EA200000770A1 - Антивирусные соединения - Google Patents

Антивирусные соединения

Info

Publication number
EA200000770A1
EA200000770A1 EA200000770A EA200000770A EA200000770A1 EA 200000770 A1 EA200000770 A1 EA 200000770A1 EA 200000770 A EA200000770 A EA 200000770A EA 200000770 A EA200000770 A EA 200000770A EA 200000770 A1 EA200000770 A1 EA 200000770A1
Authority
EA
Eurasian Patent Office
Prior art keywords
virus
connections
compounds
alkyl
formula
Prior art date
Application number
EA200000770A
Other languages
English (en)
Other versions
EA003327B1 (ru
Inventor
Кристер Сальберг
Рольф Нореен
Марита Хегберг
Пер Энгельхардт
Original Assignee
Медивир Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9800113A external-priority patent/SE9800113D0/xx
Priority claimed from SE9800116A external-priority patent/SE9800116D0/xx
Application filed by Медивир Аб filed Critical Медивир Аб
Publication of EA200000770A1 publication Critical patent/EA200000770A1/ru
Publication of EA003327B1 publication Critical patent/EA003327B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Соединения, имеющие формулу (I)где Rявляется цианогруппой или атомом брома; Rявляется атомом галогена; Rявляется C-Cалкилом, и фармацевтически приемлемые соли этих соединений и их пролекарства, обладающие антиретровирусной активностью.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000770A 1998-01-16 1999-01-15 Антивирусные соединения EA003327B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9800113A SE9800113D0 (sv) 1998-01-16 1998-01-16 Antivirals II
SE9800116A SE9800116D0 (sv) 1998-01-16 1998-01-16 Antivirals I
PCT/SE1999/000053 WO1999036406A1 (en) 1998-01-16 1999-01-15 Antivirals

Publications (2)

Publication Number Publication Date
EA200000770A1 true EA200000770A1 (ru) 2000-12-25
EA003327B1 EA003327B1 (ru) 2003-04-24

Family

ID=26663191

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000770A EA003327B1 (ru) 1998-01-16 1999-01-15 Антивирусные соединения

Country Status (26)

Country Link
US (2) US6486183B1 (ru)
EP (1) EP1054867B1 (ru)
JP (1) JP4488621B2 (ru)
KR (1) KR100566445B1 (ru)
CN (2) CN1522698A (ru)
AR (1) AR016169A1 (ru)
AT (1) ATE264305T1 (ru)
AU (1) AU739766B2 (ru)
BR (1) BR9906933A (ru)
CA (1) CA2318694C (ru)
CZ (1) CZ299387B6 (ru)
DE (1) DE69916425T2 (ru)
DK (1) DK1054867T3 (ru)
EA (1) EA003327B1 (ru)
ES (1) ES2220039T3 (ru)
HK (1) HK1036280A1 (ru)
HU (1) HU228886B1 (ru)
IL (1) IL137196A0 (ru)
MY (1) MY129292A (ru)
NZ (1) NZ505543A (ru)
PL (1) PL191832B1 (ru)
PT (1) PT1054867E (ru)
SK (1) SK285779B6 (ru)
TR (1) TR200002058T2 (ru)
TW (1) TW470645B (ru)
WO (1) WO1999036406A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1522698A (zh) * 1998-01-16 2004-08-25 ά 抗病毒药物
WO1999051613A1 (en) * 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
SE0100733D0 (sv) * 2001-03-05 2001-03-05 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
SE0102867D0 (sv) 2001-08-28 2001-08-28 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
SG149070A1 (en) 2004-01-08 2009-01-29 Medivir Ab Non-nucleotide reverse transcriptase inhibitors
ES2352216T3 (es) * 2005-08-31 2011-02-16 Cipla Limited Combinaciones farmacéuticas que contienen lamivudina, estavudina y nevirapina.
US7302330B1 (en) * 2006-09-01 2007-11-27 Gm Global Technology Operations, Inc. Torque converter clutch dynamic control
GB0623258D0 (en) 2006-11-22 2007-01-03 Remynd Nv Thiadiazole derivatives for the treatment of neuro-degenerative diseases
HUE037937T2 (hu) * 2010-07-29 2021-11-29 Oryzon Genomics Sa Arilciklopropilamin-alapú LSD1-demetiláz inhibitorok és gyógyászati alkalmazásuk
JP2015509524A (ja) 2012-03-05 2015-03-30 シプラ・リミテッド ラミブジン、フェスティナビルおよびネビラピンを含んでなる抗レトロウイルス医薬組成物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69414708T2 (de) * 1993-08-24 1999-04-15 Medivir Ab Verbindungen und methoden zur inhibition von hiv und verwandten viren
US5849769A (en) * 1994-08-24 1998-12-15 Medivir Ab N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection
CN1522698A (zh) * 1998-01-16 2004-08-25 ά 抗病毒药物

Also Published As

Publication number Publication date
HUP0100432A2 (hu) 2001-07-30
CA2318694C (en) 2009-10-27
CZ20002604A3 (en) 2001-05-16
BR9906933A (pt) 2001-11-27
PL191832B1 (pl) 2006-07-31
AR016169A1 (es) 2001-06-20
EP1054867A1 (en) 2000-11-29
ATE264305T1 (de) 2004-04-15
CN1158261C (zh) 2004-07-21
DE69916425D1 (de) 2004-05-19
JP4488621B2 (ja) 2010-06-23
EA003327B1 (ru) 2003-04-24
DK1054867T3 (da) 2004-08-09
TW470645B (en) 2002-01-01
AU2445099A (en) 1999-08-02
SK285779B6 (sk) 2007-08-02
CA2318694A1 (en) 1999-07-22
JP2002509137A (ja) 2002-03-26
CN1522698A (zh) 2004-08-25
IL137196A0 (en) 2001-07-24
AU739766B2 (en) 2001-10-18
CN1292781A (zh) 2001-04-25
ES2220039T3 (es) 2004-12-01
SK10332000A3 (sk) 2002-04-04
KR20010034194A (ko) 2001-04-25
DE69916425T2 (de) 2005-05-19
TR200002058T2 (tr) 2001-05-21
WO1999036406A1 (en) 1999-07-22
NZ505543A (en) 2002-09-27
PL341819A1 (en) 2001-05-07
HUP0100432A3 (en) 2002-12-28
CZ299387B6 (cs) 2008-07-09
HK1036280A1 (en) 2001-12-28
KR100566445B1 (ko) 2006-03-31
US7148243B2 (en) 2006-12-12
US20030119881A1 (en) 2003-06-26
MY129292A (en) 2007-03-30
HU228886B1 (en) 2013-06-28
PT1054867E (pt) 2004-09-30
US6486183B1 (en) 2002-11-26
EP1054867B1 (en) 2004-04-14

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU