DE69916425D1 - Antivirale mittel - Google Patents

Antivirale mittel

Info

Publication number
DE69916425D1
DE69916425D1 DE69916425T DE69916425T DE69916425D1 DE 69916425 D1 DE69916425 D1 DE 69916425D1 DE 69916425 T DE69916425 T DE 69916425T DE 69916425 T DE69916425 T DE 69916425T DE 69916425 D1 DE69916425 D1 DE 69916425D1
Authority
DE
Germany
Prior art keywords
antiviral agents
antiviral
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69916425T
Other languages
English (en)
Other versions
DE69916425T2 (de
Inventor
Christer Sahlberg
Rolf Noreen
Marita Hoegberg
Per Engelhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivir AB
Original Assignee
Medivir AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9800113A external-priority patent/SE9800113D0/xx
Priority claimed from SE9800116A external-priority patent/SE9800116D0/xx
Application filed by Medivir AB filed Critical Medivir AB
Application granted granted Critical
Publication of DE69916425D1 publication Critical patent/DE69916425D1/de
Publication of DE69916425T2 publication Critical patent/DE69916425T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
    • C07D213/85Nitriles in position 3
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69916425T 1998-01-16 1999-01-15 Antivirale mittel Expired - Lifetime DE69916425T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9800113A SE9800113D0 (sv) 1998-01-16 1998-01-16 Antivirals II
SE9800116 1998-01-16
SE9800113 1998-01-16
SE9800116A SE9800116D0 (sv) 1998-01-16 1998-01-16 Antivirals I
PCT/SE1999/000053 WO1999036406A1 (en) 1998-01-16 1999-01-15 Antivirals

Publications (2)

Publication Number Publication Date
DE69916425D1 true DE69916425D1 (de) 2004-05-19
DE69916425T2 DE69916425T2 (de) 2005-05-19

Family

ID=26663191

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69916425T Expired - Lifetime DE69916425T2 (de) 1998-01-16 1999-01-15 Antivirale mittel

Country Status (26)

Country Link
US (2) US6486183B1 (de)
EP (1) EP1054867B1 (de)
JP (1) JP4488621B2 (de)
KR (1) KR100566445B1 (de)
CN (2) CN1522698A (de)
AR (1) AR016169A1 (de)
AT (1) ATE264305T1 (de)
AU (1) AU739766B2 (de)
BR (1) BR9906933A (de)
CA (1) CA2318694C (de)
CZ (1) CZ299387B6 (de)
DE (1) DE69916425T2 (de)
DK (1) DK1054867T3 (de)
EA (1) EA003327B1 (de)
ES (1) ES2220039T3 (de)
HK (1) HK1036280A1 (de)
HU (1) HU228886B1 (de)
IL (1) IL137196A0 (de)
MY (1) MY129292A (de)
NZ (1) NZ505543A (de)
PL (1) PL191832B1 (de)
PT (1) PT1054867E (de)
SK (1) SK285779B6 (de)
TR (1) TR200002058T2 (de)
TW (1) TW470645B (de)
WO (1) WO1999036406A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100566445B1 (ko) * 1998-01-16 2006-03-31 메디비르 아베 항바이러스제
WO1999051613A1 (en) * 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
SE0100733D0 (sv) * 2001-03-05 2001-03-05 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
SE0102867D0 (sv) 2001-08-28 2001-08-28 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
US7915295B2 (en) * 2004-01-08 2011-03-29 Medivir Ab Non-nucleotide reverse transcriptase inhibitors
WO2007026156A1 (en) * 2005-08-31 2007-03-08 Cipla Limited Pharmaceutical combinations containing lamivudine, stavudine and nevirapine
US7302330B1 (en) * 2006-09-01 2007-11-27 Gm Global Technology Operations, Inc. Torque converter clutch dynamic control
GB0623258D0 (en) 2006-11-22 2007-01-03 Remynd Nv Thiadiazole derivatives for the treatment of neuro-degenerative diseases
EP2598482B1 (de) * 2010-07-29 2018-04-04 Oryzon Genomics, S.A. Arylcyclopropylaminbasierte lsd1-demethylasehemmer und ihre medizinische verwendung
AU2013229274A1 (en) 2012-03-05 2014-09-04 Cipla Limited Pharmaceutical antiretroviral combinations comprising lamivudine, festinavir and nevirapine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0706514T3 (da) * 1993-08-24 1999-08-02 Medivir Ab Forbindelser og fremgangsmåder til inhibering af HIV og relaterede vira
US5849769A (en) * 1994-08-24 1998-12-15 Medivir Ab N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection
KR100566445B1 (ko) * 1998-01-16 2006-03-31 메디비르 아베 항바이러스제

Also Published As

Publication number Publication date
TW470645B (en) 2002-01-01
AR016169A1 (es) 2001-06-20
PT1054867E (pt) 2004-09-30
HK1036280A1 (en) 2001-12-28
DE69916425T2 (de) 2005-05-19
CN1158261C (zh) 2004-07-21
JP2002509137A (ja) 2002-03-26
JP4488621B2 (ja) 2010-06-23
CN1522698A (zh) 2004-08-25
PL341819A1 (en) 2001-05-07
HUP0100432A3 (en) 2002-12-28
US6486183B1 (en) 2002-11-26
ATE264305T1 (de) 2004-04-15
MY129292A (en) 2007-03-30
HU228886B1 (en) 2013-06-28
AU739766B2 (en) 2001-10-18
CA2318694A1 (en) 1999-07-22
EP1054867B1 (de) 2004-04-14
EA200000770A1 (ru) 2000-12-25
CA2318694C (en) 2009-10-27
AU2445099A (en) 1999-08-02
WO1999036406A1 (en) 1999-07-22
DK1054867T3 (da) 2004-08-09
NZ505543A (en) 2002-09-27
EP1054867A1 (de) 2000-11-29
CN1292781A (zh) 2001-04-25
KR20010034194A (ko) 2001-04-25
CZ299387B6 (cs) 2008-07-09
TR200002058T2 (tr) 2001-05-21
HUP0100432A2 (hu) 2001-07-30
US20030119881A1 (en) 2003-06-26
PL191832B1 (pl) 2006-07-31
CZ20002604A3 (en) 2001-05-16
US7148243B2 (en) 2006-12-12
IL137196A0 (en) 2001-07-24
BR9906933A (pt) 2001-11-27
KR100566445B1 (ko) 2006-03-31
ES2220039T3 (es) 2004-12-01
EA003327B1 (ru) 2003-04-24
SK285779B6 (sk) 2007-08-02
SK10332000A3 (sk) 2002-04-04

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition