EA201100908A1 - Расширенные растворимые полипептиды рн20 и их использование - Google Patents

Расширенные растворимые полипептиды рн20 и их использование

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Publication number
EA201100908A1
EA201100908A1 EA201100908A EA201100908A EA201100908A1 EA 201100908 A1 EA201100908 A1 EA 201100908A1 EA 201100908 A EA201100908 A EA 201100908A EA 201100908 A EA201100908 A EA 201100908A EA 201100908 A1 EA201100908 A1 EA 201100908A1
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EA
Eurasian Patent Office
Prior art keywords
phype
petpides
extended soluble
polypeptides
soluble
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EA201100908A
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English (en)
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EA022752B1 (ru
Inventor
Ги Веи
Кришнасами Панниирселвам
Грегори Ай Фрост
Луис Букбиндер
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Галозим, Инк.
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Application filed by Галозим, Инк. filed Critical Галозим, Инк.
Publication of EA201100908A1 publication Critical patent/EA201100908A1/ru
Publication of EA022752B1 publication Critical patent/EA022752B1/ru

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    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
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    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
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    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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Abstract

Изобретение включает растворимые полипептиды РН20, включая расширенные (длинные) растворимые полипептиды РН20, и их применение. Также предусмотрены укороченные с С-конца полипептиды РН20 и частично дегликозилированные полипептиды РН20, а также их использование.
EA201100908A 2008-12-09 2009-12-09 Длинные растворимые полипептиды рн20 и их использование EA022752B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20138408P 2008-12-09 2008-12-09
US28124009P 2009-11-13 2009-11-13
PCT/US2009/006501 WO2010077297A1 (en) 2008-12-09 2009-12-09 Extended soluble ph20 polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
EA201100908A1 true EA201100908A1 (ru) 2012-03-30
EA022752B1 EA022752B1 (ru) 2016-02-29

Family

ID=42035671

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201100908A EA022752B1 (ru) 2008-12-09 2009-12-09 Длинные растворимые полипептиды рн20 и их использование
EA201500485A EA036569B1 (ru) 2008-12-09 2009-12-09 Способ получения полипептида гиалуронидазы ph20

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201500485A EA036569B1 (ru) 2008-12-09 2009-12-09 Способ получения полипептида гиалуронидазы ph20

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US (2) US8927249B2 (ru)
EP (2) EP3037529B1 (ru)
JP (2) JP5670913B2 (ru)
KR (2) KR101493644B1 (ru)
CN (2) CN102307993B (ru)
AU (1) AU2009333918B2 (ru)
BR (1) BRPI0922538A2 (ru)
CA (2) CA2746181C (ru)
CO (1) CO6341652A2 (ru)
CY (1) CY1121618T1 (ru)
DK (1) DK3037529T3 (ru)
EA (2) EA022752B1 (ru)
ES (1) ES2724588T3 (ru)
HK (1) HK1224330A1 (ru)
HR (1) HRP20190766T1 (ru)
HU (1) HUE043591T2 (ru)
IL (2) IL213150A (ru)
LT (1) LT3037529T (ru)
MX (1) MX2011006110A (ru)
NZ (1) NZ593641A (ru)
PL (1) PL3037529T3 (ru)
PT (1) PT3037529T (ru)
RS (1) RS58728B1 (ru)
SG (2) SG172064A1 (ru)
SI (1) SI3037529T1 (ru)
WO (1) WO2010077297A1 (ru)
ZA (1) ZA201104116B (ru)

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HK1224330A1 (zh) 2017-08-18
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CN102307993A (zh) 2012-01-04
EA022752B1 (ru) 2016-02-29
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JP2012511327A (ja) 2012-05-24
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CA2915783A1 (en) 2010-07-08
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US20130101577A9 (en) 2013-04-25
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CO6341652A2 (es) 2011-11-21
KR20110099126A (ko) 2011-09-06
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US8927249B2 (en) 2015-01-06
KR101493644B1 (ko) 2015-02-13

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