution, preheated to 50~C, of 191.3 g of the nitrile prepared according to Example 12 e) in 1.85 1 of CC14.
The whole is refluxed until the evolution of HBr ceases. The CC14 is evaporated off and the residue is distilled to give 115.3 g of 3-cyano-2-(4-methylphe nyl)thiophene.
Boiling point under 0.05-0.1 mm of mercury:
130-150'C.
g) 2-~(4-Bromomethyl~~enyl~-cyanothiophene ~ CN
Formula (IV): W = Br, V = S
182.2 g of the compound obtained in Example 12 f) are bromine°ted according to Example 4 to give 133.7 g of 2-(4-bromomethylphenyl)-3-cyanothiophene.
Melting point: 80-84~C.
h) Eth~l 2-f4-(3-cyano-2-thien~rl)benzyl]-3-oxohexanoate cN
Formula (V): R'1 = CHI-CH2-CH3, V = , GS c~ (1 Y~ n 'r~.r ~ ~ E t3 R8 = U-ethyl A mixture of 50 g of 2-(4-bromomethylphenyl)-3-cyanothiophene, prepared above, 40 g of ethyl 3-oxo-05 hexanoate, prepared in Example 1, 300 ml of THF, 62 ml of diisopropylethylamine and 15.6 g of Liar is refluxed for 15 h. It is concentrated under vacuum, a dilute solution of hydrochloric acid is added and the mixture is extracted with ethyl acetate. The organic phases are combined, washed with water, dried and evaporated to give 62.4 g of ethyl 2-[4-(3-cyano-2-thienyl)-benzyl]-3-oxohexanoate in the form of an oil, which is used without further purification.
Example 13: Ethyl 2-[4-(3-cyano-2-furyl)benzyl~-3-oxo-hexanoate , Formula (V) : R'1 = CHZ-CHZ-CH3, V - O ~ ~N
R8 = O-ethyl a ) Preparation of 2 =( 4-methylx~henyl L 3-furanoic acid 70.7 g of p-toluidine, cooled with a bath of water and ice, are treated with 205 ml of 36% HC1. The mixture is then stirred at 55°-60°C for 30 min before being cooled to 0°C again. A solution of 45 g of NaN02 in 220 ml of water is then introduced. The mixture is stirred for 1 h at 0°C. This cold solution is intro-duced into a mixture of 49.3 g of 3-furanoic acid, 220 ml of acetone, 23.4 g of CuCl2 and 6.3 g of water, cooled to -5°C. The whole is stirred at 0°C for 2 h and then at room temperature for 48 h. Tt is extracted twice with ether and the organic phase is decanted, .\

dried and concentrated to give an oil, which gives crystals when treated with water.. The crystals are filtered off and washed with 50 ml of a 50% methanol/
water mixture to give 13.4 g of 2-(4-methylphenyl)-3 05 furanoic acid.
Melting point: 166°C.
b) Preparation of 2-(4-methylphenyl)furan-3-carbox-amide 20 ml of SOC12 are added to a solution of 13.4 g of the furanoic acid prepared above in 70 ml of toluene. The mixture is refluxed for 3 h and the excess SOC12 and the toluene are then distilled to give an oil, which is reacted at 5°C with a solution of 100 ml of 1,2-dimethoxyethane saturated with ammonia. The precipitate is filtered off and washed with water and then with isopropyl alcohol to give 7 g of white crystals of amide.
Melting point: 174°C.
c) Preparation of 3-cyano-2-(4-methylphenyl furan A mixture of 12.2 g of the amide prepared above and 65 ml of SOC12 is refluxed for 3 h and concentrated under vacuum. The oil obtained is taken up in chloro-form, and water and ice are then added. After decanta tion, the aqueous phase is extracted with chloroform and the organic phases are combined, dried and evapora ted to give an oil. Purification by chromatography on silica gel (eluent: toluene) gives 7.5 g of an oil, which crystallizes.
Melting point: 66°C.

c i cz C) n ~.~.,',~Ji.l~l3 47 _ d) 2- ~4-Bromomethylphen~l)-3-cyanofuran CN
05 Formula (IV): W = Br, V
7.5 g of the compound obtained in Example 13 c) are brominated according to Example 4 to give, after purification by chromatography on silica gel (eluent:
pentane 50%/toluene 500), 4.6 g of 5-bromo-3-cyano-2 (4-methylphenyl)furan (melting point: 88°C), 2.2 g of 5-bromo-3-cyano-2-(4-bromomethylphenyl)furan (melting point: 114°C) and 2 g of 2-(4-bromomethylphenyl)-3 cyanofuran.
Melting point: 108°C.
The compound 5-bromo-3-cyano-2-(4-methyl-phenyl)furan is subjected to a further bromination reaction according to Example 4 to give 5-bromo-2-(4-bromomethylphenyl)-3-cyanofuran, which constitutes the compound of Example 13 d) bis.
e) Ethvl 2-[4-~(3-cyano-2-furyllbenzyll-3-oxohexanoate ~ ~ CN
Formula (V): R'1 = CH2-CHZ-CH3, V =
Rg = O-ethyl The resulting derivative 2-(4-bromomethyl-phenyl)-3-cyanofuran is treated according to Example 5 to give ethyl 2-[4-(3-cyano-2-furyl)benzyl]-3-oxo-hexanoate in the form of an oil, which is used in the crude state in the next step.

cz a c~ r~ n ~~~ ;~
-4$- rW<.JV ) Likewise, the derivative 5-bromo-2-(4-bromo-methylphenyl)-3-cyanofuran of Example 13 d) bis is treated according to Example 5 to give ethyl 2-[4-(5-bromo-3-cyano-2-furyl)benzyl]-3-oxohexanoate in the OS form of an oil, which constitutes the derivative of Example 13 bis.
Example 14: 3-[(2'-Cyanobiphenyl-4-yl)methyl]-2,4-dioxopentane Formula (V): R'1 = CH3, Re = CH3, V =
32.8 g of 2,4-dioxopentane, 68 g of 4'-bromo-methyl-2-cyanobiphenyl, prepared in Example 4, 88 ml of diisopropylamine and 10.6 g of anhydrous lithium chlo-ride in 300 ml of tetrahydrofuran are refluxed fox 27 h. The mixture is cooled and the precipitate is filtered off. The organic phase is concentrated to dryness to give 88.5 g of crystals. These are taken up in isopropanol and the mixture is filtered to isolate 38.8 g of unreacted 4'-bromomethyl-2-cyanobiphenyl.
The concentrated mother liquors yield 26.5 g of an oil which, when purified on silica gel (eluent: chloro form), gives a further 5.3 g of 4'-bromomethyl-2-cyano biphenyl and 12.2 g of the expected 3-[(2'-cyanobi phenyl-4-yl)methyl]-2,4-dioxopentane in the form of a yellow oil.

4 9 _ ~~ ~~ s~ J a G, L) Example 15: 5-[(2'-Cyanobiphenyl-4-yl)methyl]-4,6-dioxononane Formula (V): R'1 = CH2-CHZ-CHI, V = ~ .
RS = CH2_CHZ-CH3 15.6 g of 4,6-dioxononane, prepared from methyl propyl ketone and ethyl butyrate in the presence of lithium amide (according to CA 42 . 4129 f), are dis-solved in 160 ml of anhydrous DMF. 4 g of 60o NaH are added in portions. When the exothermic effect has sub-sided, the mixture is cooled to room temperature and a solution of 27.2 g of 4'-bromomethyl-2-cyanobiphenyl, prepared in Example 4, in 90 ml of DMF is introduced dropwise. The mixture is stirred for 30 min at room temperature and then heated at 60°C for 2 h. It is concentrated under vacuum and the concentrate is taken up in a water/dichloromethane mixture and acidified with a dilute solution of HC1. After decantation, the aqueous phase is extracted twice with dichloromethane.
The organic phases are washed with water, dried and then concentrated to give 36.3 g of an oil, which is purified by chromatography 'twice in succession (eluent:
chloroform, then cyclohexane 90%/ethyl acetate 10% res pectively) to give a solid identified by NMR as being the enol tautomer melting at 105°C, and an oil corres ponding to the diketone tautomeric form.
Example 15: 2,4-Dioxo-3-[(2'-(1H-tetruzol-5-yl)bi phenyl-4-yl)methyl]pentane Formula (V)v R'1 = CH3, R$ = CH3, s ~ !~ ;') J ~ n x : ;
_~ iv t_~ l) N-N
I
/ ~N~
C

A mixture of 11.8 g of 3-((2'-cyanobiphenyl-4-yl)methyl]-2,4-dioxopentane, prepared in Example 14, 200 ml of xylene and 9.3 g of trimethyltin azide is refluxed for 50 h. After 24 h, a second equivalent of trimethyltin azide is added.
mhe mixture is cooled and concentrated to give a viscous oil which, when chromatographed on silica gel (eluent: chloroform 90%/methanol 10a), gives 9.3 g of crystals.
An additional treatment with acetonitrile gives 6.2 g of analytically pure 2,4-dioxo-3-[(2'-(1H-tetra-zol-5-yl)biphenyl-4-yl)methyl]pentane.
Empirical formula: C19H1eN4o2.
Melting point: 166°C.
Example 17: Ethyl 2-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-3-oxohexanoate Formula (V): R'1 = n-propyl, R8 = O-ethyl, N-N
I ~N
_ /
v - ( H
A mixture of 69.9 g of ethyl 2-[(2'-cyanobi-phenyl-4-yl)methyl]-3-oxohexanoate, prepared according to Example 5, 700 ml of anhydrous toluene and 47.5 g of trimethyltin azide, prepared from sodium azide and tri-~N ~ ~! z ~..~

methyltin chloride, is refluxed for 24 h. A further 47.5 g of trimethyltin azide are added and reflux is continued for 16 h. The mixture is concentrated to 500. The orange solution obtained is purified by 05 chromatography twice in succession (eluent: chloroform 90o/methanol 10%, then chloroform 95%/methanol 5%) to give 58 g of an orange oil, which crystallizes.
Melting point: 65~C.
°Example 18 (method A):
6-[(2'-Cyanobiphenyl-4-yl)methyl]-7-hydroxy-5-propyl-1,2,4-triazolo[1,5-a]-pyrimidine Formula (VIIa): R'1 = n-propyl, X = N, NC
Y = CH, R1a = OH, V =
1. 7 g of 3-amino-1, 2 , 4-triazole, 7 g of the ,8-ketoester prepared in Example 5 and 30 ml of acetic acid are refluxed for 6 h. The acetic acid is evapo-rated off. The oil obtained is purified by chromato-graphy on silica gel~(eluent: CHC13 90%/MeOH 100) to give 5.2 g of the starting ~-ketoester and 1.2 g of 6-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxy-5-propyl-1,2,4-triazolo[1,5-a]pyrimidine.
Melting point: 200°205'C.
1H NMR (200 MHz; DMSO-d6): 2.65 (t, 2H, propyl CHZ); 8.2 (s, 1H, H2).
UV ( 10 ~cg/ml , MeOH ) : as = 209 .1 nm ~b = 257.7 nm ;.. _~ ~) y (~ ;~ n 52 _ I. ,~v3;1 a~ = 286.8 nm.
Example 19 (method B):
6-[(2'-Cyanobiphenyl-4-yl)methyl]-5-05 hydroxy-7-propyl-1,2,4-triazolo[1,5-a]-pyrimidine Formula (VIIb): R'1 = n-propyl, X = N, NC
Y = CH, R1o = OH, V =
7.1 g of the ,e-ketoester prepared in Example 5, 1.7 g of 3-amino-1,2,4-triazole and 70 ml of 1,2,4-tri-chlorobenzene are refluxed for 7 h. The mixture is concentrated under vacuum. The thick oil obtained is chromatographed orb silica gel (eluent: CHC13 95a/MeOH
5%) to give 0.8 g of the isomer obtained in Example 18 (melting point: 200°C) and 2.2 g of 6-[(2'-cyanobi-phenyl-4-y1)methyl]-5-hydroxy-7-propyl-1,2,4-triazolo-[1,5-a]pyrimidine.
Melting point: 212°C.
1H NMR (DMSO-d6): 2.98 (t, 2H, propyl CH2):

8.1 (s, 1H, H2).
t3V (10 ~sg/ml, MeOH) : as = 207.5 nm ab = 258.2 nm.
Example 20 (method C):
6-[(2'-Cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-propyl-1,2,4-triazolo[4,3-a]-pyrimidine Formula (VIIa): R'1 = n-propyl, X = CH, ~'\
.. ( y ,.~ j ~ ! ? ;'~ r' f7 ~~ ~ lel ~~ I,t j/ ~..7 NC
Y = N, R1o = OH, V =

a) 5-[(2'-Cyanobiphenyl-4-yl)methyl]-4-hydroxy-6-propyl-2-mercaptopyrimidine 11 g of thiourea are added with a spatula to a solution of sodium methylate prepared from 4.6 g of sodium and 150 ml of methanol. 34.9 g of the ,e-keto-ester prepared in Example 5, dissolved in 50 ml of methanol, are then introduced dropwise. The mixture is left to stand overnight and then refluxed for 7 h. It is concentrated under vacuum and the concentrate is taken up in 500 ml of water and then acidified with concentrated HC1 to bring the pH to 1. The gummy precipitate is isolated and taken up in methanol to give 17.3 g of white crystals of 5-[(2'-cyanobiphenyl-4-yl)methyl]-4-hydroxy-6-propyl-2-mercaptopyrimidine.
Melting point: 196°C.
b) 5-[(2'-Cyanobiphenyl-4-yl)methyl]-4-hydroxy-2-methylmercapto-6-propylpyrimidine NC o 3~ormula (XI): R1 = n-propyl, V =
RZ = OH
17.3 g of the compound obtained above are introduced in portions into a mixture of 340 ml of methanol and 2.9 g of KOH. After a clear solution has c;-a ~~r~,~.,>j;~
r~ n~ ;,. O ~) i .,l formed, it is cooled and 3.4 ml of ICH3 are then introduced dropwise.
The mixture is left to react for 2 h at room temperature.
05 The precipitate is filtered off to give 17.2 g of 5-[(2'-cyanobiphenyl-4-yl)methyl]-4-hydroxy-2-meth-ylmercapto-6-propylpyrimidine.
Melting point: 220°C.
a) 5-[(2'-Cyanobiphenyl-4-yl)methyl]-2-hydra-zino-4-hydroxy-6-propylpyrimidine NC
Formula (X): R1 = n-propyl, V =
R2 = OH
12.4 g of 5-[(2'-cyanobiphenyl-4-yl)methyl]-4-hydroxy-2-methylmercapto-6-propylpyrimidine, prepared above, are dissolved in 370 ml of 2-methoxyethanol. 33 ml of hydrazine hydrate are introduced and the mixture is then refluxed for 3 h. It is concentrated under vacuum and the concentrate is taken up in acetonitrile and triturated. The solid obtained is filtered off and washed with ether arid isopropyl ether to give 9.9 g of 5-[(2'-cyanobiphenyl-4-yl)methyl]-2-hydrazino-4-hydroxy-6-propylpyrimidine.
Melting point: 191°C.
d) 6-[(2'-Cyanobiphenyi-4-yl)methyl]-5-hydroxy-7-propyl-1,2,4-triazolo[4,3-a]-pyrimidine Formula (VIIa): R'1 = n-propyl, X = CH, _:, :~; f c~ r7 ;~ a) P
lVr ~_ i-.~ U :,? E °~1 NC
Y = N, R1o = OH, V =
g of 5-[(2'-cyanobiphenyl-4-yl)methyl]-2-hydrazino-4-hydroxy-6-propylpyrimidine, prepared as above, are placed in 200 ml of formic acid. The 10 mixture is refluxed for 4 h. It is concentrated under reduced pressure and the thick oil obtained is taken up in water and triturated until it crystallizes.
The compound is purified by chromatography on silica gel (eluent: CHC13 95%/methanol 50).
This gives 8.3 g of 6-[(2'-cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-propyl-1,2,4-triazolo[4,3-a]-pyrimidine.
Melting point: 217~C.
1H NMR (DMSO-ds): 2.6 (t, 2H, propyl CHI): 9 (s, 1H, H3).
UV ( 10 ~ag/ml , MeOH ) : a~ = 210 . 2 nm ab = 257.5 nm a~ = 303.4 nm.
Hxample 21: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-7-hydroxy-5-propyl-1,2,4-triazolo[4,3-a]-pyrimidine Formul;i (VIIb): R'1 = n-propyl, X = CH, NC s Y = N, R1o = OH, V = ~

j .a c1 ~ r n ~~ ~ v,~ ~ l' ~ l1 Following the procedure of Example 20, step d), 1.1 g of 6-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxy-5-propyl-1,2,4-triazolo[4,3-a]pyrimidine are obtained at the same time as the compound described above.
05 Melting point: 204-206°C.
1H NMR (DMSO-d6): 2.9 (t, 2H, propyl CH2); 9 (s, 1H, H3).
UV ( 10 ~cg/ml , MeOH ) : as - 211 . 5 nm ab = 260 nm.
The compounds of Examples 20 and 21 can also be obtained by reacting compound 20 c) with triethyl orthoformate under reflux for 5 h. Tn this case, the proportion of the compound of Example 21 is found to be slightly improved.
Example 22 (method D):
6-[(2'-Cyanobighenyl-4-yl)methyl]-7-hydroxy-5-propyl-1,2,4-triazolo[1,5-a]-pyrimidine Formula (VIIa): R'1 = n-propyl, X = N, IVC ~.
Y = CH, R1o = OH, V =
500 mg of 6-[(2'-cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-propyl-1,2,4-triazolo[4,3-a]pyrimidine, pre pared in Example 20 d) , are heated in a metal bath at 225°C for 2 h 30 min. It is left to cool and taken up in methanol and then in isopropyl acetate to give 300 mg of cream-colored crystals identical to the compound of Example 18.

>' ,' :? ry ;1 r~ n 5'J - it ~_ i.n lJ U c 't1 Melting point: 200°C.
Example 23 (method E):
6-[ ( 2'-Cyanobiphenyl-4-yl )methyl ]-5-05 hydroxy-7-propyl-1,2,4-triazolo[1,5-a]-pyrimidine Formula (VIIb): R'1 = n-propyl, X = N, CN
Y = CH, R1o = OH, V =
A mixture of 24 g of 3-amino-1,2,4-triazole and 200 g of 5-ethyl-2-methylpyridine is heated to 175°C.
100 g of the ,B-ketoester prepared in Example 5; dis-solved in 100 ml of 5-ethyl-2-methylpyridine, are introduced dropwise. The reaction is left to proceed for 6 h at 175°C. . The ethylmethylpyridine is distilled off under vacuum and the residue is taken up in a mixture of water and chloroform. After decantation, the aqueous phase is extracted with chloroform. The combined organic phases are washed with a dilute solution of HCl and then with water, dried and con-centrated to give an oil, which crystallizes when triturated in methanol. Recrystallization from n-butanol gives 35.2 g of cream-colored crystals of 6-[(2~-cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-prapyl-1,2,4-triazolo[1,5-a]pyrimidine.
Melting point: 210°C.
Purification of the mother liquors by chromato-graphy on silica gel gives a second crop of 6.9 g of the expected compound, together with 13.9 g of 'the derivative 6-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxy-;-r~_~",ai' c ._' 5-propyl-1,2,4-triazolo[1,5-a]pyrimidine obtained in Example 18.
Melting point: 196°C.
The yield of the reaction can be improved by 05 about 10a toy adding 10.5 g of 4-dimethylaminopyridine to the initial mixture.
Example 24: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-7-hydroxy-2-methyl-5-propyl-1,2,4-triazolo-[I,5-a]pyrimidine hydrochloride hemihydrate Formula (VIIa): R'1 = n-propyl, X = N, Y = C-CH3, Rio = OH, CN
p= ~
A suspension of 10 g of compound 20 c) in 100 m1 of phenyl acetate is refluxed for 4 h. It is con-centrated under reduced pressure. The concentrate is taken up in water and extracted with chloroform and the extract is dried and evaporated to give 9.8 g of white crystals melting at 205°C. These crystals are taken up in 50 ml of acetonitrile and 40 m1 of a 10% solution of hydrochloric acid in ether to give 7.5 g of 6-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxy-2-methyl-5-propyl-1,2,4-triazolo[1,5-a]pyrimidine hydrochloride.
Empirical formula: CZ3H21N50~HC1~~H20.
Melting point: 190°C.
1H NMR (DM50-ds): 2.65 (t, 2H, propyl CH2).
UV (MeOH): as = 213.7 nm ab = 257.7 nm a~ = 285 nm.

.r :~ n y r~
- 59 - ~.,<.)~J!';' Example 25: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-propyl-3-mercapto-1,2,4-triazolo-[4,3-a]pyrimidine 05 Formula (VIIa): R'1 = n-propyl, X = C-SH, Y = N, R1a = OH, CN
1o v =
5.3 ml of carbon disulfide are added to a sus-pension of 10 g of the compound prepared in Example 20 15 c) in 300 ml of butanol. The mixture is refluxed for 2 h. A further 5.3 ml of CS2 are added and reflex is then continued for 5 h. The mixture is concentrated under vacuum. The concentrate is taken up in water and extracted 3 times with chloroform. The solvent is eva-20 porated off to give 10.8 g of amorphous crystals, which are purified by chromatography on silica gel (eluent:
CHC13 90%/MeOH 10%).
A first compound weighing 1.9 g is isolated and identified as 6-[(2'-cyanobiphenyl-4-yl)methyl]-7 25 hydroxy-5-propyl-3-mercapto-1,2,4-triazolo[4,3-a]pyri midine. This constitutes the product of Example 25 bis.
Melting point: 240°C.
1H NMR (DMSO-d6): 3.5 (t, 2H, propyl CHa).
30 A second compound weighing 1 g is the expected product, namely 6-[(2'-cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-propyl-3-mercapto-1,2,4-triazolo[4,3-a]pyri-midine.
Melting point: 180°C.
35 1H NMR (DMSO-d6): 2.5 (m, propyl CH2 + DMSO-~) ;7 n ~.. ~ ;W J ~? ~ '_) d6).
The third product weicJhing 6.2 g is the star-ting hydrazino compound 20 c).
05 Example 26: 6-[{2'-Cyanobiphenyl-4-yl)methyl]-3,5-dihydroxy-7-propyl--1,2,4-triazolo[4,3-a]-pyrimidine Formula {V3Ia): R'1 = n-propyl, X = C-OH, Y = N, Ryo = OH, C (V
V = \
4.6 g of carbonyldiimidazole are added to a mixture of 10 g of the compound prepared in Example 20 c) and 500 ml of.THF, heated to 50°C. The whole is refluxed for 7 h and concentrated under vacuum. The concentrate is taken up in water and extracted three times with chloroform. Evaporation of the solvent gives 12.4 g of amorphous crystals, which are purified by chromatography on silica gel (eluent: CHC13 95o/MeOH
5%) .
A first compound weighing 3.1 g is isolated and identified as 6-[(2'-cyanobiphenyl-4-yl)methyl]-3,7-dihydroxy-5-propyl-1,2,4-triazolo[4,3-a]pyrimidine:
This constitutes the product of Example 26 bis.
Melting point: 228°C.
'-H NMR (DMSO-ds): 3 (t, 2H, propyl CHa).
The second compound weighing 3.8 g is the expected product, namely 6-[(2'-cyanobiphenyl-4-yl)-methyl]-3,5-dihydroxy-7-propyl-1,2,4-triazolo[4,3-a]-pyrimidine.

c~ ~~
- 61 - ~r~~.~i3~' i ~.) Melting point: 210°C.
1H NMR (DMSO-d6): 2.4 (t, 2H, propyl CHZ).
Using one of the methods described in Examples 05 19 or 23 (method B or method E.), the appropriate amino-triazoles are reacted with the ~-ketoesters prepared in Examples 5 to 15 to give the following compounds of Examples 27 to 43.
Example 27: 6°[(2'-Cyanobiphenyl°4-yl)methyl]-5-hydroxy-2-methyl-7-propyl-1,2,4-triazolo-[1,5-a]pyrimidine Formula (VIIb): R'1 = n-propyl, X = N, Y = C-CHI, R1o = OH, CN
V- \
Crystallization from methanol. The mother liquors are purified by chromatography on silica gel (eluent: CHC13 95%/MeOH 5%).
Melting point: 218-220°C.
A second compound is isolated and identified as 6-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxy-2-methyl-5-propyl-1,2,4-triazolo[1,5-a]pyrimidine. This consti-tutes the product of Example 27 bis.
Formula (VIIa): R'1 = n-propyl, X = N, Y = C-CH3, R1o = OH, NC
V =

-, _>,-,"~n~
' ~ ~ .',, ~ O ~ ~3 Melting point: 204-206pC.
Example 28: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-2-ethyl 5-hydroxy-7-propy:L-1,2,4-triazolo[1,5-a]
05 pyrimidine Formula (VIIb): R'1 = n-propyl, X = I3, Y = C-CH2CH3, R1o = OH, v =
Crystallization from methanol. The mother liquors are purified by chromatography on silica gel (eluent: CHC13 95%/MeOH 5%).
Melting point: 216~C.
A second compound is isolated and identified as 6-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethyl-7-hydroxy-5-propyl-1,2,4-triazolo[1,5-a]pyrimidine. This consti-tutes the product of Example 28 bis.
Formula (vIIa): R'1 = n-propyl, X = N, Y = C-CH2CH3, R1o = OH, NC /
v=
Melting point: 186'C.

F., ~" ;;, i~ .: ~ s ) Example 29: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-7-n-butyl-5-hydroxy-1,2,4-triazolo[1,5-a]pyri-midine 05 Formula (VIIb): R'1 = n-butyl, X = N, Y = CH, R1o = OH, NC
V
Purified by recrystallization from n-butanol.
Melting point: 210°C.
Example 30: 2-Amino-6-[(2'-cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-propyl-1,2,4-triazolo[1,5-a]-pyrimidine Formula (VIIb): R'1 = n-propyl, X = N, Y = C-NHm Ra.o = OH, NC
V =
Crystallization from a methanol/chloroform mixture.
Purification of the mother liquors by chromato graphy on silica gel (eluent: CHC13 90%/MeOH 200).
Melting point: 260~C.
A second compound is isolated and identified as 2-amino-6-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxy-5-propyl-1,2,4-triazolo[1,5-a]pyrimidine. This consti-:~ c~ ~ r~ r~
~~ ~ Fn U a a tutes the product of Example 30 bis.
Formula (VIIa): R'1 = n-propyl, X = N, Y = C-NH2, R1o = OH, NC
V =
Melting point: 325-330~C.
Example 31: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-5 hydroxy-2-methylthio-7-propyl-1,2,4 triazolo[1,5-a]pyrimidine Formula (VIIb): R'1 = n-propyl, X = N, Y = C-SCH3, Rio = OH, V = \
Purification by chromatography on silica gel (eluent: CHCl~ 95%/MeOH 5%):
Crystallization from isopropyl acetate, Melting point: 182°C.
Example 32: 6-[4-(3-Cyano-2-thienyl)benzyl]-5-hydroxy-7-propyl-1,2,4-triazoio[1,5-a]pyrimidine Formula (VIIb): R'1 = n-propyl, X = N, Y = CH, R1o = OH, c1 a ~ n ry ~~ ~ ~.,r v) i..) k ~_i NC
V =

Crystallization from chloroform/water. Puri-fication by recrystallization from 2-methoxyethanol.
Melting point: 246~C.
Example 33: 6-[4-(3-Cyano-2-pyridyi)benzyl]-5-hydroxy-7-propyl-1,2,4-triazolo(1,5-a]pyrimidine Formula (VIIb): R'1 = n-propyl, X = N, Y = CH, R1o = OH, N
V =
NC
Crystallization from methanol. The mother liquors are purified by chromatography on silica gel (eluent: CHzGl2 97.5%/MeOH 2.5%). The whole is puri-fied by recrystallization from methanol.
Melting point: 212~C.
Example 34: 6-[4-(3-Cyano-2-thienyl)benzyl]-5-hydroxy-2-methyl-7-propyl-1,2,4-triazolo[1,5-a]-pyrimidine Formula (VIIb): R'1 = n-propyl, X = N, Y = C-CH3, Rio = OH, NC / _ S
V =

~
; .~ :, ~ C1 r) P
f~ z r,~ trl i;S ( :,.

Crystallization from a water/chloroform mix-ture. Purification by recrystallization from 2-meth-oxyethanol.
Melting point: 277°C.

Example 35: 6-(4-(3-Cyano-2-furyl)benzyl]-5-hydroxy-7-propyl-1,2,4-triazolo(1,5-a]pyrimidine Formula (VIIb): R'~ = n-propyl, X = N, Y = CH, R1o = OH, N C.
V =
Melting point: 256°C.
Example 36: 7-Butyl-6-[(2'-cyanobiphenyl-4-yl)methyl]
5-hydroxy-2-methyl-1,2,4-triazolo[1,5-a]
pyrimidine Formula (VIIb): R'1 = n-butyl, X = N, Y = C-CH3, Rzo = OH, V =
Purified by recrystallization from n-butanal.
Melting point: 230°C.

' c i n ~ ri :, F.e _~. fen s.i s. ~ 1 ~_."

Example 37 : 6-[ ( 2'-Cyanobiphenyl-4--yl )methyl ]-5-hydroxy-2-hydroxymethyl-1,2,4-triazolo[1,5-a]pyrimidine 05 Formula (VIIb): R'1 = n-propyl, X = N, Y = C-CH20H, R1o = OH, NC
V =
Purification by chromatography on silica gel (eluent: CHC13 95%/MeOH 5%).
Melting point: 214°C.
Example 38: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-methoxymethyl-1,2,4-triazolo[1,5-a]pyrimidine Formula (VIIb): R'~ _ -CH2-OCH3, X = N, Y = CH, R1o = OH, NC
= w Purified by chromatography on silica gel (eluent: chloroform 95%/methanol 5%).
Melting point: 188°C.
A second compound is isolated and identified as 6-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxy-5-methoxy-methyl-1,2,4-triazolo[1,5-a]pyrimidine. This consti-Lutes the product of Example 38 bis.

~d~Yd'V~u3L

formula (VIIa): R'.~ _ -CHI-OCH3, X = N, Y = CH, R1o = OH, PEI C

V =
Melting point: 240'C.
Example 39: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-methyl-1,2,4-triazolo-[1,5-a]pyrimidine Formula (VIIb): R'1 = CH3, X = N, Y = CH, NC
R1o = OH, V =
The product is purified by chromatography on silica gel (eluent: CHC13 95%/MeOH 50) and crystallized from methanol.
Melting point: 212'C.
second compound is isolated and identified as 6-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxy-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine: This constitutes the product of Example 39 bis.
Formula (VIIa): R'1 = CH3, X = N, Y = CH, N~
R1o = OH, V =

-1..~ ~. f~r iJ l~ i '_S
Melting point: 252'C.
Example 40: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-7-ethyl-5-hydroxy-1,2,4-triazolo[1,5-a]pyrimidine Formula (VIIb): R'1 = ethyl, X = N, Y = CH, NC /
R1o = OH, V =
Isolated by chromatography on silica gel (eluent: CHC13 95%/MeOH 5%) and purified by recrystal-lization from n-butanol.
Melting point: 224~C.
A second compound is isolated and identified as 6-[(2'-cyanobiphenyl-4-yl)methyl]-5-ethyl-7-hydroxy 1,2,4-triazolo[1,5-a]pyrimidine. This constitutes the product of Example 40 bis.
Formula (VIIa): R'y = -CHZ-CH3, X = N, Y = CH, R1o = OH, , IVC
V = ~
Melting point: 234'C.

ff ~ ~ i~ ~) t .. .. . ~., r.n 'L.~ l f ~ i f Example 41: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-2-N,N-diethylamino-5-hydroxy-7-propyl-1,2,4-tri-azolo[1,5-a]pyrimid:ine 05 Formula (VIIb): R'1 = n-propyl, X = N, Y = C-N~ . R1o = OH, NC
V =
The product is crystallized from methanol.
Melting point: 220°C.
A second compound is isolated in the form of amorphous crystals after chromatography of the mother liquors on silica gel (eluent: CHC13 80%/isopropylamine 20~). It is identified as 6-[(2'-cyanobiphenyl-4-yl)methyl]-2-N,N-diethylamino-7-hydroxy-5-propyl-1,2,4-triazolo[1,5-a]pyrimidine. This constitutes the com-pound of Example 41 bis.
Formula (VIIa): R'1 = n-propyl, X = N, Y = C-N , R1o = OH, NC
v=

c~ ~ -; ~ r1 i~.,I ~ Fd t~ SJ A ~~J

Example 42: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-5,7-dipropyl-i,2,4-triazolo[1,5-a]pyrimidine Formula (VIIa): R'1 = n-propyl, X = N, 05 Y = CH, R1o = n-propyl, /
V =
Product purified by chromatography on silica gel (eluent: chloroform 95%/methanol 5%).
Melting point: 160'C.
Example 43: 7-Benzyloxymethyl-6-[(2'-cyanobiphenyl-4-yl)methyl]-5-hydroxy-1,2,4-triazolo[1,5-a]-pyrimidine Formula (VIIb) : R', _ '~/-(2 Q-C
X = N, Y = CH, R1o = OH, N(i V= ~ I
Purified by recrystallization from butanol followed by chromatography on silica gel (eluent:
chloroform 95o/methanol 50).
Melting point: 218'C.
A second compound is isolated and identified as 5-benzyloxymethyl-6-[(2'-cyanobiphenyl-4-yl)methyl]-7-i a c1 ~~'~ :? t~) "
- ~2 - ~~.s~J~~ . ?7 hydroxy-1,2,4-triazolo[1,5-a]pyrimidine. This consti-tutes the product of Example 43 bis.
05 Formula (VIIa) : R'1 = -~~2-Q-C1-!2 ~ ~ , X = N, Y = CH, R1o = OH, NC
V =
Melting point: 260°C.
Example 44: 5-Chloro-6-[(2'-cyanobiphenyl-4-yl)methyl]-7-propyl-1,2,4-t.riazolo[1,5-a~pyrimidine Formula (VIIIb): R'1 = n-propyl, X = N, NC
Y = CH, V
25.9 g of the compound prepared in Example 19 or 23 are added in portions to 260 ml of POC13. The mixture is refluxed for 4 h. It is concentrated under vacuum, the concentrate is taken up in 200 ml of chlo-roform stabilized with amylene, and a solution of water and ice is then added. After decantation, the aqueous phase is extracted with chloroform and the organic phases are combined. After washing with water and drying, they are concentrated under vacuum to give a thick oil. The product is crystallized from isopropyl cl ~) >-) rl n l.~ (,~ ;j ~! ~ 1 i acetate to give 21 g of 5-chloro-6-[~2'-cyanobiphenyl-4-yl)methyl]-7-propyl-1,2,4-triazolo[1,5-a]pyrimidine.
Melting point: 138°C.
05 The derivative of Example 45 is obtained by the procedure of Example 44 using the derivative prepared in Example 18.
Example 45: 7-Chloro-6-[(2'-cyanobiphenyl-4-yl)methyl]-5-propyl-1,2,4-triazolo[1,5-a]pyrimidine Formula (VIIIa): R'1 = n-propyl, X = N, NC
Y = CH, V = \
Melting point: 132°C.
Example 46: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-7-mercapto-5-propyl-1,2,4-triazolo[1,5-a]-pyrimidine Formula (IX): RZ = n-propyl, X = N, Y = CH, NC
R 1 = SH I V = \
V
A mixture of 5 g of the chlorinated compound obtained in Example 45, 2 g of thiourea and 150 ml of ethanol is refluxed for 7 h and concentrated under vacuum. The yellow solid is taken up in 60 ml of a 0.5 E f 43 :7 n n <~~;~JCJ~'t3 _ 74 _ N solution of NaOH. The small amount of insoluble material is filtered off. The filtrate is acidified with acetic acid. The yellow precipitate is filtered off and purified by chromatography on silica gel 05 (eluent: chloroform 90%/metha:nol 10%) to give 3.4 g of 6-[(2'-cyanobiphenyl-4-yl)methyl]-7-mercapto-5-propyl-1,2,4-triazolo[1,5-a]pyrimidine.
Melting point: 200-205°C.
Example 47: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-5-mer-capto-7-propyl-1,2,4-triazolo[1,5-a]pyri-midine Formula (IX): R1 = n-propyl, X = N, Y = CH, NC
R2 = SH, V = ~
A mixture of 11.1 g of the derivative prepared in Example 19 or Example 23, 350 ml of toluene and 13.4 g of Lawesson's reagent is refluxed for 2 h. The yellow solid obtained is filtered off. Purification by chromatography on silica gel (eluent: CH2C12 90%/
acetone 10%) gives 10 g of 6-[(2'-cyanobiphenyl-4-yl)-methyl]-5-mercapto-7-propyl-1,2,4-triazolo[1,5-a]pyri-midine.
Melting point: 226°C.
Example 48: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-7-propyl 1,2,4-triazolo[1,5-a]pyrimidine Formula (IX): R1 = n-propyl, X = N, Y = CH, :~ rn r-~ .
s~ ' i 7 - ,~ 5 - l.~ .f~ i,~ i1 U i :~
NC
RZ = H~ V = \

A solution of 5.4 g of the compound prepared in Example 44 in 110 ml of 2-methoxyethanol containing 1.2 g of anhydrous sodium acetate is hydrogenated at atmospheric pressure and room temperature in the pre-sence of 1.4 g of 5% Pd-on-charcoal. The system is purged with nitrogen. The catalyst is filtered off on Celite 545 and washed with hot 2-methoxyethanol. The filtrate is concentrated and the crystals obtained are taken up in ether to give 3.7 g of crude product.
Purification by chromatography on silica gel (eluent:
dichloromethane 90%/acetone 10%) gives 2.5 g of white crystals of 6-[(2'-cyanobiphenyl-4-yl)methyl]-7-propyl-1,2,4-triazolo[1,5-a]pyrimidine.
Melting point: 180'C.
Example 49: 6-j(2'-Cyanobiphenyl-4-yl)methyl]-5-meth-oxy-7-propyl-1,2,x-triazolojl,5-a]pyrimi-dine Formula (IX): R1 = n-propyl, X = N, Y = CH, NC
R2 = OCH3, V =
A solution of sodium methylate, prepared from 0.8 g of sodium and 25 ml of methanol, is added to a solution of 11.6 g of the compound of Example 44 in 120 ml of 1,2-dimethoxyethane. The mixture is stirred at - 6~~.:J~.j~ iv room temperature for 3 h. The insoluble material is filtered off and the filtrate is concentrated. The crystals obtained are taken up in water, filtered off and washed firstly with water and then with isopropyl 05 alcohol and ether to give 9.5 g of 6-[(2'-cyanobi-phenyl-4-yl~methyl]-5-methoxy-7-propyl-1,2,4-triazolo-[1,5-a]pyrimidine.
Melting point: 166°C.
Example 50: Ethyl [6-[(2'-cyanobiphenyl-4-yl)methyl]-7-propyl-1,2,4-triazolo[1,5-a]pyrimidin-5-yl]mercaptoacetate Formula (TX): R1 = n-propyl, X = N, Y = CH, I5 R~ _ -S-CH2-COOCH2-CH3, NC ' 0.6 g of 60% NaH is added in portions to a solution of 1.8 g of ethyl mercaptoacetate in 50 ml of toluene. The mixture is maintained at a temperature of 40° for ~ h and then cooled to room temperature. A
solution of 5 g of the compound prepared in Example 44 in 50 ml of anhydrous toluene is then introduced. The reaction is left to proceed at room temperature for 3 h and then at 50 ° C for 4 h. A second equivalent of the sodium salt of ethyl mercaptoacetate, prepared as above, is added to complete the reaction. After hydro-lysis and decantation, the organic phase is washed with water and then with a dilute solution of acetic acid, dried and concentrated. The oil obtained is purified by chromatography on silica gel (eluent: dichloro-~~ W ,~ t) i 1 ~ ) methane 90%/acetone 10%) to give 5.4 g of ethyl [6-[(2'-cyanobiphenyl-4-yl)methyl]-7-propyl-1,2,4-triazo-l0[1,5-a]pyrimidin-5-yl]mercaptoacetate.
Melting point: 76°C.

The compound of Example 51 is obtained by the procedure of Example 50 using 2-methoxyethanol instead of ethyl mercaptoacetate.
Example 51: [6-((2'-Cyanobiphenyl-4-yl)methyl~-7-propyl-1,2,4-triazolo(1,5-a~pyrima.din-5-yl] 2-methoxyethyl ether Formula (IX): Ry = n-propyl, X = N, Y = CH, R2 = -0-CH2-CH2-OCH3, NC
v=
Product crystallized from isopropyl ether.
Melting point: 102°C.
Example 52: 5-Amino-6-[(2'-cyanobiphenyl-4-yl)methyl]-7-propyl-1,2,4-triazolo[1,5-a~pyrimidine Formula (IX): R1 = n-propyl, X = N, Y = CH, N C
R2 = NH2~ V =
A mixture of 10 g of the derivative prepared in S~ , c'~ ; ~ ( 1 Y~~ ~, - ~~ ~ f. i' l5 E ~
Example 44 and 200 ml of a soluton of 1,2-dimethoxy-ethane saturated with ammonia is placed in an auto-clave. It is heated at 125°C for 24 h and taken up in a chloroform/water mixture. After decantation, the 05 aqueous phase is extracted. The organic phases are combined, dried and concentrated to give 8.1 g of 5-amino-6-[(2'-cyanobiphenyl-4-yl)methyl]-7-propyl-1,2,4-triazolo[1,5-a]pyrimidine.
Melting point: 206°C.
Example 53: 6-[(2'-Cyanobiphenyl-4-yl)anethyl]-7-N,N-diethylamino-5-propyl-1,2,4-triazolo-[ ~. , 5-a ] pyrimidine Formula (IX): R2 = n-propyl, X = N, Y = CH, NC

~ , R1 = N ~ = W

A mixture of 5 g of the chlorinated derivative of Example 45, 100 ml of ethanol, 16 ml of diethylamine and 2.5 g of sodium carbonate is refluxed far 4 h. It is concentrated under vacuum and the thick oil is taken up in water. It is extracted three times with dichlo-romethane and the extracts are dried and concentrated.
The compound obtained is purified by chromatography on silica gel (eluent: chloroform 95%/methanol 5%) to give 5 g of 6-[(2~-cyanobiphenyl-4-yl)methyl]-7-N,N-diethyl-amino-5-propyl-1,2,4-triazolo[1,5-a]pyrimidine in the form of an orange oil.
The following compounds of Examples 54 to 58 are obtained by reacting one of the derivatives des--., a. ~; F, :, ~~~ r~
~~r;~U~~
cribed in Examples 44 or 45 with appropriate amines by either one of the two methods described in Examples 52 and 53.
05 Example 54: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-5-N,N-diethylamino-7-propyl-1,2,4-triazolo-[1,5-a]pyrimidine Formula (IX): R1 = n-propyl, X = N, Y = CH, 1s CH2-CH3 NC ,' R2 = N V = \

Product crystallized from hot isopropyl ether.
Melting point: 133~C.
Example 55: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-7-propyl 5-(pyrrolidin-1-yl)-1,2,4-triazolo[1,5-a]
pyrimidine Formula (IX): R1 = n-propyl, X = N, Y = CH, NC
R2 = -N~ , V =
Product crystallized from hot isopropyl ether.
Melting point: 166'C.

_' c, ~ ;f ;~ :, :~ .~
- 8 O - ~ ~ 1'd w LS ~ '_~
Example 56: 6-[(2~-Cyanobiphenyl-4-yl)methyl]-7-propyl-5-(morpholin-4-ylethylamino)-1,2,4-tri-azolo[1,5-a]pyrimidine OS Formula (IX): R1 = n-propyl, X = N, Y = CH, RZ = NH--CH2-CH2- p , NC
V= \
Oily product purified by chromatography on silica gel (eluent: chloroform 95o/methanol 5%).
Example 57: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-5-(pipe-ridin-1~yl)-7-propyl-1,2,4-~triazolo[1,5-a]-pyrimidine Formula (IX): R1 = n-propyl, X = I3, Y = CH, NC
RZ=_N~, v= ~ I
Compound purified by recrystallization from 2-methaxyethanol.
Melting point: 266°C.

y i ", (~' ~'1 7~ n - 81 y ~l ~ ~.'.~ <) ;'~ ~ '_) Example 58: 6-[(2"-Cyanobiphenyl-4-yl)methyl]-5-hydra-zino-7-propyl-1,2,4-triazolo[1,5-a]pyrimi-dine 05 Formula (IX): R1 = n-propyl, X = N, Y = CH, NG o R2 = NH-NH2, V =
Product crystallized from ether.
Melting point: 161'C.
Example 59: 5-Azido-6-[(2"-cyanobiphenyl-4-yl)methyl]-7-propyl-1,2,4-triazolo(1,5-a]pyrimidine Formula (IX): R1 = n-propyl, X = N, Y = CH, 2~ NG

R2 = N3. V = \
10.3 g of the compound prepared in Example 58, 2.3 ml of concentrated HCl and 300 ml of acetic acid are mixed. A solution of 1.9 g of NaN02 in 20 ml of water is added. The mixture is left overnight at room temperature. Water is added and the mixture is decan-ted and extracted with ethyl acetate. The organic phases are combined, washed with water, dried and evaporated. Purification by chromatography twice in succession (eluent: dichloromethane 95o/methanol 5% and dichloromethane 90o/methanol 10%) gives 4.3 g of 5-azido-6-[(2"-cyanobiphenyl-4-yl)methyl]-7-propyl-1,2,4-it .j :~ r1 W ~ n - 8 2 - i'~ .~. ~ .r t1 a i I_D
triazolo[1,5-a]pyrimidine.
Melting point: 134°C.
This same compound can be considered as a tri cyclic derivative according to the known equilibrium of 05 azides in the 2-position of nitrogen-containing rings (cf. Temple and Montgomery, J. Org. Chem., 30, 826 (1965)).
Example 60: 3-Amino-5-hydroxymethyl-1,2,4-triazole Formula (II): R~ _ -CH20H
A mixture of 136 g of aminoguanidine bicarbo-nate and 80 g of glycolic acid is heated gradually to 120°C. The reaction is continued for 5 h at this tem-perature. The mixture is taken up in 100 ml of ethanol and the solid is filtered off to give 45.7 g of 3-amino-5-hydroxymethyl-1,2,4-triazole.
Melting point: 192-194°C.
Example 61: 3-Amino-5-N,N-diethylamino-1,2,4-triazole Formula (II): R~ = N
10.3 ml of diethylamine are added to a solution of 16.1 g of dimethyl N-cyanodithioiminocarbonate in 160 ml of acetonitrile. The mixture is stirred for one hour at room temperature and then refluxed until no more methylmercaptan is evolved. The solution is cooled with an ice bath and 5 m1 of hydrazine hydrate are introduced. The mixture is refluxed for 4 h.
After distillation of the solvent, the product is taken up in acetonitrile to give 8.9 g of white crystals of - 8 3 - ~ ~ i7 L' s ~.) 3-amino-5-N,N-diethylamino-1,2,4-triazole.
Melting point: 134°C.
Example 62: 7-Hydroxy-5-propyl-6-[(2'-(1H-tetrazol-5 05 y1)biphenyl-4-yl)methyl)-1,2,4-triazolo [1,5-a]pyrimidine Formula (I): R1 = OH, R2 = n-propyl, X = N, N-NH
!J
N~ i Y = CH, R3 = N
A mixture of 7.8 g of the ,e-ketoester of Example 17, 1.7 g of 3-amino-1,2,4-triazole and 70 ml of 1,2,4-trichlorobenzene is heated at 120°C for 7 h.
The precipitate obtained is purified by chromatography on silica gel (eluent: CHaCl2 80%/ methanol 20%). The compound obtained is dissolved in a 1 N solution of NaOH, the insoluble material is filtered off and the clear solution is acidified by bubbling SOz to give 2.4 g of a white precipitate of 7-hydroxy-5-propyl-6 [(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-tri azolo[1,5-a]pyrimidine.
Empirical formula: CZZHZON8OØ5H20.
Melting point: 260-265°C with decomposition.
1H NMR (DMSO-d6): 2.6 (t, 2H, propyl CH2)~ 8.2 (s, 1H, H2).
UV (MeOH): as = 210 nm a6 = 250 nm.

i 7 ~~ :) /-.' J. Vd 'v L
_ 84 Example 63: 5-Hydroxy-7-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo-[1,5-a]pyrimidine OS Formula (I): R1 = n-propyl, RZ = OH, X = N, N-NH
N~
~N
Y = CH, R3 = \ I
~ mixture of 25 g of the compound obtained according to Example 19 or 23, 750 ml of xylene and 34.5 g of trimethyltin azide is refluxed for 50 h. The white precipitate obtained is filtered off. It melts at 290°C with decomposition. This compound is suspen-ded in 500 ml of THF. Gaseous hydrochloric acid is bubbled in for 30 min to give a total solution, which.
is then concentrated under vacuum. The concentrate is taken up in water and triturated. The gum obtained is crystallized from acetonitrile. Recrystallization from isopropanol gives 15.2 g of the expected derivative.
Melting point: 242°C.
The mother liquors are concentrated, the concentrate is rendered basic with a 1 N solution of KOH and extraction is carried out with chloroform, followed by neutralization with acetic acid. The precipitate obtained is recrystallized twice from isopropanol to give 4.5 g of a second crop of the compound 5-hydroxy-7-propyl-6-[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimidine.
Empirical formula: C22H2oN80.
Melting point: 242-244°C.
1H NMR (DMSO-d6): 2.91 (t, 2H, propyl CH2)1 8.11 (s, 1H, H2).
~. . .1. . ' , ... .,.. . ~~~, . ~ . ~~ .. , .. .
' . . :,. .. , ..: . . ~ " .. , :'. .~, : , .' :~n.;,~;~
8 5 _ o-s .A~. i,~ v) t! a :.) The following compounds of Examples 64 to 95 were prepared by one or other of the procedures des-cribed in Examples 62 and 63.
05 Example 64: 7-Hydroxy-2-methyl-5-propyl-6-[(2'-(iH-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimidine hemisulfate Formula (I): R1 = OH, R2 = n-propyl, X = N, N-N H
//
i ~N
Y = C_CH3. R3 =
Empirical formula: C23H22N8O~0.5HZS04.
Melting point: 236'-238'C.
1H NMR (DMSO-ds): 2.6 (t, 2H, propyl CHZ).
UV (MeOH): as = 212.1 nm ab = 250 nm.
Example 65: 5-Hydroxy-7-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo-[4,3-a]pyrimidine Formula (I): R1 = OH, R2 = n-propyl, X = CH, Y = N, N-NH
//
~~N' /
R3 =
Empirical formula: CZZH2oN80.
Melting point: 251'C.

!-FW. i~a V ~f f t~

1H NMR (DMSO-d6): 2.55 (t, 2H, propyl CH2);
9 (s, 1H, H3).
Example 66: 5-Propyl-7-mercapto-6-[(2'-(1H-tetrazol-5-05 yl)biphenyl-4-yl)methyl]-1,2,4-triazolo-[1,5-a]pyrimidine Formula (I): R1 = SH, R2 = n-propyl, X = N, N-~N f-4 N
~N /
Y = CH, R~ _ Empirical formula: C22H2oN$S.
Melting point: 288°C.
1H NMR (DMSO-d6): 2.59 (t, 2H, n-propyl CH2);
8.6 (s, 1H, H2).
Example 67: 5,7-Dimethyl-6-[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl)methyl]-1,2,4-triazolo-[1,5-a]pyrimidine Formula (I): R1 = CH3, R2 = CH3, X = N, N-NH
II
N~Ni /
Y = CH, R3 =
This compound was obtained by the procedure of Example 62 using the 2,4-dioxo-3-[(2'-(1H-tetrazol-5 yl)biphenyl-4-yl)methyl]pentane prepared in Example 16.
Empirical formula: C21H18N8.
Melting point: 264°C.

:\
y .t :~ ;
~~ ~ 'r.r U i1 '~
_ 87 1H NMR (BMSO-d6): 2.48 (s, 3H, CH3); 2.81 (s, 3H, CH3); 8.56 (s, 1H, H2).
Example 68: 2-Ethyl-7-hydroxy-5-propyl-6-[(2'-(1H-05 a tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4 triazolo[1,5-a]pyrimidine Formula (I): R1 = OH, R2 = n-propyl, X = N, Y = C-CH2-CHI, N-NH
N~
~N
R3 =
Empirical formula: C24H2,~N8O.
Melting point: 246°C.
1H NMR (DMSO-d6): 2.57 (m, 2H, propyl CH2 +
DMSO-ds).
Example 69: 7-N,N-Diethylamino-5-propyl-6-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo(1,5-a]pyrimidine 'CH2-CH3 Formula (I): R1 = N , ~CH2-CH3 R2 - n_proPYl. X = N. Y = CH.
N-NH
N//
aN
R3 = ~ I
Empirical formula: C25N29Ns~

:-~\
- ss - ~.~~L"'r~~ ' ,o Melting point: 192~C.
1H NMR (DMSO-d6): 2.65 (t, 2H, n-propyl CH2);
8.5 (s, 1H, H2).
05 Example 70: 5-Azido-7-propyl-6-((2'-(1H-tetrazol-5-yl)-biphenyl-4-yl)methyl]-1,2,4-triazolo-[1,5-a]pyrimidine Formula (I): R1 = n-propyl, Rte= N3, X = N, N-NH
n N~ ~ /
N
Y = CH, R3 =
Empirical formula: C22H19Na1~
Melting point: 212-213~C.
1H NMR (DMSO-ds): 3.17 (t, 2H, n-propyl CH2);
4.06 (s, 2H, benzyl CH2, azido/tetrazole equilibrium 10%); 4.47 (s, 2H, benzyl CHZ); 8.56 (s, 1H, H2, azido/
tetrazole equilibrium ~ 10%);
8.7 (s, 1H, Hue).
Example 71: 3,5-Dihydroxy-5-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yi)methyl]-1,2,4-triazolo-[4,3-a]pyrimidine Formula (I): R1 = n-propyl, R2 = OH, X = COH, Y = N, s a .t cy ;
F.r r.r U y~ , ~,a _ 89 _ N-N1~
N'~ ~
R3 = N

Empirical formula: C22H2oN802.
Melting point: 252'C.
1H NMR (DMSO-ds): 2.93 (t, 2H, n-propyl CHZ);
3.7 (s, 2H, benzyl CH2).
Example 72: 5-Hydroxy-2-methyl-7-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[4,3-a]pyrimidine Formula (I): R, = n-propyl, R2 = OH, X = N, N-NH
N
'N /
Y = C-CHsr R3 = ~
Empirical formula: C23H22N8O.
Melting point: 286°C.
~H NMR (DMSO-d6): 2.85 (t, 2H, n-propyl CH2);
3.84 (s, 2H, benzyl CH2).
- Example 73: 2-Ethyl-5-hydroxy-7-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[4,3-a]pyrimidine Formula (I): R1 = n-propyl, R2 = OH, X = N, Y = C-CH2CH3, c~ ~i ,.~ ~ ., ... o~ a. :~~ J ,J ~ :l Nr-NH
~N
R3 =

Empirical formula: C24H24N80.
Melting point: 260°C.
'-H NMR (DMSO-d6): 2.86 (t, 2H, n-propyl CH2);
3.85 (s, 2H, benzyl CHZ).
Example 74: 7-Butyl-5-hydroxy-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo-[1,5-a]pyrimidine Formula (I): R1 = n-butyl, RZ = OH, X = N, N-NH
~N
Y = CHI R~ _ ~ I
ZO
Empirical formula: Cz3H22Na0.
Melting point: 255°C.
1H NMR (DMSO-dg): 2.92 (t, 2H, n-propyl CHZ);
3.86 (s, 2H, benzyl CH2);
8.11 (s, 1H, H2).
Example 75: 2-,amino-5-hydroxy-7-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimidine Formula (I): R1 = n-propyl, Rz = OH, X = N, ;: :~ :, ;;~ r- ~
G.~ .~ i;. ~ .,~5 N-NH
//
N\ i N
Y = C-NH2, R3 =

Empirical formula: C22H21N90.
Melting point: 282°C.
1H NMR (DMSO-d6): 2.76 (t, 2H, n-propyl CH2):
3.8 (s, 2H, ben2yl CHz).
Example 76: 5-N,N-Diethylamino-7-propyl-6-[(2~-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo(1,5-a]pyrimidine Formula (I): R1 = n-propyl, ~CNZ-CH3 R? = N~ , x = N, Cw2-CH3 2p N-NH
N~ ~
Y CH, R3 N
Empirical formula: C26H29N9~
Melting point: 140°C, then 205°C.
1H NMR (DMSO-d6): 2.91 (t, ZH, propyl CH2);
4.07 (s, 2H, benzyl CH2);
8.32 (s, 1H, H2).
Example 77: 5-Amino-7-propyl-6-[(2'-{1H-tetrazol-5-yl)-biphenyl-4-yl)methyl]-1,2,4-triazolo-[1,5-a]pyrimidine Formula (I): R1 = n-propyl, R2 = -NH2, '~ .l :.. !1 ;~) P
~; ~ ., .~a ;y, '~ ~
_ 92 _ X = N, Y = CH, N-NH
It N~ ~
N
05 R _ Empirical formula: C22H21N~.
Melting point: 276~C.
1H NMR (DMSO-d6): 2.98 (t, 2H, propyl CH2) 4.03 (s, 2H, benzyl CH2)p 8.1 (s, 1H, HZ).
Example 78: 5-Hydroxy-2-mercaptomethyl-7-propyl-6-[(2°-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a)pyrimidine Formula (I): R1 = n-propyl, R2 = OH, X = N, N-NH
~N
Y = C-SCH3, R3 =
Empirical formula: C23Hz2N80S.
Melting point: 260°C.
xH NMR (DMSO-d6): 2.85 (t, 2H, n-propyl CH2);
3.84 (s, 2H, benzyl CH2).
Example 79: 5-Hydroxy-7-propyl-6-[4-[3-(1H-tetrazol-5-yl)-2-thienyl]benzyl]-1,2,4-triazolo-[1,5-a]pyrimidine Formula (I): R1 = n-propyl, R2 = OH, X = N, r,'.. .~ .sj ~ ~ ~ 7 Y = CH, R3 = N
05 N~~N~N H
Empirical formula: C2oH18N80S.
Melting point: 275~C.
1H NMR (DMSO-d6): 2.95 (t, 2H, n-propyl CH2);
3.91 (s, 2H, benzyl CHz);
8.12 (s, 1H, H2).
Example 80: 5-Hydroxy-7-propyl-6-[4-[3-(1H-tetrazol-5-yl)-2-pyridyl]benzyl]-1,2,x-triazolo-[1,5-a]pyrimidine Formula (I): R1 = n-propyl, Ra = OH, X = N, ,N
N.,N
Y = CH, R3 = ~ N
N~
H
Empirical formula: C21H19N90.
Melting point: 244'C.
1H NMR (DMSO-ds): 2.91 (t, 2H, n-propyl CHa);
3.89 (s, 2H, benzyl CH2);
8.11 (s, 1H, Ha with pyridine Ha).
- \s/

Example 81: 5-Hydroxy-2-methyl-7-propyl-6-[4-[3-(1H-tetrazol-5-yl)-2-thienyl]benzyl]-1,2,4-triazolo[1,5-a]pyrimidine 05 Formula (I): R1 = n-propyl, R2 = OH, X = N, S
Y = C-CH3, R3 =
N-NwN~NN
Empirical formula: CZiH2oN80S.
Melting point: 287°C.
1H NMR (DMSO-d6): 2.9 (t, 2H, n-propyl CH2);
3.89 (s, 2H, benzyl CH2).
Example 82: 7-Butyl-5-hydroxy-2-methyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimidine Formula (I): R1 = n-butyl, R2 = OH, X = N, N-NH
i~
NON ~ /
Y = C_CHsi Rs = .\
Empirical formula: CZQHZQN80.
Melting point: 275aC.
1H NMR (DMSO-ds): 2.87 (t, 2H, n-butyl CH2);
3.84 (s, 2H, benzyl CH2).

ii ~~ :~ fl ~J "'~ :~
- 95 ° ~~.'."~J~a ) Example 83: 5-Hydroxy-2-hydroxymethyl-7-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimidine 05 Formula (I): R1 = n-propyl, RZ = OH, X = N, N-NH
II
N~ ~
N
Y = C-CHZOH, R3 =
Empirical formula: C23HZZN802.
Melting point: 274°C.
1H NMR (DMSO-d6): 2.88 (t, 2H, n-propyl CH2):
3.86 (s, 2H, benzyl CH2).
Example 84: 5-Mercapto-7-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo-[1,5-a]pyrimidine Formula (I): R1 = n-propyl, R2 = SH, X = N, N-NH
NI
~N
Y = CH, R3 =
s Empirical formula: C22H2oN8S.
Melting point: 278°C.
1H NMR (DMSO-ds): 2.87 (t, 2H, n-propyl CH2);
3.37 (s, 2H, benzyl CH2)p 8.29 (s, 1H, H2).

Example 85: 5-Hydroxy-7-methoxymethyl-6-[(2'-(1H-tetrazol-5-yl)bip:henyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimidine 05 Formula (I): R1 = -CH2-O-CH3; R2 = OH, X = N, Y = CH, N--N H
N~
'N
R _ Empirical formula: C21Hs8N802~
Melting point: 264~C.
1H NMR (DMSO-ds): 3.91 (t, 2H, benzyl CH2);
4.79 (S, 2H, O-CHa); 8.12 (S, 1H, Ha).
Example 86: 7-Propyl-5-(pyrrolidin-1-yl)-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimidine Formula (I): R1 = n-propyl, R2 = °N~ , X = N, Y = CH, N-NH
Nl 'N
R3 =
Empirical formula: C26H2~N9.
Melting point: 280~C.
1H NMR (DMSO-ds): 2.94 (t, 2H, propyl CH2);

:t ,~ ;~ r~ p r) '~
r.~ ~;, ~ ;~, f ;o 4.22 (s, 2H, benzyl CH2);
8.18 (s, 1H, HZ).
Example 87: 5-Hydroxy-7-methyl-6-[(2'-(1H-tetrazol-5 05 yl)biphenyl-4-yl):~ethyl]-1,2,4-triazolo [1,5-a]pyrimidine Formula (I): R1 = -CHI, Ra = OH, X = N, to ~N-NH
N~ ~
N
Y = CH, R3 =
15 Empirical formula: C~oH16N80.
Melting point: 248°C.
1H NMR (DMSO-d6): 2.56 (s, 3H, CH3); 3.86 (s, 2H, benzyl CHI); 8.11 (s, 1H, Hz).
Example 88: 7-Ethyl-5-hydroxy-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo-[1,5-a]pyrimidine Formula (I): R1 = -CH2-CH3, RZ = OH, X = N, N-NH
~N
Y = CH, R3 = ~
Empirical formula: C21H~SNsO.
Melting point: 245°C.
1H NMR (DMSO-d6): 2.94 (q, 2H, ethyl CH2); 3.87 (s, 2H, benzyl CH2); 8.12 (s, f ~ W
gg _ 1H, H2).
Example 89: 2-N,N-Diethylamino-5-hydroxy-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-~.,2,4-05 triazolo[1,5-a]pyrimidine Formula (I): R1 = n°propyl, RZ = OH, X = N, ~CH2-CH3 Y - C~N~
1o CH2-CH3 N-NH
N
'N /
R3 =
Empirical formula: C26H29NgO.
Melting point: 207°C.
1H NMR (DMSO-ds): 2.79 (t, 2H, n-propyl CH2);
3.80 (s, 2H, benzyl CH2).
Example 90: 5-(Morpholin-4-ylethylamino)-7-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)-methyl]-1,2,4-triazolo[1,5-a]pyrimidine Formula (I): R1 = n-propyl, R2 = NH-CH2-CH2-N O , X = N, Y = CH, N-NH
ii N~ ~
R3 = N \

-'. , :.~:~~-~«
- is .~. i~ :j ;.' ! v.) Empirical formula: CleH32N1~0.
Melting point: 236°C.
'-H NMR (DMSO-d6): 2.99 (t, 2H, n°propyl CH2);
4.02 (s, 2H, benzyl CH2);
05 8.13 (s, 1H, Hs).
Example 91: 5,7-Dipropyl-6-[(2'-(1H-tetrazol-5-yl)bi-phenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]-pyrimidine Formula (I): R1 = n-propyl, RZ = n-propyl, X = N, Y = CH, N-NH
N~[~s Empirical formula: C?SHZ~Ne.
Melting point: 226°C.
1H NMR (DMSO-ds): 2.66 (t, 2H, n-propyl CHZ);
3.15 (t, 2H, n-propyl CH2);
4.14 (s, 2H, benzyl CHZ);
8.26 (s, 1H, HZ).
Example 92: 7-Propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimi-dine Formula (I): R1 = n-propyl, R2 = H, X = N, N-NH
N~
~N
Y = CH, R3 =

sz.; :?n~~!~
~,r ~. ~,~ C) _~ t '_a Empirical formula: C2.~H2oN8.
Melting point: 238~C.
1H NMR (DMSO-d6): 3.16 (t, 2H, n-propyl CH2);
4.21 (s, 2H, benzyl CHZ);
05 8.65 (s, 1H); 8.82 (s, 1H).
Example 93: 7-Benzyloxymethyl~-5-hydroxy-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimidine Formula ( z ) . R1 = CH2-O-CH2 ~ ~ , Ra = OH, X = N, Y = CH, 1s N-NH
~N
R3 =
Empirical formula: C2~H22N802°
Melting point: 270-5°C (decomposition).
1H NMR (DMSO-d6): 3.86 (s, 2H, benzyl CHZ};
4.62 (s, 2H, O-CHZ); 4.88 (s, 2H, O-CH2); 8.11 (s, 1H, H2).
Example 94: 5-(Pigeridin-1-yl)-7-propyl-6-[(2'-(1H°
tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimidine Formula (I): R~ = n-propyl, R2 = N
X = N, Y = CH, ~r i "~ U ;'? Y,1 1 N-NH
//
N..N i R3 =

Empirical formula: CZ,H2~N9.
Melting point: 266°C.
1H NMR (DMSO-d6): 2.88 (t, 2H, n-propyl CHZ);
4.09 (s, 2H, benzyl CH2);
8.35 (s, 1H, H2).
Example 95: [a-Propyl-6-[(2'-(1H-tetrazol-5-yl)bi-phenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]-pyrimidin-5-yl] 2-methoxyethyl ether Formula (I): R1 = n-propyl, RZ = O-CHa-CHZ-O-CH3~ X = Nr N-NH
//
2o N~N~ /
Y = CI-I, R3 =
Empirical formula: C25HZSI'IsOa~
Melting point: 224°C.
1H NMR (DMSO-ds): 3.14 (t, 2H, n-propyl CH2);
4.04 (s, 2H, benzyl CHa);
8.41 (s, 1H, H2).
Example 96: 5-Chloro-7-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo-[1,5-a]pyrimidine Formula (I): R1 = n-propyl, R2 = C1, X = N, - ~ ;1 ;, ,) rl ,~

[~i ° PJ H
a~
Y = CH, R3 = \

Obtained by diazotization of the derivative of Example 77 and treatment of the diazonium salt with cuprous chloride according to the classical Sandmeyer reaction.
Example 97: 6-[(2'-Aminocarbonylbiphenyl-4-yl)methyl]-5-hydroxy-7-propyl-1,2,4-triazolo[4,3-a]-pyrimidine Formula (I): R1 = n-propyl, R2 = OH, X = CH, Y = N, O
I I
R3 = H2N~C
2 g of the compound of Example 20 d) in 200 ml of 1 N NaOH are refluxed for 4 h. The mixture is con-centrated under vacuum and the concentrate is acidified with 200 ml of 1 N ~HC1. The crystals obtained are purified by recrystallization from 2-methoxyethanol to give 1.6 g of 6-[(2'-aminocarbonylbiphenyl-4-yl) methyl]-5-hydroxy-7-propyl-1,2,4-triazolo[4,3-a]pyrimi dine .
Empirical formula: C2ZH21N5O2' Melting point: 258°C.
1H NMR (DMSO-d6): 2.61 (t, 2H, n-propyl CH2):
3.9 (s, 2H, benzyl CHZ)p 9 (s. 1H. H3).

.~ i1 ~~, ~ r~ n F.: X ,,~ ~J :.~ t ~_~

Example 98: 6-[(2'-Carboxybiphe:nyl-4-yl)methyl]-5-hydroxy-7-propyl-1,2,4-triazolo[1,5-a]-pyrimidine 05 Formula (I): R~ = n-propyl, R2 = OH, X = N, Y = CH, COON
R3 =
A mixture of 9.4 g of the product obtained in Example 97, 200 ml of ethylene glycol and 20 ml of con-centrated NaOH is refluxed for 10 h. The ethylene glycol is distilled, 200 ml of water are added and the mixture is acidified with a solution of HC1. The crys-tals obtained are purified by recrystallization from 2--methoxyethanol to give 5.8 g of 6-[(2'-carboxybiphenyl-4-yl)methyl]-5-hydroxy-7-propyl-1,2,4-triazolo[1,5-a]-pyrimidine.
Empirical formula: C22HaoNa~a~
Melting point: 265°C.
1H NMR (DMSO-d6): 2.96 (t, 2H, n-propyl CH2);
3.92 (s, 2H, benzyl CH2);
8.12 (s, 1H, H2).
The compound of Example 99 was prepared by the procedure of Example 23.
Example 99: 6-[4-(5-Bromo-3-cyano-2-furyl)benzyl]-5-hydroxy-7-propyl-1.,2,4-triazolo[1,5-a]-pyrimidine Formula (VIIb): R'1 = n-propyl, X = N, ~~ ..3. i.~ vi 9 6 ~I

Y = CH, R1o = OH, NC
r\

Br Melting point: 262°C.
Example 100: 6-[(2'-Cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-hydroxymethyl-1,2,4-triazolo-[1,5-a]pyrimidine Formula (VIIb): R'1 = CH20H, X = N, Y = CH, R1o = OH, NC
V= ~
A solution of 9 g of the compounds prepared in Example 43 in 360 ml of acetic acid is reduced by cata-lytic hydrogenation in the presence of 1.8 g of 5%
palladium-on-charcoal. The reaction is carried out at atmospheric pressure and at 50°C. The catalyst is fil-tered off on Celite 545 and washed with acetic acid and the filtrate is concentrated and then purified by chromatography on silica gel (eluent: chloroform 95%J
methanol 5a) to give 4.5 g of the starting material arid 2.2 g of 6~-[(2'-cyanobiphenyl-4-yl)methyl]-5-hydroxy-7-hydroxymethyl-1,2,4-triazolo[1,5-a]pyrimidine.
Melting point: 262°C.
This same compound can also be obtained by reaction with BBr3 in chloroform.

isr I ;

The following derivatives of Examples 101 and 102 were prepared by the procedure of Example 63.
Example 101: 5-Hydroxy--7-hydroxymethyl-6-((2'-(1H-os tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4 triazolo(1,5-a]pyrimidine Formula (I): R1 = CH20H, R2 = OH, X = N, l0 N-N H
Il N
Y = CH, R3 = ~
15 Empirical formula: C2oH15N5O2.
Melting point: >360°C (decomposition).
1H NMR (DMSO-ds): 3.93 (s, 2H, benzyl CHZ);
4.82 (s, 2H, CH2-O); 8.06 (s, 1H, H2).
Example 102: 6-[4-[5-Bromo-3-(1H-tetrazol-5-yl)-2-furyl]benzyl]-5-hydroxy-7-propyl-1,2,4-triazolo[1,5-a]pyrimidine Formula (I): R~ = n-propyl, R2 = OH, X = N, Y = CH, N-N
N! t R3 =
Br ' Empirical formula: C2oHI~BrNg02.

.~ .t cp ~y r~ ' ' ' (.v ~ .a ~d A ta! V...' Melting point: >360~C.
~H NMR (DMSO-d6): 2.93 (t, 2H, n-propyl CH2);
3.92 (s, 2H, benzyl CH2); 6.9 (s, 1H, furan proton); 8.03 05 (s, 1H, H2).
PI3ARMACO'.LOGY
A ~ Study of the adrenal angiotensin II receptors I. Principle The affinity of the products of the Examples for the angiotensin II receptors is evaluated by the technique of displacing a radioligand specifically bound to rat adrenal angiotensin II receptors.
II. Procedure An aliquot of a rat adrenal gland homogenate incubates in the presence of a single concentration of ~125I]_SIAII (Sarl,Tyr4,Ilee-angiotensin II), which is an angiotensin II receptor antagonist, and two concen trations of competing agents (10-5 M, 10-~ M) for 60 min at 25~C.
The reaction is completed by the addition of a buffer, followed by rapid filtration through glasspaper filters. The non-specific binding is determined in the presence of angiotensin II.
III. Expression of the results The results are expressed, for the concentra-tions tested, as the percentage displacement of the radioligand specifically bound to the adrenal angio-tensin II receptors.
IV. Results ..~ v,~ l) (~,j 7~! '~ 1 Product of % displacement of the labeled ligand Example 62 65 52 Example 63 61 52 Example 65 63 47 Example 68 69 59 Example 69 69 19 Example 75 61 60 Example 76 63 28 Example 77 63 31 Example 79 58 26 Example 82 58 11 B ~ Measurement of the inhibition of the cell prolife ration induced b~ growth factors (example: Platelet Derived Growth Factor, or PDGF) in rat aorta smooth muscle cells I. Principle The inhibition of the cell proliferation induced by a growth factor (example: PDGF) is evaluated by measuring the incorporation of 3H-thymidine in rat aorta smooth muscle cells (VSMC).
II. Procedure The VSMC are cultivated at 37'C in 5% C02 until subconfluence is reached, and are then placed for 24 hours at rest in a serum-poor medium. They are subse-quently pretreated for one hour with the test molecule (10-4 bI) and then stimulated for 22 hours with a growth G.~ .~ :,. ,j ~?

factor (example: PDGF). 3H-Thymidine is incorporated during the last 4 hours. All these steps are performed at 37~C in 5% C02.
The reaction is terminated by sucking off the 05 reaction medium, detaching the cells and then filtering the lyzed cells through glassfiber filters.
III. Expression of the results The results are expressed as the percentage inhibition of the stimulation of incorporation of 3H-thymidine due to the action of the growth factor.
IV. Results Product % inhibition of the incorporation of of 3H-thymidine induced by PDGF

Example 100 TOXTCOLOGY
The products of the Examples described have an excellent tolerance after oral administration.
Their 50% lethal dose in rats was found to be greater than 300 mg/kg.
CONCLUSION
The products of the Examples described have a good affinity for the angiotensin II receptors. In this respect they may be used beneficially for the various pathological conditions in which angiotensin II
is involved, in particular for the treatment of arte-~\
- 109 - ! ~) ~ ~ .~ i,W~ :j rial hypertension and cardiac insufficiency, in dosages of 1 to 400 mg by oral administration and of 0.01 to 50 mg by intravenous administration, in one or more dosage units per day. Furthermore, some of the compounds also 05 have an antiproliferative activity and in this respect are of potential value in the treatment of prolifera-tive diseases such as atherosclerosis.

Claims (13)

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. A triazolopyrimidine derivative of general formula (I):
in which:
- one of the radicals R1 and R2 is - a lower alkyl radical having 1 to 6 carbon atoms:
- an ether radical of the formula -(CH2)p OR, in which p is an integer from 1 to 6 and R is a lower alkyl radical having 1 to 6 carbon atoms or a benzyl radical; or - an alcohol radical of the formula -(CH2)p OH, in which p is as defined above; and - the other radical R1 or R2 is - the hydrogen atom:
- a halogen atom;
- a lower alkyl radical having 1 to 6 carbon atoms; or - a radical selected from the group comprising the radicals N3, OR4, SR4, NR5R6 and NH(CH2)n-NR5R6, in which:
R4 is - the hydrogen atom:
- a lower alkyl radical having 1 to 6 carbon atoms or a C3-C7-cycloalkyl radical:
- a radical (CH2)m-COOR', m being an integer from 1 to 4 and R' being the hydrogen atom or a lower alkyl radical having 1 to 6 carbon atoms; or - a radical (CH2)m-O-R', m and R' being as defined above;

R5 and R6, which are identical or different, are - the hydrogen atom; or - a lower alkyl radical having 1 to 6 carbon atoms or a C3-C7-cycloalkyl radical; or R5 and R6, taken together with the nitrogen atom to which they are attached, form a heterocycle selected from morpholine, pyrrolidine or piperidine;
and n is an integer from 1 to 4;

- X and Y, which are different, are - in one case the nitrogen atom; and - in the other case a group C-R7, in which R
is - the hydrogen atom:

- a lower alkyl radical having 1 to 6 carbon atoms or a C3-C7-cycloalkyl radical;

- a radical (CH2)n,OH, in which n' is an integer from 0 to 4;

- a radical SR', R' being as defined above; or - a radical NR5R6, in which R5 and R6, which are identical or different, are the hydrogen atom, a lower alkyl radical having 1 to 6 carbon atoms or a C3-C7-cycloalkyl radical; and - R3 is a radical of the formula in which:

- Z is CH or N or Z' is S or O;
- R11 is the hydrogen atom or a halogen atom;
and - R12 is a tetrazole radical, CN, COOH or CONH2;
and its tautomeric forms and its addition salts.

2. A derivative according to claim 1 of general formula (I) given above in which:
- one of the radicals R1 and R2 is - a lower alkyl radical having 1 to 6 carbon atoms;
- an ether radical of the formula -(CH2)p OR, in which p is an integer from 1 to 6 and R is a lower alkyl radical having 1 to 6 carbon atoms or a benzyl radical; or - an alcohol radical of the formula -(CH2)p OH, in which p is as defined above; and - the other radical R1 or R2 is - the hydrogen atom;
- a halogen atom;
- a lower alkyl radical having 1 to 6 carbon atoms; or - a radical selected from the group comprising the radicals N3 , OR4 , SR4 , NR5R6, and NH(CH2)n-NR5R6, in which:
R4 is;
- the hydrogen atom; or - a radical -(CH2)m-O-R' in which m is an integer from 1 to 4 and R' is a lower alkyl radical having 1 to 6 carbon atoms;
R5 and R6, which are identical or different, are - the hydrogen atom; or - a lower alkyl radical having 1 to 6 carbon atoms; or R5 and R6, taken together with the nitrogen atom to which they are attached, form a heterocycle selected from morpholine, pyrrolidine or piperidine;
and n is an integer from 1 to 4;
- X and Y, which are different, are - in one case the nitrogen atom; and - in the other case a group C-R7 in which R7 is - the hydrogen atom;
- a lower alkyl radical having 1 to 6 carbon atoms;
- a radical (CH2)n'OH, in which n' is an integer from 0 to 4;
- a radical SR', R' being as defined above; or - a radical NR5R6 in which R5 and R6, which are identical or different, are the hydrogen atom or a lower alkyl radical having 1 to 6 carbon atoms; and - R3 is one of the following radicals:

3. A derivative according to claim 1 or claim 2 wherein R1 is an n-propyl, n-butyl or N-diethylamino group.

4. A derivative according to any one of claims 1 to 3 wherein R2 is a hydroxyl, n-propyl or N-diethyl-amino group.

5. A derivative according to any one of claims 1 to 4 wherein R3 is a 2-(1H-tetrazol-5-yl)phenyl group.

6. A derivative according to any one of claims 1 to 5 wherein X is the nitrogen atom.

7. A derivative according to any one of claims 1 to 6 wherein Y is the group CH, C-CH3 or C-NH2.

8. A derivative according to claim 1 or claim 2 wherein R1 is a lower alkyl radical having 1 to 6 carbon atoms, R2 is a hydroxyl group, R3 is a 2-(1H-tetrazol-5-yl)phenyl group, X is the nitrogen atom and Y is the group CH or C-CH3.

9. A derivative according to claim 1 or claim 2 which is the derivative 5-hydroxy-7-propyl-6-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,4-triazolo[1,5-a]pyrimidine:

10. A derivative according to claim 1 or claim 2 which is selected from the derivatives of the formulae

11. A method of preparing the compounds of formula (I) according to any one of claims 1 to 10, which comprises:
a) preparing a compound of formula (.alpha.):
in which:
- X, Y and R3 are as defined in claim 1; and - A and B are in one case a hydroxyl group or a lower alkyl radical having 1 to s carbon atoms and in the other case a lower alkyl radical having 1 to 6 carbon atoms or an ether radical of the formula -(CH2)p OR, in which p is an integer from 1 to 6 and R is a lower alkyl radical having 1 to 6 carbon atoms or a benzyl radical, by condensing a 3-amino-1,2,4-triazole of formula (II):

in which R7 is as defined in claim 1, with a derivative of formula (.beta.):
in which R1 is a lower alkyl radical having 1 to 6 carbon atoms or an ether radical of the formula -(CH2)p OR, in which p is an integer from 1 to 6 and R is a lower alkyl radical having 1 to 6 carbon atoms on a benzyl radical, R8 is a lower alkyl radical having 1 to 6 carbon atoms or lower O-alkyl group having 1 to 6 carbon atoms, and R3 is as defined in claim 1, in a solvent selected from the group consisting of an aprotic solvent, an acid solvent, an alcohol in the presence of the corresponding sodium or potassium alcoholate, and pyridine or 2-methyl-5-ethylpyridine in the presence or absence of 4-dimethylaminopyridine, at a temperature of between 50 and 200°C;
b) if appropriate, protecting the group carried by R3 using a method known per se;
c) heating the derivative thus obtained from the derivative of formula (.beta.), when said derivative is a ketoester, in an appropriate reagent to convert the hydroxyl group represented by A or B to a chlorine atom;

d) heating this chlorinated derivative in the presence of a nucleophile containing nitrogen, oxygen or sulfur, under reflux in an alcohol or in an autoclave at 100°C, in the presence or absence of a base, to give a derivative of formula (.alpha.) in which A and B have the same meanings as R1 and R2 respectively;

e) if appropriate, deprotecting the group carried by R3;
e1) converting this group to an acid group by hydrolysis, or e2) converting this group to a tetrazole group, in the case where this group is a nitrile, by reaction with a trialkyltin azide with heating in toluene or xylene, followed by a treatment with gaseous hydrochloric acid in tetrahydrofuran;

or e3) converting this group to an amide group, in the case where this group is a nitrile, by reaction with sulfuric acid, or by reaction with hydrogen peroxide, or by reaction with polyphosphuric acid; and f) if appropriate, converting the resulting derivative to an addition salt.

12. A pharmaceutical composition, with antagonistic activity towards angiotensin II receptors, for the treatment or prevention of cardiovascular diseases, and diseases of the arterial wall, said composition containing a pharmaceutically effective amount of at least one compound of formula (I) as defined in any one of claims 1 to 10, or one of its pharmaceutically acceptable addition salts, incorporated in a pharmaceutically acceptable excipient, vehicle or carrier.

13. A pharmaceutical composition, with antiproliferative activity, for the treatment or prevention of diseases of the arterial wall, said composition containing a pharmaceutically effective amount of at feast one compound of formula (I) as defined in any one of claims 1 to 10, or one of its pharmaceutically acceptable addition salts, incorporated in a pharmaceutically acceptable excipient, vehicle or carrier.