TR200201503T2 - Heterosiklik türevler. - Google Patents

Heterosiklik türevler.

Info

Publication number
TR200201503T2
TR200201503T2 TR2002/01503T TR200201503T TR200201503T2 TR 200201503 T2 TR200201503 T2 TR 200201503T2 TR 2002/01503 T TR2002/01503 T TR 2002/01503T TR 200201503 T TR200201503 T TR 200201503T TR 200201503 T2 TR200201503 T2 TR 200201503T2
Authority
TR
Turkey
Prior art keywords
heterocyclic derivatives
antagonize
enantiomer
pyrrolidinyl
solvate
Prior art date
Application number
TR2002/01503T
Other languages
English (en)
Inventor
Orlandi Alessandra
Original Assignee
Glaxo Wellcome Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa
Publication of TR200201503T2 publication Critical patent/TR200201503T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)

Abstract

Bu bulus,7-kloro-4(2-okso-1-fenil-3-pirrolidinilden)-1,2,3,4 tetrahidro-2- kuinolin karboksilik asit A enantiomerinin yeni bir tuzu veya bir solvatiyla, hazirlanma prosesleriyle, bunlari içeren farmasötik terkiplerle ve terapide, özellikle NMDA reseptör kompleksi üzerinde uyarici amino asitlerin etkilerini antagonize etmek üzere bir ilaç olarak kullanimiyla ilgilidir.
TR2002/01503T 1999-12-08 2000-12-07 Heterosiklik türevler. TR200201503T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9929037.1A GB9929037D0 (en) 1999-12-08 1999-12-08 Heterocyclic derivatives

Publications (1)

Publication Number Publication Date
TR200201503T2 true TR200201503T2 (tr) 2002-10-21

Family

ID=10865952

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/01503T TR200201503T2 (tr) 1999-12-08 2000-12-07 Heterosiklik türevler.

Country Status (30)

Country Link
US (2) US6713491B2 (tr)
EP (1) EP1237886B1 (tr)
JP (1) JP4311901B2 (tr)
KR (1) KR100788579B1 (tr)
CN (1) CN1325488C (tr)
AR (1) AR030923A1 (tr)
AT (1) ATE323691T1 (tr)
AU (1) AU769232B2 (tr)
BR (1) BR0016235A (tr)
CA (1) CA2393303C (tr)
CO (1) CO5251474A1 (tr)
CY (1) CY1106105T1 (tr)
CZ (1) CZ301052B6 (tr)
DE (1) DE60027461T2 (tr)
DK (1) DK1237886T3 (tr)
ES (1) ES2257343T3 (tr)
GB (1) GB9929037D0 (tr)
HK (1) HK1047436B (tr)
HU (1) HUP0203650A3 (tr)
IL (2) IL150010A0 (tr)
MX (1) MXPA02005802A (tr)
MY (1) MY129892A (tr)
NO (1) NO323263B1 (tr)
PL (1) PL356713A1 (tr)
PT (1) PT1237886E (tr)
TN (1) TNSN00240A1 (tr)
TR (1) TR200201503T2 (tr)
TW (1) TW524804B (tr)
WO (1) WO2001042238A1 (tr)
ZA (1) ZA200204492B (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004234235A1 (en) 2003-04-25 2004-11-11 Nippon Chemiphar Co., Ltd. Salt of (2s,3s)-3-[[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid
GB0327912D0 (en) * 2003-12-02 2004-01-07 Glaxo Group Ltd Medicament
US7576216B2 (en) 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
WO2006042034A2 (en) 2004-10-08 2006-04-20 Abbott Laboratories Salt and crystalline forms thereof of a drug
PL1868581T3 (pl) * 2005-04-11 2012-08-31 Abbvie Inc Kompozycje farmaceutyczne słabo rozpuszczalnych leków o polepszonych profilach rozpuszczania
HUE052128T2 (hu) 2011-10-25 2021-04-28 Janssen Pharmaceutica Nv Eljárás az 1-(5,6-diklór-1H-benzo[d]imidazol-2-il)-1H-pirazol-4-karbonsav meglumin sója kristályainak elõállítására

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231102A (en) 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
US5529999A (en) 1994-03-04 1996-06-25 Eli Lilly And Company Antitumor compositions and methods of treatment
US6413959B1 (en) * 1995-04-14 2002-07-02 Boehringer Ingelheim Kg Method of treating depression with arylglycinamide derivatives
AP876A (en) 1995-09-29 2000-09-27 Glaxo Wellcome Spa Tetrahydroquinolines as NMDA antagonists.
GB9617305D0 (en) 1996-08-17 1996-09-25 Glaxo Wellcome Spa Heterocyclic compounds
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives

Also Published As

Publication number Publication date
CO5251474A1 (es) 2003-02-28
JP2003516403A (ja) 2003-05-13
DK1237886T3 (da) 2006-08-14
TW524804B (en) 2003-03-21
NO20022682D0 (no) 2002-06-06
MY129892A (en) 2007-05-31
US6943176B2 (en) 2005-09-13
CY1106105T1 (el) 2011-06-08
HK1047436B (zh) 2006-07-21
CZ20021981A3 (cs) 2003-01-15
IL150010A0 (en) 2002-12-01
NO20022682L (no) 2002-07-17
CN1407980A (zh) 2003-04-02
BR0016235A (pt) 2002-08-27
DE60027461T2 (de) 2006-09-28
CA2393303C (en) 2009-10-20
KR100788579B1 (ko) 2007-12-26
AU769232B2 (en) 2004-01-22
ES2257343T3 (es) 2006-08-01
CA2393303A1 (en) 2001-06-14
JP4311901B2 (ja) 2009-08-12
US6713491B2 (en) 2004-03-30
GB9929037D0 (en) 2000-02-02
NO323263B1 (no) 2007-02-19
CZ301052B6 (cs) 2009-10-21
HUP0203650A2 (hu) 2003-03-28
PL356713A1 (en) 2004-06-28
CN1325488C (zh) 2007-07-11
MXPA02005802A (es) 2004-08-12
TNSN00240A1 (en) 2002-05-30
HK1047436A1 (en) 2003-02-21
WO2001042238A1 (en) 2001-06-14
KR20020086854A (ko) 2002-11-20
AU2006001A (en) 2001-06-18
DE60027461D1 (de) 2006-05-24
ATE323691T1 (de) 2006-05-15
IL150010A (en) 2009-09-01
AR030923A1 (es) 2003-09-03
EP1237886A1 (en) 2002-09-11
US20040162313A1 (en) 2004-08-19
HUP0203650A3 (en) 2004-01-28
PT1237886E (pt) 2006-07-31
ZA200204492B (en) 2004-06-30
EP1237886B1 (en) 2006-04-19
US20030008899A1 (en) 2003-01-09

Similar Documents

Publication Publication Date Title
BR0315547A (pt) Derivados de quinolina como antagonistas de crth2
TR200100137T2 (tr) Obesitenin ve başka bozuklukların tedavisinde yararlı nöropeptit Y Y5 reseptörü için ligandlar olarak N-ikameli aminotetralinler.
DE50011582D1 (de) Neuartige dicarbonsäurederivate mit pharmazeutischen eigenschaften
AP1760A (en) Platinum derivative pharmaceutical formulations.
DE69922676D1 (de) N-aralkylaminotetraline als neuropeptid-y-y5-rezeptorliganden
MY144897A (en) 2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists
EE200300403A (et) N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina
ECSP055701A (es) Nuevos derivados de pirimidinamida y el uso de los mismos
BR0016543A (pt) Novos derivados de piperidina e piperazina
MY115638A (en) N-substituted heterocyclic derivatives, their preparation and pharmaceutical compositions containing them
RS103903A (en) Piperidine derivatives as nmda receptor antagonists
PT1086124E (pt) Ciclosporinas novas
ES2187300A1 (es) Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
DE60001586D1 (de) Diphenyl-piperidin derivate
TR200002969T2 (tr) Farmasötik bileşim.
TR200000737T2 (tr) İkame edilmiş kroman türevleri.
EP0337136A3 (en) Piperidine derivatives in the treatment of extrapyramidal side effects associated with neuroleptic therapy
TR200201503T2 (tr) Heterosiklik türevler.
IL131216A (en) Drugs inhibiting progress of pterygium and postoperative recurrence of the same
MD553G2 (ro) Derivaţi noi ai pirazolopirimidinelor, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice care le conţin
HUP0000307A2 (hu) Y Neuropeptid antagonisták és ezeket tartalmazó gyógyászati készítmények
MX9600165A (es) 3-alcoxicarbonil-tiadiazinonas, proceso para su preparacion y composiciones farmaceuticas que las contienen.
DE50212538D1 (de) Substituierte 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzoäcüfluoren-6-carbonsäurederivate als nmda-antagonisten
MXPA04000952A (es) Sales de derivados de acido 1,2,3-4-tetrahidro-isoquinolin-2-carboxilico.
SE9704835D0 (sv) New compound