EA201100687A1 - Соединения и композиции в качестве ингибиторов протеинкиназы - Google Patents

Соединения и композиции в качестве ингибиторов протеинкиназы

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Publication number
EA201100687A1
EA201100687A1 EA201100687A EA201100687A EA201100687A1 EA 201100687 A1 EA201100687 A1 EA 201100687A1 EA 201100687 A EA201100687 A EA 201100687A EA 201100687 A EA201100687 A EA 201100687A EA 201100687 A1 EA201100687 A1 EA 201100687A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
compositions
pyrimidine
kinase
pyridine
Prior art date
Application number
EA201100687A
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English (en)
Other versions
EA019966B1 (ru
Inventor
Пьер-Ив Мишелли
Вэй Пэй
Томас Х. Марсилдж
Вэньшо Лу
Бэй Чэнь
Тецуо Уно
Юнхо Джин
Тао Цзян
Original Assignee
АйАрЭм ЭлЭлСи
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Application filed by АйАрЭм ЭлЭлСи filed Critical АйАрЭм ЭлЭлСи
Publication of EA201100687A1 publication Critical patent/EA201100687A1/ru
Publication of EA019966B1 publication Critical patent/EA019966B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

Изобретение относится к новым производным пиримидина и пиридина, к их фармацевтическим композициям и к способам применения таких соединений. Например, производные пиримидина и пиридина согласно изобретению могут быть использованы для лечения, улучшения или предотвращения состояния, которое отвечает на ингибирование активности киназы анапластической лимфомы (ALK), очагово-адгезивной киназы (FAK), дзета-цепь-ассоциированной протеинкиназы 70 (ZAP-70), инсулинподобного фактора роста (IGF-1R) или их комбинаций.
EA201100687A 2006-12-08 2007-11-20 Соединения и композиции в качестве ингибиторов протеинкиназы EA019966B1 (ru)

Applications Claiming Priority (1)

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US86929906P 2006-12-08 2006-12-08

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EA201100687A1 true EA201100687A1 (ru) 2011-12-30
EA019966B1 EA019966B1 (ru) 2014-07-30

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EA201100688A EA019941B1 (ru) 2006-12-08 2007-11-20 Соединения и композиции в качестве ингибиторов протеинкиназы
EA201100687A EA019966B1 (ru) 2006-12-08 2007-11-20 Соединения и композиции в качестве ингибиторов протеинкиназы

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Country Link
US (6) US8039479B2 (ru)
EP (3) EP3012249A1 (ru)
KR (1) KR101364277B1 (ru)
CN (1) CN101616895A (ru)
AR (3) AR064197A1 (ru)
BR (2) BRPI0722383A2 (ru)
CL (2) CL2007003552A1 (ru)
CU (1) CU23829B1 (ru)
CY (1) CY1115898T1 (ru)
DO (1) DOP2011000074A (ru)
EA (2) EA019941B1 (ru)
EC (1) ECSP109500A (ru)
ES (2) ES2524009T3 (ru)
GE (2) GEP20125691B (ru)
HK (1) HK1134290A1 (ru)
HN (1) HN2009001145A (ru)
HR (1) HRP20141260T1 (ru)
IL (1) IL230972A (ru)
JO (2) JO2980B1 (ru)
LU (1) LU92785I2 (ru)
MY (1) MY148427A (ru)
NZ (2) NZ590601A (ru)
PE (2) PE20120814A1 (ru)
RS (1) RS53588B1 (ru)
SI (1) SI2091918T1 (ru)
SM (1) SM201000108B (ru)
TW (2) TWI410416B (ru)
UA (1) UA100846C2 (ru)
ZA (1) ZA201005313B (ru)

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EP2311807A1 (en) 2011-04-20
KR101364277B1 (ko) 2014-02-21
US20080176881A1 (en) 2008-07-24
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JO3403B1 (ar) 2019-10-20
CU23829B1 (es) 2012-10-15
TWI410416B (zh) 2013-10-01
RS53588B1 (en) 2015-02-27
AR064197A1 (es) 2009-03-18
AR107966A2 (es) 2018-07-04
US8377921B2 (en) 2013-02-19
ES2524009T3 (es) 2014-12-03
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US20150105390A1 (en) 2015-04-16
CL2007003552A1 (es) 2008-07-18
SM201000108B (it) 2012-01-18
HK1134290A1 (en) 2010-04-23
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LU92785I2 (fr) 2015-11-03
ES2559528T3 (es) 2016-02-12
US8372858B2 (en) 2013-02-12
CY1115898T1 (el) 2016-04-13
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EA019966B1 (ru) 2014-07-30

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