EA201100078A1 - Производные пиримидина в качестве ингибиторов киназы - Google Patents
Производные пиримидина в качестве ингибиторов киназыInfo
- Publication number
- EA201100078A1 EA201100078A1 EA201100078A EA201100078A EA201100078A1 EA 201100078 A1 EA201100078 A1 EA 201100078A1 EA 201100078 A EA201100078 A EA 201100078A EA 201100078 A EA201100078 A EA 201100078A EA 201100078 A1 EA201100078 A1 EA 201100078A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- pyrimidine
- kinase inhibitors
- pyrimidine derivatives
- igf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В заявке описаны новые производные пиримидина и содержащие их фармацевтические композиции и способы применения таких соединений. Например, производные пиримидина, предлагаемые в настоящем изобретении, можно применять для лечения, облегчения протекания или предупреждения патологического состояния, которое реагирует на ингибирование инсулиноподобного фактора роста (IGF-1R) или киназы анапластической лимфомы (ALK).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7558308P | 2008-06-25 | 2008-06-25 | |
PCT/US2009/048509 WO2009158431A2 (en) | 2008-06-25 | 2009-06-24 | Compounds and compositions as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201100078A1 true EA201100078A1 (ru) | 2011-08-30 |
Family
ID=41076758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201100078A EA201100078A1 (ru) | 2008-06-25 | 2009-06-24 | Производные пиримидина в качестве ингибиторов киназы |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2331526A2 (ru) |
JP (1) | JP2011526291A (ru) |
KR (1) | KR20110020940A (ru) |
CN (1) | CN102203083A (ru) |
AU (1) | AU2009262198B2 (ru) |
BR (1) | BRPI0914545A2 (ru) |
CA (1) | CA2729546A1 (ru) |
EA (1) | EA201100078A1 (ru) |
MX (1) | MX2010014568A (ru) |
UA (1) | UA101057C2 (ru) |
WO (1) | WO2009158431A2 (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2464633A1 (en) | 2009-08-14 | 2012-06-20 | Boehringer Ingelheim International GmbH | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
WO2011112666A1 (en) | 2010-03-09 | 2011-09-15 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
US8987307B2 (en) | 2011-03-03 | 2015-03-24 | Hoffmann-La Roche Inc. | 3-amino-pyridines as GPBAR1 agonists |
EP2785709B1 (en) * | 2011-11-29 | 2017-05-10 | Genentech, Inc. | Aminopyrimidine derivatives as lrrk2 modulators |
KR102156398B1 (ko) | 2012-11-06 | 2020-09-15 | 상하이 포천 파마슈티컬 씨오 엘티디 | Alk 키나아제 억제제 |
BR112015022993B1 (pt) * | 2013-03-14 | 2021-12-14 | Sumitomo Dainippon Pharma Oncology, Inc. | Inibidores de jak2 e alk2, composição farmacêutica compreendendo os referidos inibidores e uso destes |
KR101881886B1 (ko) * | 2014-05-30 | 2018-07-25 | 베이징 피어 바이오테크놀로지 리미티드 라이어빌리티 컴페니 | Alk 키나제 억제제, 이의 제조방법 및 이의 용도 |
US10377743B2 (en) * | 2016-10-07 | 2019-08-13 | Araxes Pharma Llc | Inhibitors of RAS and methods of use thereof |
CN107488148A (zh) * | 2017-06-26 | 2017-12-19 | 安徽省黄淮兽药有限公司 | 一种苯丙酰胺类杀虫剂及其制备方法 |
CA3085366A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
TW202045008A (zh) * | 2019-02-01 | 2020-12-16 | 印度商皮埃企業有限公司 | 4-取代的異噁唑/異噁唑啉(雜)芳基脒化合物、及其製備與用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
WO2003026665A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | 2-phenylamino-4-(5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, src kinase inhibitors |
US8178671B2 (en) * | 2003-07-30 | 2012-05-15 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds |
JP4741491B2 (ja) * | 2003-08-07 | 2011-08-03 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 抗増殖剤としての2,4−ピリミジンジアミン化合物および使用 |
GB0321710D0 (en) * | 2003-09-16 | 2003-10-15 | Novartis Ag | Organic compounds |
CA2538413A1 (en) * | 2003-09-18 | 2005-03-24 | Novartis Ag | 2,4-di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
AU2005322855B2 (en) * | 2004-12-30 | 2012-09-20 | Exelixis, Inc. | Pyrimidine derivatives as kinase modulators and method of use |
CA2604551A1 (en) * | 2005-05-03 | 2007-03-08 | Rigel Pharmaceuticals, Inc. | Jak kinase inhibitors and their uses |
EP2043651A2 (en) * | 2006-07-05 | 2009-04-08 | Exelixis, Inc. | Methods of using igf1r and abl kinase modulators |
EP3012249A1 (en) * | 2006-12-08 | 2016-04-27 | Novartis AG | Compounds and composition as protein kinase inhibitors |
JP5208123B2 (ja) * | 2006-12-08 | 2013-06-12 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
WO2009017838A2 (en) * | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
CN101952275B (zh) * | 2008-02-22 | 2014-06-18 | 弗·哈夫曼-拉罗切有限公司 | β-淀粉样蛋白的调节剂 |
-
2009
- 2009-06-24 WO PCT/US2009/048509 patent/WO2009158431A2/en active Application Filing
- 2009-06-24 EP EP09770964A patent/EP2331526A2/en not_active Withdrawn
- 2009-06-24 AU AU2009262198A patent/AU2009262198B2/en not_active Expired - Fee Related
- 2009-06-24 MX MX2010014568A patent/MX2010014568A/es not_active Application Discontinuation
- 2009-06-24 CN CN200980129584XA patent/CN102203083A/zh active Pending
- 2009-06-24 KR KR1020117001749A patent/KR20110020940A/ko not_active Application Discontinuation
- 2009-06-24 UA UAA201104068A patent/UA101057C2/ru unknown
- 2009-06-24 CA CA2729546A patent/CA2729546A1/en not_active Abandoned
- 2009-06-24 JP JP2011516619A patent/JP2011526291A/ja not_active Ceased
- 2009-06-24 BR BRPI0914545A patent/BRPI0914545A2/pt not_active IP Right Cessation
- 2009-06-24 EA EA201100078A patent/EA201100078A1/ru unknown
Also Published As
Publication number | Publication date |
---|---|
KR20110020940A (ko) | 2011-03-03 |
WO2009158431A3 (en) | 2010-03-11 |
CA2729546A1 (en) | 2009-12-30 |
JP2011526291A (ja) | 2011-10-06 |
EP2331526A2 (en) | 2011-06-15 |
AU2009262198A1 (en) | 2009-12-30 |
MX2010014568A (es) | 2011-03-29 |
UA101057C2 (en) | 2013-02-25 |
WO2009158431A2 (en) | 2009-12-30 |
BRPI0914545A2 (pt) | 2017-05-23 |
CN102203083A (zh) | 2011-09-28 |
AU2009262198B2 (en) | 2012-09-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201100077A1 (ru) | Производные пиримидина в качестве ингибиторов киназы | |
EA201100078A1 (ru) | Производные пиримидина в качестве ингибиторов киназы | |
MX2010002336A (es) | Derivados de 2-bifenil-amino-4-amino-pirimidina como inhibidores de cinasa. | |
EA201001597A1 (ru) | Соединения и композиции в качестве ингибиторов протеинкиназы | |
EA200970557A1 (ru) | Соединения и композиции в качестве ингибиторов протеинкиназы | |
EA201101341A1 (ru) | Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе | |
EA201001596A1 (ru) | Соединения и композиции в качестве ингибиторов протеинкиназы | |
EA201100687A1 (ru) | Соединения и композиции в качестве ингибиторов протеинкиназы | |
MX2012000711A (es) | Inhibidores de pirrolopirazina de cinasas. | |
MX2012013197A (es) | Inhibidores de indazol de cinasa. | |
NZ711376A (en) | Heteroaryl compounds and uses thereof | |
MX2015011514A (es) | Compuestos de heteroarilo y sus usos. | |
EA201100580A1 (ru) | Имидазопиридазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
GEP20135785B (en) | Pyrrolopyrimidine compounds as cdk inhibitors | |
EA200970156A1 (ru) | Пиридизиноновые производные | |
MX2012000709A (es) | Inhibidores de pirrolopiridina de cinasas. | |
AU2011276193A8 (en) | Bipyridyl derivatives useful for the treatment of kinase - induced diseases | |
MX2011012369A (es) | Pirazolopirimidinas y heterociclos relacionados como inhibidores de cinasa. | |
EA201491647A1 (ru) | Основанные на арилэфирах ингибиторы киназ | |
EA201071224A1 (ru) | Ингибиторы limk2, композиции, содержащие их, и способы их применения | |
EA201590268A1 (ru) | Ариллактамные ингибиторы киназы | |
MX2009012079A (es) | Compuestos heterociclicos condensados como inhibidores de proteina cinasas. | |
MX2009003793A (es) | Inhibidores de cinasa. | |
TN2010000602A1 (en) | Pyrimidine derivatives as kinase inhibitors | |
CU20100259A7 (es) | Derivados de pirimidina como inhibidores de quinasa |