EA199800662A1 - Индукторы апоптоза - Google Patents

Индукторы апоптоза

Info

Publication number
EA199800662A1
EA199800662A1 EA199800662A EA199800662A EA199800662A1 EA 199800662 A1 EA199800662 A1 EA 199800662A1 EA 199800662 A EA199800662 A EA 199800662A EA 199800662 A EA199800662 A EA 199800662A EA 199800662 A1 EA199800662 A1 EA 199800662A1
Authority
EA
Eurasian Patent Office
Prior art keywords
apoptosis
fucose
cleavage
inductors
polysaccharide
Prior art date
Application number
EA199800662A
Other languages
English (en)
Other versions
EA003902B1 (ru
Inventor
Такеси Сакай
Хидео Китано
Фу-Гонг Ю
Синдзи Накаяма
Каору Кодзима
Хитоми Кимура
Йосикуни Наканиси
Каору Катаяма
Икуносин Като
Таканари Томинага
Казуо Симанака
Кацусиге Икай
Original Assignee
Такара Сузо Ко., Лтд
Рисерч Инститьют Фор Гликотекнолоджи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Такара Сузо Ко., Лтд, Рисерч Инститьют Фор Гликотекнолоджи filed Critical Такара Сузо Ко., Лтд
Publication of EA199800662A1 publication Critical patent/EA199800662A1/ru
Publication of EA003902B1 publication Critical patent/EA003902B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01078—Mannan endo-1,4-beta-mannosidase (3.2.1.78), i.e. endo-beta-mannanase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/2488—Mannanases
    • C12N9/2494—Mannan endo-1,4-beta-mannosidase (3.2.1.78), i.e. endo-beta-mannanase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01044—Fucoidanase (3.2.1.44)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Индукторы апоптоза, противораковые лекарственные средства и канцеростатические лекарственные средства, содержащие сульфированный(ые) фукозусодержащий(ие) полисахарид(ы) и/или продукты его(их) расщепления, и способ индуцирования апоптоза путем использования сульфированного(ых) фукозусодержащего(их) полисахарида(ов) и/или продукта(ов) его(их) расщепления в качестве активного ингредиента. Расщепляющий фермент, который используют для получения продуктов расщепления сульфированных фукозусодержащих полисахаридов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800662A 1996-01-26 1997-01-21 Индукторы апоптоза, содержащие их противораковые и канцеростатические средства, способ индуцирования апоптоза, полисахариды и способы их получения EA003902B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP3118796 1996-01-26
JP4558396 1996-02-08
JP4559396 1996-02-08
JP17165896 1996-06-12
JP20418796 1996-07-16
PCT/JP1997/000116 WO1997026896A1 (en) 1996-01-26 1997-01-21 Apoptosis inducers

Publications (2)

Publication Number Publication Date
EA199800662A1 true EA199800662A1 (ru) 1999-02-25
EA003902B1 EA003902B1 (ru) 2003-10-30

Family

ID=27521306

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199800662A EA003902B1 (ru) 1996-01-26 1997-01-21 Индукторы апоптоза, содержащие их противораковые и канцеростатические средства, способ индуцирования апоптоза, полисахариды и способы их получения
EA200300499A EA005580B1 (ru) 1996-01-26 1997-01-21 Фермент, расщепляющий эндосульфированные фукозусодержащие полисахариды, способ его получения и содержащая его композиция

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200300499A EA005580B1 (ru) 1996-01-26 1997-01-21 Фермент, расщепляющий эндосульфированные фукозусодержащие полисахариды, способ его получения и содержащая его композиция

Country Status (9)

Country Link
US (2) US6207652B1 (ru)
EP (1) EP0919237A4 (ru)
JP (1) JP3555766B2 (ru)
KR (2) KR100555845B1 (ru)
CN (2) CN1150003C (ru)
AU (1) AU720004B2 (ru)
CA (1) CA2243543A1 (ru)
EA (2) EA003902B1 (ru)
WO (1) WO1997026896A1 (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1735097A (en) * 1996-03-15 1997-10-01 Takara Shuzo Co., Ltd. A product of heat treatment of uronic acid, food, drink or drug including the product
US6573250B2 (en) * 1996-06-12 2003-06-03 Takara Shuzo Co., Ltd. Food or beverage additive containing fucoidan and food and beverage containing fucoidan
WO1999041288A1 (fr) * 1998-02-17 1999-08-19 Takara Shuzo Co., Ltd. Saccharides sulfates
CN1637146A (zh) 1998-04-23 2005-07-13 宝生物工程株式会社 Dna的合成方法
KR100601330B1 (ko) * 1999-02-23 2006-07-14 다카라 바이오 가부시키가이샤 황산화 푸코갈락탄
EP1175907A4 (en) * 1999-04-15 2004-12-29 Takara Bio Inc REMEDIES
KR100641977B1 (ko) * 1999-06-11 2006-11-02 다카라 바이오 가부시키가이샤 항푸코이단 항체
WO2001013925A1 (fr) * 1999-08-20 2001-03-01 Takara Shuzo Co., Ltd. Medicaments
CN100480381C (zh) * 2000-04-21 2009-04-22 宝生物工程株式会社 硫酸化葡糖醛酸岩藻聚糖
CA2412600C (en) * 2000-07-10 2011-09-27 The University Of Mississippi Potent immunostimulatory polysaccharides extracted from microalgae
AU2001269508A1 (en) * 2000-07-13 2002-01-30 Takara Bio Inc. Drugs or cosmetics
EP1327448A4 (en) * 2000-09-13 2005-06-15 Takara Bio Inc AGENTS MAINTAINING HOMEOSTASE
KR20040008145A (ko) * 2001-04-18 2004-01-28 다카라 바이오 가부시키가이샤 황산화 푸코글루쿠로노만난
EP1424396A4 (en) 2001-09-05 2006-08-16 Takara Bio Inc GENE OF THE ENZYME OF DIGESTION OF FUCOGALACTANE SULFATE
EP1306389B1 (en) 2001-10-24 2004-12-29 Takara Bio Inc. Sulfated fucan oligosaccharide
US20050255564A1 (en) * 2002-01-18 2005-11-17 Takara Bio Inc Sulfated fucan
AU2003242486A1 (en) * 2002-06-20 2004-01-06 Takara Bio Inc. Enzyme for decomposition of sulfated fucan derived from sea cucumber
US20040254357A1 (en) * 2002-12-19 2004-12-16 Zaloga Gary P. Fatty acid phenolic conjugates
JP5679663B2 (ja) * 2007-02-23 2015-03-04 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 海藻抽出物からのフコイダン精製のためのプロセスの方法
JP5819189B2 (ja) * 2009-03-25 2015-11-18 国立大学法人鳥取大学 軟骨生成促進剤および軟骨損傷由来疾病の予防治療剤
EP3417865A1 (en) 2011-07-19 2018-12-26 Baxalta GmbH Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides
EP3594686A3 (en) 2012-08-14 2020-04-08 Baxalta GmbH Methods and systems for screening compositions comprising non-anticoagulant sulfated polysaccharides
CN103880975B (zh) * 2014-04-03 2015-10-21 中国海洋大学 一种岩藻聚糖硫酸酯及其制备方法和在制备抗流感病毒药物中的应用
CN105924480B (zh) * 2016-05-10 2018-09-25 浙江大学 含岩藻糖三糖硫酸酯及其制备方法和应用
CN109055460B (zh) * 2018-09-13 2021-06-29 青岛创通生物科技有限公司 一种低分子量岩藻多糖及其在制备化妆品中的应用
CN111217932A (zh) * 2020-02-25 2020-06-02 浙江工业大学 一种裙带菜硫酸化多糖及其应用
CN112553162B (zh) * 2020-12-15 2023-01-13 湖北盛齐安生物科技股份有限公司 细胞凋亡诱导剂和载药囊泡及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6158587A (ja) * 1984-08-30 1986-03-25 Seitetsu Kagaku Co Ltd α−Ｌ−フコシダ−ゼおよびその製造方法
JPS62155086A (ja) * 1985-12-26 1987-07-10 Takara Shuzo Co Ltd α−Ｌ−フコシダ−ゼの製造法
FR2605185B1 (fr) * 1986-10-17 1993-08-20 Meiji Seika Kaisha Procede de culture des plantes
IL85145A (en) * 1987-01-23 1994-08-26 Univ Australian Anti-metastatic pharmacological or veterinary preparations containing modified herpin with reduced anticoagulant activity
US5519010A (en) * 1989-02-06 1996-05-21 Taiho Pharmaceutical Co., Ltd. Sulfated polysaccharide, pharmaceutically acceptable salt thereof, process for preparing same and medicament containing same as effective component
AU620218B2 (en) * 1989-02-10 1992-02-13 Taiho Pharmaceutical Co., Ltd. Anti-hiv drug
FR2648463B1 (fr) * 1989-06-14 1993-01-22 Inst Fs Rech Expl Mer Polysaccharides sulfates, agent anticoagulant et agent anticomplementaire obtenus a partir de fucanes d'algues brunes et leur procede d'obtention
JPH0349682A (ja) * 1989-07-18 1991-03-04 Sumitomo Seika Chem Co Ltd 新規なα―Ｌ―フコシダーゼおよびその製造方法
JPH0398583A (ja) * 1989-09-12 1991-04-24 Takara Shuzo Co Ltd 新規α―Ｌ―フコシダーゼ
JPH0491027A (ja) * 1990-08-02 1992-03-24 Taiho Yakuhin Kogyo Kk 抗ヒト免疫不全症ウィルス剤
JPH04126078A (ja) * 1990-09-14 1992-04-27 Sumitomo Seika Chem Co Ltd 新規なα―Ｌ―フコシダーゼおよびその製造法
JPH0662852A (ja) * 1992-08-21 1994-03-08 Tousa Kogaku Kenkyusho:Kk フコイダン分解酵素
JP3403496B2 (ja) * 1993-09-24 2003-05-06 株式会社ヤクルト本社 抗潰瘍剤およびヘリコバクター・ピロリの定着阻害剤
JP3714426B2 (ja) * 1994-02-01 2005-11-09 株式会社糖鎖工学研究所 フコイダンオリゴ糖組成物含有癌転移抑制剤
JPH08266A (ja) * 1994-06-15 1996-01-09 Tousa Kogaku Kenkyusho:Kk フコース硫酸遊離酵素及びその製造方法
US6054577A (en) * 1995-04-28 2000-04-25 Takara Shuzo Co., Ltd. Oligosaccharides from enzymatic cleavage of fucoidan
EP0884383A4 (en) * 1996-02-29 2001-12-05 Takara Shuzo Co METHOD FOR CLEANING AND REMOVING VIRUSES.
CA2253573C (en) * 1996-06-12 2005-12-06 Takara Shuzo Co., Ltd. Fucoidan-containing foods or beverages
WO1998001537A1 (fr) * 1996-07-10 1998-01-15 Takara Shuzo Co., Ltd. Compositions cellulaires
JP4091027B2 (ja) * 2004-03-19 2008-05-28 富士通株式会社 光変調器の駆動方法、並びに、それを用いた光送信機および光伝送システム

Also Published As

Publication number Publication date
KR100555845B1 (ko) 2006-11-23
US6207652B1 (en) 2001-03-27
JP3555766B2 (ja) 2004-08-18
CN1209749A (zh) 1999-03-03
KR19990072022A (ko) 1999-09-27
US6593311B2 (en) 2003-07-15
EP0919237A1 (en) 1999-06-02
US20010034335A1 (en) 2001-10-25
KR20050044909A (ko) 2005-05-13
CA2243543A1 (en) 1997-07-31
CN1150003C (zh) 2004-05-19
EA003902B1 (ru) 2003-10-30
KR100555844B1 (ko) 2006-12-13
EP0919237A4 (en) 2004-10-13
CN1528340A (zh) 2004-09-15
EA200300499A1 (ru) 2003-08-28
CN100406023C (zh) 2008-07-30
AU1399997A (en) 1997-08-20
WO1997026896A1 (en) 1997-07-31
EA005580B1 (ru) 2005-04-28
AU720004B2 (en) 2000-05-18

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Designated state(s): AM AZ BY KZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU