KR20110020940A - 키나제 억제제로서의 피리미딘 유도체 - Google Patents
키나제 억제제로서의 피리미딘 유도체 Download PDFInfo
- Publication number
- KR20110020940A KR20110020940A KR1020117001749A KR20117001749A KR20110020940A KR 20110020940 A KR20110020940 A KR 20110020940A KR 1020117001749 A KR1020117001749 A KR 1020117001749A KR 20117001749 A KR20117001749 A KR 20117001749A KR 20110020940 A KR20110020940 A KR 20110020940A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- nrr
- halo
- optionally substituted
- formula
- Prior art date
Links
- MGKGTXZIIUUVPL-UHFFFAOYSA-N Cc1cc(Nc(nc(Nc2c(C)cc(C(CC3)CCC3=NO)c(C)c2)nc2)c2Cl)n[nH]1 Chemical compound Cc1cc(Nc(nc(Nc2c(C)cc(C(CC3)CCC3=NO)c(C)c2)nc2)c2Cl)n[nH]1 MGKGTXZIIUUVPL-UHFFFAOYSA-N 0.000 description 1
- CYASMJYJTOMAEV-UHFFFAOYSA-N Cc1cc(Nc2c(C(F)(F)F)cnc(Nc(cc(C)c(C(CC3)CCC3N3CCCCC3)c3)c3F)n2)n[nH]1 Chemical compound Cc1cc(Nc2c(C(F)(F)F)cnc(Nc(cc(C)c(C(CC3)CCC3N3CCCCC3)c3)c3F)n2)n[nH]1 CYASMJYJTOMAEV-UHFFFAOYSA-N 0.000 description 1
- CZXGLILCUAJJJX-UHFFFAOYSA-N Cc1cc(Nc2c(C(F)(F)F)cnc(Nc3c(C)cc(C(CC4)CCC4O)c(C)c3)n2)n[nH]1 Chemical compound Cc1cc(Nc2c(C(F)(F)F)cnc(Nc3c(C)cc(C(CC4)CCC4O)c(C)c3)n2)n[nH]1 CZXGLILCUAJJJX-UHFFFAOYSA-N 0.000 description 1
- OSILNRDRCGTFML-UHFFFAOYSA-N Cc1cc(Nc2nc(Nc(cc(c(CN3C4CCNCC4)c4)C3=O)c4F)ncc2Cl)n[o]1 Chemical compound Cc1cc(Nc2nc(Nc(cc(c(CN3C4CCNCC4)c4)C3=O)c4F)ncc2Cl)n[o]1 OSILNRDRCGTFML-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7558308P | 2008-06-25 | 2008-06-25 | |
| US61/075,583 | 2008-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20110020940A true KR20110020940A (ko) | 2011-03-03 |
Family
ID=41076758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117001749A KR20110020940A (ko) | 2008-06-25 | 2009-06-24 | 키나제 억제제로서의 피리미딘 유도체 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP2331526A2 (ru) |
| JP (1) | JP2011526291A (ru) |
| KR (1) | KR20110020940A (ru) |
| CN (1) | CN102203083A (ru) |
| AU (1) | AU2009262198B2 (ru) |
| BR (1) | BRPI0914545A2 (ru) |
| CA (1) | CA2729546A1 (ru) |
| EA (1) | EA201100078A1 (ru) |
| MX (1) | MX2010014568A (ru) |
| UA (1) | UA101057C2 (ru) |
| WO (1) | WO2009158431A2 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170007483A (ko) * | 2014-05-30 | 2017-01-18 | 베이징 피어 바이오테크놀로지 리미티드 라이어빌리티 컴페니 | Alk 키나제 억제제, 이의 제조방법 및 이의 용도 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2464633A1 (en) | 2009-08-14 | 2012-06-20 | Boehringer Ingelheim International GmbH | Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| EP2544672A1 (en) | 2010-03-09 | 2013-01-16 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| US8987307B2 (en) | 2011-03-03 | 2015-03-24 | Hoffmann-La Roche Inc. | 3-amino-pyridines as GPBAR1 agonists |
| EP2785709B1 (en) * | 2011-11-29 | 2017-05-10 | Genentech, Inc. | Aminopyrimidine derivatives as lrrk2 modulators |
| WO2014071832A1 (en) | 2012-11-06 | 2014-05-15 | Shanghai Fochon Pharmaceutical Co Ltd | Alk kinase inhibitors |
| CA2905993C (en) * | 2013-03-14 | 2022-12-06 | Tolero Pharmaceuticals, Inc. | Substituted 4-amino-pyrimidinyl-2-amino-phenyl derivatives and pharmaceutical compositions thereof for use as jak2 and alk2 inhibitors |
| US10377743B2 (en) * | 2016-10-07 | 2019-08-13 | Araxes Pharma Llc | Inhibitors of RAS and methods of use thereof |
| CN107488148A (zh) * | 2017-06-26 | 2017-12-19 | 安徽省黄淮兽药有限公司 | 一种苯丙酰胺类杀虫剂及其制备方法 |
| MX2020006587A (es) | 2017-12-22 | 2020-12-10 | Ravenna Pharmaceuticals Inc | Derivados de aminopiridina como inhibidores de fosfatidilinositol fosfato cinasa. |
| TW202045008A (zh) * | 2019-02-01 | 2020-12-16 | 印度商皮埃企業有限公司 | 4-取代的異噁唑/異噁唑啉(雜)芳基脒化合物、及其製備與用途 |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| WO2003026666A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors |
| DK1656372T3 (da) * | 2003-07-30 | 2013-07-01 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme |
| ES2365223T3 (es) * | 2003-08-07 | 2011-09-26 | Rigel Pharmaceuticals, Inc. | Compuestos 2,4-pirimidindiamínicos y usos como agentes antiproliferativos. |
| GB0321710D0 (en) * | 2003-09-16 | 2003-10-15 | Novartis Ag | Organic compounds |
| JP2007505858A (ja) * | 2003-09-18 | 2007-03-15 | ノバルティス アクチエンゲゼルシャフト | 増殖性障害の処置に有用な２，４−ジ（フェニルアミノ）ピリミジン |
| ATE519759T1 (de) * | 2004-12-30 | 2011-08-15 | Exelixis Inc | Pyrimidinderivate als kinasemodulatoren und anwendungsverfahren |
| EP1883302A4 (en) * | 2005-05-03 | 2009-05-20 | Rigel Pharmaceuticals Inc | JAK KINASE HEMMER AND ITS USE |
| CA2656290A1 (en) * | 2006-07-05 | 2008-01-10 | Exelixis, Inc. | Methods of using igf1r and abl kinase modulators |
| PL2091918T3 (pl) * | 2006-12-08 | 2015-02-27 | Novartis Ag | Związki i kompozycje jako inhibitory kinazy białkowej |
| ES2524009T3 (es) * | 2006-12-08 | 2014-12-03 | Irm Llc | Compuestos y composiciones como inhibidores de la proteína quinasa |
| WO2009017838A2 (en) * | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
| BRPI0907577A2 (pt) * | 2008-02-22 | 2015-07-21 | Hoffmann La Roche | Moduladores para amiloide beta |
-
2009
- 2009-06-24 EP EP09770964A patent/EP2331526A2/en not_active Withdrawn
- 2009-06-24 EA EA201100078A patent/EA201100078A1/ru unknown
- 2009-06-24 KR KR1020117001749A patent/KR20110020940A/ko not_active Application Discontinuation
- 2009-06-24 JP JP2011516619A patent/JP2011526291A/ja not_active Ceased
- 2009-06-24 UA UAA201104068A patent/UA101057C2/ru unknown
- 2009-06-24 CA CA2729546A patent/CA2729546A1/en not_active Abandoned
- 2009-06-24 MX MX2010014568A patent/MX2010014568A/es not_active Application Discontinuation
- 2009-06-24 BR BRPI0914545A patent/BRPI0914545A2/pt not_active IP Right Cessation
- 2009-06-24 AU AU2009262198A patent/AU2009262198B2/en not_active Expired - Fee Related
- 2009-06-24 CN CN200980129584XA patent/CN102203083A/zh active Pending
- 2009-06-24 WO PCT/US2009/048509 patent/WO2009158431A2/en active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170007483A (ko) * | 2014-05-30 | 2017-01-18 | 베이징 피어 바이오테크놀로지 리미티드 라이어빌리티 컴페니 | Alk 키나제 억제제, 이의 제조방법 및 이의 용도 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2729546A1 (en) | 2009-12-30 |
| WO2009158431A3 (en) | 2010-03-11 |
| BRPI0914545A2 (pt) | 2017-05-23 |
| UA101057C2 (en) | 2013-02-25 |
| AU2009262198B2 (en) | 2012-09-27 |
| WO2009158431A2 (en) | 2009-12-30 |
| CN102203083A (zh) | 2011-09-28 |
| JP2011526291A (ja) | 2011-10-06 |
| EA201100078A1 (ru) | 2011-08-30 |
| AU2009262198A1 (en) | 2009-12-30 |
| MX2010014568A (es) | 2011-03-29 |
| EP2331526A2 (en) | 2011-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E601 | Decision to refuse application |