IT1263804B - Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista - Google Patents

Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista

Info

Publication number
IT1263804B
IT1263804B ITMI930100A ITMI930100A IT1263804B IT 1263804 B IT1263804 B IT 1263804B IT MI930100 A ITMI930100 A IT MI930100A IT MI930100 A ITMI930100 A IT MI930100A IT 1263804 B IT1263804 B IT 1263804B
Authority
IT
Italy
Prior art keywords
pyrimidinonic
antagonist
activated
nitrogen heterocycles
derivatives
Prior art date
Application number
ITMI930100A
Other languages
English (en)
Inventor
Aldo Salimbeni
Carlo Scolastico
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Priority to ITMI930100A priority Critical patent/IT1263804B/it
Publication of ITMI930100A0 publication Critical patent/ITMI930100A0/it
Priority to DE69404627T priority patent/DE69404627T2/de
Priority to ES94905660T priority patent/ES2105633T3/es
Priority to AU59693/94A priority patent/AU5969394A/en
Priority to PCT/EP1994/000139 priority patent/WO1994017067A1/en
Priority to EP94905660A priority patent/EP0680480B1/en
Publication of ITMI930100A1 publication Critical patent/ITMI930100A1/it
Application granted granted Critical
Publication of IT1263804B publication Critical patent/IT1263804B/it
Priority to US08/768,791 priority patent/US5804583A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Si descrivono derivati difenilmetilpiridazinionici fusi con anelli eterociclici azotati (preferibilmente pirimidinonici o pirimididionici eventualmente sostituiti) ad attività angiotensina II antagonista.
ITMI930100A 1993-01-22 1993-01-22 Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista IT1263804B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITMI930100A IT1263804B (it) 1993-01-22 1993-01-22 Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista
DE69404627T DE69404627T2 (de) 1993-01-22 1994-01-20 Pyrimidon-derivate, die an einem stickstoff-enthaltenden heterocyclus kondensiert sind und ihre verwendung als angiotensin ii antagonisten
ES94905660T ES2105633T3 (es) 1993-01-22 1994-01-20 Derivados de pirimidinona condensada a heterociclos nitrogenados con actividad antagonista de a ii.
AU59693/94A AU5969394A (en) 1993-01-22 1994-01-20 Pyrimidinone derivatives fused to nitrogen heterocycles having a ii antagonistic activity
PCT/EP1994/000139 WO1994017067A1 (en) 1993-01-22 1994-01-20 Pyrimidinone derivatives fused to nitrogen heterocycles having a ii antagonistic activity
EP94905660A EP0680480B1 (en) 1993-01-22 1994-01-20 Pyrimidinone derivatives fused to nitrogen heterocycles having a ii antagonistic activity
US08/768,791 US5804583A (en) 1993-01-22 1996-12-18 Pyrimidinone derivatives fused to nitrogen heterocycles having a II antagonistic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI930100A IT1263804B (it) 1993-01-22 1993-01-22 Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista

Publications (3)

Publication Number Publication Date
ITMI930100A0 ITMI930100A0 (it) 1993-01-22
ITMI930100A1 ITMI930100A1 (it) 1994-07-22
IT1263804B true IT1263804B (it) 1996-09-03

Family

ID=11364728

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI930100A IT1263804B (it) 1993-01-22 1993-01-22 Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista

Country Status (7)

Country Link
US (1) US5804583A (it)
EP (1) EP0680480B1 (it)
AU (1) AU5969394A (it)
DE (1) DE69404627T2 (it)
ES (1) ES2105633T3 (it)
IT (1) IT1263804B (it)
WO (1) WO1994017067A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10050661A1 (de) 2000-10-13 2002-04-18 Gruenenthal Gmbh Substituierte 3,4-Dihydro-pyrimido[1,2-a]pyrimidine und 3,4-Dihydro-pyrazino[1,2-a]pyrimidine
CA2724008A1 (en) * 2008-01-11 2009-09-11 Prasada Rao V.S. Lingam Fused pyrimidine derivatives as trpv3 modulators
US8119647B2 (en) * 2008-04-23 2012-02-21 Glenmark Pharmaceuticals S.A. Fused pyrimidineone compounds as TRPV3 modulators
JP4892649B1 (ja) 2009-01-30 2012-03-07 武田薬品工業株式会社 縮合環化合物及びその用途
MY161870A (en) * 2009-10-16 2017-05-15 Melinta Therapeutics Inc Antimicrobial compounds and methods of making and using the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
CA2020073A1 (en) * 1989-07-03 1991-01-04 Eric E. Allen Substituted quinazolinones as angiotensin ii antagonists
EP0435827A3 (en) * 1989-12-28 1991-11-13 Ciba-Geigy Ag Diaza compounds
WO1991015209A1 (en) * 1990-03-30 1991-10-17 Merck & Co., Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines
US5250521A (en) * 1990-12-07 1993-10-05 Merck & Co., Inc. Substituted pyrazolopyrimidines as angiotensin II antagonists
FR2678618B1 (fr) * 1991-07-05 1993-11-05 Upsa Laboratoires Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
FR2687677B1 (fr) * 1992-02-24 1996-10-11 Union Pharma Scient Appl Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii ; leurs procedes de preparation, compositions pharmaceutiques les contenant.
FR2687676B1 (fr) * 1992-02-24 1994-07-08 Union Pharma Scient Appl Nouveaux derives de polyazaindenes antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5387747A (en) * 1992-02-24 1995-02-07 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present

Also Published As

Publication number Publication date
ITMI930100A1 (it) 1994-07-22
EP0680480B1 (en) 1997-07-30
DE69404627D1 (de) 1997-09-04
WO1994017067A1 (en) 1994-08-04
ITMI930100A0 (it) 1993-01-22
AU5969394A (en) 1994-08-15
US5804583A (en) 1998-09-08
ES2105633T3 (es) 1997-10-16
EP0680480A1 (en) 1995-11-08
DE69404627T2 (de) 1998-01-22

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960130