EA201070299A1 - Противовирусная композиция, содержащая сульфатированный полисахарид - Google Patents

Противовирусная композиция, содержащая сульфатированный полисахарид

Info

Publication number
EA201070299A1
EA201070299A1 EA201070299A EA201070299A EA201070299A1 EA 201070299 A1 EA201070299 A1 EA 201070299A1 EA 201070299 A EA201070299 A EA 201070299A EA 201070299 A EA201070299 A EA 201070299A EA 201070299 A1 EA201070299 A1 EA 201070299A1
Authority
EA
Eurasian Patent Office
Prior art keywords
respiratory virus
composition containing
virus composition
sulphated polysaccharide
orthomyxoviruses
Prior art date
Application number
EA201070299A
Other languages
English (en)
Other versions
EA018138B1 (ru
Inventor
Андреас Грассауэр
Ева Пришл-Грассауэр
Original Assignee
Мариномед Биотехнологи Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мариномед Биотехнологи Гмбх filed Critical Мариномед Биотехнологи Гмбх
Publication of EA201070299A1 publication Critical patent/EA201070299A1/ru
Publication of EA018138B1 publication Critical patent/EA018138B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/731—Carrageenans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Настоящее изобретение относится к применению йота- и/или каппа-каррагенана при производстве противовирусной фармацевтической композиции для профилактики или лечения патологического состояния или заболевания, вызванного инфицированием респираторным вирусом или ассоциированного с ней, респираторный вирус выбран из группы, состоящей из ортомиксовирусов, парамиксовирусов, аденовирусов и коронавирусов. Настоящее изобретение дополнительно относится к применению фукоидана, в частности высокомолекулярного фукоидана, при производстве противовирусной фармацевтической композиции для профилактики или лечения патологического состояния или заболевания, вызванного инфицированием респираторным вирусом или связанного с ней, респираторный вирус выбран из группы, состоящей из ортомиксовирусов и парамиксовирусов.
EA201070299A 2007-08-24 2008-08-22 Применение йота-каррагенана в качестве противовирусного ингредиента EA018138B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93566807P 2007-08-24 2007-08-24
PCT/EP2008/006910 WO2009027057A1 (en) 2007-08-24 2008-08-22 Antiviral composition comprising a sulfated polysaccharide

Publications (2)

Publication Number Publication Date
EA201070299A1 true EA201070299A1 (ru) 2010-08-30
EA018138B1 EA018138B1 (ru) 2013-05-30

Family

ID=40198591

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070299A EA018138B1 (ru) 2007-08-24 2008-08-22 Применение йота-каррагенана в качестве противовирусного ингредиента

Country Status (27)

Country Link
US (2) US20110059919A1 (ru)
EP (1) EP2178533B1 (ru)
JP (1) JP5647518B2 (ru)
KR (1) KR101571571B1 (ru)
CN (1) CN101784272B (ru)
AP (1) AP2630A (ru)
BR (1) BRPI0815748B8 (ru)
CA (1) CA2696009C (ru)
CY (1) CY1113949T1 (ru)
DK (1) DK2178533T3 (ru)
EA (1) EA018138B1 (ru)
ES (1) ES2406684T3 (ru)
HK (1) HK1144558A1 (ru)
HR (1) HRP20130402T1 (ru)
IL (1) IL203444A (ru)
MA (1) MA31748B1 (ru)
MX (1) MX2010001986A (ru)
MY (1) MY153900A (ru)
NO (1) NO20100097L (ru)
NZ (1) NZ583511A (ru)
PL (1) PL2178533T3 (ru)
PT (1) PT2178533E (ru)
SI (1) SI2178533T1 (ru)
TN (1) TN2010000086A1 (ru)
UA (1) UA102673C2 (ru)
WO (1) WO2009027057A1 (ru)
ZA (1) ZA201000951B (ru)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9884024B2 (en) * 2005-12-27 2018-02-06 Hemant N Joshi Physically dispersed, molecularly dissolved and/or chemically bound drug(s) in an empty, hard capsule shell composition
US20110091583A1 (en) * 2008-07-01 2011-04-21 Marinomed Biotechnologie Gmbh Antiallergic marine biopolymers
US8697670B2 (en) * 2009-01-28 2014-04-15 Life Science Nutrition As Compositions and methods of treating viral infections
JP2010248105A (ja) * 2009-04-14 2010-11-04 Bio Plan:Kk ウイルス感染阻害用組成物
US20120189706A1 (en) * 2009-10-06 2012-07-26 Knocean Sciences, Inc. Macrocystis Pyrifera Derived Health and Wellness Products and Methods of Using the Same
PL2515889T3 (pl) * 2009-12-22 2015-05-29 Marinomed Biotechnologie Gmbh Synergistyczna kompozycja przeciwwirusowa i jej stosowanie
JP2011168533A (ja) * 2010-02-18 2011-09-01 Kyosei Seiyaku Kk 抗インフルエンザウイルス剤
US10786528B2 (en) * 2010-02-22 2020-09-29 Helen Fitton Anti-viral formulations
CN101869110B (zh) * 2010-07-14 2013-03-13 山东圣鹏农药有限公司 一种抗植物病毒病组合物及其应用
WO2012018628A1 (en) 2010-07-26 2012-02-09 Board Of Regents, The University Of Texas System Methods for inducing an immune response via buccal and/or sublingual administration of a vaccine
FR2969926B1 (fr) 2011-01-04 2017-03-10 Elicityl Arabinogalactanes, apiogalacturonanes et heteroglycanes sulfates pour le traitement des maladies causees par les virus influenza
WO2012126777A1 (en) * 2011-03-18 2012-09-27 Marinomed Biotechnologie Gmbh Inhibition of neuraminidase activity
US20130028882A1 (en) 2011-07-07 2013-01-31 Humanitas Technology, LLC Antiviral compositions and methods of their use
CN102764266A (zh) * 2012-07-30 2012-11-07 吉林省辉南长龙生化药业股份有限公司 褐藻多糖硫酸酯在制备预防和治疗慢性阻塞性肺病药物中的用途
CN102988409A (zh) * 2012-11-26 2013-03-27 合肥博太医药生物技术发展有限公司 硫酸葡聚糖在制备治疗重症肝炎药物中的应用
US10149874B2 (en) 2013-01-25 2018-12-11 Marinova Pty Ltd Methods for depyrogenating a seaweed extract
US9974850B2 (en) 2013-01-25 2018-05-22 Board Of Regents, The University Of Texas System Immunogenic compositions and uses thereof
CN103301065A (zh) * 2013-06-27 2013-09-18 辽宁亿灵科创生物医药科技有限公司 一种海藻提取物的鼻喷剂及其制备方法
WO2015082356A1 (en) * 2013-12-03 2015-06-11 Gerolymatos International S.A. Ionic aqueous compositions
RS58731B1 (sr) 2014-01-22 2019-06-28 Visufarma B V Kompozicija koja sadrži jota-karagenan protiv virusnog konjuktivitisa
CN104721221B (zh) * 2015-01-29 2017-08-04 广州暨南生物医药研究开发基地有限公司 琼枝麒麟菜多糖用于制备抗呼吸道病毒药物中的用途
KR102628781B1 (ko) 2015-07-14 2024-01-24 마리노메드 바이오테크 아게 항바이러스 활성을 갖는 코막힘 차단해제 조성물
US10434119B2 (en) * 2016-01-13 2019-10-08 Gargle Water, Inc. Pharyngeal or buccal cavity rinse and process of use thereof
US20170360815A1 (en) * 2016-02-25 2017-12-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants
CN105748506B (zh) * 2016-03-03 2018-08-17 青岛海洋生物医药研究院股份有限公司 褐藻酸硫酸酯在制备预防和治疗由人乳头瘤状病毒引起的疾病的药物和保健品中的应用
CN106309470B (zh) * 2016-08-30 2021-05-18 闫滨 一种羊栖菜多糖的应用
WO2018144545A1 (en) 2017-01-31 2018-08-09 Stc.Unm Arginine-rich polypeptide compositions and methods of using same
JP7261367B2 (ja) * 2018-02-14 2023-04-20 江南化工株式会社 抗ウイルス剤及び抗ウイルス組成物
JP6942350B2 (ja) * 2018-04-26 2021-09-29 江南化工株式会社 抗ウイルス剤及び抗ウイルス用組成物
US20230140869A1 (en) * 2018-07-27 2023-05-11 ARC Medical Inc. High-molecular-weight fucans for treating fibrous adhesions and other diseases and conditions
KR101995376B1 (ko) * 2018-08-20 2019-07-02 한미약품 주식회사 카라기난을 유효성분으로 포함하는 항-바이러스 조성물
GB2579600B (en) * 2018-12-05 2023-07-05 Byotrol Plc Anti-viral composition
CN112137953A (zh) * 2019-06-26 2020-12-29 山东百骏生物科技有限公司 一种用于感冒辅助治疗的液体敷料
US11821111B2 (en) 2019-11-15 2023-11-21 Fred Hutchinson Cancer Center Barcoded influenza viruses and deep mutational scanning libraries including the same
WO2021168173A1 (en) * 2020-02-20 2021-08-26 Synkine Therapeutics, Inc. Methods and compositions for treating viral respiratory infections
AU2021235223A1 (en) * 2020-03-09 2022-09-29 Denis Barritault Composition for the treatment of lesions of the respiratory system
BR112022018200A2 (pt) 2020-03-12 2022-11-29 Sydney David Cullis Hill Tratamento para infecção por coronavírus e toxicidade de citocinas associadas
WO2021191904A1 (en) * 2020-03-26 2021-09-30 Tree Of Life Pharma Ltd. Methods for preventing and treating viral infection
WO2021202952A1 (en) * 2020-04-02 2021-10-07 Linhardt Robert John Compositions incorporating sulfated polysaccharides for inhibiting sars-cov-2
NL2025335B1 (en) 2020-04-10 2021-10-26 Logick Energetics B V Pharmaceutical composition for treatment of corona virus infection
CN111471088B (zh) * 2020-04-21 2021-02-09 北京中科微盾生物科技有限责任公司 一种抑制sars-cov-2感染的多肽、组合物及其用途
CN111686125A (zh) * 2020-06-18 2020-09-22 大连工业大学 卡拉胶在抗新型冠状病毒中的应用
WO2021253643A1 (zh) * 2020-06-18 2021-12-23 大连工业大学 硫酸化多糖在抗新型冠状病毒中的应用
EP3932411A1 (en) 2020-06-30 2022-01-05 GSK Consumer Healthcare SARL Antiviral pharmaceutical composition
EP3932412A1 (en) 2020-06-30 2022-01-05 GSK Consumer Healthcare SARL Antiviral pharmaceutical composition
EP3939597A1 (en) 2020-07-16 2022-01-19 Marinomed Biotech AG Antiviral pharmaceutical composition comprising a carrageenan component
CN114053251A (zh) * 2020-07-29 2022-02-18 苏州融析生物科技有限公司 硫酸化多糖吸入制剂及其在防治新冠病毒相关疾病中的应用
CN112220799A (zh) * 2020-11-02 2021-01-15 江苏泰德医药有限公司 一种抑制病毒的产品及用途
WO2022131283A1 (ja) * 2020-12-15 2022-06-23 正一 中村 海藻類及びその抽出物を含有する食品類及び飲料水類
WO2022131282A1 (ja) * 2020-12-15 2022-06-23 正一 中村 海藻類及びその抽出物を含有するせっけん類、消毒剤、殺菌剤及び洗浄剤
EP4079289A1 (en) 2021-04-22 2022-10-26 Dutch Renewable Energy B.V. Anti-viral composition for administration into nose, mouth or throat
EP4079300A1 (en) 2021-04-22 2022-10-26 Dutch Renewable Energy B.V. Anti-viral composition for administration into nose, mouth or throat
GB202109888D0 (en) 2021-07-08 2021-08-25 Pollinner Ltd Nasal spray
EP4130258A1 (en) 2021-08-02 2023-02-08 Evonik Operations GmbH Microorganisms displaying viral decoy receptors
WO2023031929A1 (en) * 2021-08-31 2023-03-09 Polyrizon Ltd. Mucoadhesive polymers for nasal drug delivery
CN114264530B (zh) * 2021-12-30 2023-05-05 重庆市畜牧科学院 一种基于Avicel的病毒蚀斑测定方法及其应用
CN114395538A (zh) * 2022-01-19 2022-04-26 和元生物技术（上海）股份有限公司 一种促进重组病毒载体向细胞外分泌的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783446A (en) 1985-11-22 1988-11-08 Neushul Mariculture Incorporated Method for the treatment of AIDS virus and other retroviruses
EP0293826A3 (en) 1987-06-02 1989-05-10 Stichting REGA V.Z.W. Therapeutic and prophylactic application of sulfated polysaccharides against aids
CH680265A5 (en) * 1990-06-25 1992-07-31 Madeleine Luescher Mattli Dr Polyanionic cpds. for treatment of myxo- and para-myxo-virus diseases - effective against e.g. influenza, measles, mumps and distemper and use e.g. a sulphonated polysaccharide
AU1052492A (en) * 1991-01-31 1992-08-06 Farmitalia Carlo Erba S.R.L. Synergistic composition comprising a fibroblast growth factor and a sulfated polylsaccharide, for use as antiviral agent
WO1994015624A1 (en) * 1993-01-08 1994-07-21 The Population Council Use of sulphated polysaccharides for preventing sexually transmitted diseases
US5658893A (en) * 1995-03-29 1997-08-19 Abbott Laboratories Method for inhibition of rotavirus infection with carrageenan
ATE227571T1 (de) 1996-08-12 2002-11-15 Merck & Co Inc Thrombin inhibitoren
US6391452B1 (en) * 1997-07-18 2002-05-21 Bayer Corporation Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations
JPH1180003A (ja) 1997-09-16 1999-03-23 Yakult Honsha Co Ltd 感染症予防・治療剤
DE19961307A1 (de) 1999-12-18 2001-07-12 Krewel Meuselbach Gmbh Medizinprodukt zur Befeuchtung und Reinigung der Nasenschleimhaut
JP2001181188A (ja) * 1999-12-28 2001-07-03 Marine Biotechnol Inst Co Ltd インフルエンザウイルス感染阻害剤
FR2808687B1 (fr) 2000-04-27 2003-12-05 Goemar Lab Sa Medicament contenant des substances polysaccharidiques pour l'activation de l'apoptose
ATE308329T1 (de) 2000-06-30 2005-11-15 Polydex Pharma Verwendung von cellulosesulfat und andere sulfatierte polysaccharide zu vorbeugung und behandlung von pappiloma-virus-infektionen
DE10051955A1 (de) * 2000-10-20 2002-05-02 Wella Ag Haarbehandlungsmittel in Form eines festen und formstabilen Gels
JP2003081841A (ja) 2001-06-26 2003-03-19 Kikkoman Corp 抗アレルギー体質強化剤
US20030181416A1 (en) * 2002-01-10 2003-09-25 Comper Wayne D. Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
AU2003245252A1 (en) * 2002-04-30 2003-11-17 Fmc Corporation Carrageenan based antimicrobial compositions
KR20050105490A (ko) * 2003-02-26 2005-11-04 오츠카 세이야쿠 가부시키가이샤 경폐 투여용 서방성 제제학적 조성물
US20050009782A1 (en) 2003-07-09 2005-01-13 Comper Wayne D. Antiviral charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and methods of use thereof
WO2006003521A1 (en) 2004-02-06 2006-01-12 Monash University High dose, short interval use of sulfated polysaccharides for the treatment of infections
US20080184618A1 (en) * 2005-08-03 2008-08-07 Amcol International Virus-Interacting Layered Phyllosilicates and Methods of Use
US20080241271A1 (en) * 2006-11-08 2008-10-02 Roman Stephen B Foaming anti-adhesion composition

Also Published As

Publication number Publication date
ES2406684T3 (es) 2013-06-07
CN101784272B (zh) 2014-03-12
MA31748B1 (fr) 2010-10-01
JP5647518B2 (ja) 2014-12-24
EP2178533B1 (en) 2013-03-27
KR20100045468A (ko) 2010-05-03
HK1144558A1 (en) 2011-02-25
CY1113949T1 (el) 2016-07-27
PL2178533T3 (pl) 2013-08-30
CA2696009C (en) 2016-08-02
ZA201000951B (en) 2011-04-28
US20110059919A1 (en) 2011-03-10
KR101571571B1 (ko) 2015-11-24
WO2009027057A1 (en) 2009-03-05
CA2696009A1 (en) 2009-03-05
TN2010000086A1 (en) 2011-09-26
EP2178533A1 (en) 2010-04-28
US10342820B2 (en) 2019-07-09
DK2178533T3 (da) 2013-05-27
AU2008291290A1 (en) 2009-03-05
MX2010001986A (es) 2010-03-11
NO20100097L (no) 2010-03-24
EA018138B1 (ru) 2013-05-30
MY153900A (en) 2015-04-15
BRPI0815748A2 (pt) 2015-02-18
BRPI0815748B1 (pt) 2019-04-24
SI2178533T1 (sl) 2013-07-31
PT2178533E (pt) 2013-06-03
NZ583511A (en) 2012-02-24
JP2011512319A (ja) 2011-04-21
BRPI0815748B8 (pt) 2021-05-25
CN101784272A (zh) 2010-07-21
HRP20130402T1 (hr) 2013-06-30
IL203444A (en) 2015-05-31
US20120237572A1 (en) 2012-09-20
UA102673C2 (ru) 2013-08-12
AP2010005170A0 (en) 2010-02-28
AP2630A (en) 2013-03-28

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