EA200602183A1 - Биспецифичные гибридные антитела с увеличенным периодом полувыведения из сыворотки - Google Patents

Биспецифичные гибридные антитела с увеличенным периодом полувыведения из сыворотки

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Publication number
EA200602183A1
EA200602183A1 EA200602183A EA200602183A EA200602183A1 EA 200602183 A1 EA200602183 A1 EA 200602183A1 EA 200602183 A EA200602183 A EA 200602183A EA 200602183 A EA200602183 A EA 200602183A EA 200602183 A1 EA200602183 A1 EA 200602183A1
Authority
EA
Eurasian Patent Office
Prior art keywords
serum
extraction
hybrid antibodies
increased period
hybrids
Prior art date
Application number
EA200602183A
Other languages
English (en)
Other versions
EA012622B1 (ru
Inventor
Люси Дж. Холт
Ян М. Томлинсон
Original Assignee
Домэнтис Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Домэнтис Лимитед filed Critical Домэнтис Лимитед
Publication of EA200602183A1 publication Critical patent/EA200602183A1/ru
Publication of EA012622B1 publication Critical patent/EA012622B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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Abstract

Предложены лекарственные композиции, гибриды и конъюгаты. Лекарственные гибриды и конъюгаты содержат терапевтический или диагностический агент, который слит или конъюгирован с антиген-связывающим фрагментом антитела, которое связывает сывороточный альбумин. Лекарственные композиции, гибриды и конъюгаты имеют более продолжительный период полувыведения in vivo по сравнению с неконъюгированным или неслитым терапевтическим или диагностическим агентом.
EA200602183A 2004-06-01 2005-05-31 Биспецифичные гибридные антитела с увеличенным периодом полувыведения из сыворотки EA012622B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57627104P 2004-06-01 2004-06-01
US63236104P 2004-12-02 2004-12-02
PCT/GB2005/002163 WO2005118642A2 (en) 2004-06-01 2005-05-31 Bispecific fusion antibodies with enhanced serum half-life

Publications (2)

Publication Number Publication Date
EA200602183A1 true EA200602183A1 (ru) 2007-06-29
EA012622B1 EA012622B1 (ru) 2009-10-30

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EA200602183A EA012622B1 (ru) 2004-06-01 2005-05-31 Биспецифичные гибридные антитела с увеличенным периодом полувыведения из сыворотки

Country Status (12)

Country Link
US (2) US8921528B2 (ru)
EP (2) EP2740743A3 (ru)
JP (2) JP2008500830A (ru)
KR (2) KR20070039911A (ru)
AU (1) AU2005250216B2 (ru)
BR (1) BRPI0511755A (ru)
CA (1) CA2569240A1 (ru)
EA (1) EA012622B1 (ru)
IL (1) IL179633A0 (ru)
MX (1) MXPA06014031A (ru)
TW (1) TW200607523A (ru)
WO (1) WO2005118642A2 (ru)

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